• The Journal of the Society of Korean Medicine Diagnostics
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• v.14 no.1
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• pp.57-69
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• 2010

Background: This is a study for building up the database foundation and about graphic structures of Ontology Network systems of Taeyangbyung compilation in Sanghannon in Traditonal Korean Medicine. Therefore, we began to this study about the systematic clinical ontology network systems with priority given to symptoms of Taeyangbyung compilation in Sanghannon. Purpose: We have two goals to carry out this study. The first, we will establish the minimum clinical grouping data sets about symptoms of Taeyangbyung compilation in Sanghannon. The second, we will find out graphic structures of ontology network system in this part, and analysis that. Methods: Through MS office Excel, Access and Netminer software, we will construct the minimum clinical grouping data sets and the graphic structures of ontology network system about symptoms of Taeyangbyung compilation in Sanghannon, and analysis that. Results: We established the minimum clinical grouping data sets about symptoms of Taeyangbyung compilation in Sanghannon through MS Excel and Access software, and constructed the ontology images to structurize our database through Netminer program, and analysis that. Conclusions: Further research about ontology network between symptoms and prescription and three Yang and three Um(Taeyang, Soyang, Yangmyung, Taeum, Soum, Gualum) Disease compilation is necessary.

• Journal of Sasang Constitutional Medicine
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• v.35 no.4
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• pp.42-54
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• 2023

Objectives This study aims to identify differences in clinical manifestations of COVID-19 between different Sasang constitution. Methods Subjects were recruited from August 29, 2022, to July 11, 2023. COVID-19 clinical symptoms were self-reported via questionnaires. Sasang constitutional diagnosis was performed using the K-PRISM, and Sasang constitutional specialist. Results A total of 66 subjects were recruited for the study, and the Sasang constitutional distribution of the subjects was 19 soyangin, 25 taeeumin, and 22 soeumin. For most of the COVID-19 clinical manifestations, the study found that soyangin experienced symptoms at a higher rate than other constitutions. Among the symptoms observed in the study, sore throat, pantalgia, and cough were severe in all subjects regardless of constitution. Soeumin was more likely to experience abdominal pain, chest pain, and diarrhea, while soyangin was more likely to experience chest pain, nausea/vomiting, diarrhea, and cutaneous symptoms compared to other constitutions. Taeeumin had more sputm, nasal congestion, and skin symptoms, but fewer digestive symptoms. There were differences in the onset and duration of symptoms by constitution. Conclusions This study is an important contribution to our understanding of the differences in response to the COVID-19 virus among different Sasang constitutions. Symptomatic differences between constitutions may have important implications for prevention and treatment strategies for infectious diseases, and personalized treatment and management based on these differences may be needed in the future.

• Journal of Oriental Neuropsychiatry
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• v.22 no.3
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• pp.115-125
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• 2011

Objectives : This study was aimed to review the trend of clinical studies in Journal of Oriental Neuropsychiatry since 2001 to 2010. Methods : We collected 260 clinical studies and analyzed them for publish year, sorts of disease or symptoms, pattern identification diagnosis, and classification of clinical studies. Among them, we selected 46 clinical experimental studies and these studies were further analyzed for publish year, research institution, sort of disease or symptoms, sorts of treatments, number of subject, and pattern identification diagnosis. Results : The number of clinical studies in Journal of Oriental Neuropsychiatry have increased since the year of 2001. There were 62 kinds of diseases and symptoms and Hwa-Byung had the highest number of studies followed by depression, headache, insomnia and so on. The clinical experimental studies, which took up 17% of the clinical studies, have increased since 2001 and was varied with year. There were 13 reserch institutions for clinical experimental studies and they studied about stress, dementia, Hwa-Byung, and so on. Most of studies researched treatment about acupuncture, herb medicine, and meditation treatment for persons under 144. There are only 22% of studies using pattern identification diagnosis. Conclusions : For the development of oriental medicine for psychiatric disease, we need more qualifying clinical studies like RCT. We hope more researchers for psychiatry disease of oriental medicine will be interested in the publication of clinical studies and this will serve to produce advance of oriental medicine as evidence based medecine.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.2
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• pp.53-68
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• 2001

Purpose : This Study was conducted to evaluate clinical manifestations of abdominal pain(AP) in childhood according to its symptoms and to find out characteristic of children with abdominal pain. Methods : Pacients who visited Dong-Eui Oriental Medical hospital from August to November 2001 due to abdominal pain were included. According to questionaire and history taking abdominal pain was classified by its six subtype in the Oriental Pediatic Text Book and Dong Eui Bo Gam(東醫寶鑑). Result : According to the Oriental Pediatic Text Book, among 41 children, 31.7% had symptoms of AP caused by cold in internal organs of deficiency(臟腑虛冷腹痛), 29.3% had symptoms of AP caused by diet(食積腹痛), 19.5% had symptoms of AP caused by cold(寒腹痛), 9.8% had symptoms of AP caused by both cold and diet, 7.3% had symptoms of AP caused by internal diet and external cold(內食外寒腹痛), 2.4% had symptoms of AP caused by stagnation of Ki and stasis of blood(氣滯血瘀腹痛). There is no AP caused by parasites(蟲腹痛). Otherwise, according to Dong Eui Bo Gam, 43.9% had symptoms of AP caused by cold, 26.8% had symptoms of AP caused by diet, 9.8% had symptoms of AP caused by both cold and diet, 7.3% had symptoms of AP caused by fire(熱腹痛), 7.3% had symptoms of AP caused by phlegm(痰飮腹痛), 4.9% had symptoms of AP caused by stagnated blood(瘀血腹痛). Also There is no AP caused by parasites. Conclusion : 1. The type of AP in Childhood is different from AP in adults. AP in Childhood is most occured by cold of deficiency and food, and there is few AP caused by fire. Six subtype in Dong Eui Bo Gam prefer adults to children and It is more studied that what kind of subtype is proper for AP caused by stress or drugs. So the study on subclassification and clinical Manifestations of AP in Childhood is more performed.

• The Journal of Internal Korean Medicine
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• v.44 no.2
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• pp.231-243
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• 2023

Background: Diabetic polyneuropathy is the most common complication in diabetics, occurring in 50% of all cases. About 10-20% of all diabetics are accompanied by neurological pain, showing a tendency to increase with age. Clinical aspects are very diverse, from mild abnormalities on nerve conduction tests to severe abnormalities in all sensory, motor, and autonomic nerves; however, sensory symptoms usually precede motor symptoms. Patients typically express sensory symptoms, such as positive and negative symptoms, which decrease the quality of life and have marked clinical implications, such as increased morbidity and mortality. Although Western medical drugs, such as tricyclic antidepressants, anticonvulsants, and narcotic analgesics, are used for diabetic polyneuropathy, a standard treatment has not been established. Case report: A 65-year-old male with paresthesia and pain due to diabetic polyneuropathy was treated with Uchashinki-hwan, acupuncture, electroacupuncture, moxibustion, and Jungsongouhyul pharmacopuncture for 10 days. We used the Toronto Clinical Neuropathy Scoring System, EuroQol-5 Dimension, and Visual Analog Scale to evaluate symptoms. Subsequently, the Neuropathy Scoring System, EuroQol-5 Dimension, and subjective discomfort improved. Conclusion: The present case report suggests that combined Korean medicine treatment might be an effective treatment for paresthesia and pain with diabetic polyneuropathy. Several follow-up studies should be conducted to clarify the effectiveness of the treatment.

• The Journal of Korean Medicine
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• v.40 no.1
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• pp.1-11
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• 2019

Objectives: The aim of this study is to introduce the Clinical presentation and announce the importance of developing Clinical presentation of Korean medicine and suggest about development direction of Clinical presentation of Korean medicine. Methods: To Investigate the Clinical presentation used in western medicine. I think that Clinical presentation of Korean medicine is a systematic list of Korean medicine symptoms and a standard syndrome differentiation and treatment(辨證論治). So I would like to offer "PangYakHapPyon(方藥合編)" as a basis for developing Clinical presentation of Korean medicine. Results: The clinical presentation term has become widespread in use at Calgary Medical college. Calgary Medical college created a list of 120 clinical presentations In 1991. In Korea, 101 clinical presentations were made in 2016. "PangYakHapPyon(方藥合編)" has been used effectively for over 130 years and widely used in the public. In addition, "PangYakHapPyon(方藥合編)" is summarized in the symptoms and prescriptions that occur frequently in Korea. Conclusions: For the globalization and standardization of Korean medicine, Clinical presentation of Korean medicine should be developed. The overall form of Clinical presentation of Korean medicine uses the form of Clinical presentation of Canada and a standard syndrome differentiation and treatment(辨證論治) for diagnosis and treatment is based "PangYakHapPyon(方藥合編)".

• Journal of Korean Neurosurgical Society
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• v.50 no.4
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• pp.281-287
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• 2011

Objective : Pituitary apoplexy is life-threatening clinical syndrome caused by the rapid enlargement of a pituitary tumor due to hemorrhage and/or infarction. The pathogenesis of pituitary apoplexy is not completely understood. We analyzed the magnetic resonance imaging (MRI) of pituitary tumors and subsequently correlated the radiological findings with the clinical presentation. Additionally, immunohistochemistry was also performed to determine whether certain biomarkers are related to radiological apoplexy. Methods : Thirty-four cases of pituitary adenoma were enrolled for retrospective analysis. In this study, the radiological apoplexy was defined as cases where hemorrhage, infarction or cysts were identified on MRI. Acute clinical presentation was defined as the presence of any of the following symptoms: severe sudden onset headache, decreased visual acuity and/or visual field deficit, and acute mental status changes. Angiogenesis was quantified by immunohistochemical expression of fetal liver kinase 1 (Flk-1), neuropilin (NRP) and vascular endothelial growth factor (VEGF) expression, while microvascular density (MVD) was assessed using Endoglin and CD31. Results : Clinically, fourteen patients presented with acute symptoms and 20 for mild or none clinical symptoms. Radiologically, fifteen patients met the criteria for radiological apoplexy. Of the fifteen patients with radiologic apoplexy, 9 patients presented acute symptoms whereas of the 19 patient without radiologic apoplexy, 5 patients presented acute symptoms. Of the five biomarkers tracked, only VEGF was found to be positively correlated with both radiological and nonradiological apoplexy. Conclusion : While pituitary apoplexy is currently defined in cases where clinical symptoms can be histologically confirmed, we contend that cases of radiologically identified pituitary hemorrhages that present with mild or no symptoms should be designated subacute or subclinical apoplexy. VEGF is believed to have a positive correlation with pituitary hemorrhage. Considering the high rate of symptomatic or asymptomatic pituitary tumor hemorrhage, additional studies are needed to detect predictors of the pituitary hemorrhage.

• Journal of Acupuncture Research
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• v.39 no.4
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• pp.297-303
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• 2022

Background: This retrospective study aimed to determine whether there were correlations between the number and type of accompanying symptoms of peripheral facial nerve palsy, and surface electromyography (SEMG) and clinical assessment scales to help diagnosis. Methods: There were 30, cases of peripheral facial nerve palsy at Visit 1 to the Korean Medicine Hospital, Dong-eui University, 22 cases at Visit 2 and 10 cases at Visit 3. The study period was from July 19, 2021 to November 31, 2021. Symptoms were evaluated three times (with two-week intervals which began 7 days from onset) using SEMG, clinical assessment scales and accompanying symptoms. In this study, the House-Brackmann grading system (HBGS), and the Yanagihara's unweighted grading system (Y-score) clinical assessment scales were used. The Pearson or Spearman correlation was used for statistical analysis. Results: On Visit 1, the number of accompanying symptoms of peripheral facial nerve palsy had no significant correlation with other measures. On Visits 1-3, the HBGS score had a significant negative correlation with the Y-score. On Visit 2, most of the mean values measured had significant correlations with each other although not between SEMG-Z and SEMG-O that Z means a zygomaticus muscle and O means a orbicularis oris muscle. On Visit 3, the number of accompanying symptoms significantly correlated with the clinical assessment scales. The HBGS score, Y-score, and SEMG measurements (except SEMG-Z) had significant correlations with each other. A significant positive correlation between SEMG-Z and SEMG-T was noted. Conclusion: We predict accompanying symptoms can be used to diagnose the peripheral facial nerve palsy including both clinical assessment scales and SEMG measurements at 2-5 weeks after onset.

• Korean Journal of Clinical Pharmacy
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• v.34 no.2
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• pp.118-125
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• 2024

Background: Numerous studies have consistently demonstrated that depression can be associated with cognitive function decline, primarily focusing on older adults due to the neurodegenerative characteristics of dementia. With persistent depression frequently reported in patients with early-onset or young-onset dementia, this study aimed to assess the impact of depression, specifically the changes in depressive symptoms over time, on the risk of cognitive function decline in middle-aged adults in Korea. Methods: This retrospective study utilized data from the first four waves (2006-2012) of the Korean Longitudinal Study of Aging (KLoSA), focusing on middle-aged adults with normal cognitive function at baseline. Changes in depressive symptoms were categorized into four groups based on the CES-D score, and their association with cognitive function decline was evaluated using a multivariate logistic regression model. Results: Of the initial 10,254 participants, 3,400 were included in the analysis. Depressive status, particularly newly onset (adjusted odds ratio [aOR] 1.96; 95% confidence interval [CI] 1.32-2.93) and persistent depression groups (aOR 5.59; 95% CI 2.90-10.78), were significantly associated with cognitive function decline. In contrast, recovery from depressive symptoms was not significantly associated with cognitive function decline (p=0.809). Conclusions: Our study showed a significant association between changes in depressive symptoms and cognitive function decline in middle-aged Korean adults. This suggests that management of depressive symptoms could be crucial for the prevention of cognitive function decline in this population.

• Journal of Acupuncture Research
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• v.18 no.4
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• pp.22-31
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• 2001

Objective : This study is designed to evaluate the correlation between the data of DITI (Digital Infrared Thermographic Imaging) and the clinical symptoms in the patients with low back pain. Methods : Among the outpatients with back pain who visited to Department of Acupunture & Moxibustion, Tae gu Oriental Hopital of Kyung San University from January 2000 to August, we selected 115 cases that examined DITI. We evaluated the correlation between the data of DITI examination and the clinical symptoms (Distribution of Sex and Age, Duration of Disease, Main Sign, Grade of Clinical Symptoms, Diagnosis according to Symptoms(辨證),) in the patients with low back pain. Results & Conclusion : 1. The thermal changes in terms of the duration of disease : The acutest period has the highest thermal change. Also, the longer the duration of disease was, the higher the termal change was. It increased in the order of the acutest period, the less acute period, and the the chronical period. 2. Thermal changes due to the main symptom : The degree of thermal change was as follows (from the highest to the lowest): first, back and knee pain, second, back and leg pain, third, back and buttock pain, fourth, numbness of leg, and fifth, back and dorsum pain. 3. Thermal changes in terms of the grade of clinical symptoms : The more servious the symptoms were, the higher the thermal change was. It was increased in the order of Gr 1, Gr 2, Gr 3, and Gr 4. 4. Thermal changes depdning on symptoms diagnosis : Chwaseom(挫閃) has the highest temperature, $0.87{\pm}0.49^{\circ}C$. 5. Thermal changes before and after treatment : Before treatment, the average thermal change was $0.83^{\circ}C$ but after treatment, it was decreased to $0.38^{\circ}C$. For the above symptoms, if DITI is used, the diagnosis is easier based on the medical history of the patient who has back pain, and the degree of pain. However, if thermal change is soly used for diagnosis, it will be hard to determine the nature of sickness. Therefore, it should be folllowed by other supplementary examination.