• 치위생과학회지
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• 제18권5호
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• pp.288-295
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• 2018

The purpose of this study was to investigate the attitudes and performing confidence, and factors influencing patient safety of dental hygiene students. The questionnaire contained items on the subjects' general characteristics, attitudes, and performing confidence in relation to patient safety. The self-reported questionnaire was administered to 287 dental hygiene students in Gwangju and Jeonnam, Korea from September to November 2017. We performed an independent t-test, one-way ANOVA analysis, Pearson's correlation coefficient, and multiple regression analysis using IBM SPSS ver. 21.0 software. As a result of differences in attitude, and performing confidence according to the general characteristics, attitude toward patient safety scored 3.48 out of 5 points, and was more positive in students from 4-year colleges, with high major satisfaction, and in students who answered that they needed patient safety education. Performing confidence for patient safety scored 3.57 out of 5 points, and was statistically significantly higher in 4-year college students, with higher major satisfaction, amongst those with experience in patient safety education, and when patient safety education was needed before clinical practice or employment. There were positive correlations between attitude and performing confidence for patient safety. As a result of analyzing the factors influencing attitude and performing confidence for patient safety, attitudes were higher with higher performing confidence and performing confidence had the highest satisfaction rate of the major and patient safety education experience. Therefore, it is necessary to provide systematic education at universities reflecting the characteristics of dental medical institutions, as well as developing various education contents and education methods.

• 기본간호학회지
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• 제25권1호
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• pp.68-77
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• 2018

Purpose: The aim of this study was to establish a hypothetical model on silence regarding patient safety and to verify the model's goodness of fit and hypotheses. Methods: The participants in this study were 330 registered nurses working in tertiary hospitals with over 300 beds. Data were collected between July 1, and August 30, 2017, from nurses who agreed to participate. A covariance structure analysis was performed. Results: The model of fit index was $x^2=59.54$, normed $x^2=2.29$, GFI=.97, AGFI=.93, SRMR=.05, NFI=.99, CFI=.95 and RMSEA=.05. The organizational culture had an influence on patient safety motivation (${\beta}=.26$, p=.003) and attitude (${\beta}=.43$, p<.001). RN-MD collaboration had an influence on patient safety motivation (${\beta}=.33$, p<.001), attitude (${\beta}=.35$, p<.001), and patient safety silence (${\beta}=-.17$, p=.026). Supervisory trust had an influence on patient safety motivation (${\beta}=.26$, p<.001), attitude (${\beta}=.12$, p=.036), and patient safety silence (${\beta}=-.23$, p=.002). Patient safety motivation had an influence on patient safety silence (${\beta}=-.33$, p=.006). The model of patient safety silence explained 36.0% of the variances. Conclusion: This study is meaningful in that it provides basic data for nursing education and program development for rejecting patient safety silence.

• International Journal of Safety
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• 제7권2호
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• pp.12-16
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• 2008

Lower flash points for the binary systems, carbon tetrachloride+o-xylene and water+n-butanol were measured by Pensky-Martens closed cup tester. The Raoult's law and optimization method using van Laar equation were used to predict the lower flash points and were compared with experimental data. The calculated values based on the optimization method were found to be better than those based on the Raoult's law.

• Tuberculosis and Respiratory Diseases
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• 제51권1호
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• pp.44-52
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• 2001

배 경 : 만성호흡부전증 환자에게 산소농축기는 간편하면서도 경제적인 의료장비이나 국내에서는 생산되지 않아 수입한 값 비싼 외국산산소농축기를 사용하고 있는 실정이다. 서강대학교에서 개발한 국산 산소농축기를 임상에 사용하기 전에 성능을 검증하고자, 외국산 산소농축기와 임상시험을 통하여 비교 분석함으로써 국산 산소농축기의 효능 및 안전성을 측정하였다. 대상 및 방법 : 임상시험은 1999년 4월부터 1999년 8월까지 36명의 다한증환자를 대상으로 시행되었다. 동일한 환자에게 국산 산소농축기와 외국산 산소농축기를 nasal prong을 사용하여 60분동안 분당 3리터의 양으로 교대 사용하였다 어떤 기계를 먼저 적용할 것인 지는 무작위배정방법을 이용하였다. 산소농축기 적용전후의 동맥혈 산소압, 동맥혈 COHb, 동맥혈 pH, 동맥혈 이산화탄소압, 맥박수, 혈압, 호흡수 등을 각각 측정하여 그 변화량을 비교 검증하였다. 결 과 : 효능면에서 볼 때 동맥혈 산소압의 변화량은 통계적으로 유의한 차이가 없었고, 안전성면에서도 동맥혈 pH, 동맥혈 이산화탄소압, 맥박수, 혈압, 호흡수, 혈중 COHb 등의 변화 차이를 발견할 수 없었다. 결 론 : 현재 개발중인 국산 산소 농축기의 시제품의 성능을 임상시험한 결과 외국산 산소 농축기와 비교하여 동등한 만족스러운 성능을 보였다.

• 대한한의학방제학회지
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• 제16권2호
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• pp.1-9
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• 2008

Objective : The purpose of this report was to provide the information about activity and safety of Ojeok-san by analyzing domestic/international papers about Ojeok-san. Methods : Domestic/international papers related to Ojeok-san were reviewed and analyzed. These papers were then classified by year, experimental method and subject. Results : The following results were obtained in this study. 1. The studies of Ojeok-san started from 1984 and has continuously increased. The studies were mainly focused on experimental models rather than clinical studies. 2. By subject, papers related to safety were most common with 5 papers among 20 papers. Besides there were papers related to efficacy of analgesic, anti-hyperlipidemic, anti-blood stasis and treatment for uterine myoma. 3. The papers related to safety were mainly focused on the effect of Okeok-san on liver function, renal function or metal concentration of organs such as blood, brain, liver, kidney and bone. Ojeok-san proved to be safe, but more clinical studies regarding the safety are needed hereafter. 4. Papers related to analgesic, anti-pyretic, anti-phlogistic activities of Ojeok-san were in vivo studies, and other papers were about anti-hyperlipidemic activity, apoptosis inducing activity on uterine myeloma cell line and anti blood static activity on hydrocortisone acetate induced blood statis model. 5. Case reports were about anti-lipidemia, analgesic effect for mastalgia/back pain and anxiety disorder due to climacteric changes. Conclusion : Ojeok-san is being used in various ways with analgesic, anti-pyretic, anti-phlogistic, anti-hyperlipidemic, anti-tumor or anti-blood statis activity. However, mechanism study should be conducted at the molecular biology level and more clinical studies on the efficacy of Ojeok-san are needed.

• Journal of Ginseng Research
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• 제43권4호
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• pp.676-683
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• 2019

Background: Korean Red Ginseng (KRG) is widely used for strengthening the immune system and fighting fatigue, especially in people with deficiency syndrome. However, there is concern that the long-term application or a high dose of KRG can cause "fireness" (上火 in Chinese) because of its "dryness" (燥性 in Chinese). The aim of this study was to assess the safety and efficacy of a 4-week treatment with KRG in participants with deficiency syndrome. Methods: This was a 4-week, randomized, double-blind, placebo-controlled clinical trial. A total of 180 Chinese participants were randomly allocated to three groups: placebo control group, participants were given a placebo, 3.6 g/d; KRG 1.8 g and 3.6 g groups. The primary outcomes were the changes in fireness and safety evaluation (adverse events, laboratory tests, and electrocardiogram). The secondary outcomes were the efficacy of KRG on fatigue, which include the following: traditional Chinese medicine (TCM) symptom scale and fatigue self-assessment scale. Results: Of the 180 patients, 174 completed the full study. After 4 weeks of KRG treatment, the Fire-heat symptoms score including Excess fire-heat score and Deficient fire-heat score showed no significant change as compared with placebo treatment, and no clinically significant changes in any safety parameter were observed. Based on the TCM syndrome score and fatigue self-assessment score, TCM symptoms and fatigue were greatly improved after treatment with KRG, which showed a dose- and time-dependent effect. The total effective rate was also significantly increased in the KRG groups. Conclusion: Our study revealed that KRG has a potent antifatigue effect without significant adverse effects in people with deficiency syndrome. Although a larger sample size and longer treatment may be required for a more definite conclusion, this clinical trial is the first to disprove the common conception of "fireness" related to KRG.

• 한국의료질향상학회지
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• 제27권1호
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• pp.20-25
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• 2021

Purpose: The ability to access clinical trials for cancer treatment is important. This study investigated whether regional differences exist in oncologic clinical trial protocols conducted in South Korea. Methods: Records of all approved oncologic clinical trials conducted in 2019 were downloaded from the Republic of Korea Ministry of Food and Drug Safety. The study covered Seoul, the capital area, other metropolitan cities, and provincial areas. Descriptive statistics summarized the distribution patterns of clinical trials by region. Results: A total of 202 oncologic clinical trials were conducted in 63 institutions in 2019. Of these protocols, 186 (92%) were available in Seoul, 120 (59%) in the capital area, 64 (32%) in metropolitan cities, and 66 (33%) in provincial areas. More regional differences in protocol availability were observed in domestic trials, investigator-initiated trials, phase 1 and 2 trials, and smaller-scale trials. Conclusion: Most oncologic clinical trials were conducted in medical institutions located in Seoul, with the rest conducted in the capital area, metropolitan cities, and provincial areas. The findings reveal clear differences in protocol availability between Seoul and the other regions. Measures designed to improve geographical access to oncologic clinical trials may be needed given their growing importance in cancer treatment.

• 대한한방부인과학회지
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• 제26권4호
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• pp.1-13
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• 2013

Objectives: In this study, it was carried out to evaluate the acute oral toxicity of Root of Polygala teunifolia Willd. in Sprague-Dawley (SD) rats. Methods: Male and female rats were administered orally with Root of Polygala teunifolia Willd. water extract of 1,000 mg/kg (low dosage group), 2,000 mg/kg (middle dosage group) and 4,000 mg/kg (high dosage group). We daily observed number of deaths, clinical signs and gross findings for 7 days. After 7 days, we measured body and organs weight. Also we analyzed hematological changes. Results: No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. But we found out histopathological changes in liver fat tissues of female. In addition, there were no significant changes of gross body and individual organs weight. Conclusions: These results suggest that water soluble extract of Root of Polygala teunifolia Willd. has not acute oral toxicity and oral $LD_{50}$ value was over 4,000 mg/kg in SD rats.

• 한국임상약학회지
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• 제26권2호
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• pp.172-180
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• 2016

Background: Ischemic heart disease is the most common type of heart disease and an important cause of death in Korea. Among marketed anti-anginal medications, molsidomine, nicorandil, and trimetazidine are approved in Korea with unique mechanism of actions. As these drugs are not approved by the US Food and Drug Administration, the access to the up-to-dated and comprehensive safety-related information has been less than optimal from drug information resources used by Korean pharmacists. Methods: A systematic review was conducted using Embase and Korean manuscripts to compile safety updates for these medications. Out of 418 articles from keyword searches, 52 studies were reviewed in full to compare adverse effects (AEs) with the approved package inserts (PI). Results: Molsidomine related adverse effects were mostly mild or moderate, but anxiety, palpitation, epigastric pain, and sexual potency reduction were additional AEs found from the review not listed in PI. Although PI has included ulceration in oral cavity and gastrointestinal tracts including anus by nicorandil, the Korea FDA recently recommended adding corneal, genital, and skin ulcers to the approved PI. Trimetazidine induced Parkinsonism, worsening of the symptoms for patients diagnosed with Parkinson's disease, gastrointestinal burning, and muscle cramps were additionally identified AEs not listed in PI for trimetazidine. Conclusion: Continuous evaluations of the safety profile of these agents are needed to balance the risks and benefits to provide evidence-based safety counseling to the patients. In addition, more focused efforts on spontaneous reporting are warranted by healthcare professionals to safeguard patients against AEs.

• 한방안이비인후피부과학회지
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• 제26권4호
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• pp.15-25
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• 2013

Objectives : This study was carried out to evaluate the acute oral toxicity of Alismatis Rhizoma in Sprague-Dawley(SD) rats. Methods : male and female rats were administered orally with Alismatis Rhizoma water extract of 1,000 mg/kg (low dosage group), 2,000 mg/kg(middle dosage group) and 4,000 mg/kg(high dosage group). We daily observed number of deaths, clinical signs and gross findings for 7 days. After 7 days, we measured body and organs weight. Also we analyzed hematological changes. Results : No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. In addition no significant changes of gross body and individual organs weight. Conclusions : These results suggest that water soluble extract of Alismatis Rhizoma has not acute oral toxicity and oral $LD_{50}$ value was over 4,000 mg/kg in SD rats.