• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.95-100
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• 2016

Background: Survival time of lymphoma patients can be estimated with the help of microarray technology. In this study, with the use of iterative Bayesian Model Averaging (BMA) method, survival time of Mantle Cell Lymphoma patients (MCL) was estimated and in reference to the findings, patients were divided into two high-risk and low-risk groups. Materials and Methods: In this study, gene expression data of MCL patients were used in order to select a subset of genes for survival analysis with microarray data, using the iterative BMA method. To evaluate the performance of the method, patients were divided into high-risk and low-risk based on their scores. Performance prediction was investigated using the log-rank test. The bioconductor package "iterativeBMAsurv" was applied with R statistical software for classification and survival analysis. Results: In this study, 25 genes associated with survival for MCL patients were identified across 132 selected models. The maximum likelihood estimate coefficients of the selected genes and the posterior probabilities of the selected models were obtained from training data. Using this method, patients could be separated into high-risk and low-risk groups with high significance (p<0.001). Conclusions: The iterative BMA algorithm has high precision and ability for survival analysis. This method is capable of identifying a few predictive variables associated with survival, among many variables in a set of microarray data. Therefore, it can be used as a low-cost diagnostic tool in clinical research.

• 한국전문물리치료학회지
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• 제18권1호
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• pp.64-73
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• 2011

After stroke, many people have problems with balance during movement. Balance is essential for the optimal functioning of the locomotor system and the performance of many activities of daily living. The Functional Gait Assessment (FGA) is a clinical tool for evaluating balance ability during walking. The test consists of ten tasks, seven tasks of the Dynamic Gait Index and three additional tasks. The purpose of this study was to evaluate the reliability and internal consistency of data obtained with the Korean version of the FGA when used with people after suffering a stroke. One-hundred participants, at least three months poststroke and able to walk at least six meters with or without a walking aid, participated in the study (age range=30~83 years; $mean{\pm}SD=58.8{\pm}10.9$). Two physical therapists and two physical therapy students rated the FGA. Intrarater and interrater reliability of the FGA were assessed using kappa statistic and intraclass correlation coefficients (2,1). The internal consistency of the FGA was assessed using the Cronbach alpha. The Cronbach alpha was good (${\alpha}$=.86~.93). The intrarater (intraclass correlation coefficient=.92~.95) and interrater reliability (intraclass correlation coefficient=.91, .95) of the total scores administered by the therapists and students were good, whereas the reliability for single item scores when administered by the physical therapists was moderate to good (kapa value=.42~.97). This study found that intrarater and interrater reliability for total FGA scores and internal consistency were good. Therefore, the Korean version of the FGA can be used as a reliable tool to assess the functional gait performance of patients after stroke.

• Journal of Korean Neurosurgical Society
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• 제64권6호
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• pp.853-863
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• 2021

Objective : Biodegradable poly-L-lactic acid (PLLA) with a highly biocompatible surface via tantalum (Ta) ion implantation can be an innovative solution for the problems associated with current biodegradable stents. The purpose of this study is to develop a Taimplanted PLLA stent for clinical use and to investigate its biological performance capabilities. Methods : A series of in vitro and in vivo tests were used to assess the biological performance of bare and Ta-implanted PLLA stents. The re-endothelialization ability and thrombogenicity were examined through in vitro endothelial cell and platelet adhesion tests. An in vivo swine model was used to evaluate the effects of Ta ion implantation on subacute restenosis and thrombosis. Angiographic and histologic evaluations were conducted at one, two and three months post-treatment. Results : The Ta-implanted PLLA stent was successfully fabricated, exhibiting a smooth surface morphology and modified layer integration. After Ta ion implantation, the surface properties were more favorable for rapid endothelialization and for less platelet attachment compared to the bare PLLA stent. In an in vivo animal test, follow-up angiography showed no evidence of in-stent stenosis in either group. In a microscopic histologic examination, luminal thrombus formation was significantly suppressed in the Ta-implanted PLLA stent group according to the 2-month follow-up assessment (21.2% vs. 63.9%, p=0.005). Cells positive for CD 68, a marker for the monocyte lineage, were less frequently identified around the Ta-implanted PLLA stent in the 1-month follow-up assessments. Conclusion : The use of a Ta-implanted PLLA stent appears to promote re-endothelialization and anti-thrombogenicity.

• 대한감각통합치료학회지
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• 제6권1호
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• pp.35-46
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• 2008

목적: 본 연구는 전정감각과 고유감각 제공을 기초로 한 감각통합치료를 통해 아스퍼거 아동의 전정 고유감각 처리 능력에 미치는 효과를 알아보고자 하였다. 연구방법: 연구대상은 P시에 거주하는 만 11세 2개월 된 남아로, 8세되던 해에 아스퍼거로 진단받았다. 본 연구는 개별 실험 연구 중 AB설계를 사용하였다. 실험과정은 기초선 기간(A) 3회, 중재 기간(B) 8회로 진행되었다. 기초선 기간에는 감각통합치료를 실시하지 않았으며, 중재기간에는 전정감각과 고유감각 제공을 기초로 한 감각통합치료를 실시하였다. 전정 고유감각 처리는 자세 조절 능력의 기초를 형성하므로 자세 조절 능력을 알아보기 위해 테이블 활동 후 아동의 앉은 자세 변화와 복와위 신전 자세를 평가하였다. 결과: 본 연구의 결과는 다음과 같다. 아동의 앉은 자세 조절 능력과 복와위 신전 자세는 기초선 기간과 비교하여 중재기간에 대부분 2 표준편차 이상으로 향상되었다. 따라서 전정감각과 고유감각 제공을 기초로 한 감각통합치료가 아스퍼거 아동의 전정 고유감각 처리능력 향상에 효과적이었다. 결론: 본 연구는 아스퍼거 아동이 보이는 감각처리의 어려움을 파악하여 감각통합치료를 접근하고 그 결과를 측정함으로써, 감각통합치료의 질적인 효과를 제시한데 의의가 있다.

• Child Health Nursing Research
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• 제19권1호
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• pp.1-11
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• 2013

목적 본 연구의 목적은 간호대학생을 대상으로 신생아 중환자실에 입원한 호흡곤란증후군 환아 사례의 시뮬레이션 학습 시나리오를 개발하여 지식 적용-기술 수행, 문제 해결 능력, 학습만족도를 파악하는 데 있다. 방법 단일군 사후설계를 적용하였으며, 고위험 아동간호학을 수강하고 있는 간호학과 4학년 55명을 대상으로 총 17개조를 구성하여 매주 3개조(4-5명/조)로 시뮬레이션 운영 후 디브리핑을 60분간 실시하였으며, 자신의 실습 수행에 대한 문제해결능력과 학습만족도를 평가하였다. 결과 시나리오는 간호진단을 포함하여 6단계로 구성하였으며, 20분의 운영 시간 내에 호흡곤란 증후군 환아에 대한 지식 적용 및 기술 수행 능력, OSCE 수행 능력을 평가할 수 있도록 개발하였다. 지식 적용-기술 수행 평가에서 간호진단을 제외한 5개의 범주 중 평가 단계가 지식 적용과 기술 수행 모두 가장 높게 나타났다. 지식 적용에서 가장 높은 평균 점수를 보인 항목은 사정 단계에서 산소포화도 관찰, 평가 단계에서 산소분압과 산소포화도 확인이었고, 기술 수행에서는 중재 단계의 호흡곤란 완화 간호가 높았다. 사정 단계의 검사 확인은 지식 적용 및 기술 수행 영역에서 모두 낮게 나타났다. OSCE 수행 평가에서는 흡인 수행 능력에서는 사용한 물품 정리 및 수행 후 손씻기, 산소 공급에서는 급습기 멸균증류수 확인이 가장 부족한 것으로 나타났으며, 잘 수행된 항목보다 수행되지 못한 항목이 흡인과 산소 공급 모두 많은 것으로 나타나 기본간호술기의 중요성을 확인할 수 있었다. 문제 해결 능력과 학습 만족도는 양의 상관관계가 있는 것으로 나타나 문제 해결 능력이 높을수록 학습만족도가 높은 것으로 나타났다. 결론 시뮬레이션 교육 시행 후 문제 해결 능력에 따라 학습 만족도가 높으므로 문제 해결 능력을 높일 수 있도록 아동간호영역에서 다양한 시뮬레이션 교육 프로그램이 개발될 필요가 있으며, 기본간호술기 수행 능력을 증진할 수 있는 교육 프로그램이 더욱 활발히 운영되어야 한다고 생각된다.

• 재활치료과학
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• 제7권1호
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• pp.51-62
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• 2018

목적 : 본 연구의 목적은 오차배제학습과 시간차회상을 이용한 작업기반 훈련이 경도 혈관성 치매환자의 과제학습과 만족도에 미치는 영향을 알아보기 위함이다. 연구방법 : 치매 진단을 받은 경도 인지 수준의 환자 3명을 대상으로 ABA' + follow-up 설계를 사용하였다. 중재기간동안 오차배제학습과 시간차회상을 이용한 작업기반훈련을 적용하였으며, 매회기마다 과제학습 정도를 측정하였고, 중재 전과 후에 만족도의 변화를 알아보았다. 결과분석은 그래프를 통한 시각적 분석과 막대그래프를 통해 제시하였다. 결과 : 오차배제학습과 시간차회상을 이용한 작업기반 훈련 후 모든 대상자의 과제수행 능력이 향상되었으며, 중재 후 만족도 또한 향상되었다. 결론 : 본 연구는 초기 혈관성 치매환자에게 오차배제학습과 시간차회상을 이용한 작업기반 훈련이 과제학습과 만족도를 향상시키는데 효과가 있다는 것을 확인하였고, 임상적 적용을 위한 근거를 제공했다는 것에 의의가 있다.

• 대한소아치과학회지
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• 제49권2호
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• pp.170-179
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• 2022

이 연구는 국내 소아청소년의 저작 능력을 평가하고 관련 요인들을 조사하고자 하였다. 유구치의 조기 상실, 제1대구치의 교합 정도, 제1대구치의 교합 관계, 전치부 반대교합의 유무를 고려하였다. 2020년 3월부터 2021년 7월까지 56명의 만 6세에서 12세 사이 소아청소년을 대상으로 하였다. 혼합능력지수(MAI)가 소아청소년의 저작 능력을 평가하기 위해 계산되었고 유구치의 조기 상실 개수에 따라 세 집단으로 분류한 연구대상자는 정상 치열, 유구치 1 - 2개 상실, 유구치 3개 이상 상실한 경우 각각 23명, 18명, 15명이었다. 정상치열군과 1 - 2개 유구치 상실군에서는 MAI 값에서 차이가 없었으나, 3개 이상 유구치를 상실한 경우 MAI 값이 감소했으며, 유의한 차이가 관찰되었다. 이 연구는 국내 소아청소년의 저작 능력을 평가한 최초의 연구로, 성인과 저작 능력을 비교하였으며, 임상에서 소아청소년의 저작 능력 증진을 위해 노력하는 소아치과 의사에게 도움이 될 수 있다.

• 한국멀티미디어학회논문지
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• 제18권5호
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• pp.652-662
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• 2015

It is necessary to develop small, implantable bio-telemetry systems which can measure and transmit patients' bio-signals from internal body to external receiver. When measuring bio-signals, like electrical bio-signals, acoustic bio-signal measurement has also a big clinical usefulness. But, sound signal has larger frequency bandwidth than any other bio-signals. When considering these issues, a wireless telemetry system which has rapid data transmission rate proportional to wide frequency bandwidth is necessary to be developed. The bluetooth module is used to overcome the data rate limitation caused by the large frequency bandwidth. In this paper, a novel multimedia bluetooth biotelemetry system was developed which consists of transmitter module located in the body and receiver device located outside of the body. The transmitter consists of microphone, bluetooth, and wireless charging device. And the receiver consists of bluetooth and codec system. The sound inside the skin is captured by microphone and sent to receiver by bluetooth while charging. The wireless charging system constantly supplies the electric power to the system. To verify the performance of the developed system, an in vitro experiment has been performed. The results show that the proposed biotelemetry system has ability to acquire the sound signals under the skin.

• 지역사회간호학회지
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• 제28권3호
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• pp.324-333
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• 2017

Purpose: The purpose of this study was to develop a simulation module for teaching home health care and evaluate the applicability of the program to nursing students' practical training. Methods: The simulation module was developed based on the National League for Nursing Jeffries Simulation Theory. The theme of the developed scenario was teaching nasogastric tube feeding to the caregiver of patient with Parkinson disease. Participants were 61 nursing students who had learned tube feeding, and participated in the questionnaire survey after the simulation training. Results: The evaluation of simulation design showed the highest score on feedback/guided reflection, and was highly evaluated in the order of objectives/information, problem solving and fidelity. The educational practice of the simulation was highly evaluated in the order of active learning, high expectation and diversity of learning. The nursing students showed high satisfaction and self-confidence after the simulation education. Conclusion: We suggest that the developed simulation module can be applied to practical training for home health care. In the future, the change of self-efficacy, clinical judgment and performance ability of the students after the simulation education should be identified. Also, various simulation modules related to the community health nursing competencies should be continuously developed and verified.

• 기본간호학회지
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• 제22권4호
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• pp.424-432
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• 2015

Purpose: In this study the time point of effects that repeat exposure to simulation-based nursing training has on stress, interest in learning, and problem-solving abilities were identified. Methods: Participants for this study were 75 nursing college students in Seoul. In a preliminary survey data were collected and measured for the general characteristics, stress, interest in learning, and problem-solving abilities of the students. Then, stress was assessed before performance of each of four-rounds of simulation training scenarios. After each simulation round, interest in learning and problem-solving abilities were assessed. Results: With respect to stress, no significant differences were found when comparing the results of the preliminary survey to those of each of the simulation-based training exercises. For the sub-items of interest in learning, interest in nursing knowledge and interest in clinical training significantly increased between the preliminary survey and the $4^{th}$ survey. Interest in lab training increased significantly at the $1^{st}$ survey. Problem solving abilities showed a significant increase from the preliminary at each of the survey points. Conclusion: Increasing the exposure of nursing students to simulation-based training enhances their interest in learning and problem-solving abilities. Therefore it is necessary to have education strategies that includes various simulation experiences for students.