• 대한임상검사과학회지
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• 제44권4호
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• pp.239-244
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• 2012

This study aims to analysis the curriculum problems and its improvements and to investigate curricula satisfaction among the students majoring in Clinical Pathology. A college used as a population, and 80 effective survey data were collected by sampling the graduates who carried out the clinical field training in third grade year. For statistical analysis of the collected data, the Stata(version 12.0) statistical package was used for frequency analysis, pearson correlations test and multiple regression analysis. The results of the analysis were as follows; First, the result showed that the synthetical theory curriculum has an positive effect on curricula satisfaction. Second, it was found that extension of both the clinical field training and laboratory and practice education have an significant influence direction of positiveness on curricula satisfaction. Third, as the problems of curriculum, the students selected shortage of english subjects connected with the job. We must intensify additional subjects (english ability) for job as the improvement of curriculum. Accordingly, academic, industrial circles and students are supposed to jointly seek for the plan for the enhancement of clinical field training satisfaction.

• Journal of Yeungnam Medical Science
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• 제14권2호
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• pp.430-442
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• 1997

노인의 정상 검사치를 청장년층의 정상 검사치와 비교하고 성별 차이를 파악하며 검사치를 노인병 진료에서 임상적 활용이 가능한 자료로 사용할 목적으로 본 연구를 실시하였다. 영남의료원 종합검진센터에서 검진을 받았던 사람 중 만 60세 이상이며 검진 결과 건강하다고 판정된 617명의 피검자를 노인군으로 선정하였고, 동일한 시기 및 장소에서 검진을 받고 정상으로 판정된 20세이상 35세 이하의 피검자 1,791명을 청장년군으로 선정하였다. 평균 연령은 노인군은 63.8세(60세 - 83세)였고 대조군은 31.1세였다. 대조군에 비해 평균적혈구용적, 평균적혈구혈색소량, 적혈구침강속도, C-반응성 단백, AST,ALT, ${\gamma}$GTP, 알칼리성 포스파타제, BUN, 총 콜레스테롤, 중성지방 농도는 남녀 모두 노인군에서 유의하게 높았으며 임파구(%), 총 빌리루빈과 직접 빌리루빈, 총 단백질, 알부민, 삼요오드타이로닌 농도는 노인군에서 유의하게 낮았다(P<0.05). 혈색소도는 노인군에서 유의하게 낮았다(P<0.05). 혈색소량, 혈소판, 티록신 수치는 남자 노인군에서 유의하게 낮았으며, 호산구(%), 크레아틴닌은 여자 노인군에서 유의하게 높았다. 고밀도 단백 농도는 남자 노인군에서 유의하게 높았으며(P<0.01), 백혈구 수, 호중구 수(%), 단핵 세포구(%), 갑상선 자극 호르몬 농도는 남녀 모두 노인군과 대조군 사이에 유의한 차이가 없었다. 노인에서의 임상병리 검사의 정상치는 청장년의 정상치와 차이가 나는 항목이 많은 것으로 생각되며 성별에 따라서도 큰 차이를 보이는 검사가 있었다. 노인병의 진료시 혈액, 생화학적 검사의 해석에서 이러한 차이가 고려되어야 할 것으로 생각되며 앞으로 보다 많은 수의 대상 및 검사에 영향을 미치는 변수를 고려한 연구가 필요할 것으로 생각된다.

• 대한임상검사과학회지
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• 제51권3호
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• pp.386-395
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• 2019

본 연구의 목적은 4차 산업혁명 핵심기술과 연계된 임상검사 과학기술을 소개하는 것이다. 4차 산업혁명 핵심기술 중 인공지능, 사물인터넷, 블록체인, 로봇, 나노기술, 총 5개의 핵심기술을 테마별 분석 연계하였다. 임상병리사의 업무범위는 검사의 학검사, 병리검사, 임상생리검사이다. 검사의학 분야의 최근기술은 73개, 병리학 분야는 27개, 임상생리학 분야는 47개로 조사하였다. 4차 산업혁명과 임상검사과학기술 연계는 인공지능은 4개, 사물인터넷 3개, 블록체인 4개, 로봇 3개, 나노기술 15개로 조사하였다. 본 연구의 제한점은 모든 자료를 수집 분석에는 한계가 있었다. 비임상분야는 분석하지 못했다. 그리고 타당성 확인이 없었고 비슷한 연구가 없었다. 결론으로 4차 산업혁명 핵심기술과 임상검사과학기술은 밀접한 관련이 있다. 따라서 임상검사과학기술의 사회적 이익과 분야별 관련 후속 연구가 필요하다.

• BMB Reports
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• 제36권2호
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• pp.237-242
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• 2003

Hepatic lipase is a key enzyme that is involved in HDL-C metabolism. The goal of this study was to find out the frequency of the hepatic lipase C514T polymorphism, and evaluate its relationship with plasma HDL-C levels and coronary artery disease (CAD) in Koreans. Two hundred and twenty four subjects with no previous history of lipid-lowering therapy, 118 patients with significant CAD, and 106 controls were examined with respect to their genotypes, lipid profiles, and other risk factors for CAD. The frequency of the -514T allele was 0.37 in men and 0.35 in women, which were higher than the frequency that was reported in Caucasians, but lower than the frequency that was reported in African-Americans. The -514T allele was associated with significantly higher HDL-C levels in women. After controlling for age, gender, BMI, DM, and smoking, the non-CC genotype was significantly associated with HDL-C levels, and explained 6% of the HDL-C variation in this study. When the genotypes-distribution was compared between the CAD and non-CAD patients, the hepatic lipase C-514T polymorphism was not associated with the presence of CAD. Koreans have a higher frequency of the hepatic lipase gene 514T allele than Caucasians, and the -514T allele is associated with higher plasma HDL-C levels in Korean women, and perhaps non-smoking men. However, our data does not suggest an association between the polymorphism and an increased risk of CAD.

• 대한의생명과학회지
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• 제27권2호
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• pp.99-104
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• 2021

Treatment techniques that affect homeostasis by non-invasive regulation in peripheral organs will advance disease research. Here, we demonstrate a non-invasive method of conditioning within an organ using a low-frequency stimulator superposition of alternating microcurrent wave in stages. It is first applied to the inflammatory response in H3N2-infected sinusitis mice. To check the progress of the treatment, mice were sacrificed every week for 3 weeks, nasal tissue was removed, and the inflammatory response was investigated through H & E staining. The low-frequency stimulation treatment group was found to alleviate the proliferation of epithelial cells and invasion of inflammatory cells compared to the control group as the passage of treatment time. The reduction of inflammatory cytokines in the nasal lavage fluid was observed in H3N2-infected sinusitis mice treated with of low-frequency stimulation using superposition of alternating microcurrent wave compared to H3N2-infected sinusitis mice after 3 weeks. These data demonstrate that low-frequency stimulation device in the form of using alternating current wave superposition on within organs provides a new method to regulate specific physiological functions. Therefore, it is necessary to prove the inhibitory effect of low-frequency stimulation using alternating current wave superposition on inflammatory diseases by various methods through further studies and clinical studies.

• 한국전문물리치료학회지
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• 제30권2호
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• pp.102-109
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• 2023

Background: While efforts have been made to differentiate fall risk in older adults using wearable devices and clinical methodologies, technologies are still infancy. We applied a decision tree (DT) algorithm using inertial measurement unit (IMU) sensor data and clinical measurements to generate high performance classification models of fall risk of older adults. Objects: This study aims to develop a classification model of fall risk using IMU data and clinical measurements in older adults. Methods: Twenty-six older adults were assessed and categorized into high and low fall risk groups. IMU sensor data were obtained while walking from each group, and features were extracted to be used for a DT algorithm with the Gini index (DT1) and the Entropy index (DT2), which generated classification models to differentiate high and low fall risk groups. Model's performance was compared and presented with accuracy, sensitivity, and specificity. Results: Accuracy, sensitivity and specificity were 77.8%, 80.0%, and 66.7%, respectively, for DT1; and 72.2%, 91.7%, and 33.3%, respectively, for DT2. Conclusion: Our results suggest that the fall risk classification using IMU sensor data obtained during gait has potentials to be developed for practical use. Different machine learning techniques involving larger data set should be warranted for future research and development.

• 대한임상검사과학회지
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• 제54권4호
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• pp.285-292
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• 2022

국제표준직업분류나 일본·미국의 법률시스템, 양성시스템를 통해서 본 안과검사인력은 안과전문의, 검안사, 시능훈련사, 검안기사, 안과기사가 포함된다. 국가통계포털 자료에 의하면 2022년 안과에 근무하는 안경사의 수는 의료기관 종별에 따라 파악이 가능하지만, 임상병리사의 수는 파악이 불가능하다. 다만, 본 연구를 통해서 상급종합병원의 경우 임상병리사가 안경사보다 많이 근무하는 것으로 조사되었다. 우리나라 안과검사실 인력의 경우 국제표준직업분류, 국제표준교육분류, 의료법, 의료기사 등에 관한 법률 및 고등교육법에 비추어 봤을 때, 미국의 검안사는 비교 대상이 아니며 안과전문의나 검안사의 지도를 받아 업무수행하는 검안기사가 부합되는 직업일 것이다. 민간자격으로 대한안과학회 및 대한검안학회에서 안과검사실에 종사하는 임상병리사 및 안경사에게 '임상검안사'라는 호칭을 부여하여 새로이 자격관리를 정립한다면 국민 안(眼)보건 향상에 더욱 도움이 되리라 생각된다.

• 대한의생명과학회지
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• 제27권2호
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• pp.45-50
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• 2021

Coagulase-negative staphylococci (CoNS) are a typical group of microorganisms, and the recent advances in laboratory technology and medicine has dramatically modified their significance in medical practice. CoNS, which were previously classified as normal bacterial flora, have recently been reported to be associated with serious infectious diseases, such as surgical wound infection or periprosthetic joint infection. Representative CoNS include Staphylococcus epidermidis, S. haemolyticus, and S. saprophyticus, which are known to cause serious problems in biomaterial-based and prosthetic device infections, as well as to cause simple urinary tract infections in sexually active women. Over the last decade, the clinical isolation rate of CoNS has been increasing, and antibiotic resistance has also been occurring. This review aimed to investigate the incidence of CoNS infection and to use the results as basic data for the management of CoNS, with a focus on the isolation rate and antibiotic resistance in clinical surgery.

• 대한임상검사과학회지
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• 제42권1호
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• pp.16-21
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• 2010

It has been well known that organic industrial solvents such as toluene, xylene and styrene are environmental health hazards causing occupational diseases to workers. The detection of biological metabolites of toluene, xylene and styrene in blood, urine, breast milk, saliva, and hair of workers exposed to these organic industrial solvents is a useful tool for assessing the amount of organic industrial solvents. Therefor, the external analytical quality assurance program is extremely important work for increasing reliability of the data analyzed in the special health examination laboratory. We evaluated the results of analysis by Korean analytical quality assurance program from the second half 2007 to the first half 2009. The number of participants for analytical quality assurance program for both mandatory item and one of optional items, hippuric acid and methylhippuric acid were 116-122, 116-122 and 105-115 laboratories, respectively. The proficient rate of the special health examination laboratories analyzed both mandatory item and optional item, hippuric acid and methylhippuric acid were 92-98%, 92-98% and 96-98%, respectively. We can conclude from our data that the analytical quality assurance program is a essential tool for improvement of reliability on the data analyzed in the special health examination laboratories.

• Journal of Genetic Medicine
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• 제11권2호
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• pp.63-68
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• 2014

Purpose: The mutation of the SLC26A4 gene is the second most common cause of congenital hearing loss after GJB2 mutations. It has been identified as a major cause of autosomal recessive nonsyndromic hearing loss associated with enlarged vestibular aqueduct and Pendred syndrome. Although most studies of SLC26A4 mutations have dealt with hearing-impaired patients, there are a few reports on the frequency of these mutations in the general population. The purpose of this study was to evaluate the prevalence of SLC26A4 mutations that cause inherited deafness in the general Korean population. Materials and Methods: We obtained blood samples from 144 Korean individuals with normal hearing. The samples were subjected to polymerase chain reaction to amplify the entire coding region of the SLC26A4 gene, followed by direct DNA sequencing. Results: Sequencing analysis of this gene identified 5 different variants (c.147C>G, c.225G>C, c.1723A>G, c.2168A>G, and c.2283A>G). The pathogenic mutation c.2168A>G (p.H723R) was identified in 1.39% (2/144) of the subjects with normal hearing. Conclusion: These data provide information about carrier frequency for SLC26A4 mutation-associated hearing loss and have important implications for genetic diagnostic testing for inherited deafness in the Korean population.