• Journal of Korean society of Dental Hygiene
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• v.18 no.2
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• pp.239-251
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• 2018

Objectives: The purpose of this study was to investigate the effects of dental hygiene students' clinical practice stress, satisfaction and major satisfaction on career preparation behaviors. Methods:This study was conducted targeting the dental hygiene students who have clinical practice experience. The final 305 subjects were analyzed using SPSS 22.0 program. Results: The correlation between clinical practice stress and career satisfaction and career preparation behavior decreases with the higher degree of clinical practice and career preparation behavior. Analysis results about the affecting factors on the level of satisfaction with major satisfaction factors showed the highest factor of preparation behavior, followed by clinical practice and clinical practice stress in order. Analysis results about the affecting factors on the showed the highest factor of preparation behavior, followed by clinical practice and clinical practice stress in order. Conclusions: The results of this study showed that the higher the satisfaction of clinical practice and the higher the satisfaction of career, the more positive the career preparation behavior. Therefore, it's recommended to support continuous education programs to be coherent with dental hygiene student's career preparation behavior based on reinforcing individual competency by obtaining self-confidence and satisfaction from clinical practice.

• Journal of the Korea Convergence Society
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• v.9 no.11
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• pp.569-579
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• 2018

The purpose of this study was to identify experiences of core basic nursing skills(CBNS), self-confidence during clinical practice and clinical competence in 208 nursing students attending nursing department and understand which factor, either experiences of CBNS or self-confidence during clinical practice has an impact on clinical competence. Our research findings are as follows. There was a positive correlation between experiences of CBNS, self-confidence during clinical practice and clinical competence. The factor that had the biggest impact on clinical competence was self-confidence during clinical practice and the explanation power of both factors was 31.2%, based on multiple regression analysis. Based on these findings, nursing educate need to develop a curriculum to increase self-confidence during clinical practice in students.

• Clinical and Experimental Pediatrics
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• v.53 no.10
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• pp.913-916
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• 2010

Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder. Bleeding manifestations and clinical findings vary widely, ranging from asymptomatic subjects to patients with hemorrhages that may cause significant handicaps. Treatment has traditionally involved factor VII(FVII) replacement therapy using fresh frozen plasma, prothrombin complex concentrates or plasma-derived FVII concentrates. Recombinant activated FVII ($NovoSeven^{(R)}$) is currently considered the first-line treatment for replacement therapy of FVII deficiency. Here we present a case of severe intracerebral and intraventricular hemorrhage in a neonate with congenital FVII deficiency.

• Biomolecules & Therapeutics
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• v.2 no.1
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• pp.77-81
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• 1994

The acute toxicity of recombinant human epidermal growth factor, DWP-401 was evaluated in ICR mice of both sexes. Six groups of mice were administered orally or subcutaneously with 0, 0.125, 0.25, 0.5, 1 and 2 mg/kg of DWP-401. Abnormal clinical signs related to the compound were not observed, and no deaths occurred. Gross findings of necropsy revealed no evidence of specific toxicity related to DWP-401. LD$_{50}$ values for both male and female mice were evaluated to be over 2 mg/kg, which is approximately 2, 000 fold of presumed clinical dose.e.

• Clinical and Experimental Pediatrics
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• v.59 no.6
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• pp.271-275
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• 2016

Purpose: A limited number of studies have examined the link between F-wave abnormalities and clinical presentation in pediatric Guillain-$Barr{\acute{e}}$ syndrome (GBS). Therefore, this study examined the importance of F-wave abnormalities as a prognostic factor in pediatric GBS patients. Methods: The records and electrodiagnostic studies (EDS) of 70 GBS patients were retrospectively evaluated, and divided into 2 groups according to the results of EDS. Group A (n=33) presented with F-wave abnormalities, and group B (n=26) exhibited normal findings. We compared laboratory reports, clinical features, response to treatment, and prognosis between the 2 groups. Results: Motor weakness was the most frequently observed symptom for either group. Clinically, the incidence of fever and upper respiratory symptoms differed between the 2 groups, while the prevalence of abnormal deep tendon reflex (DTR) was significantly higher in group A than B (P<0.05). Patients diagnosed with GBS had received intravenous immunoglobulin treatment: 94% in group A and 58% in group B. Furthermore, significantly greater numbers of patients in group A showed H-reflex abnormalities and poor prognosis compared with group B (P<0.05). Conclusion: This study demonstrated that F-waves are a clinically important prognostic factor in GBS. F-wave abnormalities were associated with abnormal DTR and poor prognosis in patients. Limited studies have examined the link between F-wave abnormalities and clinical results; therefore, further randomized controlled studies are needed to confirm the clinical characteristics and efficacy of treatments.

• Journal of Korean Dental Science
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• v.16 no.2
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• pp.172-181
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• 2023

Purpose: To investigate the effect of epidermal growth factor (EGF) with collagen matrix (CM) for increasing gingival thickness. Materials and Methods: In five mongrel dogs, bilateral gingival defects were surgically made on the maxillary canines. After two months, either a subepithelial connective tissue graft (group SCTG) or CM with EGF (0.1 ug/ml, group EGF) was grafted, and the flap was coronally positioned to cover the graft materials. The animals were sacrificed after three months. Intraoral scanning was performed for soft tissue analysis. Histologic and histomorphometric analyses were performed. Result: Two animals exhibited wound dehiscence during the healing phase, leaving three for analysis. No statistically significant difference was found in soft tissue changes (P>0.05). The level of gingival margin (GM) increased in both groups (1.02±0.74 mm in group SCTG vs. 1.24±0.83 mm in group EGF). Linear increases at the GM pre-augmentation in the soft tissue profile were 1.08±0.58 mm in group SCTG and 0.96±0.73 mm in group EGF. Histomorphometric parameters (keratinized tissue height, tissue thickness, and rete peg density) were not significantly different between the groups (P>0.05). Conclusion: EGF loaded onto CM led to comparable gingival phenotype enhancement to SCTG.

• Physical Therapy Rehabilitation Science
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• v.13 no.1
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• pp.71-77
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• 2024

Objective: The purpose of this study is to present practice guidelines on what physical therapy students must learn during clinical training and how to evaluate them. Design: Design & development research Methods: A Delphi survey was conducted with 16 experts. Experts who participated in the study were asked to respond to 15 musculoskeletal system, 14 nervous system, and 12 physical factor therapy items through an online survey with a 5-point Likert score for each item regarding suitability and importance. Results: As a result of defining the core basic physical therapy skills that students in the Department of Physical Therapy must learn through clinical practice and in the process of evaluating them, there was a strong opinion that among the specific fields of physical therapy, evaluation items related to the musculoskeletal system, nervous system, and cardiorespiratory system were important. On the contrary, physical factor therapy showed poor results. Conclusions: In a previous study, opinions on the specialty of physical therapists were collected from current physical therapists, and the field of physical factor therapy was evaluated low. I think this reflects the perception that treatment using electricity has been commonly used in the field of physical therapy for a long time and does not require deep expertise among clinicians. Physical therapy clinical practice guidelines and efficient operation plans for clinical practice were presented. Through this, it can be usefully applied in hospitals where physical therapy students undergo clinical training in the future.

• The Korean Journal of Health Service Management
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• v.8 no.4
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• pp.149-161
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• 2014

The purpose of this study was to identify the association of factors related to clinical practice training for clinical competence among nursing students, and to analyze those factors influencing clinical competence, providing recommendations for improving their clinical competence and clinical learning environment. This descriptive correlative study completed organized questionnaires from 557 nursing students. The data was analyzed by SPSS 19.0. The most important factor affecting the clinical competence among nursing students was teaching effectiveness (${\beta}=.22$). followed by critical thinking (${\beta}=.19$). and the professional self-concept (${\beta}=.19$). The explained variable for clinical competence was 45.2% in nursing students. Thus, the development of an effective clinical internship program is important for strengthening nursing students' clinical competence. We suggest that the capability of nursing students should be strengthened and effective clinical internship programs should be developed to improve the clinical competence of nursing students.

• Korean Journal of Clinical Pharmacy
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• v.18 no.2
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• pp.75-83
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• 2008

Purpose: Currently lung cancer ranks second in cancer for incidence rate and is a disease that ranks first for a death rate by cancerous growth because it is already advanced at the time of diagnosis. The purpose of this paper was to analyze the factors that affect the effectiveness of and rash occurrence by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI) in patients with non-small cell lung cancer. Methods: A retrospective chart review of 100 patients, who took EGFR TKI (erlotinib, gefitinib) among patients who were diagnosed with non-small cell lung cancer in a Hospital in Korea between May 2005 and February 2008, was conducted. The drug effectiveness was evaluated by Response Evaluation Criteria In Solid Tumor. Results: EGFR mutation was the only factor associated with drug response (complete response and partial response). When stable disease was added to drug response as the evaluation parameter, ECOG and rash as well as EGFR mutation were found to be important factors. Survival, however, was not affected by EGFR mutation. The factors influenced on survival were older age (${\geq}65$), low ECOG ($1{\sim}2$), adenocarcinoma and rash. In the case of rash, group with EGFR mutation or low ECOG showed significantly higher chance of occurrence. There was no significant difference in rash occurrence between gefitinib and erlotinib groups. Conclusions: Based on the results, EGFR mutation positive and low ECOG ($1{\sim}2$) were significantly important factors for both effectiveness of EGFR TKI and rash occurrence. Also, rash itself was found to be an independently significant factor for the disease control and survival. Therefore, while administering EGFR TKI, patients who have the factors associated with rash occurrence should be closely monitored for effective and safe drug therapy.

• The Journal of the Korea Contents Association
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• v.13 no.1
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• pp.311-321
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• 2013

This study was done to investigate and compare satisfaction of clinical practice and its influencing factors between associate and bachelor nursing students. The participants were 420 nursing students in two cities. Data were collected through self-report questionnaires, and analyzed using the SPSS/WIN 19.0 program. Satisfaction of clinical practice in associate and bachelor nursing students correlated with self-esteem, self-efficacy, interpersonal relationships, and satisfaction of major. Significant factor influencing satisfaction of clinical practice in associate nursing students was satisfaction of major, and this factor accounted for 26.8% of the variance in satisfaction of clinical practice. And significant factors influencing satisfaction of clinical practice in bachelor nursing students were satisfaction of major, interpersonal relationships and gender, and these factors accounted for 31.9% of the variance in satisfaction of clinical practice. The above findings indicate that satisfaction of clinical practice in nursing students is influenced by satisfaction of major and interpersonal relationships. Therefore, when nursing interventions are developed to improve satisfaction of clinical practice in nursing students, these factors need to be considered.