Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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A case of intracranial hemorrhage in a neonate with congenital factor VII deficiency

  • Lee, Won-Seok (Department of Pediatrics, Kyung Hee University School of Medicine) ;
  • Park, Young-Sil (Department of Pediatrics, Kyung Hee University School of Medicine)
  • Received : 2010.08.13
  • Accepted : 2010.09.30
  • Published : 2010.10.15
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Abstract

Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder. Bleeding manifestations and clinical findings vary widely, ranging from asymptomatic subjects to patients with hemorrhages that may cause significant handicaps. Treatment has traditionally involved factor VII(FVII) replacement therapy using fresh frozen plasma, prothrombin complex concentrates or plasma-derived FVII concentrates. Recombinant activated FVII ($NovoSeven^{(R)}$) is currently considered the first-line treatment for replacement therapy of FVII deficiency. Here we present a case of severe intracerebral and intraventricular hemorrhage in a neonate with congenital FVII deficiency.

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References

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