• The Journal of Advanced Prosthodontics
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• v.3 no.1
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• pp.25-32
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• 2011

PURPOSE. The purpose of this study was to assess the prevalence and extent of clinical attachment loss of periodontal tissue and to find out variables related to clinical attachment loss (CAL) in Korean adults older than 40 years of age. MATERIALS AND METHODS. Data were collected from 2,519 subjects who were part of a cohort study conducted in Ansan city by Korea University Medical School for Korean Genome project. Age, sex, smoking, drinking, fast glucose, blood pressure, obesity and total cholesterol levels were examined. The oral examination included probing pocket depth, gingival recession and CAL of Ramford's teeth. The severity of periodontitis was classified based on the mean value of CAL. The relationship between each risk factor and the severity of CAL was independently estimated using the chi-square test, the test or one-way ANOVA. Multiple regression analysis was used to determine the significance of each factor in the periodontal disease. RESULTS. The prevalences of clinical attachment between 1 and 3 mm, between 3 and < 5 mm, and ${\geq}$ 5 mm were 80.27%, 16.75% and < 1%, respectively. Although the univariate analysis showed age, gender, smoking, fasting glucose, blood pressure and total cholesterol levels were significantly related to the severity of CAL, multiple regression analysis indicated that age (P < .0001), gender (P < .0001) and smoking (P < .05) were only significantly related. CONCLUSION. Older age, male gender and smoking were significant risk factor for the increase of CAL, and these may be useful indicators of periodontitis high-risk groups.

• Korean Journal of Clinical Laboratory Science
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• v.45 no.2
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• pp.60-65
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• 2013

Data from repeated measurements are accomplished through repeatedly processing the same subject under different conditions and different points of view. The power of testing enhances the choice of pertinent analysis methods that agrees with the characteristics of data concerned and the situation involved. Along with the clinical example, this paper compares the analysis of the variance on ex-post tests, gain score analysis, analysis by mixed design and analysis of covariance employable for repeating measure. Comparing the analysis of variance on ex post test, and gain score analysis on correlations, leads to the fact that the latter enhances the power of the test and diminishes the variance of error terms. The concluded probability, identified that the gain score analysis and the mixed design on interaction between "between subjects factor" and "within subjects factor", are identical. The analysis of covariance, demonstrated better power of the test and smaller error terms than the gain score analysis. Research on four analysis method found that the analysis of covariance is the most appropriate in clinical data than two repeated test with high correlation and ex ante affects ex post.

• Journal of dental hygiene science
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• v.16 no.1
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• pp.62-69
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• 2016

The purpose of this study was investigate the relationship between the degree of satisfaction of the clinical practice and the stress factors for dental hygiene students. Dental hygiene students to 232 people from May 21, 2012 to June 22, 2012 and analyzed using by SPSS for Windows ver. 12.0 program. Regarding the stress factors, by the school system, all the factors, including the environmental factor, the role factor, the interpersonal relationships factor, the ideal and value factor, and the Brief Encounter Psychosocial Instrument (BEPSI) were higher in the 3-year system than in the 4-year system (p<0.01). Regarding the stress factors according to the degree of satisfaction regarding the practices, all the factors were high when unsatisfied. Among these, the environmental factor was the highest (p<0.001). According to the practice organization, the environmental factor was the highest among the university dental hospital. The interpersonal relationship factor and the ideal and value factor were the highest among the dental hospitals. The role factor and the BEPSI were the highest among the dental clinics (p<0.01). When the hospital atmosphere was bad, the environmental factor was the highest (p<0.001). As a result of analyzing the correlations between the stress factors of the hospital practices, there were the positive correlations among the environment, the roles, the interpersonal relationship, the ideals and values, and the BEPSI (p<0.01). The stress factor that showed the biggest influence on the BEPSI was interpersonal relationships. In the clinical practice, because of the unfamiliar environment and the insufficiency of the interpersonal relationships, the stress indices of the students can be higher than at ordinary times. I believe that, as such, a systematic management plan for the clinical practice for raising the ability of the students to cope with the stress by themselves must be prepared.

• Molecules and Cells
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• v.45 no.11
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• pp.789-791
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• 2022

Targeting fibroblast growth factor receptors (FGFRs) has been slow compared to other targeted cancer therapies for receptor tyrosine kinases, such as epidermal growth factor receptors. The low efficacy and variable response have limited the growth of FGFR inhibitors in clinical use. Nevertheless, recent systematic and genomic approaches have identified the biological conditions for effectively targeting FGFRs and can accelerate the development of targeted drugs. Under clinical and preclinical trials, the inhibitors started fast growing furious races to target FGFRs. Finally, FGFRs will be more actionable and targetable with more precise and effective drugs at the end of the race, passing the finish line.

• The Korean Journal of Nuclear Medicine
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• v.33 no.3
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• pp.316-326
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• 1999

Purpose: We evaluated the feasibility of extracting pure left ventricular blood pool and myocardial time-activity curves (TACs) and of generating factor images from human dynamic N-13 ammonia PET using factor analysis. The myocardial blood flow (MBF) estimates obtained with factor analysis were compared with those obtained with the user drawn region-of-interest (ROI) method. Materials and Methods: Stress and rest N-13 ammonia cardiac PET imaging was acquired for 23 min in 5 patients with coronary artery disease using GE Advance tomograph. Factor analysis generated physiological TACs and factor images using the normalized TACs from each dixel. Four steps were involved in this algorithm: (a) data preprocessing; (b) principal component analysis; (c) oblique rotation with positivity constraints; (d) factor image computation. Area under curves and MBF estimated using the two compartment N-13 ammonia model were used to validate the accuracy of the factor analysis generated physiological TACs. The MBF estimated by factor analysis was compared to the values estimated by using the ROI method. Results: MBF values obtained by factor analysis were linearly correlated with MBF obtained by the ROI method (slope = 0.84, r = 0.91), Left ventricular blood pool TACs obtained by the two methods agreed well (Area under curve ratio: 1.02 ($0{\sim}1min$), 0.98 ($0{\sim}2min$), 0.86 ($1{\sim}2min$)). Conclusion: The results of this study demonstrates that MBF can be measured accurately and noninvasively with dynamic N-13 ammonia PET imaging and factor analysis. This method is simple and accurate, and can measure MBF without blood sampling, ROI definition or spillover correction.

• The Journal of Korean Academic Society of Nursing Education
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• v.6 no.1
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• pp.132-146
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• 2000

The purpose of this study was to explain the relationship between empowerment and satisfaction of clinical practice in nursing students. The instrument of this study was a structured questionnaire included empowerment and satisfaction of clinical practice. The data was collected from september 28, 1999 to March 31, 2000 and analyzed by Cronbach alpha, descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient and simple regression by using SPSS Win program. The result of research were as follows: 1. There was significant difference according to the general characteristic factor. The total empowerment was predicted by meaning of nursing, university and college, relationship of peer, clearance of study purpose. Satisfaction of clinical practice was predicted by university and college, clearance of study purpose. 2. There was a significant correlation between empowerment and satisfaction of clinical practice(r=0.442, p=0.000). 3. Empowerment was the highest factor predicting satisfaction of clinical practice. A total of 19.5% of the variance was explained in the total satisfaction of clinical practice. It was found that the higher the degree of perceived empowerment, the higher the degree of satisfaction of clinical practice. Therefore, nursing faculty should plan interventions to inspire satisfaction level of clinical practice by empowerment.

• Korean Journal of Clinical Laboratory Science
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• v.44 no.3
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• pp.118-123
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• 2012

Nosocomial infection and community-acquired infection with Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), has become a strong concern in human body sites and related effects. The aim of this study is investigate the isolation rate of MRSA from nasal cavity inferior regions and cellular phones to assess the risk factor of nosocomial infection and community-acquired infection. 34.7% and 37.2% isolates were MRSA from the nasal cavity inferior regions and cellular phones according to a Mannitol salt agar (added oxacillin $6{\mu}g/mL$) culture and PCR according to S. aureus specific 16S rRNA and mecA primers. Thus, the distribution of S. aureus and the isolation rate of MRSA represent a very high risk factor regards nosocomial infection and community-acquired infection.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.2
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• pp.554-561
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• 2012

The purpose of this study was to identify the relationship between anxiety, anger and fatigue among stress factor in clinical practice of nursing students. The subjects were 197 nursing students who have practiced at the hospital in T city. Data was analyzed by using descriptive statistics, ANOVA, t-test and pearson's correlation coefficient. The mean score for stress was 3.82. The mean score for anxiety was 48.82. The mean score for anger was 1.17. The mean score for fatigue was 30.96. The factor of stress was a significant difference of anxiety according to conference, theory and practice, satisfaction of clinical practice. The factor of stress was a significant difference of anger according to report, theory and practice, orientation, nurse, environment. The factor of stress was a significant difference of fatigue according to conference, orientation, environment, patient relationship. In results, This study revealed that there was a significant correlation among stress, anxiety, anger and fatigue of nursing students in clinical practice.

• Journal of Korean Academy of Nursing
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• v.48 no.1
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• pp.70-84
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• 2018

Purpose: This study was conducted to evaluate the validity and reliability of the Korean version of the clinical learning environment, supervision and nurse teacher evaluation scale (CLES+T) that measures the clinical learning environment and the conditions associated with supervision and nurse teachers. Methods: The English CLES+T was translated into Korean with forward and back translation. Survey data were collected from 434 nursing students who had more than four days of clinical practice in Korean hospitals. Internal consistency reliability and construct validity using confirmatory and exploratory factor analysis were conducted. SPSS 20.0 and AMOS 22.0 programs were used for data analysis. Results: The exploratory factor analysis revealed seven factors for the thirty three-item scale. Confirmatory factor analysis supported good convergent and discriminant validities. The Cronbach's alpha for the overall scale was .94 and for the seven subscales ranged from .78 to .94. Conclusion: The findings suggest that the 33-items Korean CLES+T is an appropriate instrument to measure Korean nursing students'clinical learning environment with good validity and reliability.

• Tuberculosis and Respiratory Diseases
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• v.85 no.3
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• pp.221-226
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• 2022

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation due to chronic airway inflammation and destruction of the alveolar structure from persistent exposure to oxidative stress. The body has various antioxidant mechanisms for efficiently coping with such oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) is a representative system. Dysregulation of the Nrf2-ARE pathway is responsible for the development and promotion of COPD. Furthermore, COPD severity is also closely related to this pathway. There has been a clinical impetus to use Nrf2 for diagnostic and therapeutic purposes. Therefore, in this work, we systematically reviewed the clinical significance of Nrf2 in COPD patients, and discuss the value of Nrf2 as a potential COPD biomarker.