• Archives of Plastic Surgery
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• 제35권1호
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• pp.100-103
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• 2008

Purpose: Eccrine porocarcinoma is a very rare, potentially fatal tumor which arises from the intraepidermal portion of the eccrine sweat ductal apparatus. It does not have a characteristic clinical feature but does have a high incidence of metastasis. It may be developed de novo or in a preexisting benign eccrine poroma. It usually affects older people and is located most commonly on lower extremities. We report a rare case of eccrine porocarcinoma which developed on the back without metastasis. Methods: The patient was a 94-year-old woman who showed a painful, ulcerated, dark brown colored polypoid $3.5{\times}3.0cm$ sized mass on the back for 3 years. We totally excised the lesion including normal tissue. Results: After wide excision of the lesion, pathologist reported an eccrine porocarcinoma. Histopathologic findings reveal that the classic type of eccrine gland carcinoma, eccrine porocarcinoma. Immunocytochemical studies showed a positive reactivity to anti-EMA antibody and anti-CEA antibody. Conclusion: Authors experienced a rare case of primary eccrine porocarcinoma on the back. Because of the propensity to develop local recurrence, wide excision of the primary tumor with histologic confirmation of negative margins represents the only curative treatment regimen for eccrine porocarcinoma.

• Archives of Plastic Surgery
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• 제41권5호
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• pp.472-479
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• 2014

Background Speech problems are a common clinical feature of the 22q11.2 deletion syndrome. The objectives of this study were to inventory the speech history and current self-reported speech rating of adolescents and young adults, and examine the possible variables influencing the current speech ratings, including cleft palate, surgery, speech and language therapy, intelligence quotient, and age at assessment. Methods In this cross-sectional cohort study, 50 adolescents and young adults with the 22q11.2 deletion syndrome (ages, 12-26 years, 67% female) filled out questionnaires. A neuropsychologist administered an age-appropriate intelligence quotient test. The demographics, histories, and intelligence of patients with normal speech (speech rating=1) were compared to those of patients with different speech (speech rating>1). Results Of the 50 patients, a minority (26%) had a cleft palate, nearly half (46%) underwent a pharyngoplasty, and all (100%) had speech and language therapy. Poorer speech ratings were correlated with more years of speech and language therapy (Spearman's correlation=0.418, P=0.004; 95% confidence interval, 0.145-0.632). Only 34% had normal speech ratings. The groups with normal and different speech were not significantly different with respect to the demographic variables; a history of cleft palate, surgery, or speech and language therapy; and the intelligence quotient. Conclusions All adolescents and young adults with the 22q11.2 deletion syndrome had undergone speech and language therapy, and nearly half of them underwent pharyngoplasty. Only 34% attained normal speech ratings. Those with poorer speech ratings had speech and language therapy for more years.

• 대한방사선기술학회지:방사선기술과학
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• 제43권5호
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• pp.397-404
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• 2020

Coronavirus disease(COVID-19) is highly infectious disease that directly affects the lungs. To observe the clinical findings from these lungs, the Chest Radiography(CXR) can be used in a fast manner. However, the diagnostic performance via CXR needs to be improved, since the identifying these findings are highly time-consuming and prone to human error. Therefore, Artificial Intelligence(AI) based tool may be useful to aid the diagnosis of COVID-19 via CXR. In this study, we explored various Deep learning(DL) approach to classify COVID-19, other viral pneumonia and normal. For the original dataset and lung-segmented dataset, the pre-trained AlexNet, SqueezeNet, ResNet18, DenseNet201 were transfer-trained and validated for 3 class - COVID-19, viral pneumonia, normal. In the results, AlexNet showed the highest mean accuracy of 99.15±2.69% and fastest training time of 1.61±0.56 min among 4 pre-trained neural networks. In this study, we demonstrated the performance of 4 pre-trained neural networks in COVID-19 diagnosis with CXR images. Further, we plotted the class activation map(CAM) of each network and demonstrated that the lung-segmentation pre-processing improve the performance of COVID-19 classifier with CXR images by excluding background features.

• 사상체질의학회지
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• 제19권2호
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• pp.82-93
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• 2007

1. Objectives Functional medicine is a system which utilizes certain Investigative and treatment methods that are primarily oriented toward the recognition of functional disorder. The 7-zone-diagnostic system(VEGA-DFM722 and ABR-2000, etc) is a diagnostic device which applies pulse signals to predetermined bodily locations. We think that we can discriminate between Soeumin, Soyangin and Taeumin with this system. 2. Methods The subject of our study is no disease men and women who are decided the same constitution both survey of the QSCC II and diagnosis of specialist of the Sasang Constitution. All subject are 76(Soeumin(N=24), Soyangin(N=17), Taeumin(N=35)) cases. We make an analysis of a distinctive feature on the result of the VEGA-DFM722. 3. Results and Conclusions 1) Soeumin or Taeumin women had that the red bar graphs of and 1, 2 and 3 are lower than the red bar graphs of zone 4, 5, 6 and 7 in factor AA on the result of the VEGA-DFM722 with the naked eye. Soyangin or Taeumin men had that the red bar graphs of zone 1,2 and 3 are higher than the red bar graphs of tone 4, 5, 6 and 7 in factor AA on the result of the VEGA-DFM722 with the naked eye. 2) The typical discrimination between Soeumin and Soyangin showed statistical significance(p<0.05) in Factor PF 4(red bar) on the result of VEGA-DFM722.

• 대한골관절종양학회지
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• 제18권1호
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• pp.45-49
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• 2012

골육종에서 드물게 발생하는 도약전이 병소는 불량한 예후 인자로서 중요한 연관성이 있기 때문에 골육종 환자의 광범위 절제술 시에 절제범위에 포함되어야 한다. 따라서 수술 전 검사에서 골육종의 골수 내 침범에 대한 정밀한 평가가 필수적이며, 골스캔 검사는 도약전이의 발견에 있어서는 높은 위음성률을 보일수 있으며 자기공명영상 검사는 종양이 위치한 골 전체를 촬영하지 않는 경우 임상적인 증거가 없으면 간과하기가 쉽다는 단점이 있다. 이에 저자들은 주 종양 부위만을 포함한 국소 자기공명영상 촬영과 골스캔에서 발견되지 않았으나 FDG-PET/CT에서 도약 전이가 진단된 대퇴 원위부의 골육종 증례에 대해 문헌 고찰과 함께 보고하고자 한다.

• Tuberculosis and Respiratory Diseases
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• 제41권3호
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• pp.289-298
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• 1994

연구배경 : 유행 질환인 마이코플라스마 폐렴의 일반적인 특성을 파악하는데 병원 자료의 이용에 제한점을 극복하고, 이 질환의 좀더 가까운 자연상을 알아보기 위하여 한 지역사회를 중심으로 관찰하였다. 방법 : 1993년 6월 부터 12월 까지 6개월 동안 전남의 한 해안지방에서 유행한 마이코플라스마 폐렴의 혈청학적으로 확진된 105예와 이에 더하여 같은 기간에 발생한 모든 폐렴으로서 확진되지는 않았으나, 의심되는 경우를 포함한 224명을 대상으로 하여 역학적 및 방사선 소견을 분석하였다. 결과 : 1) 남녀비는 1.5:1 이었다. 2) 연령분포는 5-9 세 사이가 57%로 평균 나이는 6.5세였고, 유행의 시간이 지남에 따라 시기별 평균연령은 낮아지는 추세를 보였다. 3) 인구 집단의 크기보다 집적성이 발생 빈도의 모형에 영향을 준다고 추정되었다. 4) 방사선 소견으로서는 단일 형태로서 간질성 폐렴이 가장 많았으며, 67예(74.5%)에서 한 엽에 국한된 병변을 보였다. 또한 대엽성 폐렴은 학동기에, 간질성 이나 미만성 폐렴은 유아기에 많았다. 결론 : 이상의 특성들은 향후 이 질환의 진단에 도움을 줄 수 있으리라 사료된다.

• 생물정신의학
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• 제3권1호
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• pp.109-114
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• 1996

정신분열증에서 interleukin의 변화는 그 질환에서의 면역학적 가설의 부가적인 증거로 제시되어 왔다. 본 연구에서는 quantitative "sandwich" ELISA 법을 이용하여 26명의 정신분열증 환자를 대상으로 연령을 상응시킨 정상대조군과 비교해 IL-$1{\beta}$, IL-2, IL-6 농도의 차이가 있는지 알아보았다. 또한 정신분열증 환자에서 IL농도와 양성증상 및 음성증상, 연령, 유병기간 등의 임상변인과의 상관관계를 조사하여 다음과 같은 결론을 얻었다. 1) 정신분열증군이 정상대조군보다 IL-2 농도의 유의한 중가를 나타내었으며, IL-$1{\beta}$와 IL-6는 유의한 차이가 없었다. 2) 정신분열증군에서 IL-2, IL-6와 음성증상간의 유의한 상관관계가 있었다. 본 연구는 정신분열증의 연역학적 가설을 지지하고 있으며, IL은 정신분열증의 음성증상에 관련된다고 생각된다. 앞으로 국내에서도 이러한 환자들의 임상적 특징, 진단, 치료에 관심을 갖아야 할 것으로 사료된다.

• Tuberculosis and Respiratory Diseases
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• 제43권2호
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• pp.285-290
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• 1996

저자들은 특징적인 임상 증상과 함께 전형적인 흉부 x-선 및 고해상 흉부 전산화 단층 촬영을 보이는 미만성 법세기관지염 환자에서 흉강경을 이용한 폐생검으로 확진하여 erythromycin 소량 투여로 임상적 효과를 얻은 1예를 문헌 고찰과 함께 보고는 바이다.

• Clinical and Experimental Reproductive Medicine
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• 제47권2호
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• pp.108-113
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• 2020

Objective: Endometrial fibrosis, the primary pathological feature of intrauterine adhesion, may lead to disruption of endometrial tissue structure, menstrual abnormalities, infertility, and recurrent pregnancy loss. At present, no ideal therapeutic strategy exists for this fibrotic disease. Eupatilin, a major pharmacologically active flavone from Artemisia, has been previously reported to act as a potent inducer of dedifferentiation of fibrotic tissue in the liver and lung. However, the effects of eupatilin on endometrial fibrosis have not yet been investigated. In this study, we present the first report on the impact of eupatilin treatment on transforming growth factor beta (TGF-β)-induced endometrial fibrosis. Methods: The efficacy of eupatilin on TGF-β-induced endometrial fibrosis was assessed by examining changes in morphology and the expression levels of fibrosis markers using immunofluorescence staining and quantitative real-time reverse-transcription polymerase chain reaction. Results: Eupatilin treatment significantly reduced the fibrotic activity of TGF-β-induced endometrial fibrosis in Ishikawa cells, which displayed more circular shapes and formed more colonies. Additionally, the effects of eupatilin on fibrotic markers including alpha-smooth muscle actin, hypoxia-inducible factor 1 alpha, collagen type I alpha 1 chain, and matrix metalloproteinase-2, were evaluated in TGF-β-induced endometrial fibrosis. The expression of these markers was highly upregulated by TGF-β pretreatment and recovered to the levels of control cells in response to eupatilin treatment. Conclusion: Our findings suggest that suppression of TGF-β-induced signaling by eupatilin might be an effective therapeutic strategy for the treatment of endometrial fibrosis.

• 대한기관식도과학회지
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• 제6권1호
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• pp.102-107
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• 2000

Monocytoid B-cell lymphoma is uncommon, low grade lymphoma originating from monocytoid B lymphocytes. Monocytoid B-cell lymphoma usually presents as a localized lymphadenopathy. Peripheral lymph nodes are most often involved, particularly those in the frequent in the head and neck area. A distinctive feature is the association of monocytoid B-cell lymphoma with autoimmune diseases. Sjogren Syndrome had been present in 22% of patient with monocytoid lymphoma. Extranodal involvement by monocytoid lymphoma was reported in the salivary gland, breast, thyroid, and stomach. There were also occasional extensions to the liver and retroperitoneum. The bone marrow and peripheral blood involvement by monocytoid lymphoma is very rare, which is frequently seen in hairly cell leukemia. Fever, weight loss, and other constitutional signs are usually absent. Most patients have no symptoms, and the only sign is enlarged lymph nodes. The clinical course remains indolent; most patients are in complete remission and recurrence with progression to a high-grade lymphoma of large cell type was recorded only in a few cases. Authors experienced a case of monocytoid B-cell lymphoma associated with Sjogren Syndrome mistaken to simple cervical lymphadenitis in a 60-year-old female. We report this case with a review of literatures.