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FDG-PET/CT Complements Bone Scan with Respect to the Detection of Skip Metastasis of Osteosarcoma: A Case Report

골육종의 도약전이 진단에서 골스캔의 보완검사로서의 FDG-PET/CT: 증례 보고

  • Cheon, Gi-Jeong (Department of Nuclear Medicine, Korea University Hospital) ;
  • Choe, Jae-Gol (Department of Nuclear Medicine, Korea University Hospital) ;
  • Chae, In-Jung (Department of Orthopedic Surgery, Korea University Hospital) ;
  • Lee, Dae-Hee (Department of Orthopedic Surgery, Korea University Hospital) ;
  • Song, Sang-Heon (Department of Orthopedic Surgery, Korea University Hospital) ;
  • Kim, Myo-Jong (Department of Orthopedic Surgery, Korea University Hospital) ;
  • Park, Jong-Hoon (Department of Orthopedic Surgery, Korea University Hospital)
  • 천기정 (고려대학교 의과대학 안암병원 핵의학교실) ;
  • 최재걸 (고려대학교 의과대학 안암병원 핵의학교실) ;
  • 채인정 (고려대학교 의과대학 안암병원 정형외과학교실) ;
  • 이대희 (고려대학교 의과대학 안암병원 정형외과학교실) ;
  • 송상헌 (고려대학교 의과대학 안암병원 정형외과학교실) ;
  • 김묘종 (고려대학교 의과대학 안암병원 정형외과학교실) ;
  • 박종훈 (고려대학교 의과대학 안암병원 정형외과학교실)
  • Received : 2012.03.02
  • Accepted : 2012.05.30
  • Published : 2012.06.30

Abstract

Skip lesion is not uncommon feature in osteosarcoma and considered to be importantly associated with poor prognosis factor, and thus, should be excised with the main mass. The accurate pre-operative evaluation of the intramedullary extent of osteosarcoma is essential, because it determines the level of bone resection. Among the reliable detection methods, bone scan has a drawback of high rate of false negative results and regional MRI has a difficulty to cover the whole involved lesions without clinical suspicion. The authors report a case of osteosarcoma of the distal femur with a proximal skip lesion that was not detected by either regional MR imaging or by bone scan, but which was visualized by FDG-PET/CT.

골육종에서 드물게 발생하는 도약전이 병소는 불량한 예후 인자로서 중요한 연관성이 있기 때문에 골육종 환자의 광범위 절제술 시에 절제범위에 포함되어야 한다. 따라서 수술 전 검사에서 골육종의 골수 내 침범에 대한 정밀한 평가가 필수적이며, 골스캔 검사는 도약전이의 발견에 있어서는 높은 위음성률을 보일수 있으며 자기공명영상 검사는 종양이 위치한 골 전체를 촬영하지 않는 경우 임상적인 증거가 없으면 간과하기가 쉽다는 단점이 있다. 이에 저자들은 주 종양 부위만을 포함한 국소 자기공명영상 촬영과 골스캔에서 발견되지 않았으나 FDG-PET/CT에서 도약 전이가 진단된 대퇴 원위부의 골육종 증례에 대해 문헌 고찰과 함께 보고하고자 한다.

Keywords

References

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