• Restorative Dentistry and Endodontics
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• 제17권1호
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• pp.22-35
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• 1992

The aim of this study was to investigate the effect of herbal organic extracts on the pain response provoked by noxious stimuli on dental nerve and the peripheral nerve conduction. Cats (2-2.5Kg regardless of sex) that were chosen as experimental animals were classified into control group, Asiasari radix application group and Zingiberis rhizoma application group. They were anesthetized with ${\alpha}$-chloralose, then anterior belly of digastric muscle of both sides were exposed and wire electrodes were inserted for recording of Electromyogram (EMG). Cavities were prepared on canines until pulp of the teeth were exposed. And after the drugs solubilized for 2% and 4% concentration (W/V) in vehicle were applied, their effects were compared through the recording of EMG immediately after drug application, 30 minutes, 60 minutes, 120 minutes and 5 days after, respectively. And after both inferior alveolar nerves were exposed, 4% organic extracts of Zingiberis rhizoma and Asiasari radix were applied for 30 minutes then the change of jaw opening reflex provoked by noxious stimuli on pulpal nerves were observed immediately after washing out, at 30, 60 and 90 minutes after drug had been washed out. After saphenous nerve of both sides were exposed, one side of nerve was used for vehicle application and the other side was used for drug application for 30 minutes. Then conduction of action potential of A-${\delta}$ and C-fiders of saphenous nerves, which have changed with time, was recorded. With analysis of these records, the following results were obtained: 1. Organic extract of Zingiberis rhizoma (2% or 4% concentration) greatly suppressed EMG of digastric muscle provoked by noxious stimuli on pulpal nerve at five days after application, the suppressive: effect was greater than that of organic extract of Asiasari radix. 2. Organic extract of Asiasari radix (2% or 4% concentration) suppressed jaw opening reflex provoked by noxious stimuli on pulpal nerve, at 5 days after drug application. 3. Organic extract of Zingiberis rhizoma and Asiasari radix (immediately after 30 minutes application) suppressed neural conduction of A-${\delta}$ and C-fibers, the suppressive effect was greater on A-${\delta}$ fibers than on C-fibers. 4. Jaw opening reflex provoked by noxious stimuli on pulpal nerve in inferior alveolar nerve was greatly suppressed 30 minutes after drug application, this effect was greater by Zingiberis rhizoma than by Asiasari radix.

• 보존과학연구
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• 통권32호
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• pp.53-60
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• 2011

조선 왕실의 의궤를 기록된 옻칠 공예품에 관한 제작방법 및 사용재료를 연구하여, 칠기 유물의 보존처리 방안 수립 시 응용하고자 한다. 문헌조사는 "영조정순왕후가례도감의궤(1759)", "정조국장도감의궤(1800)"를 중심으로 하였다. 의궤에 기록된 옻칠 공예품의 경우, 옻칠은 주홍칠朱紅漆, 흑진칠黑眞漆, 석간주칠石磵朱柒로 나타난다. 왕에게 진상되는 물품에는 밑칠에 주로 콩가루를 사용하였고, 그 외에는 콩가루와 골회를 혼용하였다. 밑칠에 송연을 첨가하여 사용하기도 하였다. 왜주홍칠은 전칠을 칠한 후 매칠에 왜주홍을 배합하여 사용한다. 당주홍칠에는 일부 석간주와 주토를 혼용하여 사용하였다. 흑진칠은 전칠과 매칠을 이용하여 칠하는 것을 기본으로 일부 송연을 첨가하여 사용하기도 한다. 석간주칠에는 석간주를 기본으로 주토를 혼용하여 사용하였다. 마지막으로 명유를 이용하여 광택을 내어주었다고 사료된다. 문헌을 통해 조사된 옻칠 공예품의 제작방법과 전통재료가 옻칠 공예품의 보존처리 방안 수립 시 응용된다면 보다 나은 결과를 도출할 수 있을 것이다.

• 한국임상수의학회지
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• 제33권2호
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• pp.107-112
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• 2016

The objective of this study was to determine potential contributing factors associated with biosecurity level of farrow-to-finish pig farms and to develop a classification tree model to explore how these factors related to each other based on prediction model. To this end, the author analyzed data (n = 193) extracted from a cross-sectional study of 344 farrow-to-finish farms which was conducted between March and September 2014 aimed to explore swine disease status at farm level. Standardized questionnaires with information about basic demographical data and management practices were collected in each farm by on-site visit of trained veterinarians. For the classification of the data sets regarding biosecurity level as a dependent variable and predictor variables, Chi-squared Automatic Interaction Detection (CHAID) algorithm was applied for modeling classification tree. The statistics of misclassification risk was used to evaluate the fitness of the model in terms of prediction results. Categorical multivariate input data (40 variables) was used to construct a classification tree, and the target variable was biosecurity level dichotomized into low versus high. In general, the level of biosecurity was lower in the majority of farms studied, mainly due to the limited implementation of on-farm basic biosecurity measures aimed at controlling the potential introduction and transmission of swine diseases. The CHAID model illustrated the relative importance of significant predictors in explaining the level of biosecurity; maintenance of medical records of treatment and vaccination, use of dedicated clothing to enter the farm, installing fence surrounding the farm perimeter, and periodic monitoring of the herd using written biosecurity plan in place. The misclassification risk estimate of the prediction model was 0.145 with the standard error of 0.025, indicating that 85.5% of the cases could be classified correctly by using the decision rule based on the current tree. Although CHAID approach could provide detailed information and insight about interactions among factors associated with biosecurity level, further evaluation of potential bias intervened in the course of data collection should be included in future studies. In addition, there is still need to validate findings through the external dataset with larger sample size to improve the external validity of the current model.

• 대한소아신경학회지
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• 제26권4호
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• pp.240-245
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• 2018

목적: 병원 외 심정지 후 회복된 혼수 상태의 소아 환자에서 신경학적 예후를 예측하는 것은 어렵다. 본 연구는 병원 외 심정지 후 자발순환회복 된 소아 환자에서 뇌파와 혈액 검사를 통해 신경학적 예후를 예측할 수 있는지 알아보았다. 방법: 2006년부터 2015년까지 병원 외 심정지로 가천대학교 의과대학 길병원에 방문한 1개월 이상 18세 미만의 소아 환자를 대상으로 하였다. 뇌파 분석은 배경파 점수화(background scoring), 자극에 대한 반응성(reactivity)의 유무 및 뇌파 상 경련(electrographic seizures)의 유무를 포함하였다. 배경파는 0점(nomal/organized), 1점(slow and disorganized), 2점(discontinuous or burst suppression), 3점(suppressed and featureless)으로 분류하였다. 신경학적 예후는 심정지 발생 후 최소 6개월 후에 PCPC에 따라 분류하였다. 결과: 좋은 신경학적 예후군(PCPC 1-3점) 9명과 불량한 신경학적 예후군(PCPC 4-6점) 17명으로 총 26명의 환자를 분석하였다. 불량한 예후군 환자의 88.2%, 좋은 예후군 환자의 44.4%에서 suppressed and featureless 소견을 보여 두 군간의 차이가 있었다(P=0.028). non-convulsive status epilepticus를 제외한 electrographic ictal discharges는 좋은 예후군의 44.4%, 불량한 예후군의 5.9%에서 보여 두 군간의 차이가 있었다(P=0.034). 불량한 예후군에서 산혈증, 젖산혈증, 고암모니아혈증이 좋은 예후군에 비해 의미있게 증가되어 있었다. 결론: 병원 외 심정지 후 회복된 소아 환자에서 뇌파 배경파가 suppressed and featureless 패턴을 보이는 경우 불량한 예후와 관련이 있고 electrographic ictal discharges 가 있는 경우 좋은 신경학적 예후와 관련이 있다.

• 한방비만학회지
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• 제13권1호
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• pp.33-45
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• 2013

Objectives: This study was aimed to find out the characteristics of ordinary symptoms between the control and patient groups, diagnosed as overweight or obesity, in Soyang, Taeeum, and Soeum Constitutions and among those 3 groups. Methods: As a prospective cross-sectional study based on medical records, 9213 patients, who visited Kyung Hee University Medical Center from May in 2007 to June in 2010, were included. To diagnose the constitution, Revised Questionnaire for the Sasang Constitution Classification II and examinations by oriental medical doctors who majored in Sasang Constitution Medicine were performed. Based on the World Health Organization criteria for Asian obesity assessment, body mass index (BMI) was classified into 3 groups; more than 25 as obesity, 23 to 25 as overweight, and less than 23 as normal. Ordinary symptoms questionnaire, which consists of 46 questions in 8 categories, were given to the subjects. One-way ANOVA test in continuous variables and chi-square test in categorical variables were carried out to analyze statistical significance. Results and Conclusions: 1) In general characteristics, we could find out the significant differences in age, sex, height, weight, BMI, waist circumference, blood pressure, total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, fasting blood sugar, and hemoglobin A1c among the 3 Constitutional groups. 2) Soyang Constitution of overweight and obesity has tendency to have higher appetite, like cool or cold water, defecate more, swear more, dislike heat, and have warmer or hotter extremities in the ordinary symptoms, compared with the control group. 3) Taeeum Constitution of overweight and obesity has tendency to have higher appetite, like cool or cold water, defecate more, swear more, dislike heat, and have warmer or hotter extremities in the ordinary symptoms, compared with the control group. 4) Soeum Constitution of overweight and obesity has tendency to have higher appetite and less fatigue in the ordinary symptoms, compared with the control group. 5) Soeum Constitution showed the slightest increase in appetite, preference about room temperature water, less number of feces, and feeling of chill and warmer extremities in ordinary symptoms, compared with Soyang and Taeeum Constitutions. Taeeum Constitution showed the distinct increase in appetite and sweating in ordinary symptoms, compared with Soyang and Soeum Constitutions.

• 대한임상독성학회지
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• 제8권2호
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• pp.97-105
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• 2010

Purpose: Although cardiac toxicity is a key parameter of significant toxicity, in antidepressant intoxication, there are few studies on the cardiac toxicity of serotonin reuptake inhibitor and the intoxication with the new generation of antidepressants. The aim of this study is to investigate the relative cardiac toxicity of serotonin reuptake inhibitor and intoxication with the new generation of antidepressants as compared with that of tricyclic antidepressant intoxication. Methods: We retrospectively reviewed the medical records of 109 antidepressant intoxicated patients who visited the Emergency Department from January, 2005 to December, 2009 to collect and analyze the demographic and clinical data. Sixteen patients were excluded. The enrolled seventy eight patients were classified into three groups: the tricyclic antidepressant group (TCA) (n=32), the selective serotonin reuptake inhibitor subgroup (SSRI) (n=28) and the new generation antidepressant subgroup (NGA) (n=18). Results: The demographic and clinical data of the SSRI and NGA groups were not significantly different from that of the TCA group. The QRS duration of the SSRI subgroup ($86.4{\pm}12.0$ msec) and the NGA subgroup ($91.8{\pm}11.9$ msec) was not significantly different from that of the TCA group ($90.0{\pm}13.5msec$) (p=0.598). The QTc interval of the SSRI group ($444.5{\pm}33.5msec$) and the NGA group ($434.9{\pm}35.9msec$) (p=0.260) were not significantly different from that of the TCA group ($431.2{\pm}44.1msec$) (p=0.287). Conclusion: Intoxication with SSRI and the new generation antidepressants seemed to show significant cardiac toxicity, like what is seen in tricyclic antidepressant intoxication. Clinicians must pay attention to SSRI and new generation antidepressant intoxication.

• 디지털융복합연구
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• 제19권5호
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• pp.175-186
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• 2021

국내 공공도서관의 역할과 기능은 다양해지고 있는 반면, 내부적으로는 편향된 도서 대출로 다양한 문제들이 나타나고 있다. 또한 최근 4차 산업혁명으로 공공도서관에서 인기도서 위주의 도서 추천시스템이 도입되고 있으나, 이용자가 접할 수 있는 도서의 다양성은 제한되고 있다. 이에 본 연구에서는 공공도서관 이용자의 만족을 제고하기 위해 공간적으로는 대구시 두류도서관으로 한정하여 대출이력 자료(213,093건), 회원정보(35,561명) 등을 활용하여 군집분석과 토픽 모델링, 콘텐츠 기반 필터링 추천 알고리즘으로 공공도서관 미대출 도서 추천시스템을 구현하였으며, 이에 대한 실제 이용자들의 만족도 설문조사를 실시하여 미대출 도서 추천시스템의 가능성과 시사점을 제시하였다. 분석 결과 대다수의 이용자들이 높은 만족도로 응답하였으며, 특정 성·연령대, 직업, 평소 독서량 등으로 분류된 계층에서 만족도가 상대적으로 높게 나타난 것을 확인할 수 있었다. 본 연구결과를 통해 공공도서관의 편향된 도서 대출, 운영 효율성 저하 등의 문제를 일부 개선할 수 있을 것으로 기대하며, 연구의 한계점 또한 제시하였다.

• 대한한방소아과학회지
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• 제35권4호
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• pp.16-33
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• 2021

Objectives This study aims to provide directions for future Korean pediatric medicine treatment and researches by analyzing the characteristics of diseases of Korean pediatric outpatients before and after the COVID-19 epidemic. Methods We analyzed the medical records of 10,868 new patients aged 0-18 who visited the Korean pediatrics at Kyung Hee university hospital from January 1, 2019 to June 30, 2021. All patients were divided into 2 groups; patients who visited from January 1, 2019 to December 31, 2019, before the coronavirus epidemic, and patients who visited from January 1, 2020 to June 30, 2021, after the coronavirus epidemic. Within the two groups, the diagnosis distribution was performed for the entire population, by gender and by age group. Diagnoses were classified as allergy, growth, gastrointestinal, respiratory, general body supplementation, neuropsychiatric, skin, urogenital, musculoskeletal, and other systems. Results According to the comparative analysis results of before and after the COVID epidemic, there was a decreasing trend of diagnoses in relates to allergy, respiratory, urogenital, musculoskeletal system. On the other side, there was an increasing trend in gastrointestinal, general body supplementation, growth, neuropsychiatric, skin and other system. Changes in diagnosis based on gender and age group will be described below. Conclusions This study analyzed the characteristics of diseases of Korean pediatric outpatients before and after the COVID-19 epidemic, and suggested the direction of future Korean medicine treatment and researches for pediatrics. Also, this study aimed to propose proper treatments for children by showing the role of Korean pediatric medicine related to growth and development of children during the epidemic. However, this study has limitations such as failure to track the long-term impact of COVID-19. Thus, long term follow-up studies are needed to show the effect of COVID-19 on Korean pediatric medicine.

• 동의신경정신과학회지
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• 제30권3호
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• pp.165-175
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• 2019

Objectives: This study was conducted to investigate the emotional characteristics of the patients within one year after stroke using the Core Seven Emotions Inventory-Short Form. Methods: It analyzed the medical records of 39 stroke patients who had visited W University hospital and completed the Core Seven-Emotions Inventory-Short Form (CSEI-S), the K-MBI, the PWI-SF, and the HADS. Patients data were analyzed by descriptive analysis, frequency analysis, the Mann-Whitney U test, and the nonparametric test of the CSEI according to the period of stroke onset in patients and Spearman's correlation analysis using the SPSS (Statistical Package for the Social Science, IBM, United States of America) Version 23.0. Results: First, in the case of depression, all subjects were in the danger group, although more than half of the joy, anger, thinking, sadness and fear were included in the normal group in the shortening of the key seven-point scale. Secondly, in measuring the social and psychological stress and hospital anxiety and depression, social and psychological stress were indicated to be a potential danger group, while anxiety and depression were shown to be a healthy group. Thirdly, the emotional characteristics were explored according to the sub-factor of the shortening of the key seven-figure emotional scale after being classified within two months, between two and six months and over six months depending on the duration of the outbreak. As a result, statistically significant, Joy was the highest score over six months and the lowest score between two and six months. On the other hand, the case of depression was depicted to be significantly lower at over six months, and was highest between two and six months. Finally, the correlations on each scale were statistically significant. Conclusions: This study provided that the CSEI-S can be used to simply to measure the emotions of patients according to the period of the onset of stroke in the clinical scene.

• 헤리티지:역사와 과학
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• 제47권4호
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• pp.178-191
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• 2014

진상제는 지방의 특산물을 왕실에 봉진하는 제도이다. 진상물은 물품의 성격, 봉진시기, 용도에 따라 제향진상, 방물진상, 물선진상, 약재진상으로 구분된다. 이 중에서 물선진상은 전국의 산해진미를 봉진하는 것으로, 주로 식재료로 구성되었다. 그리고 물선진상은 다른 진상물과 달리 물품의 수량 경감 내지 일시적인 봉진 중지가 빈번하였다. 이는 물선진상의 경감을 통해 백성에게 물질적인 혜택을 줌으로써 자애로운 군주상을 확보하기 위한 국왕의 의도였다. 숙종 역시 재위기간 동안 빈번히 물선진상을 경감하거나 폐지하였다. 그러나 이 같은 물선진상 변경내역의 문서 보완이 미비하면서, 영조 즉위 직후 물선진상의 물종 및 수량이 불분명한 상태였다. 이에 영조는 "진상별단등록" 간행을 통해 물선진상의 물종 및 수량, 경감내역을 분명히 하였다. "진상별단등록"은 진상지역, 봉진시기, 봉진대상, 물종 및 수량, 경감내역이 기재되어 있다. 이 중에서 물선진상의 물종 및 수량은 다른 내용에 비해 중요하다. "진상별단등록"에 수록된 물선진상은 총 176종에 이르는데, 이 중에서 어류, 패류, 건어류 등 수산물이 117종으로 약 67%를 차지하고 있었다. 그리고 대부분의 물선진상이 원재료로 구성되어 있었고, 생물 이외에 말리거나 절이는 등 다양한 형태로 가공되었다. 물선진상의 지역별 분정특징을 살펴보면, 경상도, 함경도, 강원도 순으로 물선진상이 많이 수록되어 있다. 그리고 이들 지역은 동해안과 접해 있다보니, 수산물의 비중이 상대적으로 높은 편이다. 경상도와 전라도는 석류, 유자 등 양남지역의 대표적인 과실류가 분정되어 있었고, 제주도는 감귤류, 각종 전복가공품 등 전국에서 유일하게 분정된 물종이 대부분을 차지하고 있었다. 그리고 서울과 지리적으로 먼 곳에 위치한 도에는 건어류, 염어류 등을 집중적으로 분정하였다.