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Ligand Design of 5,5'-Diphenylimidazolidine-2,4-dione Analogues as A New Class of Potent Inhibitors of Fatty Acid Amide Hydrolase (새로운 Fatty Acid Amide Hydrolase 저해제로서 5,5'-Diphenylimidazolidine-2,4-dione 유도체의 리간드 설계)

  • Cho, Jong-Un;Soung, Min-Gyu;Sung, Nack-Do
    • Applied Biological Chemistry
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    • v.51 no.2
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    • pp.119-123
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    • 2008
  • 3D-QSARs (3 dimensional quantitative structrue-activity relationships) on the inhibition activities of 3-substituted-5,5'-diphenylimidazolidine-2,4-dione derivatives (1-22) against FAAH (fatty acid amide hydrolase) were studied quantitatively using CoMFA (comparative molecular field analysis) and CoMSIA (comparative molecular similarity indice analysis) methods. The statistical results of the CoMFA 1A and CoMSIA 2F model are better predictability and fitness. And also, the designed X=I, Y=$N_{2}^{+}$-substituent (P1: $Pred.pI_{50}$=6.55), according to the contour maps with information of the two models, showed the most inhibition activity against FAAH.

The study of relations between CEO characteristics and performance of Woman's Enterprise (여성기업의 경영자 특성과 기업성과간의 관계 연구;여성창업기업을 중심으로)

  • Choi, Tak-Yeol;Lee, Sang-Suk
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.2 no.3
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    • pp.123-143
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    • 2007
  • The world has become the most globalize in the new millenium since the beginning of the human being history. In proportion to female economic activity has increased, we have seen many women CEO. Top class sociologists have already started to study female Cooperation. Gradually, they are using highly advanced statistical methods and scientific tools to demonstrate their theory. As survey, this study of relations between CEO characteristics and performance of Woman's Enterprise, we are looking forward to provide a implication about between strengthen the competitiveness and improvement in outcome theoretically and practically. This study executed to woman establishment enterprise among national woman enterprise and to collect achieved data. Analysis result, Woman founder's characteristic and enterprise have been shown to influence school ability among demographic characteristic. Also, management ability, entrepreneurship, technological ability have been shown to influence sales, market share, profitability. According to research, it IS important for business women to know management, improving of technology ability and entrepreneurship.

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Position Effects on Abortion of Reproductive Characters in Vicia cracca (Leguminosae) (등갈퀴나물 ( Vicia cracca : Leguminosae ) 번식기관의 발육정지에 대한 위치효과)

  • Kang, Hyesoon
    • The Korean Journal of Ecology
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    • v.19 no.2
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    • pp.107-123
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    • 1996
  • The position effects on the abortion of flowers, fruits, and ovules were examined in relation to the resource limitation hypothesis using a temperate legume species, Vicia cracca. Fifty plants were randomly sampled from a natural population located at the Belmont Conservation Site in Belmont, MA, USA. Due to indeterminant growth and acropetal flowering of this species, the position of flower or fruit on the plant was able to be coded by the combination of architectural levels such as plant half (lower and upper half) and inflorescence half (lower and upper half) within each plant half. Overall, only 17.3% of the flowers on an inflorescence began to develop into fruits, while overall 36.0% of the fruits initiated failed to mature. Consequently, 11.5% of the flowers successfully matured into fruits. The mean flower number per inflorescence differed significantly among plants as well as between plant halves. Although the probability of fruit initiation was higher in the lower halves of both plant and inflorescence than in the upper halves of the latter, fruit abortion rate differed significantly only between plant halves. The overall mean seed set was 33.6%, implying that about two out of six ovules in a fruit matured into seeds. The seed set was independent of both plant identity and architectural level unlike other reproductive characters examined. When the ovule developmental stage was examined on data pooled over all fruits, the proportion of ovules in varying developmental stages decreased in order of early abortion, seed maturation, late abortion, and seed predation (48.4, 34.9, 12.2, and 4.5%, respectively). A within-fruit ovule position was also used as a class variable for the analysis of position effects on ovule development. All architectural levels considered exerted singificant influence over the ovule development. In particular, ovule development was strongly affected by the within-fruit ovule position. Ovules in both extreme ends within a fruit tended to abort early, while those in the middle position were more likely to mature into seeds. The strong position effects detected from the flowering to seed maturation stage were interpreted as an indication of competitive interaction among reproductive characters which are largely constrained by plant architecture.

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Impact of urbanization and industrialization on irrigation water quality of a canal - a case study of Tongi canal, Bangladesh

  • Zakir, H.M.;Islam, Md. Mahidul;Hossain, Md. Sohrab
    • Advances in environmental research
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    • v.5 no.2
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    • pp.109-123
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    • 2016
  • The Dhaka city, the capital of Bangladesh is one of the most densely populated cities in the world. Tongi canal is situated on the north of the city, which connected the Turag river to the west and the Balu river to the east. A total of 26 water samples were collected from the canal to measure irrigation water quality on the basis of their trace metal and major ionic constituents. Trace metals concentrations in water samples were determined using an Atomic Absorption Spectrophotometer. The amount of Fe, Mn, Zn and Pb in water samples ranged from 0.01-0.80, trace-1.02, trace-0.054 and $0.43-0.64{\mu}g\;mL^{-1}$, respectively. The mean concentration of Ca, Mg, Na, K, $HCO_3{^-}$, $Cl^-$, $BO{_3}^{3-}$, $PO{_4}^{3-}$ and $SO{_4}^{2-}$ in water samples were 45.32, 15.33, 151.65, 11.98, 516.06, 94.69, 0.33, 14.02 and $56.21{\mu}g\;mL^{-1}$, respectively. In respect of $HCO_3{^-}$, $SO{_4}^{2-}$, $PO{_4}^{3-}$ and K contents, most of the water samples were found problematic for irrigation. In context of RSC and hardness, 96 and 92% of water samples were graded as unsuitable and hard class, respectively. The study concluded that Pb content in canal water was comparatively high, so it is desirable to take necessary initiative to minimize the contamination level and to monitor its concentration in water routinely.

A study on the reflective teaching evaluation based on teacher knowledge in school mathematics (수학 교과에서의 교사 지식에 기초한 반성적 수업 평가에 관한 연구)

  • Hwang, Hye-Jeang
    • Journal of the Korean School Mathematics Society
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    • v.14 no.2
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    • pp.123-142
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    • 2011
  • Recently, a number of researches acknowledge the importance of 'reflection' and 'reflective teacher education,' and they highlight the implication of 'reflection' on the teacher's profession or the teacher education. The reflective thought is interpreted as a subject that should be taught or a sort of strategy that a teacher should learn, while the aspect is excluded that reflection is the interaction between the innate knowledge and the practice. As a result, the reflective teacher education programs that increase the level of reflection are developed and practiced, and the reflection is accepted as a tool for increasing teacher professionalism. Reflective teaching is en essential and basic element for the development of teacher knowledge. In particular, such teacher knowledge might be being gradually expanded by a teacher's self-assessment on reflection on his own instruction. For this reason, this study develops an assessment framework on instruction which is comprized of teacher knowledge and instructional process. To accomplish this, in this study, teacher knowledge is considered as a whole practice knowledge combined by subject matter knowledge, understanding of learners, teaching and learning methods and assessment, and instructional environment. Also, success on instruction in mathematics class might depend on the acquisition of teacher knowledge, instructional planning, instructional execution, and furthermore reflection on instruction. Especially, this study emphasizes that 'reflection on instruction', the most important step of instruction be reflected and examined by the teacher himself.

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Development on the Questionnaire of Cold-Heat Pattern Identification Based on Usual Symptoms for Health Promotion - Focused on Reliability Study (건강 증진을 위한 평소 증상 기반의 한열변증 설문지 개발 - 신뢰도를 중심으로)

  • Yeo, Minkyung;Park, Kihyun;Bae, Kwangho;Jang, Eunsu;Lee, Youngseop
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.30 no.2
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    • pp.116-123
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    • 2016
  • This study was performed to develop questionnaire of cold-heat pattern identification(PI) based on usual symptoms for general people, and we analyzed reliability of the questionnaire. We reviewed cold-heat PI questionnaire of advanced research and selected twenty-three items through three time experts meeting. Three hundred and fifty nine healthy subjects were joined in this study. As a results, Cronbach's α of cold-heat PI questionnaire was 0.79 and 0.83. According to the factor analysis about fifteen-chosen cold-heat PI questionnaires, each cold-heat consisted of two factors and each Convergence was 56.46% and 65.93%. Intra-class Correlation Coefficient was 0.67-0.83. Based on the median of samples of primary source, we classified subjects into four category as Cold, Heat, No Cold-Heat, and Cold-heat complex. We examined agreement of diagnosis and coefficient of kappa, and agreement rate of diagnosis was 64.2%, and coefficient of kappa was 0.51. Based on research result, we expect that validity study about questionnaire of cold-heat PI based on usual symptoms will be continued, and hope to be used as subsidiary diagnosis in clinical practice.

An Approach to the Theoretical Design Standard and Effective Practice of Museum Showcase Lighting (진열장 조명의 이론적 기준과 시설에 대한 고찰)

  • Kim, Hong-Bum
    • 보존과학연구
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    • s.17
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    • pp.123-160
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    • 1996
  • There have been many studies and experiments regarding exhibition lighting. Many experiments on photochemical damaging effect and visibility resulted in a practice limited to assigning light levels and adjusting annual exposure time. The three damaging factors to the artifacts are intrinsicsusceptibility to absorb radiant energy, spectral distribution of light source and intensity of illumination and time of exposure. Dividing all the artfacts into three categories to suggest a recommended illuminance level causes some problems. Blue wool, for example, used as the reference material for susceptibility, is not a standard material representing museum artifacts. In the most light sensitive category, ISO class I or anything below have been excluded. The exposure time of one soure can be three times more than another sourece. The spectral distribution of the light source and the relative spectral responsibility of the artifact are not considered in the practice. So in case of very light sensitive material, the recommended illuminance is only the referring value and it is indispensable to check the characteristic of susceptibility of each artifacts. Daylighting is prevailing method to solve the psychological need of the visitors. However, it sould transparent, and should not diffused, and the green-house effect must be considered. llluminance uniformity should based on the maximum illuminance to handle the limitation of exposure for the conservation of a large sensitive object such as a painting. Damage index is not absolute reference for selecting the lighting source because it is experimented from the paper of low grade then calculated. Visibility should be increased by reducing the visual noiseand by planning of appropriate luminance contrast. This paper reviews the problems with the previous studies and experiment sand the current exhibition lighting design practice. The plan for museum showcase lighting is to check the susceptibility and to raise the visibility simultaneously.

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The Educational contents of Rehabilitation Nursing (재활간호학 교과목 내용 구성을 위한 기초조사)

  • Lee, Myung-Hwa;Lim, Nan-Young;Suh, Moon-Ja;Kang, Hyun-Sook;Kim, Jung-Hwa;Suh, Yeon-Ok;So, Hee-Young;Jo, Bok-Hee
    • The Korean Journal of Rehabilitation Nursing
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    • v.4 no.1
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    • pp.118-123
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    • 2001
  • The purpose of this study was to provide fundamental data to propose further directions of education on rehabilitation nursing by investigating the adequacy of the educational contents of rehabilitation nursing. This study was a descriptive survey study. The data collected at 25 universities and 24 junior colleges through questionnaires to answer the research questions from August 10 to September 30, 2000. The questionnaire was consisted of 24 items. The contents of rehabilitation nursing education were developed by consulting with the rehabilitation nursing professionals. The results are as follows Rehabilitation nursing was taught as an independent class in 15 universities and 9 junior colleges. Most professors majoring in adult nursing (66.8%) were in charge of teaching the courses. For the adequacy of the teaching contents of rehabilitation nursing, conceptual bases for rehabilitation was the highest score (4.0), and interdisciplinary rehabilitation team, activities of daily living, clients of rehabilitation, nursing process in rehabilitation nursing, functional evaluation, movement and mobility, physical therapy, occupational therapy, sensation and perception, communication/language, eating and swallowing, bladder elimination, community based rehabilitation nursing, sleep, rest &, fatigue, bowel elimination, historical perspectives of rehabilitation nursing, sexuality, pulmonary rehabilitation, pain, cardiac rehabilitation, skin integrity, family care was ordered.

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Effects of 3,3',4,4',5-pentachlorobiphenyl on human Kv1.3 and Kv1.5 channels

  • Kim, Jong-Hui;Hwang, Soobeen;Park, Seo-in;Jo, Su-Hyun
    • International Journal of Oral Biology
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    • v.44 no.3
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    • pp.115-123
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    • 2019
  • Among the environmental chemicals that may be able to disrupt the endocrine systems of animals and humans are polychlorinated biphenyls (PCBs), a chemical class of considerable concern. PCB consists of two six-carbon rings linked by a single carbon bond, and theoretically, 209 congeners can form, depending on the number of chlorines and their location on the biphenyl rings. Furthermore, 3,3',4,4',5-pentachlorobiphenyl (PCB126) exposure also increases nitric oxide production and nuclear factor kappa-light-chain-enhancer of activated B cells binding activity in chondrocytes, thus contributing as an initiator of chondrocyte apoptosis and resulting in thymic atrophy and immunosuppression. This study identified whether cardiac and immune abnormalities from PCB126 were caused by the Kv1.3 and Kv1.5 channels. PCB126 did not affect either the steady-state current or peak current of the Kv1.3 and Kv1.5 channels. However, PCB126 right-shifted the steady-state activation curves of human Kv1.3 channels. These results suggest that PCBs can affect the heart in a way that does not block voltage-dependent potassium channels including Kv1.3 and Kv1.5 directly.

Comparative Analysis of Dimensionality Reduction Techniques for Advanced Ransomware Detection with Machine Learning (기계학습 기반 랜섬웨어 공격 탐지를 위한 효과적인 특성 추출기법 비교분석)

  • Kim Han Seok;Lee Soo Jin
    • Convergence Security Journal
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    • v.23 no.1
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    • pp.117-123
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    • 2023
  • To detect advanced ransomware attacks with machine learning-based models, the classification model must train learning data with high-dimensional feature space. And in this case, a 'curse of dimension' phenomenon is likely to occur. Therefore, dimensionality reduction of features must be preceded in order to increase the accuracy of the learning model and improve the execution speed while avoiding the 'curse of dimension' phenomenon. In this paper, we conducted classification of ransomware by applying three machine learning models and two feature extraction techniques to two datasets with extremely different dimensions of feature space. As a result of the experiment, the feature dimensionality reduction techniques did not significantly affect the performance improvement in binary classification, and it was the same even when the dimension of featurespace was small in multi-class clasification. However, when the dataset had high-dimensional feature space, LDA(Linear Discriminant Analysis) showed quite excellent performance.