• Bulletin of the Korean Chemical Society
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• v.27 no.5
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• pp.657-662
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• 2006

Identification of accessible sites in targeted RNAs is a major limitation to the effectiveness of antisense oligonucleotides. A class of antisense oligodeoxynucleotides, known as the “10-23” DNA enzyme or DNAzyme, which is a small catalytic DNA, has been shown to efficiently cleave target RNA at purine-pyrimidine junctions in vitro. We have designed a strategy to identify accessible cleavage sites in the target RNA, which is hepatitis C virus nonstructural gene 3 (HCV NS3) RNA that encodes viral helicase and protease, from a pool of random DNAzyme library. A pool of DNAzymes of 58 nucleotides-length that possess randomized annealing arms, catalytic core sequence, and fixed 5'/3'-end flanking sequences was designed and screened for their ability to cleave the target RNA. The screening procedure, which includes binding of DNAzyme pool to the target RNA under inactive condition, selection and amplification of active DNAzymes, incubation of the selected DNAzymes with the target RNA, and target site identification on sequencing gels, identified 16 potential cleavage sites in the target RNA. Corresponding DNAzymes were constructed for the selected target sites and were tested for RNA-cleavage in terms of kinetics and accessibility. These selected DNAzymes were effective in cleaving the target RNA in the presence of $Mg^{2+}$. This strategy can be applicable to identify accessible sites in any target RNA for antisense oligonucleotides-based gene inactivation methods.

• Journal of Korean Library and Information Science Society
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• v.35 no.4
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• pp.171-191
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• 2004

This study presents revision scheme of Korean Decimal Classification appropriate for classification of children-related materials, mainly centered on social science(300) and pure science(400) occupying the majority of children-related materials in school Libraries. Towards this goal, 1 have studied the development and use of classification system for children-related materials available in domestic and overseas school libraries or children's libraries, and researched elementary school 4th, 5th, and 6th grade students' degree of understanding on classification item terms and children-related materials terms used for KDC's social science and Pure science. Based on the results of analysis, f have presented revision scheme of Korean Decimal Classification item terms and class numbers for children-related materials.

• Journal of the Korean Society for information Management
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• v.22 no.4 s.58
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• pp.5-22
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• 2005

As the development of advertising industry and media the research about an advertisement get accomplished. As the result information resources called on the advertising materials are on an Increasing trend. However, it looks into the classification system In advertising field of KDC, the problems are as the follows : (1) the classification items are too incomplete, (2) the main class is badly arranged. The reason have no regard for the correlation with a science. So, it gives rise to confusion to the librarian and user. The purpose of the study is to present the improvement plan on the classification system in advertising field of KDC. In order to build the improvement plan, the four steps are utilized. The first step Is to investigate the characteristic of sciences on advertising and a type. The second one is to survey the current status of the library classification as KDC, NDC, DDC, and LCC. The third one is to analyse the classification system of library and web site on the advertising. The forth one is to grasp the problems on the classification system In advertising field of KDC.

• Journal of Korean Library and Information Science Society
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• v.47 no.3
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• pp.187-211
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• 2016

The present study investigates the seventh and the eighth graders' perception of Free Learning Semester Programs offered by libraries by developing a survey questionnaire on students' needs for Free Learning Semester Programs of Libraries. The skills that middle school students want to improve in Free Learning Semesters are career exploration skills, and the type of Free Learning Semester that is most intensively implemented is career exploration activities. Programs are often offered in the form of experiential classes. Regarding the activities that the students want to participate during Free Learning Semester, the most preferred activities included field experience activity in the career exploration domain, cooking class in the student choice program, smartphone app development in club activities, design activity in the art domain, the badminton in the physical education domain, and using iPad in the information use skills. In addition, among the library programs in coordination with Free Learning Semester, the students liked the occupational experience program most. Future studies need to include the development and implementation of Free Learning Semester Programs based on students' opinions, and investigate their satisfaction with the Free Learning Semester Programs offered by libraries.

• Journal of Korean Library and Information Science Society
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• v.34 no.2
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• pp.143-161
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• 2003

This study intends to analyze the library classification of agriculture in DDC, from the Int edition to the 21th edition. Since Dewey Decimal Classification(DDC) was the first published in 1876, number of total items increased significantly a newly-organized and subdivision of them in the 8th, 10th and 12th edition. According as the discipline developed and was specialized, the agricultural division in DDC was fractionized, and new subjects were continuously added to it. After that time the first edition, the major changes arranged an class and order in the 15th and 17th edition. That is to say, ‘Farm economics’ in 631.1 was relocated to 338.1 in the 17th and ‘Veterinary sciences’ in 619 was relocated to 636.089 in the 15th. Especially, up to now ‘Farm Economics’ deals with an important branch in the science of agriculture. Here the matter of argue heatedly arranges it from economics to agriculture.

• The Transactions of the Korea Information Processing Society
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• v.3 no.5
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• pp.1093-1102
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• 1996

For the reuse, configuration management, and version control of softwares, the composition of retrieval systems and library are most important matters, which makes it possible to retrieve the concerned software components. Retrieval systems, which is able to store many components, must make it possible to retrieve the concerned components with deadwoods in the fastest way. Based either on keyboards or the concept of inverted file on the part of content is usually used in the current retrieval systems. However, in this paper, new retrieval systems are suggested with using set and bag class with Smalltalk language, one of object- oriented programming language, based either on the keywords or on the part of content to find out the concerned components. This method is improved the function of user interface and its management, In this paper, library is also suggested along with the new retrieval systems, and user interface is designed and implemented for its management and control. The new retrial systems of this paper can be employed by interface in another language, and this system is to provide the concerned user with the appropriate retrieval systems and library for the version control.

• Journal of the Korean Society for Library and Information Science
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• v.27
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• pp.215-228
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• 1994

This study is to analyze the background and circumstances of the bibliographical description method appearing in the Hong-ssi Tok-so-rok, or an annotated classified bibliography of Korean and Chinese books edited for the Hongs and their clan. The conclusions are as follows. Each entries of the bibliography are entered under titles, and generally followed by bibliographic elements of volumes, written age, author's name, functional word of authorship, and annotation. The written age is stated by the dynasty name for the first authors within each classes. However some anonymous works and government compiled works are recorded the king's shrine name or the reign title. Entries of the bibliography are arranged by the chronological order in each classes. The writer's name is generally described by 'surname + given name'. However it is sometimes also recorded in the one of the following forms; Appellation (hao, 호) or posthumous title + surname + given name. Sumame + appellation or posthumous title + given name. Appellation ( (hao, 호) or posthumous title + sumame + Sonsaeng (선행) + given name. Sumame + government position title + given name. Appellation (hao, 호) + surname + cha(자, master). surname + ssi(씨). ect. Married women's names are stated by her husband's surname followed by the Chinese character 부 or 절부 which signifies wife or virtuous women, and then her given name. The works written or compiled by King's order (명찬서) are generally described in the form of 명제신+ functional word of authorship. Names of government agencies are occasionally stated as the authors' for the government publications or government compiled works. The functional words of authorship are described in the phrase of 소작야, 소편야 instead of 저, 찬, ect. It is more noticeable that in the case of the collections of individual writers' works the wording of 지문야, 지시야 is written after the name of the author. More complicated descriptive forms are seen in the entries of works for the shared authorship and mixed responsibility. Two or more than two monographic works of the same author classed in the same class are annotated all together.

• Journal of the Korean Society for Library and Information Science
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• v.36 no.3
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• pp.311-330
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• 2002

A public librarian is an occupation, which requires long-term. continuous training and difficult study to acquire and cultivate professional knowledge and skills. It is a necessity to achieve new knowledge, information and skills via appropriate retraining. A training system is the method which gives chances of retraining to public librarians. After examining some of the problems with the existing training system, it is apparent that the direction of training system needs to be decentralized. That is each local branch should be autonomous in terms of new training for librarians. For the method of training system, each autonomous unit would integrate the different theories to apply to the community-at-large and invite practical specialists from the local community to lecture. The training classes would be elective in that the each librarian could choose the classes he/she wants to take and give them credits for that, but the certificate for the class would also go towards completion for the required technical training. Finally, the utilization of cyber-education should be introduced, and the library association's role strengthened, to help public librarians cultivate their specialties.

• Journal of the Korean Society for Library and Information Science
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• v.50 no.2
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• pp.5-23
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• 2016

The purpose of this study is to analyze common inquiry tasks of middle school history textbooks and find out it's implications on teacher librarians' educational information services. There are 84 common inquiry tasks according to examinations of inquiry tasks related to world history in 18 kinds of middle school history textbooks. Results of the analysis show that almost all of common inquiry tasks of world history make middle school students who should resolve them research the pictures and reading materials included in the textbooks individually and verbalize under the information literacy process. Compared with information literacy process of the "Library and Information Skills" for middle schools, the First step of task definition and figuring out information needs and the Third step of representation of information are being implemented. For this reason, teacher librarian could reduce history studies teachers' burden of running the class and promote students' inquiry activities by teaching skills of information analysis and interpretation, synthesis and organization and evaluation of their information literacy process and results.

• Journal of the Korean Society for Library and Information Science
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• v.49 no.3
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• pp.233-252
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• 2015

The purpose of this study is to analyze inquiry tasks of textbooks in middle schools social studies under the information literacy process and find out teacher librarians' educational information service on the side of information literacy education. Results of the analysis show that middle school students who carry out the inquiry tasks of social studies should select sources, seek its' related information and create their products through writing reports or presentation. Compared with information literacy process of the "Library and Information Skills", the First step of task definition and figuring out information needs and the Third step of representation of information are being implemented. For this reason, teacher librarian could reduce social studies teachers' burden of class and promote students' inquiry activities by teaching skills of suitable materials seeking strategies for solving their task, understanding and synthesizing the information and evaluating their process and result. Therefore, it is necessary to activate collaborative teaching between the teacher librarian and the social studies teacher based on the information literacy.