• The Journal of the Society of Stroke on Korean Medicine
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• v.6 no.1
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• pp.1-7
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• 2005

Objectives: Chungpyesagan-tang is a famous oriental Objectives: medicine treatment frequently used to stroke in Korea. The objective of this study is to evaluate the mechanism of the therapeutic effect of Chungpyesagan-tang on stroke in rat. Methods: We compared the difference in regional cer Methods: ebral blood flow, nitric oxide (NO) synthesis between the control and the Chungpyesagan-tang-treated group after ligating middle cerebral artery. Results: In our study, cerebral blood flow increased more in the stroke rats which had been fed by Chungpyesagan-tang than in the control. Chungpyesagan-tang induced vascular NO synthesis, but had no effect on neuronal NO synthesis. Conclusion: The mechanism of Chngpyesagan-tang's therapeutic effect on ischemic stroke could be explained by increasing cerebral blood flow and vascular NO synthesis.

• The Journal of Korean Medicine
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• v.23 no.4
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• pp.9-14
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• 2002

To assess the clinical efficacy of Chungpyesagan-tang on acute stroke, we prescribed this medicine to 88 acute stroke patients without thrombolytic treatment. The rate of progressive stroke type was 2.3%, remarkably lower than in previous reports. 1.1 % felt an itching sensation, and 17.0% complaxined of loose stool and diarrhea. Chungpyesagan-tang decreased Stroke-Pattern Identification and National Institute of Health Stroke Scale (NIHSS), and increased Modified Barthel Index (MBI). Thus, we could suggest that this medicine has a desirable effect to reduce the severity of stroke and improve functional recovery. As to the laboratory findings, ALT had anupward tendency and increased over normal value in 16 cases (18.2%). However, the mean serum level 2 weeks later was within the normal value and the other hepatic enzymes did not increase.

• The Journal of the Society of Stroke on Korean Medicine
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• v.11 no.1
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• pp.36-45
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• 2010

Objective : The aim of this study was to examine the characteristics of the acute stroke patient who took Chungpyesagan-tang, and provide the basis of Chungpyesagan-tang prescription. Method : We studied hospitalized patients within 4 weeks after their occur who were admitted at Kyunghee University Oriental Medical Center, Kyunghee University East-West Neo Medical Center, Kyungwon University Oriental Medical Center, Semyung University Oriental Medical Center from February 2010 to July 2010. We compared the general characteristics of acute stroke patient with herbal medicine. Result : The patient who took Chungpyesagan-tang showed significant difference for age, family history of hypertension, ALT, coffee drinking, fastfood eating, stool, Oriental Medical Diagnosis. Conclusion : The above result show that Chungpyesagan-tang can be prescribed to stroke patient whose stool is hard, whose Oriental Medical Diagnosis is fever type. Further studies will be needed to better understand the difference between Chungpyesagan-tang group and Other herbal medicine among acute stroke patients.

• The Journal of Internal Korean Medicine
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• v.28 no.1
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• pp.199-207
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• 2007

This study is clinical report of one patient on a middle cerebral artery territory infarction who improved with the administration of an herbal medication. We prescribed Chungpyesagan-tang to the patient, and then CAVI(cardio-ankle vascular index), NIHSS, and MBI were followed up 1, 2 and 3 weeks later. After 1, 2 and 3 weeks,, CAVI and NIHSS decreased and MBI increased. These findings suggest that Chungpyesagan-tang has an effect on improvement of neurologic deficit of MCA infarction.

• Journal of Sasang Constitutional Medicine
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• v.25 no.1
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• pp.71-79
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• 2013

Objectives The purpose of this case thesis paper is to report the improvement of symptoms for a 58-year-old male patient who experienced refusing food intake 1 month after onset of stroke by treating the patient with Chungpyesagan-tang. Methods We have determined the patient to have the Taeeumin type physique with Dry Heat Syndrome and provided Chungpyesagan-tang to alleviate the patient's symptoms. The level of improvement was measured based on changes of food intake amount. Results The patient was hospitalized to receive treatment for roughly 2 weeks. The symptom of refusing food intake as well as other symptoms that simultaneously appeared including insomnia, headache, dizziness, and general weakness have improved. Conclusions In this case, the symptom of refusing food intake appeared one month after experiencing stroke, and the patient refused not only meals, but the intake of all other forms of food including water and medicine. The cause of such symptoms were deemed to be emotional rather than the types of food which generally provide the causes for Oh Shik Jeung. As the patient was deemed to have the Taeeumin type physique with Dry Heat Syndrome. Chungpyesagan-tang was provided for treatment. Acupuncture and oriental cupping therapy were also provided concurrently, and the main symptom and other accompanying conditions have largely improved after 2 weeks of hospitalized treatment.

• Journal of Sasang Constitutional Medicine
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• v.19 no.3
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• pp.257-269
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• 2007

1. Objectives The purpose of this case report is to evaluate the effects of Sasang constitutional diagnosis and treatment of two delirium patients who were diagnosed Taeumin Dry-Heat Syndrome(燥熱證). 2. Methods Two delirium patients were diagnosed Taeumin Dry-Heat Syndrome(燥熱證) based on their Nature & Emotion (性情), physical characteristics, symptoms. They were medicated Chungpyesagan-tang(淸肺瀉肝湯) through of sleep, complexion, thirst, stool, coating of the tongue, and MMSE(Mini-Mental State Exanmination) score were used of measure improvement. 3. Results and Conclusions Two delirium patients who were treated with Chungpyesagan-tang(淸肺瀉肝湯) showed improvement in delirium symptoms, thirst, constipation, redness of complexion, white coating of tongue, and general condition. These case reports describe the effects on delirium and symptoms of Sasang Constitutional Medication. The necessity of managing the psychological aspects of the pathology through Nature & Emation(性情) is also mentioned.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.1
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• pp.40-49
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• 2023

Objectives : This study was conducted to confirm the skin anti-aging effect of Chungpyesagan-tang(CPSGT) extract. Methods : We performed MMT assay to confirm the cytotoxicity of CPSGT. After inducing matrix metalloproteinase-1(MMP-1) with tumor necrosis factor-α(TNF-α), we investigated mRNA expression and protein secretion of MMP-1 by real-time RT-PCR and ELISA. In addition, we measured the protein expression of mitogen-activated protein kinases(MAPKs) and transcription factors by western blot. Results : CPSGT was not cytotoxic at 25-800㎍/㎖. The mRNA expression and protein secretion of MMP-1 decreased when treated with CPSGT. The protein expression of p-ERK, p-JNK, p-p38 was decreased by CPSGT. In addition, the protein expression of p-c-jun and p-NF-κB, which are transcription factors, were also decreased. Conclusion : This suggests that CPSGT can inhibit MMP-1 and thus be a potential anti-aging substance.

• The Journal of Internal Korean Medicine
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• v.27 no.2
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• pp.416-428
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• 2006

Objectives : Arterial stiffness and pulse pressure are related to cardiovascular and cerebrovascular survival and longevity. This study is aimed at examining the effects of Chungpyesagan-tang on arterial stiffness and Pulse pressure in acute stroke Patients. Methods: The subject of this study was acute strike Patients within 1 week after ictus, with Cardio-ankle vascular index(CAVI) higher than 9.0. They were divided into two groups: A treatment group (n=44) and a control group(n=46). For two weeks, Chungpyesagan-tang was given to the former, other herbal medicines to the latter. used for stroke patients for the control group for 2 weeks. At the end of first and second week, CAVI, pulse Pressure, National Institute of Health stroke scale(NIHSS), Modified Barthel Index(MBI) were measured. Serum lipid Profile, aspartate transaminase(AST), alanine transaminase(ALT). blood urea nitrogen(BUN), creatinine were also measured at the end of the study. Results : After 2 weeks, CAVI and Pulse Pressure in Chungpyesagan-tane group were significantly tower than those in the control group(P<0.05). NIHSS and MBI were improved in both groups. But there was no significant difference between the treatment group and the control group in terms of the NIHSS and MBI. Conclusions : We suggest Chungpyesagan-tanghas desirable effects on arterial stiffness and Pulse Pressure of acute stroke patients. It can improve morbidity and mortality of patients on the basis of influencing vascular stiffness and increased pulse pressure.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.34 no.4
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• pp.24-36
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• 2021

Objectives : This study was conducted to confirm the anti-oxidative effect of Chungpyesagan-tang(CPSGT) extract. Methods : In this study, MTT assay was performed to confirm cell viability, and DPPH and ABTS were performed to confirm radical scavenging ability. The ROS scavenging ability and the protective effect against DNA damage were confirmed by 2,7-dichlorofluorescin diacetate(DCF-DA) and 4',6-diamidino-2-phenylindole(DAPI) staining and comet assay. mRNA expression of Heme oxygenase-1(HO-1) was measured by real-time PCR, and expression of HO-1 and Kelch-like ECH-associated protein 1(Keap1) proteins was measured by western blot. Results : CPSGT was not cytotoxic at 50-400㎍/㎖. The radical scavenging activity was increased, and the ROS scavenging activity and the protective effect against DNA damage were increased compared to the LPS-treated group. The mRNA expression and protein expression of HO-1 were increased in a concentration-dependent manner. The protein expression level of Keap1 was decreased in a concentration-dependent manner. Conclusion : This suggests that CPSGT has an antioxidant effect and can be used as a potential material for skin diseases.

• Journal of Sasang Constitutional Medicine
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• v.20 no.3
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• pp.218-224
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• 2008

1. Objectives Constipation is a common symptom affecting 16.5% of general population in Korean countries. However, many people are looking for constipation due to the hospital. The clinical studies in herbal medicine to cure rectal tenesmus and constipation caused by the stress of the case. 2. Methods We have tried researching effect of herbal medicines(Chungpyesagan - tang and kalkunseunggi-tang) treatments to Stress caused by Taeumin rectal tenesmus and constipation patient. 3. Results A Taeumin patient diagnosed to rectal tenesmus and constipation was treated with Taeumin herbal medicines (Kalkunseunggi - tang treatments) and change of patient's the feces number of times and abdomen discomfort were improved. 4. Conclusions The cause of constipation variety as was treatments is various. The constitutional treatment with Kalkunseunggi - tang may have an effect on management of constipation. So we report the healing process and results of this patient in this study.