The Journal of the Society of Stroke on Korean Medicine (대한중풍순환신경학회지)

The Society of Stroke on Korean Medicine (대한중풍순환신경학회)
권호 표지

An Eperimental Study of Chungpyesagan-tang on Cerebral Blood Flow and Nitric Oxide in Cerebral Ischemia of Rat

뇌허혈시 청폐사간탕이 뇌혈류 및 산화질소에 미치는 영향에 대한 실험적 연구

  • Kim, Young Suk (Department of Cardiovascular ＆ Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Jung, Woo Sang (Department of Cardiovascular ＆ Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Park, Seong Uk (Department of Cardiovascular ＆ Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Moon, Sang Kwan (Department of Cardiovascular ＆ Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Go, Chang Nam (Department of Cardiovascular ＆ Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Cho, Ki Ho (Department of Cardiovascular ＆ Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Bae, Hyung Sup (Department of Cardiovascular ＆ Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Kyung Sup (Department of Cardiovascular ＆ Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Doo Ick (Department of Anesthesiology, College of Medicine, Kyung Hee University)
  • 김영석 (경희대학교 한의과대학 심계내과학 교실) ;
  • 정우상 (경희대학교 한의과대학 심계내과학 교실) ;
  • 박성욱 (경희대학교 한의과대학 심계내과학 교실) ;
  • 문상관 (경희대학교 한의과대학 심계내과학 교실) ;
  • 고창남 (경희대학교 한의과대학 심계내과학 교실) ;
  • 조기호 (경희대학교 한의과대학 심계내과학 교실) ;
  • 배형섭 (경희대학교 한의과대학 심계내과학 교실) ;
  • ;
  • 이두익 (경희대학교 의과대학 마취과학 교실)
  • Published : 2005.12.01
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Abstract

Objectives: Chungpyesagan-tang is a famous oriental Objectives: medicine treatment frequently used to stroke in Korea. The objective of this study is to evaluate the mechanism of the therapeutic effect of Chungpyesagan-tang on stroke in rat. Methods: We compared the difference in regional cer Methods: ebral blood flow, nitric oxide (NO) synthesis between the control and the Chungpyesagan-tang-treated group after ligating middle cerebral artery. Results: In our study, cerebral blood flow increased more in the stroke rats which had been fed by Chungpyesagan-tang than in the control. Chungpyesagan-tang induced vascular NO synthesis, but had no effect on neuronal NO synthesis. Conclusion: The mechanism of Chngpyesagan-tang's therapeutic effect on ischemic stroke could be explained by increasing cerebral blood flow and vascular NO synthesis.

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