• Korean Journal of Adult Nursing
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• v.27 no.1
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• pp.106-116
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• 2015

Purpose: The purpose of this review was to assess the quality and to evaluate the effectiveness of music interventions in reducing agitation in older adults with dementia. Methods: Randomized controlled studies and randomized crossover studies were identified by searching MEDLINE, EMBASE, CINAHL, PsycINFO, AGELINE, Cochrane Central Register of Controlled Trials, Korea Med, Kmbase, RISS, National Assembly Digital Library, KISS, and RICH. Two reviewers independently retrieved articles, extracted data, and assessed the quality of studies. Results: In total, 10 studies were selected from 1095 unique citations. All included studies were conducted in long term care settings. Overall, risk of bias for included studies was low to moderate. The weighted average effect size across studies was -0.39 (95%CI [-0.69, -0.10], p=.009, $I^2=63%$). Music therapy was effective to reduce agitation of the older adults with dementia. Conclusion: Music intervention can be an effective non-pharmacological intervention for the reduction of agitation in dementia. Future studies need to use rigorous research method and to provide description of research methods in greater detail. In addition, future studies are required to explore the effects of music therapy according to severity of agitation and dementia.

• Journal of KIISE
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• v.44 no.10
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• pp.1019-1025
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• 2017

Binary similarity analysis is used in vulnerability analysis, malicious code analysis, and plagiarism detection. Proving that a function is equal to a well-known safe functions of different versions through similarity analysis can help to improve the efficiency of the binary code analysis of malicious behavior as well as the efficiency of vulnerability analysis. However, few studies have been carried out on similarity analysis of the same function of different versions. In this paper, we analyze the similarity of function units through various methods based on extractable function information from binary code, and find a way to analyze efficiently with less time. In particular, we perform a comparative analysis of the different versions of the OpenSSL library to determine the way in which similar functions are detected even when the versions differ.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.5
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• pp.932-940
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• 2011

This study describes computational simulation results in 2-dimensional and 3-dimensional space concerning large scale gap test(LSGT) by using commercial hydrocode such as AUTODYN and LS-DYNA to analyze the detonation phenomenons of high explosives. To consider the possibilities of LSGT simulation, we used Lee - Tarver reaction rate model of PBX-9404 and Comp-B which were implemented AUTODYN's material library. Also we have tried the diverse numerical schemes such as Lagrangian, Eulerian and ALE(Arbitary Lagrangian Eulerian), SPH(Smoothed Particle Hydrodynamics) in LSGT simulations. After LSGT simulations, we compared the simulation results with published results to verify the LSGT simulations. According to the LSGT simulations, we have concluded as follows. In 2-dimensional and 3-dimensional space, Lagrangian solver provided the most reliable results based on analysis time and accuracy. When using two hydrocodes in 2-dimensional space, the simulation results are almost same except one explosive model. We have verified the modeling method and simulation results of the LSGT by using the commenrcial hydrocode in this study.

• The KIPS Transactions:PartC
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• v.8C no.5
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• pp.557-564
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• 2001

Many people use Linux and FreeBSD because it is freeware and excellent performance. The open source code is very important feature but it also has some problem which may be attacked by hackers frequently. This paper describes the SecuROS of secure operating system that is best solution to this problem and introduces user and programmer interface for active use of secure operating system. Developed secure operating system is composed of the access control method MAC and ACL and conforms to the POSIX which is universally used.

• Journal of Photoscience
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• v.7 no.2
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• pp.53-58
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• 2000

We performed the cloning of a chalcone synthase (CHS) gene, the key enzyme in the anthocyanin biosynthesis, from the cDNA library constructed with grape suspension cells irradiated UV-B. The PCR fragment was used to cloning the CHS gene. One CHS cDNA clone containing an open reading frame and a partial stilbene synthase (STS)cDNA, the stilbene-type phytoalexin, were isolated. The CHS cDNA clone (VCHS) showed 87% sequence homology with VvCHS (V.vinifea) and 72.3% identity with VSTSY(V.vinifea). its amino acid sequences were longer than any other CHS genes as 454 residues. Two genes were weakly expressed in white light irradiated cells, but highly induced in UV-B irradiated condition during 32 hours. Interestingly, the STS was quickly and abundantly expressed from 2 hours when supplemented with jasmonic acid (JA) and the maximum expression was observed at 4 hours and then gradually decreased. But, the additional UV-B or white light quickly degraded the STS expression than only JA treated grape suspension cells. The CHS also was rapidly induced with JA and the synergistical effect was observed at the addigional light treatment of UV-B or white light. These results are indicated that CHS and STS have different response mechanisms against the environmental stresses.

• Journal of Microbiology and Biotechnology
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• v.17 no.7
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• pp.1083-1089
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• 2007

Because of their selectivity and catalytic efficiency, BVMOs are highly valuable biocatalysts for the chemoenzymatic synthesis of a broad range of useful compounds. In this study, we investigated the microbial Baeyer-Villiger oxidation and sulfoxidation of thioanisole and bicyclo[3.2.0]hept-2-en-6-one using whole Escherichia coli cells that recombined with each of the Baeyer-Villiger monooxygenases originated from Pseudomonas aeruginosa PAOl and two from Streptomyces coelicolor A3(2). The three BVMOs were identified in the microbial genome database by a recently described protein sequence motif; e.g., BVMO motif(FXGXXXHXXXW). The reaction products were identified as (R)-/(S)-sulfoxide and 2-oxabicyclo/3-oxabicyclo[3.3.0]oct-6-en-2-one by GC-MS analysis. Consequently, this study demonstrated that the three enzymes can indeed catalyze the Baeyer-Villiger reaction as a biocatalyst, and effective annotation tools can be efficiently exploited as a source of novel BVMOs.

• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.2
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• pp.47-66
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• 2016

Objectives : The purpose of this study was to present the clinical practice guidelines for breast cancer through the analysis of existing clinical practice guidelines in Western and Chinese medicine. Methods : The literature search was performed regarding conventional and integrative medical treatment of breast cancer using Google Scholar, KIOM OASIS, PUBMED and Jisan library of Daejeon university. Results : Breast cancer is the fifth most common cancer in Korea. Recent studies revealed that combining conventional and integrative medical treatment can reduce the sequela of surgical operation and improve survival rate. However there isn’t still a systemic clinical guideline for breast cancer in korean medicine. This study will be a preliminary study to establish clinical practice guidelines of Korean Medicine for breast cancer.Conclusions : Further objective and systemic clinical studies related to Korean Medicine are needed to develope more advanced clinical practice guidelines of breast cancer.

• Journal of Korean Society on Water Environment
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• v.22 no.6
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• pp.1014-1021
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• 2006

SMMIAR (Submerged Moving Media Intermittent Aeration Reactor) Process is a very efficient system which remove ammonia to nitrogen gas in one reactor. In this study, we determined the diversity of ammonia oxidizing bacteria and denitrifying bacteria using specific PCR amplification and the clone library construction. An ammonia monooxygenase gene(amoA) was analyzed to investigate the diversity of nitrifiers. Most of amoA gene fragments (27/29, 93%) were same types and they are very similar (>99%) to the sequences of Nitrosomonas europaea and other clones isolated from anoxic ammonia oxidizing reactors. ANAMMOX related bacteria have not determined by specific PCR amplification. A nitrite reductase gene(nirK) was analyzed to investigate the diversity of denitrifying bacteria. About half (9/20, 45%) of denitrifiers were clustered with Rhodobacter and most of others were clustered with Mesorhizobium (6/20, 30%) and Rhizobium (3/20, 15%). All of these nirK gene clones were clustered in alpha-Proteobacteria and this result is coincide with other system which also operate nitrification and denitrification in one reactor. The molecular monitoring of the population of nitrifiers and denitrifiers would be helpful for the system stabilization and scale-up.

• Publications of The Korean Astronomical Society
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• v.19 no.1
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• pp.77-81
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• 2004

A high performance computing cluster for astronomical computations has been built at Korea Astronomy Observatory. The 64 node cluster interconnected with Gigabit Ethernet is composed of 128 Intel Xeon processors, 160 GB memory, 6 TB global storage space, and an LTO (Linear Tape-Open) tape library. The cluster was installed and has been managed with the Open Source Cluster Application Resource (OSCAR) framework. Its performance for parallel computations was measured with a three-dimensional hydrodynamic code and showed quite a good scalability as the number of computational cells increases. The cluster has already been utilized for several computational research projects, some of which resulted in a few publications, even though its full operation time is less than one year. As a major resource of the $K^*Grid$ testbed, the cluster has been used for Grid computations, too.

• BMB Reports
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• v.34 no.4
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• pp.342-346
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• 2001

The Mycobacterium bovis BCG panB gene, encoding ketopantoate hydroxymethyltransferase (KPHMT), was cloned from a ${\lambda}gt11$ genomic library and sequenced. The DNA sequence encodes a protein that contains 281 amino acid residues (M, 29,337) with a high similarity to the KPHMTs. Subcloning of a 846 by open reading frame (ORF), but not a 735 by ORF, into the vector pUC19 led to complementation of the panB mutant of Escherichia coli. The BCG pang gene was overexpressed in E. coli and the KPHMT purified to homogeneity The recombinant protein was further confirmed by an enzymatic assay.