• The Korean Journal of Physiology and Pharmacology
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• v.26 no.6
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• pp.541-556
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• 2022

Myocardial fibrosis is a key link in the occurrence and development of diabetic cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte apoptosis is an important cause of myocardial fibrosis. The purpose of this study was to investigate the effect of gaseous signal molecule sulfur dioxide (SO₂) on diabetic myocardial fibrosis and its internal regulatory mechanism. Masson and TUNEL staining, Western-blot, transmission electron microscopy, RT-qPCR, immunofluorescence staining, and flow cytometry were used in the study, and the interstitial collagen deposition, autophagy, apoptosis, and changes in phosphatidylinositol 3-kinase (PI3K)/AKT pathways were evaluated from in vivo and in vitro experiments. The results showed that diabetic myocardial fibrosis was accompanied by cardiomyocyte apoptosis and down-regulation of endogenous SO₂-producing enzyme aspartate aminotransferase (AAT)_1/2. However, exogenous SO₂ donors could up-regulate AAT_1/2, reduce apoptosis of cardiomyocytes induced by diabetic rats or high glucose, inhibit phosphorylation of PI3K/AKT protein, up-regulate autophagy, and reduce interstitial collagen deposition. In conclusion, the results of this study suggest that the gaseous signal molecule SO₂ can inhibit the PI3K/AKT pathway to promote cytoprotective autophagy and inhibit cardiomyocyte apoptosis to improve myocardial fibrosis in diabetic rats. The results of this study are expected to provide new targets and intervention strategies for the prevention and treatment of diabetic cardiomyopathy.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.1704-1705
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• 2011

MEMS(Micro Electro Mechanical Systems) 기술과 니켈 전기도금공정을 이용하여 수십 내지 수백개의 탐침을 갖는 일체형 탐침 패드(Probe Pad)를 제작하였다. PI(Polyimide) Film은 일본 UBE사의 $50{\mu}m$ 두께를 갖는 유피렉스를 사용하였다. 일체형 탐침 패드는 Polyimide Film에 Cu를 증착 후 사진식각공정을 통하여 PR Mold 형성한 후 전류가 흐르는 Cu 라인(line) 배선을 형성하기 위해 Cu를 식각하였으며 형성된 Cu Line 위에 니켈 전해도금공정을 실시하여 니켈 배선을 형성하였다. Ni 배선 위에 니켈 범프를 형성하기 위하여 PR Strip을 실시한 후 다시 PR Mold를 형성하였다. PR Mold 형성 후 다시 니켈 전해도 금을 실시하여 니켈 범프(bump)를 형성하였다. 제작된 탐침패드의 니켈배선의 폭은 $18.0{\mu}m$이고 피치(Pitch)는 $35{\mu}m$이며, 니켈 범프의 두께(Thickness)는 $10.0{\mu}m$로 제작되었다. 본 연구에서 제작된 탐침패드를 더욱 더 고집적화(Fine Pitch)하여 일체형 탐침 패드를 제작하게 되면 이를 사용하는 프로브유니트의 제작에 있어서 비용 절감 및 생산성(Throughput)을 크게 향상 시킬 수 있을 것이다.

• Journal of Navigation and Port Research
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• v.38 no.4
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• pp.349-356
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• 2014

In the underwater communication, the performance of system is reduced because of the inter-symbol interference occur by the multi-path. In the recent years, to deal with poor channel environment and improve the throughput, the efficient concatenated structure of equalization, channel codes and Space Time Codes has been studied as MIMO system in the underwater communication. Space Time Codes include Space Time Block Codes and Space Time Trellis Codes in underwater communication. Space Time Trellis Codes are optimum for equalization and channel codes among the Space Time Codes to apply in the MIMO environment. Therefore, in this paper, turbo pi codes are used for the outer code to efficiently transmit in the multi-path channel environment. The inner codes consist of Space Time Trellis Codes with transmission diversity and coding gain in the MIMO system. And Zero Forcing method is used to remove inter-symbol interference. Finally, the performance of this model is simulated in the underwater channel.

• Applied Biological Chemistry
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• v.43 no.1
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• pp.52-56
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• 2000

The influence of the 2-(4-(6-chloro-2-benzoxazolyloxy)phenoxy)-N-phenyl- propionamide derivatives on the herbicide activities against rice plant with pre-emergence and post-emergence in down land were examined and the structure activity relationship (SAR) were analyzed by Free-Wilson and Hansch method. In pre-emergence, the SAR approach is shown that the optimal, $({\pi})_{opt}=0.91$, hydrophobicity with electron donating effect of the ortho substituted mono substituents and 2,3,4-substituted three substituents were found to be contribute the herbicidal activity. Whereas, in post-emergence, the optimal, ({\pi})_{opt}=0.50$, hydrophobicity with electron withdrawing effect of meta substituted mono subsituents and 2,3-substituted two substituents were found to be contribute the herbicide activity. The herbicide activities with post-emergence more increase than that of pre-emergence. It is assumed from the SAR equations that the 2-methyl-3-methoxy-4-cyano group substituent is selected as the most lowest herbicide activity against rice plant with post-emergence in green house. The hydrolysis reaction was proceeded through nucleophilic addition-elimination (Ad_{Nu-E})$ with the orbital control between LUMO of substrate and HOMO of water molecule. And molecular electrostatic potential (MEP) of none (H) substituent was discussed.

• Korean Journal of Environment and Ecology
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• v.29 no.6
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• pp.858-864
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• 2015

Developmental changes in the vocal signals of serotine bats (Eptesicus serotinus) during their infancy were examined in this study. The analysis was conducted on 4 infant serotine bats from 1 to 40 days after their birth. Pulse duration (PD), pulse interval (PI), peak frequency (PF), maximum frequency ($F_{MAX}$), minimum frequency ($F_{MIN}$), and bandwidth (BW) were measured. As the bats grew, their vocalizations became increasingly consistent and similar to those of adults. For infant bats, PD and PI decreased as they grew older, whereas PF, $F_{MAX}$, $F_{MIN}$, and BW increased. The greatest change in vocalizations was observed between the $10^{th}$ and $20^{th}$ days after birth. Also, PF, $F_{MAX}$, $F_{MIN}$ and BW, which describe sound frequency, increased dramatically during the period between the $10^{th}$ and the $20^{th}$ days. In contrast, the greatest change in PD occurred between the $30^{th}$ and $40^{th}$ days after birth. The results collected in this study suggest that frequency increased as the contraction ability of the muscles developed by around 20 days of age. Muscle relaxation ability, which is related to PD, was found to develop significantly at 30 to 40 days of age. According to the results of this study, although 40 day-old infant bats are not yet able to fly, their vocal signals were similar to those of adults. This indicates that vocal development and flying activity develop separately in young bats.

• Bulletin of the Korean Chemical Society
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• v.35 no.9
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• pp.2699-2703
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• 2014

We solve the Klein-Gordon equation with the modified Rosen-Morse potential energy model. The bound state energy equation has been obtained by using the supersymmetric shape invariance approach. The relativistic vibrational transition frequencies for the $6^1{\Pi}_u$ state of the $^7Li_2$ molecule have been computed by using the modified Rosen-Morse potential model. The calculated relativistic vibrational transition frequencies are in good agreement with the experimental RKR values.

• Biotechnology and Bioprocess Engineering:BBE
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• v.9 no.4
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• pp.241-244
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• 2004

Protein A molecular thin film was fabricated as a platform of antibody-based biosensor. For the immobilization of the protein A thin film, a viologen multilayer was built up using the Langmuir-Blodgett (LB) technique, and then, protein A was adsorbed on the viologen LB film by an electrostatic interaction force, which was formed as a hetero-film structure. For the deposition of viologen, surface pressure area ($\pi$-A) isotherm was investigated. The fabricated protein A-viologen hetero LB film was investigated using atomic force microscopy (AFM). Using the developed molecular film, antibody immobilization and fluorescence measurement was carried out.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.2177-2178
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• 2011

In this paper, adaptive speed sensorless vector control, sliding mode observer to be present. Adaptive sliding mode observer of the motor stator coordinate system using the voltage equations of the rotor flux components are observed. Lyapunov function of the induction motor speed is estimated by the relationship further. In order to establish such a control scheme based on the way conventional PI controller and sliding mode observer annexing characteristics of the system through simulation and experiment were compared. Analyzed and compared according to the results presented confirmed the usefulness of the system.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.957_958
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• 2009

2DOF is applied to induction moor in order to supply these weak points of PI speed control method in this paper. and proposed method utilize the combination of the voltage model based on stator equivalent model and the current model based on rotor equivalent model, which enables stable estimation of rotor flux. And it also emphasizes the improvement of the control characteristics in low speed region where established schemes have many problems. To prove the propriety of this paper, the various simulations carried out adequacy and stability using Matlab, and at the same time real system is made, so it is proved. As the results of embodying the system, the robust system is realized.

• Proceedings of the KIPE Conference
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• 2010.07a
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• pp.393-394
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• 2010

본 논문은 LCL필터를 이용한 분산전원용 계통연계형 PCS의 전류제어기를 비교 분석하였다. 주요 비교대상은 PI(Proporional-intergral)제어기, PR(Proportional-Resonant), 제어기, DeadBeat (DB)제어기 등의 선형 제어기 이며, 각 제어기의 과도상태 응답특성과 정상상태 응답특성을 시뮬레이션으로 비교하였다. 또한 DSP의 특성에 의한 1 주기 지연, 리액턴스와 저항 변화 등에 강인한 DB제어기 관하여 논의 하겠다.