• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권10호
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• pp.2627-2642
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• 2023

Parkinson's disease (PD) is a typical, chronic neurodegenerative disease involving the concentration of dopamine, which can disrupt motor activity and cause different degrees of gait disturbance relevant to PD severity in patients. As current clinical PD diagnosis is a complex, time-consuming, and challenging task that relays on physicians' subjective evaluation of visual observations, gait disturbance has been extensively explored to make automatic detection of PD diagnosis and severity rating and provides auxiliary information for physicians' decisions using gait data from various acquisition devices. Among them, wearable sensors have the advantage of flexibility since they do not limit the wearers' activity sphere in this application scenario. In this paper, an attention-based temporal network (ATN) is designed for the time series structure of gait data (vertical ground reaction force signals) from foot sensor systems, to learn the discriminative differences related to PD severity levels hidden in sequential data. The structure of the proposed method is illuminated by Transformer Network for its success in excavating temporal information, containing three modules: a preprocessing module to map intra-moment features, a feature extractor computing complicated gait characteristic of the whole signal sequence in the temporal dimension, and a classifier for the final decision-making about PD severity assessment. The experiment is conducted on the public dataset PDgait of VGRF signals to verify the proposed model's validity and show promising classification performance compared with several existing methods.

• 대한족부족관절학회지
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• 제10권2호
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• pp.247-249
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• 2006

Purpose: The neural injuries by the sprain around the ankle joint may contribute the chronic pain. Authors analyzed the incidence and the contributing factor of the neural injuries in ankle sprain. Materials and Methods: 52 patients (54 cases) were involved in this retrospective study. Patient with diabetes or spinal disease were excluded. Plain radiograph and MR image were evaluated. Treatments were consisted of cast immobilization for 4 weeks with weight bearing ambulation following bracing for 8 weeks. Neurologic evaluation were performed at 3 months, 6 months, 12 months post-injury period and each neural injury were confirmed by electromyography or lidocaine block test. Results: The average age was 39 years old and 34 cases were male and 20 cases were female. Rupture of the anterior talofibular ligament was observed in 48 cases, distal anterior tibiofibular ligament in 37 cases, calcaneofibular ligament in 6 cases. One cases revealed no injury of the ligament. Neural injuries around ankle was observed in 13 cases ; superficial peroneal nerve in 9 cases, sural nerve in 5 cases, saphanous nerve in 1 case. Neural injury was not influenced by the degree of ligament injuries but by the incidence numbers of ankle sprain. All cases were treated conservatively and symptom was subsided in all but 2 cases. Conclusion : Although the incidence is relatively low, the neural injuries in ankle sprain may occur in the recurrent ankle sprain and conservative treatment for neural injuries is satisfactory.

• 보건교육건강증진학회지
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• 제22권4호
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• pp.179-202
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• 2005

Purpose: The purpose of this study was to develop the health promotion program for rural elderly through PRECEDE process. Method: The health promotion program was developed based on the preliminary diagnosis. The data collection was performed from March 10th to April 9th, 2003. The subjects were selected at Mari Myun, Geochang Gun, in Korea. The preliminary diagnosis was examined with the 115 elders. Data was analyzed by descriptive statistics and Cronbach's n test with SPSS/Win 10.0 program. Results: The health promotion program was developed based on diagnostic result using PRECEDE model. The developed program was corrected and revised with the advices from 6 experts. The final program included health responsibility(cancer prevention and early detection, hygienic, false teeth management no smoking and moderation in drink, and chronic disease prevention and management), physical activity(6 kinds of exercise), nutrition(low sodium diet calcium intake, and right eating habit), spiritual growth(spiritual demand and death preparation teaching), interpersonal relations(relationship with couple, children, grandchildren, neighborhood), and stress management(sports dance, foot massage, positive thought, and song class). Conclusion: I propose that it is necessary to identity the effect of health promotion program for rural elderly. And strategy development that can spread the health promotion program elderly is needed.

• Archives of Plastic Surgery
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• 제49권1호
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• pp.80-85
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• 2022

The instep flap and medialis pedis flap are both originate based on the medial plantar artery. The medialis pedis flap is based from the deep branch and the instep flap is based from the superficial branch. To increase the axial rotation, it is acceptable to ligate the lateral plantar artery. However, this can partially affect the blood supply of the plantar metatarsal arch. We restored the blood flow with a vein graft between the posterior tibial artery and the ligated stump. From 2012 to 2020, 12 cases of heel reconstruction, including seven instep flaps and five medialis pedis flaps, were performed with ligation of the lateral plantar artery. The stump of the lateral plantar artery was restored with a vein graft and between the posterior tibial artery and the ligated stump. Patients were followed for 18 months. Long-term results showed the vascular restoration of the lateral plantar artery remained patent demonstrated by doppler ultrasonography. Restoring blood flow to the lateral plantar artery maintains good blood supply to the toes. If the patient in the future develops a chronic degenerative disease, with microvascular complications, bypass surgery can still be performed because of the patency of both branches.

• Childhood Kidney Diseases
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• 제4권1호
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• pp.48-56
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• 2000

목 적 : Alport증후군은 유전성 신질환 중 가장 많은 형태로서 흔히 빠른 속도로 진행하는 신질환과 감각신경성 난청, 눈의 이상, 전자현미경상 특징적 소견, 그리고 대부분의 경우 가족력 동반을 특징으로 한다. 저자들은 Alport증후군의 임상적 특징을 관찰하여 진단에 도움이 되고자 후향적 조사를 실시하였다. 대상 및 방법 : 1991년 4월부터 1999년 6월까지 경희의대 부속병원 소아과에서 Alport증후군으로 진단된 환아 12명을 대상으로 하였으며 진단 기준으로 신질환, 가족력, 감각신경성 난청이나 눈의 이상 및 전자현미경상 특징 등 4가지를 설정하여 의무기록을 통하여 비교분석하였다. 결 과 : 12예중 설정된 4가지의 진단 기준에 모두 부합되는 경우는 2예였으며 가족력이 확실치 않았던 예가 3예, 감각신경성 난청이나 눈의 이상 소견이 없었던 예가 6예였다. 또한 1예에서는 만성신부전에 빠져 신생검을 시행치 못하였으나 나머지 진단 기준을 충족시켰다. 12예 중 남녀의 비는 1:2였으며 신질환 발견시의 연령은 평균 5.6세 였다. 처음 나타난 증상으로 신질환이 먼저 나타난 예는 10예 였으며 나머지 2예에서는 청각장애와 백내장이 각각 처음 증상으로 나타났다. 12예 중 신질환의 가족력을 동반한 경우는 9예였으며 11예에서 청력검사와 안과적검사를 시행하여 6예의 감각신경성난청과 2예의 눈의 이상을 발견하였다. 전자현미경 소견은 11예중 9예에서 사구체기저막의 두께가 불규칙하게 두꺼워지고 고밀도층의 박층화와 족돌기 융합의 소견을 보였고 나머지 2예에서는 기저막이 얇아져있고 박층화와 족돌기 융합 소견을 보였다. 평균추적기간은 3년 6개월로 현재 만성신부전에 이른 경우는 1예 있어 신이식을 시행하였다. 결 론 : Alport증후군의 진단에 신질환의 가족력, 감각신경성 난청, 눈의 이상 및 전자현미경상 특징적 소견은 중요하며 이러한 특성을 분석함으로써 앞으로 많은 환자의 발견에 도움이 되리라 생각된다. 알 수 있었다 (P<0.05). 결 론 : 저자의 경우 전체 환아 중 65$\%$만이 완전 회복을 보였고 35$\%$에서 사망이나 말기 신부전으로 이행하여, 병의 경과를 좋게 하고 사망률을 줄이는데 조기 진단과 조기 투석을 시행하는 것이 중요한 역할을 하는 것으로 알 수 있었다. 내원하여 시행한 검사 소견상 혈색소치가 불량한 예후를 보인 환자군에서 유의하게 감소하여, 낮은 혈색소치가 불량한 예후인자로서의 역할을 할 것으로 사료된다. 용혈성 요독 증후군은 아직 국내에서 드문 질환중의 하나이지만, 소아 영역에 있어서 급성 신부전증의 가장 흔한 원인중의 하나로 지속적인 연구가 필요할 것으로 사료된다.므로 임상적 위험인자로 자반의 지속기간과 함께 HS자반증 환아의 신침범에 대한 예측인자로 활용할 수 있을 것이며 따라서 HS신염의 예방과 치료에 있어서 TNF-$\alpha$에 대한 생성억제제나 특이항체 등의 이용가능성에 대한 연구가 필요할 것이다.야간 수분 섭취 제한의 중요성이 강조되어야 한다고 생각된다.임상상으로는 추정할 수 없었으며 그러므로 환아에 대한 장기적인 관리 계획을 수립하기 위해서는 신생검을 시행하여 정확한 조직학적 병변을 확인함이 필요하다고 생각된다.89$개월, FSGS군 $5.27{\pm}12.48$개월로 각 군간의 의미있는 차이는 없었다. 결 론 : 미세변화형 신증후군에서 치료 경과중 국소성 분절성 사구체 경화증으로 이행된 예는 전체 MCNS의 249명중 8명으로 $3.2\%$였다. 이들의 임상양상의 특징을 비교 고찰한 결과 이행여부를 예측할 수 있는 위험요인은 없었다. 미세변화형 신증후군으로 진단된 환아 중에서 스테로이드 치료에 반응이 없거나 자주 재발하는 경우, 또는 강력한 면역치료에도 관해가 오지 않는 경우 등에는 신장 조직 생검을 재시행하여 국소성 분절성 사구체 경화증으로의 이행 여부를

• 대한한방소아과학회지
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• 제29권4호
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• pp.67-76
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• 2015

Objectives The purpose of this review is to investigate the domestic and foreign studies of pediatric Chuna treatment and propose the directions of future studies and clinical applications. Methods We searched for the study at RISS, KISS, DBPIA, Pubmed, CNKI by keywords, '추나', 'Osteopathic', 'Chiropractic', 'Manipulation', '推拿', '導引', '按摩', After 2010. Results 1. Selected 3 domestic studies were categorized as 1 survey study and 2 case reports. Selected 41 foreign studies from Pubmed were categorized as 15 systemic reviews, 8 survey studies, 12 case reports and 6 control studies. Selected 82 foreign studies from CNKI were categorized as 10 systemic reviews, 22 case reports and 50 control studies. 2. 2 clinical domestic studies researched on idiopathic Scoliosis. The foreign clinical studies from Pubmed are 18 cases, and those studies were categorized into Premature baby care (3), Infant colic (2), ADHD (2), Congenital talipes equinovarus (1), Somatic dysfuntion (1), Nonsynostotic occipital plagiocephaly (1), Conversion disorder (1), Lower back pain (1), Chronic bilateral dorsal foot pain and stiffness (1), plantar fasciitis (1), Migraine headaches (1), Cyclic vomiting syndrome (1), Acute otitis media (1) and Cerebral palsy (1). The other 72 foreign clinical studies were from CNKI, and they studied 39 different diseases. Systematically, they studied about digestive diseases (25), respiratory diseases (20), fever (6), musculoskeletal diseases (5), nervous system diseases (5), dermatology diseases (2) and other disease states. The Chuna treatment was used in variety of studies. 3. 2 clinical domestic studies adopted techniques of Osteopathy Chuna. The foreign clinical studies from Pubmed adopted techniques of Osteopathic manipulation (10) and Chiropractic manipulation (8). The other foreign clinical studies from CNKI adopted techniques of Acupressure (69), Abdominal manipulation (23), Spinal manipulation (21), Thoracic manipulation (11), Traction manipulation (2), Muscular manipulation (2), Squeezing Sha manipulation (1), Spine correction (1), Joint manipulation (1) and Fascia manipulation (1). Conclusions In addition to musculoskeletal disorders, variety of pediatric diseases could be treated with Chuna treatment instead of acupuncture.

• 한국식품영양과학회지
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• 제45권6호
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• pp.797-804
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• 2016

감국 추출물 0.5~10 g/kg을 투여한 급성독성 실험에서는 고용량인 10 g/kg 경구투여에서도 급성독성을 발생시키지 않은 것으로 나타나 안전성이 높은 물질로 확인되었다. 만성독성 실험에서도 최대 2 g/kg까지 13주간 경구 투여하였으나 간 독성이 없는 것으로 나타났다. 감국 추출물을 2~4 g/kg 투여한 그룹에서는 통풍의 염증 및 부종 억제 효과가 있었으나, 10 g/kg 투여군에서는 다소 염증이 증가되는 경향을 나타내었다. 그러므로 통풍억제 효과가 있으나 염증성 사이토카인을 더 증가시키지 않는 4 g/kg의 농도 이하로 감국 추출물을 투여하는 것이 적당한 농도라고 판단되었다. 따라서 감국 추출물은 고용량에서도 비교적 안전한 물질로 monosodium urate crystal에 의한 염증작용을 억제하므로 통풍예방물질로서의 가치가 있다고 생각되었다.

• Mycobiology
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• 제45권3호
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• pp.178-183
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• 2017

Diabetes mellitus is a chronic disorder which affects millions of population worldwide. Global estimates published in 2010 reported the world diabetic prevalence as 6.4%, affecting 285 million adults. Foot ulceration and wound infection are major forms of disabilities arising from diabetic diseases. This study was aimed to develop a natural antimicrobial finishing on medical grade textile that meets American Association of Textiles Chemists and Colorists (AATCC) standard. The textile samples were finished with the ethanolic extract of Penicillium amestolkiae elv609, an endophytic fungus isolated from Orthosiphon stamineus Benth (common name: cat's whiskers). Endophyte is defined as microorganism that reside in the living plant tissue, without causing apparent disease symptom to the host. The antimicrobial efficacy of the ethanolic extract of P. minioluteum was tested on clinical pathogens isolated from diabetic wound. The extract exhibited significant inhibitory activity against 4 bacteria and 1 yeast with the minimal inhibitory concentration ranged from 6.25 to 12.5 mg/mL. The results indicate different susceptibility levels of the test microorganism to the ethanolic extract. However, the killing activity of the extract was concentration-dependent. The finished medical textile showed excellent antimicrobial efficacy on AATCC test assays. All the microbial cultures treated with the textile sample displayed a growth reduction of 99.9% on Hoheinstein Challenge Test. The wash durability of the finished textile was found good even after 50 washes with commercial detergent. Besides, the gas chromatography mass spectrometry analysis showed that 6-octadecenoic acid and diethyl phthalate were the main bioactive constituents of the extract. In conclusion, the developed medical textile showed good antimicrobial efficacy on laboratory tests. This work can be extended to in vivo trials for developing healthcare textile products for antimicrobial applications.

• 대한본초학회지
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• 제24권4호
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• pp.127-135
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• 2009

Objectives : Gagam-Gongjin-dan (GGD) composited with Cervi parvum Cornu, Corni Fructus, Angelica gigantis Radix, Lycii Fructus, Dioscoreae Rhizoma, Citri Pericarpium, Gastrodiae Rihzoma, Agastachis Herba, Cassiae cortkex, Scutellariae Radix, Schisandrae Fructus has been traditionally used for chronic diseases or weakness after illness in oriental countries. However, little is known about the effects of methanol extract of GGD on immune responses to ovalbumin (OVA) plus alum. Therefore, the purpose of this study was to investigate the effects of GGD on immune responses to ovalbumin plus alum in Balb/c mice. Methods : In this study, the extract of GGD was prepared by extracting with methanol for 7 days. The extract was freeze-dried following filtration through vacuum distillation system. Mice were orally administrated with or without GGD extract of different doses (50-200 mg/kg/day) for 30 days. We examined the effects of GGD extract on the serum levels of total IgE, OVA-specific IgE, IgG1, IgG2a, and CTACK/CCL27 production and CCR10 expression in lymph node cells and body weight change and foot pad swelling responses in ovalbumin treated Balb/c. Results : The oral administration of GGD dose-dependently reduced the serum levels of total IgE, OVA-specific immunoglobulin (IgE, IgG1 and IgG2b) and CTACK/CCL27 production in ovalbumin treated BALB/c mice. The levels of CCR10 expression from lymph node cells of OVA treated mice were markedly suppressed by treatment with GGD in a concentration dependent manner. Furthermore, foot pad swelling responses were also markedly suppressed by GGD. However, body weight were significantly increased dose dependently by GGD treatment. Conclusions : These results suggest that GGD treatment suppresses immune responses to ovalbumin, and these properties may contribute to allergic disease care.

• Journal of Acupuncture Research
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• 제25권4호
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• pp.81-94
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• 2008

Rheumatoid arthritis(RA) is a general, chronic, inflammatory and auto-immune disease and it can lead to joint edema, pain, stiffness which are caused by an inflammation in synovium covering our joints. Ulmus davidiana Planchon is a traditional herb used for the treatment on various inflammations, gastrointestinal trouble, ENT(ear, nose, and throat) disease, edema, cancer etc. and it works effectively on arthritis as well. In these study to search for the treatment efficacy of Ulmus davidiana Planchon in RA, I measure manifestation of cytokine gene in synoviocyte treated with Ulmus davidiana Planchon herbal acupuncture and in EL-4 cell, manifestation of cytokine gene cell related to T-cell. And after Ulmus davidiana Planchon herbal acupuncture treatment in Collagen induced arthritis(CIA) which has been known by a general model of RA, DBA mice, I observed foot thickness, general shape of synovium, early cytokine induce CIA and, generation and mutation of cytokine related to the control of T-cell specialization. It comes to conclusion as belows. 1. In synovium treated with Ulmus davidiana Planchon herbal acupuncture, there was the decrease in MIF mRNA does-dependently. Incase of CIA mice treated with Ulmus davidiana Planchon herbal acupuncture, there were the decrease in the damage in synovium and generation of the MIF which is related to induction of the early RA cytokine and IL-6 proinflammatory cytokine. 2. In case of EL-4 treated with Ulmus davidiana Planchon herbal acupuncture, there were decrease in the manifestation of the IL-2 mRNA, but the increase in the manifestation of the IL-4 does-dependently. 3. In the synovium of CIA mice treated with Ulmus davidiana Planchon herbal acupuncture, there were the decrease in generation of IL-2, IL-12 and CD-28, but the increase in generation of IL-4. These result suggest that Ulmus davidiana Planchon can block the process of the early RA by Inhibiting MIF activation, and mitigate Rheumatoid Arthritis by controlling Tcell specialization.