• 대한약침학회지
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• 제7권3호
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• pp.47-57
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• 2004

Objective : In order to study effects of ${\lceil}Persicae\;Semen{\rfloor}$ on the hyperlipidemia rats induced by Triton WR, we have made hyperlipidemia rats by administering Triton WR-1339 for 3 days, then have administered. The results were summerized as follows : 1. The Total cholesterol, triglyceride, LDL-cholesterol, Free fatty acid, phospholipid and CRF(Cardiak Risk Factor) by hypercholesteremic rats injected by Triton WR-1339 of the herb-Acupuncture group were decreased as compared with those of the control group, especialy hypercholesteremic rats injected by Triton WR- 1339 of the herb-Acupuncture+Acupuncture group were some more decreased as compared with those of the control group. 2. The HDL-cholesterol by hypercholesteremic rats injected by Trion WR -1339 of the herb-Acupuncture group were increased as compeared those of control group, especialy hypercholesteremic rats injected by Triton WR-1339 of the herb-Acupuncture+Acupuncture group were some more increased as compared with those of the control group. According to the above results, Persicae Semen showed inhibition on decrease of serum total cholesterol, triglyceride and phosholipid contents as well as inhibition on increase of HDL-cholesterol contents in hyperlipidemia.

• Journal of Nutrition and Health
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• 제30권7호
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• pp.789-796
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• 1997

The effects of MCC and palm oil at different levels on lipid metabolism were assessed in adolescent rat. Dietary fat levels were 20% and 40% (kcal/kcal) and MCC level were 0%, 2%, and 4% (wt/wt). The experimental period took 8 weeks. During the experiment, weight gain and food efficiency ration were not affected by dietary factors. The weight of thymus however, was lower in high fat groups than in middle fat groups. The contents of total lipid and total cholesterol in plasma and HDL-cholesterol in plasma and HDL-cholesterol were significantly affected by dietary factors. The concentrations of cholesterol in LDL and VLDL , and the triglyceride content of VLDL was higher in high fat groups than in middle fat groups. Adding MCC lowered the LDL triglyceride in the high fat groups. The analysis of plasma fatty acids generally reflected the composition of the dietary palm oil. MCC had significant effects on total lipid and triglyceride of feces, but not on total cholesterol . In conclusion, the level of MCC had little hypolipodemic effects on lipid metabolism in rats fed a high fat diet. the middle fat group that contained 4% MCC showed increased contents of fecal triglyceride than the others, indicating that MCC had an effect on lipid absorption. Therefore, the other physiological functions of MCC need to be tested for their useful applications.

• 한국식품영양과학회지
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• 제19권2호
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• pp.180-186
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• 1990

For the investigation of the effects of G. lucidum on prevention and attention of hypercholeste-rolemia and atherosclerosis dietary hypercholesterolemic rats were fed with 2.0g% G. lucidum extracts for 4 weeks. And then concentrations of total cholesterol triglyceride phospholipid in serum and liver and those of HDL-cholesterol lipid peroxide glucose in serum were analyzed. Concentration of total cholesterol in serum was the lowest in the control group(basal diet+ wa-ter) and HDL-cholesterol in serum were significantly higher in groups of control 2(hyperchole-sterolemic ratslongrightarrowbasal+water) and 4(hypercholesterolemic ratslongrightarrowbasal+G.l. extract) The concentration of triglyceride in serum were signficantly lower in groups 4 and 5(hypercholeste-rolemic ratslongrightarrowcholesterol+G. l. extract) than in the control group. Phospholipid content in serum were not significantly different among all groups. Ttal cholesterol in liver was significa-ntly higher in hypercholesterolemic rats than in the control group and triglyceride concentration were signficantly higher in groups of 3(hypercholesterolemic ratslongrightarrowcholesterol+water) and 5 than others. Phospholipid in liver was significantly higher in group 3 than in the control group but groups of 4 and 5 were lower. As for lipid peroxide in serum was the lowest in group 4 and glucose concentration was lowest in group 5 than in other groups.

• 한국환경보건학회지
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• 제10권1호
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• pp.99-106
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• 1984

The diets used to this experiment were composed only of stock diet for group A, a mixture of stock diet and 2% cholesterol for group B, and 5%, 10% perilia powder for group C, D and 5%, 10% pine nut for group E, F in addition to group B diet respectively. All groups fed with these experimental diets for 3 weeks were fasted for 15 hours at the end of the experiment, and then they were decapitated to take serum. The serum was used to measure the level of glucose, total cholesterol, triglyceride, HDL-cholesterol and lipoprotein composition. The results were summarized as follows. 1. Perilla and pine nut diets have no influence on body weight and food intake in cholesterolfed male rats 2. The blood glucose level was not changed significantly at groups C-F. 3. Total cholesterol level was significantly decreased by 21.6% ~ 29.7% at group C-F than at group B. 4. HDL-cholesterol level was increased by 51.3% ~ 86.1% at group C-F than at Group B. 5. The $\alpha/\beta$ ratio which is 0.51 at the group A was risen to 0.99 at the group B. However, this ratio was decreased to 0.5 0 - 0.51 at group C, D and to 0.68 - 0.69 at group E.F.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6295-6298
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• 2012

Oxidant/antioxidant balance has been suggested as an important factor for initiation and progression of cancer. The objective of this study was to determine changes in the levels of malondialdehyde (MDA), nitric oxide (NO), total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, total antioxidant capacity (TAC), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities in serum samples of breast cancer patients (n=30) and healthy subjects (n=100). MDA and NO levels were found to be increased in breast cancer patients compared to the healthy subject group (p<0.05). Total cholesterol and triglycerides were elevated; and HDL-cholesterol level was found to be decreased in the cancer patients as compared to the healthy subjects (p<0.05). Compared to the healthy group, both serum TAC levels (p<0.001) and activity of SOD and GSH-Px (p=0.05) were found to be decreased in the breast cancer patients as compared to the healthy controls. Considering the data presented in this study, we suggest that free radicals induce lipid eroxidation and peroxidation of unsaturated fatty acid with decreased activity of enzymatic antioxidants in breast cancer.

• 한국자원식물학회지
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• 제19권2호
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• pp.273-276
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• 2006

탱자 추출액이 비만을 유도한 흰쥐의 지질강하 및 항산화효과에 미치는 영향을 검토했다. 혈장유리지방산 및 triglyceride 량은 대조군과 비교하여 탱자 처리군이 유의하게 낮은 값을 보였다. 그러나 정상군의 수준까지 나타내지는 않았다. 총콜레스테롤 및 LDL-cho.농도는 탱자 처리군 모두가 대조군보다 현저하게 하락한 값을 나타내었다. HDL-cho.은 대조군을 비롯하여 전 처리군에서 유의한 차이를 나타내지 않았다. 간장내 총콜레스테롤과 triglyceride량은 정자 처리군이 대조군 보다 현저하게 낮은 값을 보였다. 혈장 및 간장의 TBARS 농도는 탱자처리량이 증가함에 따라 감소하였다. GSH-Px, SOD 및 CAT 활성치는 탱자 처리군에서 높은 활성치를 보였다. 그러나 SOD의 활성치는 대조군과 유의한 차이를 나타내지는 않았다.

• 동의생리병리학회지
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• 제29권5호
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• pp.422-433
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• 2015

This study was conducted to investigate the anti-hyperlipidemic and anti-oxidative activities of Ikgihwaetang-gamibang (IK). We observed the effect of IK on lipid factor, inflammation factor, body weight and organ weight, and liver after administering IK to hyperlipidemia mice triggered by high fat diet. Additionally, we used Raw 264.7 cells to investigate the changes in anti-oxidative activity and the effects of anti-inflammation. Administration of IK resulted in reduction of total cholesterol, LDL cholesterol, TG, and glucose in blood serum while a clear increase in HDL cholesterol. The production of IL-1β and IL-6, and ROS and NO also decreased. The results showed that IK has anti-hyperlipidemic and anti-oxidative effects, and suggested its potential use in prevention and treatment of hyperlipidemia and its associated diseases.

• 한국식품위생안전성학회지
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• 제13권1호
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• pp.68-75
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• 1998

흰주의 체중은 실험기간동안 증가하였으며, 식이 별로는 대조군이 가장 높은 체중 증가를 보였다. 콜레스테롤의 첨가는 흰쥐의 정상적인 성장을 억제하였으며, 콜레스테롤 첨가군에서는 콜레스테롤 대조군의 체중증가량이 유의하게 가장 낮았다. Rutin과 메밀 채소를 식이에 첨가하였을 때 흰쥐의 콜레스테롤에 의한 성장억제 작용을 효과적으로 감소시키는 것으로 나타났으며, 첨가량의 증가에 따라 혈청의 총 콜레스테롤 함량과 과산화지질 함량은 낮아지는 반면에 HDL-cholesterol 함량은 높아지는 경향을 보였다.

• 대한한의학회지
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• 제30권6호
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• pp.103-111
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• 2009

Objectives: To investigate the possibility of GamiSamgieum (SGMX) as a combination therapy with statins on hyperlipidemia using an animal model. Methods: Forty eight ICR mice (male) were divided into six groups of eight mice each: naive, induced, Lipitor 5 mg/kg, Lipitor 5 mg/kg plus SGMX 100 mg/kg, Lipitor 10 mg/kg, and Lipitor 10 mg/kg plus SGMX mg/kg treatment group. Hyperlipidemia was induced by feeding a purified high fat diet for all groups (except naive) along with treatment of drugs for 6 weeks, and then biological parameters were examined on the last experiential day. Results: Lipitor treatment lowered total cholesterol and increased HDL-cholesterol compared to the induced group with no statistical significance. However, co-treatment of SGMX with Lipitor revealed synergic effects on total cholesterol and HDL-cholesterol significantly (P < 0.05) in both. SGMX co-treatment also significantly protected liver tissues from the oxidative stress in liver tissues (P < 0.05) and augmented inhibitory effect of Lipitor against fat accumulation in the body. Conclusion: These results indicate the possibility of that SGMX can be used for patients having hyperlipidemia as a combination therapy with statin drugs.

• Journal of Nutrition and Health
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• 제20권1호
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• pp.38-45
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• 1987

This study was performed to investigate the effect of dietary vitamin E supplement and kinds of lipid on the vitamin E concentration and lipid composition in serum of the rats fed fro seven weeks. Supplemented vitamin E was 300mg/kg diet as DL-α-tocopherol acetate, and 15% of corn oil or beef tallow was added to standard diet. The results were as follows ; 1) Body weight and feed efficiency ratio were significantly increased by supplement with vitamin E, corn oil and beef tallow. 2) Serum vitamin E concentration increased significantly by supplement of vitamin E and beef tallow on the diets, while one of corn oil fed group decreased significantly . 3) The contents of triglyceride, total cholesterol, phospholipid in serum were significantly increased in the beef tallow group, and the vitamin E only -supplemented group showed significantly lower serum cholesterol in serum increased significantly in the vitamin E only -fed group and vitamin E plus corn oil-fed group. 4) The content of HDL-cholesterol in serum increased significantly in the vitamin E only -fed group and vitmain e plus corn oil -fed group. 5) The ratio of VLDL, LDL-cholesterol content to HDL-cholesterol one in serum was significantly low in the vitamin E only-supplemented group and corn oil group, and was significantly higher in the beef tallow group than in the corn oil group.