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http://dx.doi.org/10.15188/kjopp.2015.10.29.5.422

Anti-hyperlipidemic and Anti-oxidant effects of Kgihwaetang-gamibang in High Cholesterol Diet-induced Mice Model  

Shin, Yong Jeen (Department of Internal Medicine, College of Korean Medicine, Wonkwang University)
Jeon, Sang Yun (Department of Internal Medicine, College of Korean Medicine, DongShin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.29, no.5, 2015 , pp. 422-433 More about this Journal
Abstract
This study was conducted to investigate the anti-hyperlipidemic and anti-oxidative activities of Ikgihwaetang-gamibang (IK). We observed the effect of IK on lipid factor, inflammation factor, body weight and organ weight, and liver after administering IK to hyperlipidemia mice triggered by high fat diet. Additionally, we used Raw 264.7 cells to investigate the changes in anti-oxidative activity and the effects of anti-inflammation. Administration of IK resulted in reduction of total cholesterol, LDL cholesterol, TG, and glucose in blood serum while a clear increase in HDL cholesterol. The production of IL-1β and IL-6, and ROS and NO also decreased. The results showed that IK has anti-hyperlipidemic and anti-oxidative effects, and suggested its potential use in prevention and treatment of hyperlipidemia and its associated diseases.
Keywords
Ikgihwaetang-gamibang; Hyperlipidemia; HDL Cholesterol; Anti-oxidation;
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