• 동의생리병리학회지
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• 제23권3호
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• pp.540-547
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• 2009

There needs disease-predictable signs in order to enable preventive diagnosis and therapy. Then traditional Chinese medicine applies various medical diagnostic equipments used in western medicine to diagnosing sub-healthy state. But such data are not originated from inherent oriental medicine, and not obtained easily in ordinary clinical practice. This paper is to provide synopsis of the ante-disease diagno-therapeutics partly and to show predictable data based on the facial shapes and signs, especially of gall bladder's versus bladder's body and masculine versus feminine shape. Ante-disease means not only the complete healthy state, but also the state unseen any symptoms in macrographically in the course of outbreak of disease. It contains two stages, first one is the former state of disease and second one is untransmitted state of disease. The patterns of ante-disease consist of latent disease, pre-disease, transmission type like senescent syndrome, abnormal reactive syndrome(變證), syndrome of transmission and transmutation. The classification with gall bladder and bladder type manifests the differences of shape, color and size of each organ in comparison of the universal and standard figures of the human being. On the other hand, the classification with masculine and feminine shape contrasts the innate sexual difference and the shape, characteristics originated from in itself. These two classification theories have their own pathologic types and syndrome types with each disease so that disease-predictable data can be constructed based on such a relationship. In addition, this diagnostic method by facial shapes and signs is able to be applied to whole stages from prenatal to present state of disease even if the cause and inducement are not clear. Ante-disease diagno-theraputic system by Gall Bladder's versus Bladder's Body and Masculine versus Feminine Shape is getting more important in the chronic and internal disease in comparison of the acute and traumatic disease. So this study is able to make up for the limit of diagnosis on ante-disease in the field of oriental medicine clinic.

• 동의생리병리학회지
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• 제22권5호
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• pp.1062-1070
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• 2008

The human body and nature respond to each other. The change of nature influences to directly human body. One of the change is the weather change. and there is order in the change. The order is twelve months. To explain the weather change of the cold, hot. dry and wet. we can use Four seasons, The twenty-four seasons, or The twelve month. To explain the five elements of the chinese cosmogony, The four season is useful, and the change of weather, the twenty-four seasons is good. But, the viscera is explained by the ten celestial stems and the twelve horary sings. Thus the twelve horary sings is most useful to explain, because one year is composed by twelve months. The twelve season and fancy of the ten celestial stems is explained fully by Diao-hou-yong-shen. Diao-hou-yong-shen is expressed by the zodiac signs, and explained by the disposition of the zodiac sings. In addition to the oriental medical science is also explained and expressed by the zodiac signs. Therefore, I think that the change of viscera, according to weather, is based on the Diao-hou-yong-shen, and I get some results. In the acting of viscera, there are some relationship between organs. The relationship is not influenced directly by the weather of four seasons, unless there are some special details. If the energy of the month, which rules one specific organ, is weak, doctor should fill up the organ. If not, the organ tends to get sick. According to the full or weak of the five elements which is under the month, the useless or harmful elements should be taken off, and useful and needful elements should be serviced. The balance between cold, hot, dry and wet should be maintained. However, the fancy of the viscera is very different. So, doctor should be careful to maintain balance. The full and weak between Yin and Yang should be considered when doctor think about cold and hot in the month.

• 한국식품저장유통학회지
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• 제12권1호
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• pp.80-85
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• 2005

일상생활에서 식용 또는 약용으로 이용되고 있는 12종의 버섯 추출물을 제조하여 이들 추출물의 항산화능 검색과 함께 인간유래의 혈액암 세포주 및 정상 임파구세포의 성장에 미치는 영향에 대하여 조사하였다. 그 결과, 향버섯, 번데기동충하초, 만가닥버섯, 아가리쿠스, 영지버섯, 표고버섯 메탄올 추출물에서 $30\~60\%$정도의 DPPH radical 소거 활성을 보였고, 목이버섯, 그물버섯, 새송이버섯에서 $10\~30\%$의 활성을 보였다. 또한 chinese hamster V79 cells에서 만가닥 버섯, 번데기동충하초, 향버섯 메탄올추출물의 경우 H2O2로 유도된 세포 독성에 대한 $39\~53\%$ 정도의 유의적인 생존율을 나타내었다. 그리고 인간유래 혈액암세포인 HL6O과 U937에 대해 향버섯, 만가닥버섯, 번데기동충하초, 아가리쿠스, 영지버섯 추출물들이 높은 증식 억제 활성이 보였다. 특히 버섯 메탄올추출물 1.0 mg/mL 처리시 HL 60에 대해 향버섯이 $70.5\%$로 가장 높은 저해율을, U937에 대해서는 번데기동충하초가 $81.5\%$의 가장 높은 저해율을 나타내었다. 그리고 버섯 열수추출물들은 메탄올추출물보다 낮은 저해 활성을 보였다. 그러나 모든 버섯추출물들은 인간의 정상 임파구세포에 대해 $95\%$ 이상의 높은 생존율을 나타내어, 정상 세포에 대한 성장 저해 효과가 없음을 보여주었다. 번데기동충하초, 아가리쿠스, 만가닥버섯, 영지버섯, 향버섯 추출물은 항산화 할성 및 혈액암 세포주에 대한 증식 억제 활성이 높음을 확인할 수 있었다.

• Journal of Ginseng Research
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• 제24권2호
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• pp.99-105
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• 2000

본 논문은 인삼의 한의학적 응용과 현재 각국별 인삼의 복용기준 및 그 동안 수행된 임상실험을 중심으로 인삼의 응용과 복용량에 대한 문헌적 고찰을 하였다. 인삼분말 기준 복용량은 특별히 처방에 기술되어 있지 않은 한 1회 3~4 g정도 복용하는 것이 보편적 복용량으로 간주되며, 인삼제품도 이에 상당하는 인삼량으로 복용하면 될 것으로 사료된다. 다만 서구권의 경우는 인삼을 의약품으로 분류하여 복용량을 하루 1-2정도로 규정하고 있고 임상실험에서 사용된 인삼투여용량은 대부분 1g 이하로 되어 있다 서구에서의 인삼복용량 설정은 그 동안 인삼의 안전성(부작용과 역작용 등)과 관련된 사례보고 등에 근거하여 그 복용기준을 설정한 것으로 이해된다. 그러나 동서양간 인삼복용량의 차이점에 대해서는 동양인과 서구인들 간의 식생활 차이 또는 인종적 차이에 기인한 인삼의 복용 반응의 차이인지에 대해서 추후 검토되어야 할 사항이다. 아울러 인삼의 투여용량별 효과의 차별성이 있는지, 금후 인삼의 적정 투여용량 설정과 관련하여 인체실험을 통한 활성성분의 체내동태(Pharmacokinetics)와 자생체내 이용효율(Bioavailability)에 대한 연구가 이루어져야할 것이다.

• 한국인터넷방송통신학회논문지
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• 제18권4호
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• pp.191-203
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• 2018

초기 창업업체 및 기술 창업 중소기업에 ISO 품질경영관리 시스템의 적용 여부에 따라 기업의 영속성에 어떤 영향을 끼치는지 확인한다. 특히 기술창업 중소기업의 품질경영관리 시스템이 전체 SYSTEM 에서 중요하게 차지하는 부분이 연구개발보다는 재무, 관리, 품질관리 부문의 경영관리 SYSTEM 적용이 중요함을 인지하고 있다. 각 사업구조별 의료기기 제작업체, 핸드폰 중개기 제작업체, 해외 중국업체이며 디젤엔진용 부품 제작업체 3개사의 성공 사례와 실패 사례 1개사를 통해 품질경영관리 SYSTEM을 적용하지 않은 업체의 문제점과 품질관리, 제품관리, 생산관리가 효율적 관리가 이루어지지 않아 생기는 재무적, 경제적, 관리적 문제점에 대해서 알아보고 그 원인에 대해서 연구하고 분석해본다. 사례 대상 업체에 품질경영관리 SYSTEM을 적용 후 부적합사항을 개선한 사례를 알아본다. 또한, 실패한 1개사를 선정 실패 사례를 통해 기업의 안정성과 영속성을 유지하기 위해 품질경영관리 SYSTEM을 적용 후 품질경영관리 매뉴얼과 절차서에 의거 실천 여부에 따라 사업의 성공과 실패가 판가름 남을 알 수 있음을 알 수 있었다. 최근 기업내부에서는 내부 심사원등을 선임하여 지속 개선활동을 시행해야 하고 기업의 발전과 영속성을 원하는 업체는 반드시 품질경영관리시스템을 반영하여야만 함을 설명한다.

• 사상체질의학회지
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• 제8권2호
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• pp.69-94
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• 1996

The main purpose of this work is comparing the difference between Soumin Bojungyikgitang of constitutional medicine and Li Dongyuan's Bojungyikgitang Bojungyikgitang, the prescription originated from the Pi-Wei theory(脾胃論) of Li Dongyuan who was a medical man in the Jin Yuan dynasty, had been used widely for many kinds of disease caused by the singking of the qi of middle energizer due to the weakness of the spleen and stomach. But in the singking of the qi of middle energizer due to the weakness of the spleen and stomach. But in the end of Choseon dynasty Li Je Ma, the creator of the constitutional medicine, modified the Bojungyikgitang and applied to Soumin's disease. In this paper, the difference between the two prescription were investigated from the viewpoint of chinese herb pharmacology and purpose of prescription. Additionally the problems which could be brought out by applying Bojungyikgitang to the Soyangin and the Taeumin were studied. And the conclusion could be summarized as follows: 1. The prescription of the Li Dongyuan's Bojungyikgitang is based on the deficiency of vital energy due to internal damage and the Soumin Bojungyikgitang is useful to only a certain stage of progressing disease on the basis of Shanghanlun(傷寒論). 2. In the Li Dongyuan's Bojungyikgitang, Cimicifugae Rhizoma and Bupleuri Radix were used for emphasizing the ascending action and have the antipyretic action and the effect of elavating of yangqi as they are bitter in taste and cold in nature. 3. In the Soumin Bojungyikgitang, Pogostemonis Herba and Perillae Folium have the ascending-descending action and strengthen the stomach with the effect of mild sweating by pungent taste and warm nature. 4. The effect of elavating of yangqi in the Li Dongyuan's Bojungyikgitang offers the pathway where vital qi go up by eleminating the pathogenic fire with the action of Cimicifugae Rhizoma and Bupleuri Radix in the triple energizer and yangming muscular striae. On the other hand, the Soumin Bojungyikgitang depends on the effect of reinforcing qi and elavating yangqi by Astrgalli Radix entirely and supply vital qi by reinforcing yangqi with Ginseng Rsdix. 5. The exahausion of yin(亡陰證) in the Soyangin exterior syndrome and cold limbs(寒厥證) in Taeumin exterior syndrome are similar to the indication of Li Dongyuan's Bojungyikgitang. As the causes of the disease are fundamentally different in the view of constitutional medicine, the diseases could be aggravated by applying Li's Bojungyikgitang. These results suggest that Li Dongyuan's Bojungyikgitang is proper to the exterior syndrome of Soumin and Soumin Bojungyikgitang seems to be appropriate to the Soumin's disease.

• 정보관리연구
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• 제40권3호
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• pp.79-97
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• 2009

많은 검색엔진의 개발과 웹 기술의 발전으로 기존의 키워드 검색에서 검색어에 의미를 부여하는 시맨틱 검색이 출현하게 되었다. 이런 흐름에 맞추어 한국한의학연구원에서 제공하는 한의학술논문시스템(오아시스)의 개선도 필요하게 되었다. 그리하여 오아시스를 사용해 본 경험이 있는 회원을 대상으로 소속이나 지위, 경력에 대한 인구사회학적 분석과 오아시스의 편리성 및 제공되는 논문의 가치에 대해 분석하였다. 뿐만 아니라, 오아시스의 개선해야 할 방향으로 한의학연구를 위해 분야별 중요도를 조사하였다. 설문의 조사를 통해 얻은 결과, 한자 위주의 검색어에 대한 의미를 파악할 수 있는 자동화검색이 필요하며 키워드 검색방식을 탈피하고 동음이의어를 판별할 수 있는 전거시스템의 도입이 필요한 것으로 나타났다. 또한, 참고문헌 인용지수 정보와 관련기관의 임상정보와의 연계 필요성 및 Open API를 이용한 해외 주요 사이트와의 연계검색이 필요하다는 결론을 얻었다. 오아시스는 한의학술논문을 서비스하는 국내 유일의 사이트인 만큼 한의계의 요구를 충분히 분석하고 검색의 문제점을 보완한다면 한의학발전의 중추적인 역할을 할 수 있을 것으로 기대된다.

• 한국약용작물학회지
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• 제23권4호
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• pp.277-283
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• 2015

This study was conducted to investigate the selected chemical properties of soils in Saururus chinensis Baill (Chinese lizard's tail) cultivation fields to provide optimal fertilizer application rates and to examine the growth and pharmaco-consitituents of Saururus chinensis Baill as influenced by different amounts of nitrogen (N) fertilizer applications. Based on the results of selected soil chemical properties in 37 cultivation sites of the plant, soil pH, organic matter content, and exchangeable $K^{+}$ concentration were lower than optimal values for cultivating general medicinal crops even though relatively high standard deviations were found in some of the values. At the harvesting stage of the plant aerial parts, soil pH, electrical conductivity (EC), available $P_2O_5$, and exchangeable $Ca^{2+}$, $Mg^{2+}$, $Na^{+}$ decreased as comparing with those before transplanting the plant, whereas the concentration of exchangeable $K^{+}$ increased in the plot treated with N 100% and compost. Fresh weight of the plant aerial parts were highest, 492.5kg/10, in the N 100% treatment plot. Correlation equation between N levels treated (X) and yield of the plant aerial parts (Y) presented as $Y=-2.1609X^2+30.082X+344.12$($R^2= 0.7113$) and the optimal rate of N fertilizer application for the plant was 6.6kg/10a. Carbon concentrations in the plant were not different among the different N levels applied. N and K concentrations in the plant were highest in the plot of N 100% with compost applications, the highest P concentration was in N 100% plot, and the highest Ca and S concentrations were in N 200% plot. Quercetin and quercitrin were highest in the N 150% plot and tannin was highest in N 100% or N 100% with compost application plot.

• Korean Journal of Acupuncture
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• 제37권3호
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• pp.172-182
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• 2020

Objectives : In this study, we conducted a focus group interview among expatriates living in Korea, to investigate their experiences and perceptions of acupuncture and Korean Medicine in order to improve the usage of Korean Medicine in the medical tourism market. Methods : The inclusion criteria for the focus group interview was: (1) participants between the age of 20 to 75 years old; (2) those who had lived in Korea for more than 90 days, and (3) those who were able to express their thoughts freely in English. The participants were informed that the interviews will be recorded and transcribed. We ended recruitment once saturation of materials was met. Semi-structured interviews were conducted, and the data was analyzed after each interview. Results : The interviews were held between June to December 2016. Twenty-four participants were recruited but four dropped out and a total of twenty participants successfully finished the interviews. Six focus group interviews were conducted. Analysis revealed that Korean Medicine was relatively less known compared to Traditional Chinese Medicine or Complementary and Alternative Medicine. Participants automatically associated acupuncture with the management of pain or stress and replied that these were the areas that they thought acupuncture would be most effective. Positive experiences with acupuncture and with the acupuncture practitioners were factors that promoted the use of acupuncture whereas lack of awareness, accessibility and accreditation were factors that hindered its use. Other factors that hindered the use of acupuncture was needle phobia and the perception that acupuncture lacks scientific evidence. Conclusions : Awareness on Korean Medicine and acupuncture is low. Participants lack awareness on what diseases acupuncture can treat, the scientific evidence behind the mechanism of action, and the rigorous education system that Korean Medicine doctors must go through to get their license. Rigorous marketing should be encouraged, which includes greater exposure in the media, more honest reviews from patients, and promotion of the scientific evidence base.

• 대한화장품학회지
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• 제31권4호
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• pp.305-310
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• 2005

본 연구에서는 한방 천연 미백 소제를 개발하기 위하여 삼릉추출물의 미백 효과에 대하여 연구하였다. 삼릉추출물은 프리 라디칼 소거활성(DPPH)에서 $IC_{50}=638{\mu}g/mL$, superoxide radicals 소거활성은 $IC_{50}=21.7{\mu}g/mL$을 나타냈다. 삼릉추출물의 B16 melanoma 세포에서의 멜라닌 생합성 저해효과는 $100{\mu}g/mL 삼릉추출물을 48 h 처리한 세포에서는 멜라닌 합성량이 27% 감소되었다. 삼릉 추출물은 농도에 비례하여 B16 melanoma 세포내의 타이로시네이즈 활성을 저해하였으며, western blot을 이용하여 타이로시네이즈와 타이로시나아제 관련 단백질(TRP-1)의 발현감소를 확인하였다. 또한, RT-PCR을 이용하여 삼릉추출물이 멜라닌 생성 과정에 관련하는 유전자 발현을 조사한 결과 타이로시네이즈와 TRP-1의 mRNA발현을 억제하는 것을 확인하였다. 그러므로 삼릉추풀물은 항산화 효과와 함께 멜라닌 저해 효과가 우수하여 새로운 미백 화장품으로 응용할 수 있을 것으로 생각된다.