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Antioxidant Activity and Inhibitive Effects on Human Leukemia Cells of Edible Mushrooms Extracts  

Kim Hyun Jeong (The Center for Traditional Microorganism Resources, Keimyung University)
Bae Joon-Tae (Dept. of Oriental Medical Food and Nutrition, Asia University)
Lee Ji-Won (Dept. of Food Science and Technology, Keimyung University)
Hwang Bo Mi-Hyang (Dept. of Food Science and Technology, Keimyung University)
Im Hyo Gwon (Dept. of Food Science and Technology, Keimyung University)
Lee In-Seon (The Center for Traditional Microorganism Resources, Keimyung University)
Publication Information
Food Science and Preservation / v.12, no.1, 2005 , pp. 80-85 More about this Journal
Abstract
The effect of 12 edible mushroom species on the antioxidant and cytotoxicity on cancer cells were studied Methanol extract of Lyophyllum ulmarium, Cordyceps militaris and Sarcodon aspratus showed $30\~60\%$ DPPH radical scavenging activity and $39\~53\%$ protective effects against the cytotoxicity of $B_2O_2$. Methanol extracts of Sarcodon aspratus, Lyophyllum ulmarium, Cordyceps militaris, Agaricus blazei and Ganoderma lucidum revealed high inhibitive activities in cytotoxicity on human leukemia tells such as promyelocytic leukemia cell (HL60) and histiocytic lymphoma cell (U937). Highest toxicity was observed against HL60 cells in Sarcodon aspratus methanol extract showing $70.5\%$ inhibition at 1mg/mL whereas Cordyceps militaris methanol extract showed $81.5\%$ inhibition against U937 cells. Most water extracts of edible mushrooms exhibited the lowest effect against HL60 and U937 cells compared to methanol extract. These extract did not show cytotoxic effects against human lymphocyte. Results revealed 5 kinds of edible murshroom (Cordyceps militaris, Agaricus blaxei, Lyophyllum ulmarium, Ganoderma lucidum and Sarcodon aspratus) have strong antioxidative and in vitro anticancer efforts.
Keywords
antioxidative effect; anticancer effect; edible mushrooms;
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