• CELLMED
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• v.2 no.2
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• pp.14.1-14.7
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• 2012

Cordycepin, a nucleoside derivative, was extracted from $Cordyceps$ $sinensis$, and then proved to be a bioactive compound present in traditional Chinese medicine Cordyceps. Early investigations revealed cordycepin possessed anti-microbial activity mainly by inhibiting nucleic acid synthesis. Although cordycepin is not used as antibacterial agents in clinic, its other pharmacological effects and possible mechanisms have gradually been deeply studied. This review serves to summarize the research progress of cordycepin.

• Journal of Microbiology and Biotechnology
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• v.27 no.6
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• pp.1078-1089
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• 2017

Biofilm formation of Staphylococcus aureus is one of its mechanisms of drug resistance. Anti-biofilm screening of 106 compounds from marine-derived fungi displayed that 12 compounds inhibited S. aureus biofilm formation by >50% at the concentration of $100{\mu}g/ml$, and only secalonic acid D (SAD) and B inhibited by >90% at $6.25{\mu}g/ml$ without inhibiting cell growth after 24-h incubation. Meanwhile, it was found that the double bond between C-1 and C-10 of citrinin derivatives and the C-C connection position of two chromone monomers may be important for their anti-biofilm activities. Moreover, SAD slightly facilitated biofilm eradication and influenced its architecture. Furthermore, SAD slowed the cell growth rate in the preceding 18-h incubation and differentially regulated transcriptional expression of several genes, such as agr, isaA, icaA, and icaD, associated with biofilm formation in planktonic and biofilm cells, which may be the reason for the anti-biofilm activity of SAD. Finally, SAD acted synergistically against S. aureus growth and biofilm formation with other antibiotics. These findings indicated that various natural products from marine-derived fungi, such as SAD, could be used as a potential biofilm inhibitor against S. aureus.

• Korean Journal of Oriental Medicine
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• v.17 no.3
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• pp.9-15
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• 2011

The Qiantang Medical School(錢塘醫派) formed on the basis of the education provided by L$\ddot{u}$shantang(侶山堂) in the specific area of Hangzhou(杭州) displays clear differences from other medical schools in that it combined medicine with educational and research activities. The Qiantang Medical School(錢塘醫派) played an important part in the history of the traditional Chinese medicine via providing the education through Confucian academies and the researches conducted to find appropriate treatment methods based on the climate and natural environment of the southern part of China. The tradition of joint researches on the classical works of Chinese medicine is equally important in terms of the traditional Chinese medicine.

• Journal of Ginseng Research
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• v.45 no.2
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• pp.273-286
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• 2021

Background: Prostate carcinoma is the second most common cancer among men worldwide. Developing new therapeutic approaches and diagnostic biomarkers for prostate cancer (PC) is a significant need. The Chinese herbal medicine Panax quinquefolius saponins (PQS) have been reported to show anti-tumor effects. We hypothesized that PQS exhibits anti-cancer activity in human PC cells and we aimed to search for novel biomarkers allowing early diagnosis of PC. Methods: We used the human PC cell line DU145 and the prostate epithelial cell line PNT2 to perform cell viability assays, flow cytometric analysis of the cell cycle, and FACS-based apoptosis assays. Microarray-based gene expression analysis was used to display specific gene expression patterns and to search for novel biomarkers. Western blot and quantitative real-time PCR were performed to demonstrate the expression levels of multiple cancer-related genes. Results: Our data showed that PQS inhibited the viability of DU145 cells and induced cell cycle arrest at the G1 phase. A significant decrease in DU145 cell invasion and migration were observed after 24 h treatment by PQS. PQS up-regulated the expression levels of p21, p53, TMEM79, ACOXL, ETV5, and SPINT1 while it down-regulated the expression levels of bcl2, STAT3, FANCD2, DRD2, and TMPRSS2. Conclusion: PQS promoted cells apoptosis and inhibited the proliferation of DU145 cells, which suggests that PQS may be effective for treating PC. TMEM79 and ACOXL were expressed significantly higher in PNT2 than in DU145 cells and could be novel biomarker candidates for PC diagnosis.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4613-4617
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• 2012

National cancer incidence data were utilized to analyze trends in esophageal cancer incidence in China in order to provide basic information for making cancer control strategy. We retrieved and re-sorted valid esophageal cancer incidence data from National Central Cancer Registry Database over 20 years period from 1989 to 2008. Crude incidence and age-standardized incidence rates were calculated for analysis, with annual percent change estimated by Joinpoint software for long term trend analysis. The crude incidence rate of esophageal cancer was found to have remained relatively stable in both urban and rural areas over the 20 year period. Age standardized incidence rate (ASR) in cancer registration areas decreased from 39.5/100,000 in 1989 to 23.0/100,000 in 2008 in all areas (AAPC=-3.3%, 95% CI:-2.8~-3.7). The trend was no change in urban areas and 2.1% average annual decrease observed in rural aras. Before the year of 2000, esophageal cancer incidence rates significant decreased with 2.8% annually and then the rates kept stable. Over 20 years from 1989 to 2008, esophageal cancer age standardized incidence rate in cancer registration areas decreased with time. However, esophageal cancer is still a big issue and efforts for control should be continuously enhanced. Cancer registration is playing an important role in cancer control with the number of registries increasing and data quality improving in China.

• Journal of Korean Medical classics
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• v.36 no.1
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• pp.1-16
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• 2023

OObjectives : This paper aims to document the journal's history by researching academic achievements of a retiring faculty member and his contribution to the academy. Methods : To expand the boundaries of medical humanities and sociology within the Colleges of Korean Medicine, the methodology for taking oral history was followed in investigating the faculty member's scholarly and academic achievements, which will contribute to the preservation of the academy's history for years to come. Results : Yoon taught subjects such as Medical Chinese, Medical Classics, Classical Chinese, Reading Classical Texts, Medical Philosophy, Medical I-Ching at the University, while vigorously studying basic Korean Medical fields such as the Huangdineijing and the Five Circuits and Six Qi Theory. He also pushed for international communication and implemented the overseas studying program for students and faculty. At the academy, he stabilized the organization's finances, strengthened the journal's status, and built the foundation for the standardization of Medical Classics education by publishing a common textbook. Conclusions : Yoon's various achievements were made possible by other members of the organization, which was in reciprocation to Yoon's effort to bring the members together to form cooperative relationships.

• Korean Journal of Oriental Medicine
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• v.13 no.3
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• pp.179-184
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• 2007

Yifangleiju is a collection of medical books that consists of 266 volumes. It is a very important set of data in studying ancient Asian medicine because it systematically organized the many medicine-related data of Eastern Asia. But it was never published again after its 30th volume was published in 1477, and only a single copy remains in Japan today. Because this book is valuable it has been republished in China based on the copy in Japan. This study is a study of the many problems that occurred in the process of republishing Yifangleiju in China.

• Korean Journal of Oriental Medicine
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• v.16 no.3
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• pp.45-52
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• 2010

This study aims to discuss the establishment and development of the Qiantang Medical School(錢塘醫派) represented by Zhang Zhicong(張志聰) via focusing on an academy of Chinese medicine named L$\"{u}$shantang(侶山堂). The teaching method in L$\"{u}$shantang(侶山堂) displays a representative feature of the Qiantang Medical School(錢塘醫派), but the foundation of the method consisting of lectures and discussions had already been laid by Lu Zhiyi(盧之頤) during the Ming-Qing transition period. The tradition was succeeded by Zhong Xuelu(仲學輅) in the Hangyuan Medical Board(杭垣醫局) even after L$\"{u}$shantang(侶山堂) was burnt down during a war taken place under the Qianlong(乾隆) period. That the function and the role of the local Confucian academies, which had been focused on the discussion of Confucian classics and local issues, were changed to adopt the education of medicine which had been treated as a lesser subject may be interpreted as a gradual change in the social perception of medicine. The change in the function of the Confucian academies combined with the tendency in which the literati elites of the period left the Confucian philosophy for medicine presents one of many examples showing the changes occurred during the Ming-Qing transition period. The education of medicine provided by the Confucian academies is regarded historically significant in that it was offered by ordinary civilians rather than the government before the formal school education system was established in the modern period. This educational tradition played an important role in bridging the Chinese medicine in the medieval times with that in the modern period.

• Natural Product Sciences
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• v.22 no.2
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• pp.82-86
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• 2016

Six compounds were isolated from the secondary metabolites of the jellyfish-derived fungus Aspergillus fumigates, whose structures were identified by chemical methods and spectroscopic analysis as pseurotin F1 (1), azaspirofurans B (2), $(22E,\;24R)-24-methyl-5{\alpha}-cholesta-7,22-diene-3{\beta},5,6{\beta}-triol$ (3), $5{\alpha},8{\alpha}-epidioxyergosta-6,22-dien-3{\beta}-o1$ (4), $cyclo-({\small{L}}-Pro-{\small{L}}-Tyr)$ (5), fumitremorgin C (6). The compounds 1 - 5 were isolated from the fungus Aspergillus fumigates for the first time. The isolated compounds (1 - 6) were evaluated for antibiotic activity and cytotoxicity against six bacterial strains and ten human tumor cell lines, respectively.

• Korean Journal of Medicinal Crop Science
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• v.14 no.2
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• pp.117-123
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• 2006

The purpose is to study the identification method of Huangjinju powder for injection and the medicinal materials by the fingerprint off-ray Diffraction Fourier (XRDF). We used the same method on both the studying of Huangjinju and the medicinal materials. Then we selected a few components alignment to compare. We analyzed the data by setting up the deviation $d({\AA})$ as ${\pm}0.05$ to calculate the rate of special mark on the sample (Px) and on the patent (P). The special XRDF of Huangjinju$[d({\AA})/(I/I_0)]$ have 5 peaks that have not expressed in medicinal materials. Therefore Px is 22.73%. Flos Trollii Chinensis has 3 special marks and Px is 17.65%. Flos Chrysanthemi Indici has 1 special mark and Px is 3.57%. Its coincided interplanar spacing with the patent is $2.907{\AA}$. Flos Lonicerae Japonicae has 6 special marks and Px is 23.08%. Its special mark in the patent are 4.95/14 and 4.50/15, respectively. The P is 9.09%. Its coincided interplanar spacing with the patent is $2.910{\AA}\;and\;3.05{\AA}$, respectively. The number of special XRDF mark peaks of baicalin is 9 and Px is 18.37%. Its coincided interplanar spacing with the patent is $2.910{\AA}$. It has visible mark and specificity adopting XRDF fingerprint to identify Huangjinju and medicinal materials. Establishing the quality standard is a synthetic index that depends both on special marks in the medicinal materials of the patent and on the coincidence peak data.