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http://dx.doi.org/10.20307/nps.2016.22.2.82

Compounds from a jellyfish-derived fungus Aspergillus fumigates  

Tao, Guan-yu (Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences)
Liu, Juan (Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences)
Jung, Jee H. (College of Pharmacy, Pusan National University)
Guo, Wei (School of Traditional Chinese Medicine, Southern Medical University)
Wen, Xiao-qiong (School of Traditional Chinese Medicine, Southern Medical University)
Liu, Yonghong (Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences)
Publication Information
Natural Product Sciences / v.22, no.2, 2016 , pp. 82-86 More about this Journal
Abstract
Six compounds were isolated from the secondary metabolites of the jellyfish-derived fungus Aspergillus fumigates, whose structures were identified by chemical methods and spectroscopic analysis as pseurotin F1 (1), azaspirofurans B (2), $(22E,\;24R)-24-methyl-5{\alpha}-cholesta-7,22-diene-3{\beta},5,6{\beta}-triol$ (3), $5{\alpha},8{\alpha}-epidioxyergosta-6,22-dien-3{\beta}-o1$ (4), $cyclo-({\small{L}}-Pro-{\small{L}}-Tyr)$ (5), fumitremorgin C (6). The compounds 1 - 5 were isolated from the fungus Aspergillus fumigates for the first time. The isolated compounds (1 - 6) were evaluated for antibiotic activity and cytotoxicity against six bacterial strains and ten human tumor cell lines, respectively.
Keywords
Nemopilema nomurai; Jellyfish-derived fungus; Aspergillus fumigates; Isolation; Structural elucidation;
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1 Mille-Lindblom, C.; Fischer, H.; Tranvik, L. J. OIKOS. 2006, 113, 233-242.   DOI
2 Zhang, H. W.; Song, Y. C.; Tan, R. X. Nat. Prod. Rep. 2006, 23, 753-771.   DOI
3 Blunt, J. W.; Copp, B. R.; Keyzers, R. A. Munro, M. H.; Prinsep, M. R. Nat. Prod. Rep. 2014, 31, 160-258.   DOI
4 Uye, S. Plankton Benthos Res. 2008, 3, 125-131.   DOI
5 Wink, J.; Grabley, S.; Gareis, M.; Thiericke, R.; Kirsch, R. European Patent Application 1993, EP0546474A1.
6 Frisvad, J. C.; Rank, C.; Nielsen, K. F. Med. Mycol. 2009, 47, S53-S71.   DOI
7 Wenke, J.; Anke, H.; Sterner, O. Biosci. Biotech. Biochem. 1993, 57, 961-964.   DOI
8 Ren, H.; Liu, R.; Chen, L. Zhu, T.; Zhu, W. M.; Gu, Q. Q. Arch. Pharm. Res. 2010, 33, 499-502.   DOI
9 Mohr, P.; Tamm, C. Tetrahedron 1981, 37, 201-212.   DOI
10 Mohr, P.; Tamm, C. Tetrahedron Lett. 1987, 28, 391-394   DOI
11 Tsunematsu, Y.; Fukutomi, M.; Saruwatari, T. Noguchi, H.; Hotta, K.; Tang, Y.; Watanabe, K. Angew. Chem. Int. Ed. Engl. 2014, 53, 8475-8479.   DOI
12 Vincenzo, P.; Donato, S. J. Nat. Prod. 1987, 50, 915-920.   DOI
13 Wang, X.; Wang, H.; Liu, T.; Xin Z. Appl. Microbiol. Biotechnol. 2014, 98, 4875-4885.   DOI
14 Ioannou, E.; Abdel-Razik, A. F.; Zervou, M.; Christofidis, D.; Alexi, X.; Vagias, C.; Alexis, M. N.; Roussis, V. Steroids 2009, 74, 73-80.   DOI
15 Gauvin, A.; Smadja, J.; Aknin, M. Can. J. Chem. 2000, 78, 986-992.
16 Bu, M.; Yang, B. B.; Hu, L. Med. Chem. 2014, 4, 709-716.
17 Jayatilake, G. S.; Thornton, M. P.; Leonard, A. C. J. Nat. Prod. 1996, 59, 293-296.   DOI
18 Zhang, D.; Noviendri, D.; Nursid, M.; Yang, X.; Son, B. W. Nat. Prod. Sci. 2007, 13, 251-254.
19 Cimmino, A.; Puopolo, G.; Perazzolli, M.; Andolfi, A.; Melck, D.; Pertot, I.; Evidente, A. Chem. Heterocycl. Compds. 2014, 50, 290-295.   DOI
20 Borthwick, A. D. Chem. Rev. 2012, 112, 3641-3716.   DOI
21 Puopolo, G.; Cimmino, A.; Palmieri, M. C. Giovannini, O.; Evidente, A.; Pertot, I. J. Appl. Microbiol. 2014, 117, 1168-1180.   DOI