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흰쥐를 이용한 플루르비프로펜 겔의 약물동력학적 특성평가 (Pharmacokinetic Evaluation of Flurbiprofen Gel Using Rats)

  • 길형준;이우영;지상철
    • 약학회지
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    • 제38권5호
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    • pp.483-487
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    • 1994
  • The pharmacokinetic characteristics of an 1% flurbiprofen gel were evaluated using rats in reference to IV bolus and oral administration of the drug using rats. Following the transdermal application of the gel at the dose of 2 mg/kg as flurbiprofen, the $C_{max}$ and $T_{max}$ of the drug were $2.14\;{\mu}g/ml$ and 2 hr, respectively, whereas those after the oral administration of the drug as a suspension were $9.90\;{\mu}g/ml$ and 0.25 hr, respectively. These results indicate that, by the transdermal administration fo flubiprofen as the gel, the absorption of the drug was much slowed down and the lower $C_{max}$ compared to the oral administration may reduce the systemic side effects of the drug. The relative bioavailability of the flurbiprofen gel in reference to the oral dose was 48.5%. Tissue levels of flurbiprofen following the application of 50 mg of the 1% flurbiprofen gel onto ventral skin of rats showed that the maximum drug concentrations in the skin $(8.52\;{\mu}g/g)$ and the muscle $(2.06\;{\mu}g/g)$ occurred at 2 hrs postdose. The drug concentration in the both tissues remained relatively constant over the next 6 hrs following the peak concentration.

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The Effect of the Change in Neck Position on Muscle Activity during Arm Flexion Exercise

  • Cho, Sung-Hak;Kim, Chi-Hwan
    • 대한물리의학회지
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    • 제16권1호
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    • pp.9-16
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    • 2021
  • PURPOSE: This study was to investigate the effect of applying neck flexion during elbow flexion exercise on muscle activity of the biceps brachii, the anterior deltoid and the sternocleidomastoid (SCM). METHODS: Twenty healthy adults participated in this study. The subjects measured %MVIC (Maximal volumetric control) and collected the maximum electromyography (EMG) values in the biceps brachii, anterior deltoid, SCM. The first action was to sit in a sitting position with the eyes facing front and maintained the weight of each section by performing elbow flexion using a tension gauge. The second action was to sit in a sitting position with the head down and maintained the weight of each section by performing elbow flexion using a tension gauge. Paired T-test was used for comparison of the before-and-after neck flexion to analyze the muscle activity of the Biceps brachii of next flexion and extension, the SCM, and the Anterior deltoid during elbow flexion exercise. The Repeated measured ANOVA was used for comparing %MVIC in each muscle. The significance level (?) was set at .05. RESULTS: Neck flexion during elbow flexion increased the muscle activity of the Biceps brachii and Anterior Deltoid muscle in the maximal muscle strength 50 ~ 60%, 70 ~ 80% and decreased the muscle activity of the SCM (p < .05). CONCLUSION: The applic has been confirmed to reduce the mobilization of the SCM and increase the mobilization of the Biceps brachii and Anterior Deltoid to increase the mobilization. Therefore, it seems effective to apply neck flexion when elbow flexion exercise.

Information Distribution of Sport Social Networking Sites: Their Use in Promoting Psychological Well-Being

  • Seung Hwan PARK;Min Soo KIM;Miok KIM;Seungmin LEE;Taeyeon OH;Sun Ju KIM;Won Jae SEO
    • 유통과학연구
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    • 제22권3호
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    • pp.83-92
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    • 2024
  • Purpose: With the rapid information distribution of sport-related SNS, sport industry has utilized SNS as technical solution to distribute sport and health-related information. The current study examined the effect of SNS information use for running-specific content on running engagement and psychological well-being. Research design, data and methodology: Data were collected via online survey of participants in marathon events of United States. Descriptive statistics and Chi-square test were conducted to compare demographics and psycho-behavioral outcomes among SNS information users and non-users for running-specific contents. Multivariate hierarchical regression was next employed to examine research hypotheses. Results: A mass-participant running event was used to test seven hypotheses related to the potential role of SNS for running content in promoting running engagement and life satisfaction. In general, findings revealed that use of SNS for running content along with frequency of use can perhaps facilitate running intensity and influence participation in running-related outdoor activities. Furthermore, while overall life satisfaction did not appear to be influenced by use of SNS for running content, there was a demonstrated influence on the individual satisfaction domains. Conclusions: The findings of current study suggest that sport SNS is information distribution media enhancing users' engagement and their six life satisfaction domains. Further implications were discussed.

한국 근로자의 식품섭취 기호도에 관한 연구 (A Study on the Preferences for Food Intake of Korean Industrial Workers)

  • 김창숙;안명수
    • 한국식생활문화학회지
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    • 제8권1호
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    • pp.1-9
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    • 1993
  • This study was carried on the preferences for food intake pattern of Korean industrial workers. The survey was conducted from Feb 17, to March 31, 1992 by questionnaires which was composed of 21 items. The subjects of this study were composed of 426 clerical workers, and 439 physical workers. The results were obtained as follows. 1. In the educational background, clerical workers was almost of highschool or collage graduates, and physical workers was almost of highschool graduates. Marginal food cost of per person for lunch a day was from 500 Won to 1,000 Won. They replied that amount of staple food and side dishes were appropriate, and the type of preferable foods was Korean style cooked rice. Also it was known that physical workers thought their nutritive condition more badly than that of clerical workers. So the physical workers considered their health very much when they had meal. It was represented that unbalanced diet, without diet and drinking alcohol effected badly to food intake and taste of food was the most important point in food intake. 2. Preferences for staple foods; Cooked rice was preferred the most by the subjects. Cooked rice with redbean was preferred by clerical workers and cooked rice with soybean was preferred by physical workers and cooked rice with soybean was preferred by physical workers. Also clerical and physical workers liked Kalkooksoo (hot noodle), Nangmyun (cold noodle), bread, vegetable bread and disliked Sphagetti, Ramyun (Instant noodle) in same rate. In the next, cooked rice covered with raw fish pieces (Sushi) was preferred by clerical workers and Mandu-kook was preferred by physical workers. Also they disliked Curriedrice and Hashrice in same pattern. 3. Preference for side-dishes; The Acceptances for side-dishes were high soybean paste soup (clerical workers:43.7%, physical workers:34.4%), Kim chi stew, fried potatoes, crab steaming (37.8%, 36.9%), broiled fish (34.6%, 33.9%), fried green pepper, Ham, Chinese cabbage Kim chi, and pickled garlic by clerical and physical workers all together. But in clerical workers, Wooghugi beef-rib tang, Deodeok muchim, spinach namul, beef jangjeorim, fried shrimp were shown to have high preference in physical workers, beef-rib tang, wild onion and shepherd's purses muchim, soybean sprout, fish jeorim, fried sweet potatoes were high preference. 4. Preference of Snacks; The preferences for snacks were high in strawberry (clerical:36.3%, physical:34.3%), milk (49.9%, 44.4%), waxy rice Doek (30.7%, 30.2%), coffee (40.1%, 38.9%) by two groups in same order.

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국내 한의사의 팔강변증에 관한 인식 및 활용현황 조사 (An On-line Survey on the Perception and Usage of Korean Medicine Doctors about Pattern Identification of Eight Principles)

  • 배정현;박신형;이인선;김종원;전수형;강창완;지규용
    • 동의생리병리학회지
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    • 제35권6호
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    • pp.211-218
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    • 2021
  • In order to increase the clinical value of an identification of patterns according to the eight principles (IPEP) in Korean medicine practice, The research on the Clinical Practice Guideline (CPG) of IPEP should comprehend the situation of clinical usage of IPEP practiced by Korean medicine doctors at first. Google survey form were emailed to Korean Medicine doctors registered in the Association of Korean Medicine on 04/15/2021 and the survey was closed at 04/22/2021. Data of 505 answered cases were analyzed by Frequency analysis, Chi-Square analysis, correlation analysis for understanding differences by groups. Out of 505 respondents, 57.6% have answered that they are using IPEP. It means that 42.4% of KM doctors don't use in the medical practice reversely in spite of fundamental diagnostic theory. The 64.7% respondents of no using IPEP presented their opinion about the theoretical problem that it is difficult to use because the concept of IPEP is ambiguous. And next, the 52.1% of the respondents expressed that there is no objective tools to measure and record the IPEP evidences in actual implementation. And 49.6% of the respondents also suggested that it is hard to trust and use IPEP similar to the previous comment. Even about 50% of the respondents are carrying out diagnosis and treatment using IPEP, it showed that there were several unsolved problems such as lack of understanding and practical tools or objective indicators for diagnosis of IPEP. Through the above results, the concept, usage, measurement requirements with indices and discriminant logic of IPEP were manifested as the main hopes of attending members of Korean medicine in the survey, so the IPEP CPG should make clear about these difficult but necessary assignment in the near future.

병원 근무자와 공무원의 건강증진 행위 비교 (Comparison on Practice of Health promoting Behavior between Hospital Workers and Government Officers)

  • 문정순;김윤수
    • 한국보건간호학회지
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    • 제13권2호
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    • pp.45-58
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    • 1999
  • This study was conducted to compare the practice of health promoting behaviors between hospital workers and government officers. The subjects for this study were consisted of 344 hospital workers in four university hospitals and 340 government officers in four district offices in the Kyong-in area. Data were collected by using constructed questionnaires from January to February in 1997 and analyzed by Chi-square test, t-test. ANOVA, Pearson correlation coefficient and stepwise multiple regression. The results were as follows : 1. There was no significant difference between hospital workers and government officers in practice of health promoting behaviors as a whole. but among five domains of the health promoting behaviors, hospital workers was significantly higher than that of government officer in the domain of health responsibility, while they were significantly lower than those of government officer in the domain of exercise & nutrition and stress management. The mean score of health promoting behavior for hospital workers and government officer were 2.40, and 2.47, respectively. The health promoting behavior in relation to the characteristics of the hospital workers varied significantly according to sex and age. The domain of self-actualization ranked highest in health promoting behaviors of hospital workers, interpersonal support came next. stress management, health responsibility and exercise & nutrition followed them. While those of government officers. the domain of self-actualization ranked highest. interpersonal support came next, stress management, exercise & nutrition and health responsibility followed them. 2. There were no significant difference between hospital workers and government officers in the health perception with mean score of 3.32 and 3.34 respectively, in the self esteem with mean score of 2.82 and 2.84 respectively, in the self-efficacy with mean score of 70.50 and 72.35 respectively. in the internal health locus of control with mean score of 2.95 and 3.03, respectively, m the chance health locus of control with mean score of 2.10 and 2.13, respectively, m the powerful others health locus of control with mean score of 2.39 and 2.46, respectively. 3. The practice of health promoting behavior of hospital workers were strongly associated with self-esteem and self-efficacy, and self-esteem was strongly correlated with self-efficacy. And the practice of health promoting behavior of government officers were strongly associated with self-esteem, powerful others health locus of control and internal health locus of control. and self-esteem was strongly correlated with self-efficacy. 4. The combination of self-esteem, powerful others health locus of control. health perception. self-efficacy. internal health locus of control. age and marital status explained $45.7\%$ of variance of likelihood to engage in health promoting behavior of hospital workers. And the combination of self-esteem. powerful others health locus of control. health perception. self-efficacy. internal health locus of control. sex and marital status explained $48.2\%$ of variance of likelihood to engage in health promoting behavior of government officers.

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행정복합도시의 인구수 및 유형별 가구수 추정에 대한 연구: 1단계 사업성과를 기반으로 (Research on the Number of Households and Population Estimates of Administrative Composite City)

  • 남영우;권치흥;김종림;김용순
    • 토지주택연구
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    • 제7권4호
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    • pp.165-175
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    • 2016
  • 2012년 7월 1일에 세종특별자치시가 출범하게 되고 행정복합도시의 1단계 건설사업이 2015년 말에 완료되었다. 따라서 1단계 사업의 결과를 통해서 나타난 결과를 통해 2030년까지 계획하고 있는 인구 및 가구수 목표를 달성할 수 있는 지 점검하고 향후 공급해야 할 주택의 수 및 유형을 결정하는데 활용할 필요가 있다. 따라서 본 연구에서는 1단계 사업기간 중에 나타난 결과를 기반으로 2030년까지의 인구수 및 가구수를 예측하였다. 인구수의 예측은 통계청의 장래인구추계에서 나타난 세종시의 인구증가율과 1단계에서 나타난 계획대비 실적을 활용하는 방법을 사용하였다. 분석결과 기존의 행정복합도시가 2030년까지 목표로 하고 있는 인구수 50만명과 가구수를 유치하기는 어려운 것으로 나타났다. 유형별 가구수에 대한 분석에서는 현재 행정복합도시는 공공기관의 대규모 이전으로 인해 3-4인 가구의 비중이 크고 소득수준이 상대적으로 높으며, 자가주택에 거주하는 주택이 많은 것으로 나타났다. 하지만 도시의 규모가 커지면서 1-2인 가구와 임차주택의 비중이 높아지고 소득수준이 조정될 가능성이 높아 향후 주택공급시 이를 반영할 필요가 있을 것으로 판단된다.

생태자연도 등급 하락에 영향을 미치는 인위적 토지피복 변화 분석 (The Impact of Anthropogenic Land Cover Change on Degradation of Grade in Ecology and Nature Map)

  • 최철현;임치홍;이성제;서현진
    • 한국환경복원기술학회지
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    • 제22권6호
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    • pp.77-87
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    • 2019
  • The first grade zones in Ecology and Nature Map are important regions for the conservation of the ecosystem, but it would be degraded by various anthropogenic factors. This study analyzes the relationship between potential land cover change and degradation of the first grade zones using land cover transition probability. As a result, it was shown that most of the first grade zones with degraded were converted from forest to urban(5.1%), cropland(27.2%), barren(11.0%) and grass(27.5%) in Gangwon and forest to urban(18.0%), cropland(15.3%), grass(28.4%), barren(12.3%) in Gyeonggi. The result of the logistic regression analysis showed that the probability of degradation of first grade zone was higher in area where was expected the higher probability of urban, cropland, barren, grass transition. The barren transition probability was the most influential and grass was the next highest. There were regional differences in the probability of urban transition and cropland transition, and the urban transition probability was more influential in Gyeonggi-do. This is because development pressure such as housing site development is high in Gyeonggi-do. Due to the limitations of the Act on Mountain Districts Management, even in the first grade zones, the grade may be degraded. Therefore, if Ecology and Nature Map are used to prevent deforestation or conversion of mountainous districts, it may contribute to the preservation of the ecosystem.

유니버설미들웨어기반 생명주기 보안에너지 서비스플랫폼 연구 (The Security Life Cycler Energy Service Platform for Universal Middleware)

  • 이해준;황치곤;윤창표
    • 한국정보통신학회논문지
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    • 제21권6호
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    • pp.1197-1202
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    • 2017
  • 전력서비스를 지원하는 융합보안시스템 단말장치는 상대적으로 고도의 신뢰성이 요구된다. 특히, 에너지서비스의 복합적인 통신과 데이터 인터페이스장치간의 보안시스템이 유기적으로 연동되어야 한다. 기존의 서비스와 연관성을 두어 시스템을 구축하기 위해서는 시스템독립성과 확장성을 지원하는 생명주기 방식의 보안 서비스플랫폼이 요구된다. 생명주기를 지원하는 유니버설미들웨어방식의 Security Layer를 활용하는 것이다. 이 융합보안 플랫폼은 첫째, 실시간으로 운영되는 통신과 데이터 및 응용서비스에 대해 독립적으로 동작 가능하도록 서비스 단위로 모듈화 하였다. 둘째, 보안 레이어 개념을 적용하여 외부 보안 서비스에 대하여 보안모듈의 설치, 삭제, 시작, 중지 및 갱신을 통해 생명주기 모듈로 배포하는 플랫폼 모델을 구성하고 평가하였다. 그리하여, 실시간으로 운용되는 프로토콜의 실행상태에서 프로토콜 전송 서비스의 안정성과 하드웨어시스템에 독립적인 모듈단위의 보안서비스를 지원하도록 하였다.

Incidence of apical crack formation and propagation during removal of root canal filling materials with different engine driven nickel-titanium instruments

  • Ozyurek, Taha;Tek, Vildan;Yilmaz, Koray;Uslu, Gulsah
    • Restorative Dentistry and Endodontics
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    • 제42권4호
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    • pp.332-341
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    • 2017
  • Objectives: To determine the incidence of crack formation and propagation in apical root dentin after retreatment procedures performed using ProTaper Universal Retreatment (PTR), Mtwo-R, ProTaper Next (PTN), and Twisted File Adaptive (TFA) systems. Materials and Methods: The study consisted of 120 extracted mandibular premolars. One millimeter from the apex of each tooth was ground perpendicular to the long axis of the tooth, and the apical surface was polished. Twenty teeth served as the negative control group. One hundred teeth were prepared, obturated, and then divided into 5 retreatment groups. The retreatment procedures were performed using the following files: PTR, Mtwo-R, PTN, TFA, and hand files. After filling material removal, apical enlargement was done using apical size 0.50 mm ProTaper Universal (PTU), Mtwo, PTN, TFA, and hand files. Digital images of the apical root surfaces were recorded before preparation, after preparation, after obturation, after filling removal, and after apical enlargement using a stereomicroscope. The images were then inspected for the presence of new apical cracks and crack propagation. Data were analyzed with ${\chi}^2$ tests using SPSS 21.0 software. Results: New cracks and crack propagation occurred in all the experimental groups during the retreatment process. Nickel-titanium rotary file systems caused significantly more apical crack formation and propagation than the hand files. The PTU system caused significantly more apical cracks than the other groups after the apical enlargement stage. Conclusions: This study showed that retreatment procedures and apical enlargement after the use of retreatment files can cause crack formation and propagation in apical dentin.