• Natural Product Sciences
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• v.14 no.1
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• pp.27-31
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• 2008

We have evaluated the combined antifungal effects of the essential oil from Eucalyptus globulus or its main component 1,8-cineole with ketoconazole. Checkerboard microtiter tests were used to analyze their effects against three Candida and six Trichophyton species. The susceptibility of the Trichophyton species to E. globulus essential oil differed distinctly. The fractional inhibitory concentration indices (FICIs) against the tested Candida species ranged between 0.09 and 0.38 for ketoconazole combined with E. globulus essential oil or 1,8-cineole, indicating significant synergism between ketoconazole and the oil samples. Similar experiments using Trichophyton species resulted in FICIs between 0.28 and 0.63, indicating relatively weaker combined effects than those observed with Candida species. Thus, the data reported here show that the anti-Candida effects of ketoconazole can be significantly improved in the presence of E. globulus essential oil or 1, 8-cineole.

• 한국정보디스플레이학회:학술대회논문집
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• 2005.07a
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• pp.187-190
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• 2005

Alignment pattern of checkerboard was constructed by the stylus of atomic force microscope. Orientational bistability of the nematic liquid crystal was realized on that frustrated surface alignment. Macroscopic orientational switching between two perpendicular directions took place by an appropriate in-plane electric field. The threshold electric fields decreased in both switching directions as temperature increased. The focused laser heated up only the limited domains in the cell including a light-absorbing medium. Irradiating the laser concurrently with an appropriate electric field, we switched the selected unit domains in the alignment pattern. The switched domains maintained stably the switched direction without the disturbance from the exterior. Extending and repeating this process, we realized extremely fine devices of bistable switching.

• YAKHAK HOEJI
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• v.46 no.3
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• pp.203-207
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• 2002

The antifungal activities of the essential oils from Anthemis nobilis, Ciderus atlantica, Juniperus communis, Lavandula angustifolia, Pelargonium graveolens, Pogestemon patchouli, Rosmarinus officinalis, and Styrax tonkinensis which are recommended for the treatment of microbial infections in aromatherapy and complementary medicines were tested against Candida spp. The activities were measured by broth dilution method and disk diffusion assay. Most of the test oils inhibited growth of Candida albicans, C. utilis and C. tropicalis. Especially, the essential oil from Pelargonium graveolens and its main component, citronellol showed the strongest activity among the herbs except benzoic acid from Styrax tonkinensis which is well-known antimicrobial compound. As a result of checkerboard microtiter test. synergistic effect of citronellol, was shown when the component was combinated with ketoconazole, displaying a fractional inhibiting concentration (FIC) index of 0.37 against C. albicans.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2001.10a
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• pp.183-190
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• 2001

Topology optimization. has been evolved into a very efficient conceptual design tool and has been utilized into design engineering processes in many industrial parts. In recent years, topology optimization has become the focus of structural optimization design and has been researched and widely applied both in academy and industry. Traditional topology optimization has been using homogenization method and optimality criteria method. Homogenization method provides relationship equation between structure which includes many holes and stiffness matrix in FEM. Optimality criteria method is used to update design variables while maintaining that volume fraction is uniform. Traditional topology optimization has advantage of good convergence but has disadvantage of too much convergency time and additive checkerboard prevention algorithm is needed. In one way to solve this problem, element remove method is presented. Then, it is applied to many examples. From the results, it is verified that the time of convergence is very improved and optimal designed results is obtained very similar to the results of traditional topology using 8 nodes per element.

• Nuclear Engineering and Technology
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• v.32 no.2
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• pp.169-179
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• 2000

A detailed numerical analysis of the evolution of thermal stratification in a curved piping system in a nuclear power plant is performed. A finite volume based thermal-hydraulic computer code has been developed employing a body-fitted, non-orthogonal curvilinear coordinate for this purpose. The cell-centered, non-staggered grid arrangement is adopted and the resulting checkerboard pressure oscillation is prevented by the application of momentum interpolation method. The SIMPLE algorithm is employed for the pressure and velocity coupling, and the convection terms are approximated by a higher-order bounded scheme. The thermal-hydraulic computer code developed in the present study has been applied to the analysis of thermal stratification in a curved duct and some of the predicted results are compared with the available experimental data. It is shown that the predicted results agree fairly well with the experimental measurements and the transient formation of thermal stratification in a curved duct is also well predicted.

• Proceedings of the Korean Nuclear Society Conference
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• 1998.05a
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• pp.33-39
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• 1998

기존 가압형 경수로에서 전체 반응도가의 상당부분을 제어하고 있는 붕산수를 사용하지 않고 가연성독봉 및 쟤어봉을 확대 사용하는 전략으로 1300MWe급 차세대원자로(KNGR)를 대상으로 무붕산 노심 개념설계를 수행하였다. 가연성독봉으로는 기존 PYREX 독붕의 독물질을 농축한 농축 PYREX 독봉을 도입하여 주기초 반응도 제어효과 및 전 주기동안 평평한 잉여반응도 유지에 매우 효과적인 결과를 도출하였다. 또한, 무붕산 노심이 필연적으로 갖게되는 축방향 출력분포의 노심 하단부치중현상을 제어하기 위하여 부분장 제어봉(Part Length Control Red)을 보조적으로 사용, 매우 간단한 형태의 핵연료집합체 축방향 zoning 설계를 수행하였다. 부분장 제어봉의 사용으로 모든 핵연료집합체를 축방향으로 zoning 하지 않고도 축방향 출력분포를 효과적으로 제어할 수 있었다. 제어봉으로는 큼 제어봉가를 확보하기 위하여 B$_4$C를 재질로하는 Checkerboard 형태의 제어봉 설계를 수행하였고, 효과적인 제어봉 운영을 통하여 무붕산 노심의 잉여반응도 및 출력분포 제어가 가능하였으며 제어봉이 운전중에 상당부분 삽입될지라도 약 7%$\delta$p 의 충분한 운전정지 여유도를 확보할 수 있다는 가능성을 확인할 수 있었다.

• Proceedings of the Korean Nuclear Society Conference
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• 1998.05a
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• pp.137-142
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• 1998

이 연구의 목적은 혼합핵연료 장전노심에서와 같이 스펙트럼이 상이한 인접핵연료의 영향으로 나타나는 노드내 스펙트럼 이력효과를 보정해 주고자 하는 것이다. 이를 위해 이 연구에서는 노드내 13개 지역에서 국부적 미시연소를 수행하여 스펙트럼 이력이 각각 다른 13 개의 독립적인 핵단면적을 구하였고 이로부터 노드내 핵단면적의 분포를 다항식으로 근사하였다. 스펙트럼 이력구배 효과의 보정은 노드내 중성자속 가중평균 핵단면적과 노드내 핵단 면적의 분포에 따른 불연속인자로 보정하였다. 이 스펙트럼 이력구배 효과 보정방법을 혼합 핵연료와 우라늄핵연료가 Checkerboard 형으로 무한히 장전된 경우에 대하여 검증계산을 수행하여 참조해인 CASMO-3 결과와 비교하였다. 스펙트럼 이력분포가 고려되지 않은 경우는 연소도 40 MWD/kgHM에서 노심 반응도에서 약 0.38%, 봉출력에서 최대 11.2 %, 평균 4.3%의 오차를 보였으나 스펙트럼 이력분포를 반영함으로서 노심 반응도에서 0.12 %, 봉출력에서 최대 4.9%, 평균 1.3%의 오차를 보였다.

• Archives of Pharmacal Research
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• v.17 no.6
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• pp.438-442
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• 1994

Antimicrobial activity of GL (the aqueous extract from the carpophores of Ganoderma lucidum ($F_RK_{KARST}$) was tested in vitro aginst Gram positive and Gram negative bacteria by serial broth dilution method, and the antimicrobial activity was expressed by minimal inhibitory concentration (MIC). Among fifteeen species of bacteria tested, the natimicrobial activity of GL was of antimicrobial combinations of GL with four kinds of antibiotics (ampicilin, cefazolin, oxytet-racycline and chloramphenicol), the fractional inhibitory concentraction index (FICI) was determined by checkerboard assy for each stain. The antimicrobial combinations of GL with four antibiotics resulted in additive effect in most instances, synergism in two instances, and antagonism in two instances. Synergism was obversed when GL was combined with cefazolin against Bacillus subtilis and Klebsiella oxytoca.

• YAKHAK HOEJI
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• v.56 no.5
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• pp.320-325
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• 2012

To develop a new effective and safe natural antibiotics and antioxidant the essential oil was extracted from the roots of Anthriscus sylvestris by steam distillation. Its composition was analyzed by GC-MS. The activities of the essential oil fraction and its main components were evaluated against antibiotic-susceptible and -resistant strains of some food-born bacteria. In addition the synergism was examined with this oil combined with antibiotic by checkerboard titer test. The antioxidant activities were determined by in 1,1-diphenyl-2-picryl-hydrazil (DPPH) free radical scavenging activity test and reducing power assay. The essential oil fraction of A. sylvestris revealed significant inhibiting activities against antibiotic-susceptible and -resistant species of Vibrio and Shigella with MICs ranged from 1.00~4.00 mg/ml. It showed synergistic or additive effects when it was combined with amphicillin or trimethoprim/sulfamethoxazole (1 : 9). Additionally, the essential oil fraction of A. sylvestris exhibited significant DPPH free radical scavenging activity and the reducing power.

• Archives of Pharmacal Research
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• v.28 no.8
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• pp.897-901
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• 2005

The in vitro inhibitory activities of essential oils from Thymus magnus and T. quinquecostatus as well as their main constituents were evaluated against susceptible and resistant species of Streptococcus pneumoniae, Staphylococcus aureus, Salmonella enteritidis, and Salmonella typhimurium. Notably, the essential oil fraction of T. magnus and its main components displayed significant inhibitory action against both antibiotic-susceptible and resistant strains of S. pneumoniae, S. aureus, and S. typhimurium with minimum inhibitory concentrations (MICs) ranging from 0.125 to 8 mg/mL. The differential MIC values imply that the oil fraction and its main components exhibit distinct patterns of activity against the tested bacterial species. Moreover, the disk diffusion test revealed that the inhibitory activities of oil fraction and components were dose-dependent. Data from the checkerboard titer test confirmed synergism between the antibiotic, norfloxacin, and T. magnus oil or thymol, particularly against the resistant strains of S. aureus.