Browse > Article

In Vitro Inhibitory Activities of Essential Oils from Two Korean Thymus species against Antibiotic-Resistant Pathogens  

Shin, Seung-Won (College of Pharmacy, Duksung Women's University)
Kim, Ji-Hyun (College of Pharmacy, Duksung Women's University)
Publication Information
Archives of Pharmacal Research / v.28, no.8, 2005 , pp. 897-901 More about this Journal
Abstract
The in vitro inhibitory activities of essential oils from Thymus magnus and T. quinquecostatus as well as their main constituents were evaluated against susceptible and resistant species of Streptococcus pneumoniae, Staphylococcus aureus, Salmonella enteritidis, and Salmonella typhimurium. Notably, the essential oil fraction of T. magnus and its main components displayed significant inhibitory action against both antibiotic-susceptible and resistant strains of S. pneumoniae, S. aureus, and S. typhimurium with minimum inhibitory concentrations (MICs) ranging from 0.125 to 8 mg/mL. The differential MIC values imply that the oil fraction and its main components exhibit distinct patterns of activity against the tested bacterial species. Moreover, the disk diffusion test revealed that the inhibitory activities of oil fraction and components were dose-dependent. Data from the checkerboard titer test confirmed synergism between the antibiotic, norfloxacin, and T. magnus oil or thymol, particularly against the resistant strains of S. aureus.
Keywords
Thymus magnus; T. quinquecostatus; Essential oils; Resistant bacteria;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 11  (Related Records In Web of Science)
Times Cited By SCOPUS : 14
연도 인용수 순위
1 Davidson, P. M. and Parish, M. E., Methods for testing the efficacy of food antimicrobials. Food Technol., 43, 148-155 (1989)
2 Logue, C. M., Sherwood, J. S., Elijah, L. M., Olah, P. A., and Dockter, M. R., The incidence of antimicrobial-resistant Salmonella spp. on freshly processed poultry from US Midwestern processing plants. J. Appl. Microbiol., 94, 16-24 (2003)   DOI   ScienceOn
3 Shin, S. and Kim J. H., Antifungal activities of essential oils from Thymus quinquecostatus and T. magnus, Planta Med., 70, 1087-1090 (2004)   DOI   ScienceOn
4 Kim, Y. H., Lee, J. C., Choi, Y. H., Essential oils of Thymus quinquecostatus Celakov. and Thymus magnus Nakai. Korean J. Medicinal Crop Sci., 2, 234-240 (1994)
5 Dougherty, T. J., Beaulieu, D., and Barrett, J. F., New quinolones and the impact on resistance. Drug Discov. Today, 6, 529-536 (2001)   DOI   ScienceOn
6 Bidlack, W. R., Omaye, S. T., Meskin, M. S., and Topham, D. K., Phytochemicals as bioactive agents, Technomic Publishing Company, Lancaster, pp. 106-110 (2000)
7 Esposito, S. and Principi, N., Emerging resistance to antibiotics against respiratory bacteria; impact on therapy of community-acquired pneumonia in children. Drug Resist. Update, 5, 73-87 (2002)   DOI   ScienceOn
8 Giamperi, L., Fraternale, D., and Ricci, D., The in vitro action of essential oils on different organisms. J. Essent. Oil Res., 14, 312-318 (2002)   DOI   ScienceOn
9 Ito, T., Okuma, K., Ma, S. S., Yuzawa, H., and Hiramasu, K., Insights on antibiotic resistance of Stahylococcus aureus from its whole genome: genomic island SCC. Drug Resist. Update, 6, 41-52 (2003)   DOI   ScienceOn
10 Shin, S., Essential oil compounds from Agastache rugosa as antifungal agents against Trichophyton species. Arch. Pharm. Res., 27, 295-299 (2004)   DOI   PUBMED   ScienceOn
11 Dillard, S. C., Waites, K. B., Brookings, E. S., and Moser, S. A., Detection of oxacillin-resistance in Staphylococcus aures resistance by microscan MIC panel in comparision to other methods. Diagn. Microbiol. Infect. Dis., 24, 93-100 (1996)   DOI   ScienceOn
12 Shin, S. and Lim, S., Antifungal effects of herbal essential oils alone and in combination with ketocoanzole agains Trichophyton spp. J. Appl. Microbiol., 97, 1289-1296 (2004)   DOI   ScienceOn
13 Zarzuelo, A. and Crespo, E. T., The medicinal and nonmedicinal uses of thyme. In: Thyme-the genus Thymus. Stahl-Biskup E., Saez, F., editors. London, New York: Taylor & Francis, p. 263-292 (2003)
14 Chang, S. C., Hsieh, W. -C., and Luh, K. -T., Influence of ${\beta}$- lactamase inhibitors on the activity of oxacillin against methicillin-resistant Staphylococcus aureus. Diagn. Microbiol. Infect. Dis., 21, 81-84 (1995)   DOI   ScienceOn