• Parasites, Hosts and Diseases
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• 제44권4호
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• pp.361-366
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• 2006

Sustained-releasing praziquantel (SRP) tablet was designed for single dose treatment regimen of clonorchiasis. A previous pre-clinical study confirmed its sustained-releasing characteristics and a better cure rate than conventional praziquantel (PZQ). In this clinical study, the pharmacokinetics of this SRP tablet were investigated in human volunteers (phase 1; 12 volunteers), and its curative efficacy was examined in clonorchiasis patients (phase 2; 20 volunteers). In the phase 1 clinical study, blood concentrations of both tablets showed wide individual variation. The $AUC_{last}$ of SRP was $497.9{\pm}519.0ng{\cdot}hr/ml\;(mean{\pm}SD)$ and PZQ of $628.6{\pm}695.5\;ng{\cdot}hr/ml$, and the $AUC_{inf}$ of SRP was $776.0{\pm}538.5\;ng{\cdot}hr/ml$ and of PZQ $658.6{\pm}709.9\;ng{\cdot}hr/ml$. $C_{max}$ values of SRP and PZQ were $90.7{\pm}82.2ng/ml\;and\;214.9{\pm}251.9\;ng/ml$, and $T_{max}$ values were $3.42{\pm}1.43\;hr\;and\;1.96{\pm}1.23\;hr$, respectively. SRP tablets showed similar AUC values, but lower $C_{max}$ and longer $T_{max}$ values than PZQ. In the phase 2 study, SRP at 30 mg/kg (single dose) achieved a 60% cure rate and a 95.5% egg reduction rate. The cure rate of a single dose SRP was unsatisfactory compared with that of the conventional PZQ dose, but much better than that achieved by a single dose PZQ.

• 대한후두음성언어의학회지
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• 제11권1호
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• pp.87-97
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• 2000

1999년 4월 일주일간 전국 101개 병의원의 이비인후과 외래를 방문한 신환을 대상으로 설문을 실시하고 이비인후과 전문의의 진찰을 통하여 인.후두 위산역류중(LPR)의 발병빈도와 그와 관련된 사항들을 조사하여 다음과 같은 결과를 얻었다. 1) 이비인후과 신환 전체 진단 병명의 24%, 이비인후과 신환 환자 중 25%에서 LPR 관련 증상 또는 진찰소견이 확인되었다. 2) LPR 관련 진단명으로는 인두이물감증후군(Glo-bus syndrome)이 27%로 가장 많았으며, 역류성후두염, 만성후두염 등의 순이었다. 3) 여성에서 남성보다 많았으며, 40, 50, 60대에 흔하여 노인성 변화와의 관련이 의심되었다. 4) 비만도와는 큰 상관관계가 없었음. 5) LPR의 3대 주증상은 인두이물감, 만성적 목청소, 원인모를 쉰 목소리였음. 6) LPR을 악화시키는 요인으로는 피곤함, 정신적 스트레스, 술, 담배, 자극성있는 음식, 커피 등이었음. 7) 목소리를 직업적으로 쓰는 사람에서 LPR 증상의 발현이 높았음. 8) 과거 병력상 위질환과 잦은 편도염이 많았음.

• 대한간호학회지
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• 제26권2호
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• pp.359-371
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• 1996

This study has been done for the purpose of testing the effect of health education on the performance of health promoting behavior in college students, and identifying the factors affecting health promoting behaviors. A Nonequivalent control group posttest research design was used. Two hundred thirty college students at K College in T city were studied. Of them, 114 who attended a systematic health education session for three hours a week during one semester were the experimental group. And 116 college students who were chosen of matched sampling of grade, class and sex were the control group. This study was conducted from March 1 to July 2, 1995. The instruments used for this study included a survey of general characteristics, perceived health status, self-esteem, health promoting behavior and health locus of control. Analysis of data was done by use of mean, 1-test, Pearson correlation coefficient and multiple regression. The results of this study are summarized as follows : 1) The average item score for the health promoting behavior was low at 2.52. In the sub-categories, the highest degree of performance was ‘harmonious relationships’, following ‘sanitary life’, ‘self-esteem’, ‘rest and sleep’, and ‘emotional support’ and the lowest degree was ‘professional health management’. 2) Hypothesis 1 that the college students who get health education will have a higher degree of health promoting behavior than the college students who do not get health education was accepted. There was a statistically significant difference between the average of the experimentalgroup, 2.60, and the average of the control group, 2.45.（t＝11.30, p＝0.0009）. 3) Hypothesis 2 that the college students who get health education will have a higher score of perceived health status than college students who do not get the health education was rejected. （t＝1.13, p＝0.289） 4) Performance of health promoting behavior was positively correlated with self-esteem and grade and negatively correlated with perceived health status. 5) The most important factor affecting performance of health promoting behavior was self-esteem. The following suggestions are made based on the above results : 1) Replication of the research is needed to confirm effects of health education. 2) More effective health education programs need to be developed through by modification of teaching methods and content analysis of health education. 3) Other factors affecting health promoting behavior should be identified. 4) Nursing colleges or departments of nursing should make an effort to develop and carry out various health education programs for the health promotion of all college students.

• 기술혁신연구
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• 제25권3호
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• pp.233-263
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• 2017

본 연구는 한국의 현행 규제영향분석과정이 기술규제의 중요한 특성들을 반영하는가를 확인하기 위해 기술규제영향평가 차원에서 규제영향분석의 적절성을 검토하고자 하였다. 기술규제에 대한 분석 틀을 도출하고 이를 이용하여 정부부처가 제출한 규제영향분석서의 적절성에 대한 분석 평가를 수행하였다. 분석결과, [규제의 기술적 타당성], [국내 기술규범 부합성], [국제 기술규범 부합성], [적합성평가의 타당성]의 관점에서 각 부처가 현행 규제영향분석서에 기재한 사항을 객관적 사실, 대체분석 가능, 전문가적 판단가능 등을 고려하여 "적절"하다고 판단된 경우는 23.4%에 불과하였고, 각 부처별로도 특별한 차별성은 없었다. 규제 속성에 따른 규제영향분석서의 적절성을 검토해 본 결과, 사회적 규제와 간접적 규제들의 속성을 갖고 있는 기술규제에 대한 규제영향분석서의 적절성이 다소 높았다. 종합하면 실질적 의미의 기술규제영향평가를 수행하기에 현재 우리나라 규제영향분석서 수준은 상당히 미흡한 편으로 나타났다. 즉, 각 부처가 기술규제를 도입하면서, 해당 규제의 기술적 속성에 대한 이해가 완전하지 않은 것일 수 있다는 것이다. 과학기술적 근거를 제대로 반영하지 못한 규제영향분석서는 해당 기술규제에 대한 타당성을 과장하여 여타의 규제 대안에 대한 진지한 검토를 저해하는 한편, 글로벌 경쟁체제에서 기업과 국민의 경쟁력 확보를 방해하는 심각한 문제를 초래할 수 있을 것이다.

• 대한간호
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• 제37권4호
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• pp.72-84
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• 1998

This study has been done for the purpose of testing the effects of education for women's health on the performance of health promoting behavior and self esteem of college women. The study was designed as simulated control group pretest-posttest design, the experimental group was composed 182 college women and the control group was composed 151 college women at D University in Seoul. The instruments used for this study were Health Promoting Behavior Scale developed by Walker et al(1987)were modified by Shin(1997) and Self Esteem Scale developed by Rosenberg(1965). The data were analyzed by chi-square test, t-test and ANCOVA using $SPSSIPC^+$ program. The results were as follows: 1. The result of the homogeneity test in terms of the demographic characteristics of two group showed that there were significant difference in major discipline($x^2=155.854$, p=.000), religion($x^2=6.325$, p=.011), and disease experience($x^2=3.949$, p=.046). 2. Hypotheses 1 that the college women who get women's health education will have a higher score of health promoting behavior than the college women who do not get women's health education was supported. The score of health promoting behavior between two group showed statistically difference(t=7.25, p= .000). Mer control of covariates(major discipline, religion, and disease experience), the score of health promoting behavior between two group showed statistically difference(F=31.817, p= .000). 3. Hypotheses 2 that the college women who get women's health education will have a higher score of self esteem than the college women who do not get women's health education was supported. The score of self esteem between two group showed statistically difference(t=4.91, p= .000). After control of covariates(major discipline, religion, disease experience), the score of self esteem between two group showed statistically difference(F=12.688, p= .000). The following suggestions are made based on the above results : 1) Replication of the research is needed to confirm effects of health education including the college man and various demographic differences. 2) More effective health education programs appropriate to subject need to be developed. 3) Nursing college or departments of nursing should make an effort to develop and carry out various health education program for health for all.

• 대한한의학원전학회지
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• 제23권5호
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• pp.11-22
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• 2010

Treatise on the Pathogenesis and Manifestations of All Diseases(諸病源候論)was written by Chao Yuanfang that was most active during the Sui Dynasty at A.D. 610. It classified clinical medicine by some departments of internal medicine, surgery, obstetrics and gynecology, pediatrics, and otorhinolaryngology and within each specific department, categorizes etiology and pathology according to characteristics of various diseases. It was the total disease classification book that based on the bibles of the Oriental medicine, (Huangdi''s) Internal Classic(黃帝內經), Classic of Difficult Issues(難經) and Treatise on Cold Damage and Miscellaneous Diseases(傷寒雜病論), A-B Classic of Acupuncture and Moxibustion(鍼灸甲乙經), Essential Prescriptions Worth a Thousand Gold for Emergencies(備急千金要方) and Medical Secrets of an Official(外臺秘要). It was arranged tussive causes, classes, diagnosis, prognosis and stretching for treatment by Volume 13, all symptoms of tussiculation. Dialectic part was divided into cough(咳嗽), cough with dyspnea(咳逆上氣), cough with pus and blood(咳嗽吐膿血), cough with duck crying sound(?嗽), sudden cough(暴氣咳嗽), cough with dyspnea(咳逆), cough with dyspnea and vomiting(咳逆上氣嘔吐). Disease situation part was divided into the new cough(新咳) and old cough(舊咳), deficiency syndrome(虛證) and excess syndrome(實證), visceral cough(藏府咳), etc. Out of these, cough with counterflow(咳嗽上氣), cough with dyspnea(咳逆上氣), cough with dyspnea and vomiting(咳逆上氣嘔吐), cough with shortness of breath(咳逆短氣) have a close connection with dyspnea(上氣), counterflow of qi(逆氣), dyspnea and vomiting(上氣嘔吐) and shortness of breath(短氣) in the Pathogenesis and Manifestations of All qi(氣病諸候) of vol 13. So two parts may be refer to each other. However, the content on the original book has been addition and subtraction on the original context along with many reprints. Therefore, this paper, with regard to the prints of former editions, tried to help in better comprehension of the original context through readings and Korean translation.

• 대한소아치과학회지
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• 제41권2호
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• pp.134-144
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• 2014

본 연구는 환자분포 및 치료경향을 조사하여 소아치과의 변화하는 진료 양상을 알기 위해 시행하였다. 2008년 1월부터 2012년 12월까지 연세대학교 치과대학병원 소아치과에 내원한 환자를 대상으로 전자의무기록을 수집하고 분석하였다. 조사 결과 초진환자와 비선택 진료의사 1인당 환자 수는 감소하였고 외국인 환자수가 급증하였다. 신환은 만 0~2세의 연령층이 가장 많았고, 내원 주소는 치아우식증, 외상, 부정교합 순으로 높게 나타났다. 수복치료의 분포 결과 복합레진 수복, 아말감 수복, 치면열구전색술은 감소하였고, 자가중합형 글라스아이오노머, 예방적 레진수복이 증가하는 추세였다. 다내원근관치료가 감소하고 당일발수 근관 충전이 증가했으며, 치수복조술과 치수절단술과 같은 보존적 치수치료의 비율이 증가하였다. 환자의 불안을 감소시키기 위해 진정법을 선택하는 경우가 증가하였으며 아산화질소의 이용이 주를 이루었다. 내원 환자의 분포 및 특성을 파악하고, 최신 치료 경향을 제공함으로써 환자의 요구에 부합하는 적절한 치료계획을 수립하는데 도움이 될 것으로 생각된다.

• 치위생과학회지
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• 제11권1호
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• pp.7-14
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• 2011

본 연구는 치위생학과 졸업예정자들의 진로계획과 직업관을 파악하여 진로선택 및 취업에 대한 학사학위 과정 졸업예정자들의 특성을 규명하고 전문학사학위 과정 졸업예정자들과 비교하여 향후 진로를 개발하는데 필요한 기초 자료로 활용하고자 한다. 2011년 졸업생을 배출할 예정인 8개 대학교의 치위생학과 가운데 6개 대학교 졸업예정자 184명과 3년제 전문학사학위 과정 치위생과 졸업예정자 251명에 대한 조사 결과 다음과 같은 결론을 얻었다. 1. 학사학위 과정 치위생학과 졸업예정자에서는 대학원 진학 희망자가 전문학사학위 과정 졸업예정자 보다 많았으며, 취업 후 치과위생사로서 활동기간에 대해서는 '정년까지'가 가장 많았다. 이는 전문학사학위 과정 치위생과와 유의한 차이가 있는 것으로 나타났다. 2. 학사학위 과정 졸업예정자들은 장래 발전 가능성이 있고, 정년까지 안정적으로 근무기간이 보장되며, 급여가 높다는 이유로 병원급 치과의료기관을 선호하는 것으로 나타났다. 3. 취업 시 고려사항으로는 급여, 월차유무 및 휴가일수, 근무시간 등과 같은 근무조건이 높은 순위를 차지하였고 이는 학사학위 과정과 전문학사학위 과정에서 동일하게 나타났다. 4. 학사학위 과정 졸업예정자는 치과위생사의 직업관에서 '사회적으로 인정받는 직업이다'가 전문학사학위 과정에 비해 낮게 나타났다. 5. 학사학위 과정 졸업예정자 중 대학원 진학을 희망하는 학생들의 직업에 대한 만족도가 취업을 희망하는 학생들에 비하여 낮게 나타났다.

• 대한영양사협회학술지
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• 제6권2호
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• pp.136-147
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• 2000

The aim of this research was to examine the management practices related to foodservice.clinical nutrition service provided by hospital foodservice operations. A survey of 30 hospital food nutrition service departments was undertaken and detailed information was collected from each, including surveys of 176 dietitians and 30 foodservice managers. Statistical data analysis was completed using the SAS/win 6.11 package for descriptive analysis and t-test. The results of this study can be summarized as follows : Out of 30 hospitals, 73.3%(22) were directly operated and 26.7%(8) were under contract foodservice management. Licensed number of beds were 768.7, with an average length of 11.4 days. The general characteristics of the dietitians were that 49.4% were aged between 25-29, and 60.8% were ordinary dietitians. 76.7% had bachelor's degree, 15.9% with master's degree and 7.4% were college graduates. Most hospital dietitians had internship training and 35.2% took a training course of 6 to 12 months. The average space of kitchen was 452.52 $m^2$, with 133.63$m^2$ for modified diet space and 18.13$m^2$ for nutrition counselling room space. The total number of normal meals was 1,255.47, with 502.93 of modified meals. The average calorie of normal meals was 2,145.04kcal, with 91.9g of protein contained in normal meal. The total food waste was 351.40kg. An average monthly cost for disposing food waste was 745,171.67 won. 83.3% of the kitchens were on the 1st basement and only 66.7%(20) of 30 hospitals had its own nutrition counselling room. 80% used dishwashers and 66.7% had an exclusive elevator for delivering meals. 80.0% of hospitals used centralized delivery service. 90% had established an area for hygiene division, 70% used dry zone within the dishwashers for sterilization, 66.7% provided spoon and chopstick, and 100% used dish cover. As means of food waste treatment, most hospitals(56.7%) used animal feed by contracters, followed by means of collection by contracters(30%) and in-house high speed fermentation machines(13.3%). It was found that only 33.3% hospitals regularly checked temperatures of the meals given to patients. Total productivity index was 3.72(meals/hour) in average, with an average productivity index for normal diet of 5.41. Average productivity index for modified diet was 4.62. Productivity indices for patient meals and clinical nutrition were 5.01(meals/hour) and 1.12(cases/hour) respectively and hospitals under self-operated foodservice management received higher points on clinical nutrition productivity index(P<0.01) than hospitals under contract foodservice management.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제22권4호
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• pp.7-17
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• 2016

Purpose: As our population ages and becomes an elderly society the number of elderly care hospitals is rapidly increasing. Because physical functions and spatial perception in the elderly decrease with age, these hospitals require more systematic and intelligent space designs. The design of these spaces are even more complex because they must accommodate medical programs to treat various different diseases and ailments and also because there are many first time patients and irregular short term patients that seek out outpatient treatment services. Also by analyzing the spatial configuration systems and systematic relationships between each of the functional spaces of the outpatient treatment service departments for hospitals specialized in care for the elderly by focusing on the hallway and corridor systems of these hospitals, the according characteristics and trends were examined. Methods: Based on preceding research, the types of hallway and corridor systems of these hospitals were categorized into five types, including gallery corridors, middle corridors, hall-type, mixed type and cyclic type corridors, and into six types according to function including by medical diagnosis, patient registration, examination, administration and convenience and shared common space to derive any interconnecting relationships between the corridor systems. Also by comprehensively examining the types and combined utilization of the corridor types and the integration and the intelligibility of the space syntax, any trends within the corridor system were derived. The elderly care hospitals examined in this research study were twelve hospitals that opened after the year 2000 in Korea with more that 150 sick beds with areas larger than $1000m^2$ and with all outpatient medical service related rooms located entirely on a single floor of the hospital. Results: The following results could be confirmed based on this research study. 1) The spaces where medical diagnosis and examination occurred were adjacent, and the movement lines for first time patients and re-visiting patients were taken into consideration by separating the treatment space. 2) This research study confirmed that the larger the size of the hospital was, there were more detailed categorizations of treatment services and that there was a tendency for treatment areas to be separated and independent from examination areas. 3) There was a tendency for integration and intelligibility to decrease the more complex and diverse the combination of hall types designed into the corridor systems of these hospitals was. cyclic type corridors dramatically decreased the intelligibility of the corridor systems of these hospitals. 4) The priority rank of these spaces were confirmed to be highest in the order of registration, diagnosis, examination, treatment, administration and shared common spaces. However it was confirmed for the local integration that the diagnosis scope had the highest priority rank. Implications: There were exceptional cases confirmed where the number of unit spaces did not have an absolute effect on integration and intelligibility. These results can be interpreted to mean that this can be overcome through efficient architectural planning.