• Title/Summary/Keyword: Channel effect

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DAMGO, a ${\mu}-Opioid$ Agonist and Cholecystokinin-Octapeptide Have Dual Modulatory Effects on Capsaicin-Activated Current in Rat Dorsal Root Ganglion Neurons

  • Eun, Su-Yong;Kim, Ji-Mok;Lee, Ji-Hye;Jung, Sung-Jun;Park, Joo-Min;Park, Yun-Kyung;Kim, Dong-Kwan;Kim, Sang-Jeong;Kwak, Ji-Yeon;Kim, Jun
    • The Korean Journal of Physiology and Pharmacology
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    • v.5 no.1
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    • pp.71-78
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    • 2001
  • Capsaicin, a pungent ingredient of hot pepper, elicits an intense burning pain when applied cutaneously and intradermally. Activation of capsaicin-gated channel in C-type dorsal root ganglion (DRG) neurons produces nonselective cationic currents. Although electrophysiological and biochemical properties of capsaicin-activated current $(I_{CAP})$ were studied, the regulatory mechanism and intracellular signaling pathway are still unclear. In the present study, we investigated the modulations of $I_{CAP}$ by DAMGO $({\mu}-opioid\;agonist)$ and cholecystokinin octapeptide (CCK-8). In 18 out of 86 cells, the amplitude of $I_{CAP}$ was significantly increased by DAMGO and completely reversed after washout, while $I_{CAP}$ was decreased by DAMGO in 25 cells. In 43 cells, DAMGO had no effect on $I_{CAP}$. Mean action potential duration was significantly different between 'increased-by-DAMGO' group and 'decreased-by-DAMGO' group. Mean amplitudes of $I_H$ were not significantly different between both groups. CCK-8 reversibly enhanced the amplitude of $I_{CAP}$ (5/13). DAMGO also increased $I_{CAP}$ amplitude significantly in the same cells. The amplitude of $I_{CAP}$ was increased in additive manner by combined applications of DAMGO and CCK-8 in these cells. These results suggest that DAMGO and CCK-8 can either increase or decrease $I_{CAP}$ presumably depending on the subtypes of DRG cells and classified by electrophysiological properties.

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Interpretation of Migration of Radionuclides in a Rock Fracture Using a Particle Tracking Method (입자추적법을 사용한 암반균열에서 핵종이동 해석)

  • Chung Kyun Park;Pil Soo Hahn;Douglas J. Drew
    • Nuclear Engineering and Technology
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    • v.27 no.2
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    • pp.176-188
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    • 1995
  • A particle tracking scheme was developed in order to model radionuclide transport through a tortuous flow Held in a rock fracture. The particle tacking method may be used effectively in a heterogeneous flow field such as rock fracture. The parallel plate representation of the single fracture fails to recognize the spatial heterogeneity in the fracture aperture and thus seems inadequate in describing fluid movement through a real fracture. The heterogeneous flow field une modeled by a variable aperture channel model after characterizing aperture distribution by a hydraulic test. To support the validation of radionuclide transport models, a radionuclide migration experiment was performed in a natural fracture of granite. $^3$$H_2O$ and $^{131}$ I are used as tracers. Simulated results were in agreement with experimental result and therefore support the validity of the transport model. Residence time distributions display multipeak curves caused by the fast arrival of solutes traveling along preferential fracture channels and by the much slower arrival of solutes following tortous routes through the fracture. Results from the modelling of the transport of nonsorbing tracer through the fracture show that diffusion into the interconnected pore space in the rock mass has a significant effect on retardation.

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CMOS 소자 응용을 위한 Plasma doping과 Silicide 형성

  • Choe, Jang-Hun;Do, Seung-U;Seo, Yeong-Ho;Lee, Yong-Hyeon
    • Proceedings of the Korean Vacuum Society Conference
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    • 2010.02a
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    • pp.456-456
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    • 2010
  • CMOS 소자가 서브마이크론($0.1\;{\mu}m$) 이하로 스케일다운 되면서 단채널 효과(short channel effect), 게이트 산화막(gate oxide)의 누설전류(leakage current)의 증가와 높은 직렬저항(series resistance) 등의 문제가 발생한다. CMOS 소자의 구동전류(drive current)를 높이고, 단채널 효과를 줄이기 위한 가장 효율적인 방법은 소스 및 드레인의 얕은 접합(shallow junction) 형성과 직렬 저항을 줄이는 것이다. 플라즈마 도핑 방법은 플라즈마 밀도 컨트롤, 주입 바이어스 전압 조절 등을 통해 저 에너지 이온주입법보다 기판 손상 및 표면 결함의 생성을 억제하면서 고농도로 얕은 접합을 형성할 수 있다. 그리고 얕은 접합을 형성하기 위해 주입된 불순물의 활성화와 확산을 위해 후속 열처리 공정은 높은 온도에서 짧은 시간 열처리하여 불순물 물질의 활성화를 높여주면서 열처리로 인한 접합 깊이를 얕게 해야 한다. 그러나 접합의 깊이가 줄어듦에 따라서 소스 및 드레인의 표면 저항(sheet resistance)과 접촉저항(contact resistance)이 급격하게 증가하는 문제점이 있다. 이러한 표면저항과 접촉저항을 줄이기 위한 방안으로 실리사이드 박막(silicide thin film)을 형성하는 방법이 사용되고 있다. 본 논문에서는 (100) p-type 웨이퍼 He(90 %) 가스로 희석된 $PH_3$(10 %) 가스를 사용하여 플라즈마 도핑을 실시하였다. 10 mTorr의 압력에서 200 W RF 파워를 인가하여 플라즈마를 생성하였고 도핑은 바이어스 전압 -1 kV에서 60 초 동안 실시하였다. 얕은 접합을 형성하기 위한 불순물의 활성화는 ArF(193 nm) excimer laser를 통해 $460\;mJ/cm^2$의 에니지로 열처리를 실시하였다. 그리고 낮은 접촉비저항과 표면저항을 얻기 위해 metal sputter를 통해 TiN/Ti를 $800/400\;{\AA}$ 증착하고 metal RTP를 사용하여 실리사이드 형성 온도를 $650{\sim}800^{\circ}C$까지 60 초 동안 열처리를 실시하여 $TiSi_2$ 박막을 형성하였다. 그리고 $TiSi_2$의 두께를 측정하기 위해 TEM(Transmission Electron Microscopy)을 측정하였다. 화학적 결합상태를 분석하기 위해 XPS(X-ray photoelectronic)와 XRD(X-ray diffraction)를 측정하였다. 접촉비저항, 접촉저항과 표면저항을 분석하기 위해 TLM(Transfer Length Method) 패턴을 제작하여 I-V 특성을 측정하였다. TEM 측정결과 $TiSi_2$의 두께는 약 $580{\AA}$ 정도이고 morphology는 안정적이고 실리사이드 집괴 현상은 발견되지 않았다. XPS와 XRD 분석결과 실리사이드 형성 온도가 $700^{\circ}C$에서 C54 형태의 $TiSi_2$ 박막이 형성되었고 가장 낮은 접촉비저항과 접촉저항 값을 가진다.

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Numerical Analysis of Grout Flow and Injection Pressure Affected by Joint Roughness and Aperture (절리 거칠기와 간극 변화에 따른 그라우트 유동과 주입압에 관한 수치해석적 연구)

  • Jeon, Ki-Hwan;Ryu, Dong-Woo;Kim, Hyung-Mok;Park, Eui-Seob;Song, Jae-Jun
    • Tunnel and Underground Space
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    • v.20 no.2
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    • pp.82-91
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    • 2010
  • Grouting technology is one of the ground improvement methods used in water controlling and reinforcement of rock mass in underground structure construction. It is necessarily required to find out the characteristics of grout flow through discontinuities in a rock mass for an adequate grout design and performance assessment. Laminar flow is not always applicable in simulating a grout flow in a rock mass, since the rock joints usually have apertures at a micro-scale and the flow through these joints is affected by the joint roughness and the velocity profile of the flow changes partially near the roughness. Thus, the influence of joint roughness and aperture on the grout flow in rough rock joint was numerically investigated in this study. The commercial computational fluid dynamics code, FLUENT, was applied for this purpose. The computed results by embedded Herschel-Bulkley model and VOF (volume of fluid) model, which are applicable to simulate grout flow in a narrow rock joint that is filled with air and water, were well compared with that of analytical results and previously published laboratory test for the verification. The injection pressure required to keep constant injection rate of grout was calculated in a variety of Joint Roughness Coefficient (JRC) and aperture conditions, and the effect of joint roughness and aperture on grout flow were quantified.

Investigation of Convective Heat Transfer Characteristics of Aqueous SiO2 Nanofluids under Laminar Flow Conditions (층류유동 조건에서 SiO2 나노유체의 대류 열전달 특성에 대한 연구)

  • Park, Hyun-Ah;Park, Ji-Hyun;Jeong, Rag-Gyo;Kang, Seok-Won
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.9
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    • pp.1-11
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    • 2016
  • The effect of the migration of nanoparticles near the wall of a channel on the convective heat transfer in a laminar flow of $SiO_2$ nanoparticle suspensions (nanofluids) under constant wall heat flux boundary conditions was numerically and experimentally investigated in this study. The dynamic thermal conductivity of the aqueous $SiO_2$ nanofluids was measured using T-type thermocouples attached to the outer surface of a stainless steel circular tube (with a length of 1 m and diameter of 1.75 mm). The nanofluids used in this study were synthesized by dispersing $SiO_2$ spherical nanoparticles with a diameter of 24 nm in de-ionized water (DIW). The enhancement of the thermal conductivity of the nanofluids (e.g., an increase of up to 7.9 %) was demonstrated by comparing the temperature profiles in the flow of the nanofluids with that in the flow of the basefluids (i.e., DIW). However, this trend was not demonstrated in the computational analysis, because the numerical models were based on continuum assumptions and flow features involving nanoparticles in a stable colloidal solution. Thus, to explore the non-continuum effects, such as the modification of the morphology caused by nanoparticle-wall interactions on the heat exchanging surfaces (e.g., the isolated and dispersed precipitation of the nanoparticles), additional experiments were performed using DIW right after the measurements using the nanofluids.

Case Study on the Distribution of Disaster Risk Information in China (중국의 재난위험 정보유통에 관한 사례 연구)

  • Choi, Choong-Ik;Li, Cheng
    • Journal of Distribution Science
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    • v.14 no.4
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    • pp.55-66
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    • 2016
  • Purpose - This article aims to explore the characteristics of disaster risk distribution information in China. Also, this research attempts to analyze the findings of risk communication using case study in chronological order in terms of social amplification of risk. To achieve the purpose, the paper reviews the trends and issues of risk communication in China, with an emphasis on examining earthquakes by a chronological approach. In these regards, we hope that some relevant findings from this empirical study with cases will be able to enhance national risk communication and provide implications in Korea as well. Research design, data, and methodology - The conceptual framework of this study is theoretically based on the risk amplification model, which describes signals about risk transmitted and processed by individuals and social groups. The social amplification of risk also reflects the interactions of social groups about disaster-related risk issues, which are potential amplifiers or attenuators of communication signals. The key concept of social amplification implies that the risks pertaining to natural disasters interact with social, psychological, institutional, and cultural processes in ways that can affect public perceptions of risk. SMCRE Model is methodologically employed to examine risk communication history of China with the focus on natural disaster. Four earthquakes are selected to figure out the chronological characteristics of risk communication since 1970s. He bei Tang Shan earthquake is selected as an example disaster before 1990's, while the earthquake in Yun Nan Jiang is explored for the case study of 1990's. The earthquake in Si Chuan Wen Chuan is also examined as a example disaster of 2000's. The recent earthquake in Si Chuan Ya An Lu Shan is selected as a case of 2010s. Results - SMCRE model in this case study is operationally defined as a methodology and applied to the four earthquakes occurred in China. SMCRE model describes the exchange of risk information and is also applied to all forms of communication between stake holders. Each factor of risk communication includes source, message, channel, receiver and effect. It is notable that a big progress has been made on disaster risk communication in China for the past 40 years. We also found that highly developed information technology has enabled Chinese society to better cope with natural disaster, leading to enhanced disaster risk communication. It is mainly found from case study that the disaster risk communication of China has been involved with political situation, which derived from the change of government for the past 40 years. Conclusion - From this historical research, it can be inferred that the policies and politics of Chinese leaders have had a more critical role to play in the process of source of risk communication than those of any other countries. The results of this paper also support that the effective risk communication involves not only the improved reliability of local government as a key factor of disaster risk communication, but also is accompanied by international cooperation for substantial collaboration with stake holders.

Height Control of Pot Chrysanthemum according to Daminozide Applications at Different Planting Period in C-Channel mat Irrigation System (C-형강 매트 저면관수 시스템을 이용한 분화 국화 재배 시 정식시기와 Daminozide 처리에 따른 초장 조절)

  • Kang, Seung Won;Seo, Sang Gyu;Lee, Gung Pyo;Pak, Chun Ho
    • FLOWER RESEARCH JOURNAL
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    • v.19 no.1
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    • pp.30-36
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    • 2011
  • Effect of daminozide concentration and application methods, in combination with different planting period, on the growth of chrysanthemum was investigated for small pot-plant production. Daminozide, a plant growth regulator widely used for plant height control, was applied by drench or sub-application. For pot chrysanthemums of first planting time, plant height was reduced over $4,000mg{\cdot}L^{-1}$, when daminozide was drenched directly into the pot medium. However, $5,000mg{\cdot}L^{-1}$ of daminozide drench affected plant height reduction for secondarily planted pot chrysanthemum. Analysis of variance revealed the plant height was affected by planting time. For sub-application experiment of daminozide, it showed that the daminozide affected the number of flower buds formation and fresh and dry weight. These results suggest that planting period affected growth retardation of chrysanthemum. Therefore, application of growth retardant in combination with planting time and application methods may provide more efficient growth control for pot-chrysanthemum production.

Analysis of Rainfall-Runoff Characteristics in Gokgyochun Basin Using a Runoff Model (유출모형을 이용한 곡교천 유역의 강우-유출 특성 분석)

  • Hwan, Byungl-Ki;Cho, Yong-Soo;Yang, Seung-Bin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.2
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    • pp.404-411
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    • 2019
  • In this study, the HEC-HMS was applied to determine rainfall-runoff processes for the Gokgyuchun basin. Several sub-basins have large-scale reservoirs for agricultural needs and they store large amounts of initial runoff. Three infiltration methods were implemented to reflect the effect of initial loss by reservoirs: 'SCS-CN'(Scheme I), 'SCS-CN' with simple surface method(Scheme II), and 'Initial and Constant rate'(Scheme III). Modeling processes include incorporating three different methods for loss due to infiltration, Clark's UH model for transformation, exponential recession model for baseflow, and Muskingum model for channel routing. The parameters were calibrated using an optimization technique with trial and error method. Performance measures, such as NSE, RAR, and PBIAS, were adopted to aid in the calibration processes. The model performance for those methods was evaluated at Gangcheong station, which is the outlet of study site. Good accuracy in predicting runoff volume and peak flow, and peak time was obtained using the Scheme II and III, considering the initial loss, whereas Scheme I showed low reliability for storms. Scheme III did not show good matches between observed and simulated values for storms with multi peaks. Conclusively, Scheme II provided better results for both single and multi-peak storms. The results of this study can provide a useful tool for decision makers to determine master plans for regional flood control management.

An Experimental Study on the Effect of Air Temperature and Humidity on Humidification Performance of the Humidifying Element Used for Air Conditioning (공기 온습도가 공조용 가습 소자의 가습 성능에 미치는 영향에 대한 실험 연구)

  • Kim, Nae-Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.2
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    • pp.732-740
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    • 2019
  • Evaporative humidification using a humidifying element is widely used for humidification of a building or a data center. The performance of a humidifying element is commonly expressed as humidification efficiency, which is used independent of air temperature, humidity and water temperature. In this study, a series of tests were conducted at two air conditions (data center and commercial building) using two different humidifying elements (cellulose/PET and Glasdek) changing the frontal air velocity and water temperature. Results showed that the measured humidification efficiency was dependent on the air condition and water temperature. In fact, even dehumidification occurred at the inlet of the humidifying element at the air condition of commercial building. The reason was due to the inlet water temperature, which was lower than the dew point air temperature. As the difference between the inlet water and the dew point air temperature increased, the humidification efficiency decreased. This suggest that proper thermal model should account for the inlet region, where the amount of moisture transfer may be different from the other part of the humidification element. A simple analysis on the thermal performance of the cellulose/PET humidification element showed that the Sherwood number was adequately predicted, whereas the friction factor was ovepredicted, probably due to the simplification of the channel geometry and the neglection of the water film on the element surface.

A Study on the Cultural Function of Space and Place: Its Focus on Travel Program (공간과 장소의 문화적 기능: 여행 프로그램 <어서와 한국은 처음이지?>를 중심으로)

  • Hahm, Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.3
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    • pp.168-175
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    • 2019
  • The purpose of this paper is to examine the characteristics of organic relations according to the characteristics of space and place in which human activities are spreading. The diffusion of various human experiences and the interaction of space and place that form a mutual construction network create momentum for expanding individual or collective experiences. The space and place that lead to the interactions of human activities are expressed in various ways. Through the domestic travel program especially, the ways of expressing space and place are spreading as various "fields of experience." The composition and the expression system of a travel program is transformed into a subject of thought, not a mere experience of space and place through the formation of a "field of experience" that can be thought out and thought of as an existing travel style. Therefore, in this study, we examine the characteristics of the MBC Plus channel from a socio-cultural perspective, expressed through the experience of space and place characteristics expressed through a travel program. The result of an analysis of story development composition for this study shows that the experience of space and place minimizes the boundaries of various cultural discounts according to their relationships to food and communication. In addition, the analysis results of a three-way communication structure show that the emotional code of the audience is maximized through the process of maximizing the effect of reality, and minimizing the gap between the cultural differences and the boundaries through the empathic situation and the empathic subject.