• Archives of Pharmacal Research
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• 제26권1호
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• pp.28-33
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• 2003

Ginsenosides, major active ingredients of Panax ginseng, are known to regulate excitatory ligand-gated ion channel activity such as nicotinic acetylcholine and NMDA receptor channel activity. However, it is not known whether ginsenosides affect inhibitory ligand-gated ion channel activity. We investigated the effect of ginsenosides on human recombinant $GABA_A$ receptor (${\alpha}_1{\beta}_1{\gamma}_{2s}$) channel activity expressed in Xenopus oocytes using a two-electrode voltage-clamp technique. Among the eight individual ginsenosides examined, namely, $Rb_1$, $Rb_2$, Rc, Rd, Re, Rf, $Rg_1$ and $Rg_2$, we found that Rc most potently enhanced the GABA-induced inward peak current ($I_{GABA}$). Ginsenoside Rc alone induced an inward membrane current in certain batches of oocytes expressing the $GABA_A$ receptor. The effect of ginsenoside Rc on $I_{GABA}$ was both dose-dependent and reversible. The half-stimulatory concentration ($EC_{50}$) of ginsenoside Rc was 53.2$\pm$12.3 $\mu$M. Both bicuculline, a $GABA_A$ receptor antagonist, and picrotoxin, a $GABA_A$ channel blocker, blocked the stimulatory effect of ginsenoside Rc on $I_{GABA}$. Niflumic acid (NFA) and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), both $CI^{-1}$ channel blockers, attenuated the effect of ginsenoside Rc on I$I_{GABA}$. This study suggests that ginsenosides regulated $GABA_A$ receptor expressed in Xenopus oocytes and implies that this regulation might be one of the pharmacological actions of Panax ginseng.

• 전기전자학회논문지
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• 제21권3호
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• pp.284-287
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• 2017

본 연구에서는 3차원 소자 시뮬레이션을 통하여 단일 게이트 피드백 전계효과 트랜지스터의 전기적 특성과 채널 길이에 따른 메모리 윈도우 특성 변화를 확인하였다. 소자의 채널 길이는 50 nm에서 100 nm까지 변화시켜가며 시뮬레이션을 수행하였다. 시뮬레이션 결과 0에 가까운 문턱전압이하 기울기(< 1 mV/dec)와 ${\sim}1.27{\times}10^{10}$의 $I_{on}/I_{off}$ 비율을 얻었다. 또한 메모리 윈도우를 확인한 결과 채널 길이 50 nm의 소자는 0.31 V의 메모리 윈도우가 생성되었으나 채널 길이 100 nm의 소자는 메모리 윈도우가 생성되지 않았다.

• The Korean Journal of Physiology and Pharmacology
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• 제3권3호
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• pp.305-313
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• 1999

To explore whether $Cl^-$ channel blockers interact with the ATP-sensitive $K^+\;(K_{ATP})$ channel, I have examined the effect of two common $Cl^-$ channel blockers on the $K_{ATP}$ channel activity in isolated rat ventricular myocytes using patch clamp techniques. In inside-out patches, 4,4'-diisothio-cyanatostilbene- 2,2'-disulfonic acid (DIDS) and niflumic acid applied to bath solution inhibited the $K_{ATP}$ channel activity in a concentration-dependent manner with $IC_{50}$ of 0.24 and 927 ${\mu}M,$ respectively. The inhibitory action of DIDS was irreversible whereas that of niflumic acid was reversible. Furthermore, DIDS-induced block was not recovered despite exposure to ATP (1 mM). In cell-attached and inside-out patches, DIDS blocked the pinacidil- or 2,4-dinitrophenol (DNP)-induced $K_{ATP}$ channel openings. In contrast, niflumic acid did not block the pinacidil-induced $K_{ATP}$ channel openings in inside-out patches, but inhibited it in cell-attached patches. DIDS and niflumic acid produced additional block in the presence of ATP and did not affect current-voltage relationship and channel kinetics. All these results indicate that DIDS among $Cl^-$ channel blockers specifically blocks the cardiac $K_{ATP}$ channel.

• 복식문화연구
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• 제27권2호
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• pp.98-108
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• 2019

With the expansion of various distribution channels in online and offline stores, TV, and mobile, consumers now have more information search and retail selection channels to choose from than ever before. Major retailers now use multi- and omni-channel strategies. This study focused on cross-channel consumption, which involves the use of different information search and purchase channels. Using cross-channel consumption, consumers can search for information online and then make purchases offline and vice versa. The purpose of this study was to examine the relationship between channel strategies and other consumer variables, and the study also assessed the effect of product type. To conduct this empirical study, the researchers developed a consumer questionnaire concerning three consumer channel strategies-on-on, cross, and off-off-and four product categories-clothing, cosmetics, books, and electronics. The results indicated that gender and marital status did not influence consumer channel strategies, but that age did have a significant influence. The analysis showed that consumers in their 40s preferred the cross channel strategy, perceiving it to be effective, satisfactory, and rewarding. Compared to other products, clothing products showed higher levels of cross channel strategies. Consumers indicated that they prefer searching for information online and then purchasing clothing offline. Overall, clothing products generated higher levels of channel satisfaction and channel switch intentions. Cross-channel clothing shoppers reported effective information retrieval times but longer delivery times.

• ETRI Journal
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• 제30권6호
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• pp.765-773
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• 2008

Spatial correlation is a result of insufficient antenna spacing among multiple antenna elements, while temporal correlation is caused by Doppler spread. This paper compares the effect of spatial and temporal correlation in order to investigate the performance of multiuser scheduling algorithms in multiple-input multiple-output (MIMO) broadcast channels. This comparison includes the effect on the ergodic capacity, on fairness among users, and on the sum-rate capacity of a multiuser scheduling algorithm utilizing statistical channel state information in spatio-temporally correlated MIMO broadcast channels. Numerical results demonstrate that temporal correlation is more meaningful than spatial correlation in view of the multiuser scheduling algorithm in MIMO broadcast channels. Indeed, the multiuser scheduling algorithm can reduce the effect of the Doppler spread if it exploits the information of temporal correlation appropriately. However, the effect of spatial correlation can be minimized if the antenna spacing is sufficient in rich scattering MIMO channels regardless of the multiuser scheduling algorithm used.

• JSTS:Journal of Semiconductor Technology and Science
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• 제16권5호
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• pp.635-640
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• 2016

Tunnel field-effect transistor (TFET) is a promising candidate for the next-generation electron device. However, technical issues remain for their practical application: poor current drivability, shor-tchannel effect and ambipolar behavior. We propose herein a novel recessed-channel TFET (RTFET) with the asymmetric source and drain. The specific design parameters are determined by technology computer-aided design (TCAD) simulation for high on-current and low S. The designed RTFET provides ${\sim}446{\times}$ higher on-current than a conventional planar TFET. And, its average value of the S is 63 mV/dec.

• 전기전자학회논문지
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• 제16권2호
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• pp.153-158
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• 2012

A new diversity combining scheme is proposed for time-of-arrival (TOA) estimation of chirp signal in dense multipath channel. In the multipath channel, the performance of TOA estimation using conventional correlation matrix-based diversity combining scheme is degraded due to the lack of de-correlation effect. To increase the de-correlation effect, the proposed diversity scheme employs interleaving method based on the property of de-chirped signal. As a result, the proposed scheme increases de-correlation effect and also reduces the noise of TOA estimation. Finally, the diversity achieved from the proposed scheme improves TOA estimation performance. The de-correlation effect is analyzed mathematically. The estimation accuracy of the proposed diversity scheme is superior to that of conventional diversity scheme in multipath channel.

• 한국전자파학회논문지
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• 제29권1호
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• pp.28-31
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• 2018

본 논문에서는 균일원형배열(UCA) 안테나를 이용한 궤도각운동량(OAM) 다중모드 전송시스템의 채널용량에 대하여지면 반사가 미치는 영향을 수치적으로 분석하였다. 지면 반사는 OAM 다중모드 간 간섭을 유발하고 시스템의 심각한 성능 저하를 가져온다. 전송거리가 증가함에 따라 OAM 다중모드 채널용량은 지면 반사의 영향으로 인하여 매우 작아진다. 지면 반사의 영향을 줄이기 위해서는 UCA의 높이를 높이고, 배열 소자의 지향성을 높이는 것이 필요하다.

• 유통과학연구
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• 제16권3호
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• pp.13-21
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• 2018

Purpose - This study examined the effect of the importance of selective attribute of HMR(Home Meal Replacement) on customers' satisfaction and repurchase intention which is rapidly increasing with the changes of demographic, social and cultural trends as well as the influence of on and offline shopping channel moderating role. Research design, data, and methodology - Based on the research of previous studies, it assumed the selection attributes of HMR products were price, convenience, menu, freshness. With 231 surveyed questionnaires, this study was conducted by AMOS 21.0 and the SEM(structural equation model) was used as statistical method for examining the hypotheses in this study. Results - The analysis showed that price, convenience, and freshness had a significant effect on satisfaction, whereas menu did not affect satisfaction and the effect of satisfaction on repurchase intention was statistically significant. However, the results were different depending on the on and offline shopping channel for customers to buy HMR products. Price, menu and freshness are affected by online shopping, meanwhile convenience is more influenced by offline. Conclusions - This study analyzed the effect of selection attribute of HMR products on the satisfaction, repurchase intention, and the influence of each shopping channel, and provided practical implications.

• The International Journal of Costume Culture
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• 제3권1호
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• pp.41-52
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• 2000

The Purposes of this study ar (1) to identify types and levels of channel conflicts between an apparel manufacturer and a franchised agency, (2) to investigate the effect of economic dependence on conflicts, and (3) to examine the effect of conflicts on satisfaction in a franchised agency's perspective in distributive channel of Korean apparel industry. For this study, questionnaires were administered to the owner or manager of 300 franchised agencies. Employing a sample of 209, data were analyzed by using means, factor analysis, pearson correlation and multi-regression analysis. Major findings are as follows: 1) Types of conflicts between apparel manufacturers and franchised agencies are identified as goal divergence, difference in perception, ineffective communication and lack of role clarity. The highest level of conflicts are lack of role clarity, followed by goal divergence, difference in perception and ineffective communication. 2) Economic dependence leads to channel conflicts in part. Greater levels of economic dependence foster greater conflicts such as lack of role clarity and lower conflicts such as ineffective communication. 3) With respect to effect of conflict on satisfaction, the greater the levels of conflict, the lower the degree of satisfaction with ole performance and with business decision and overall satisfaction.