• Journal of Animal Reproduction and Biotechnology
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• v.35 no.2
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• pp.113-118
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• 2020

Hepatic stellate cells (HSCs) play essential roles in normal and pathophysiological function in liver. In steady state, HSCs contribute to retinoid storage, immune tolerance, and extracellular matrix (ECM) homeostasis. Upon liver injury, they become activated and lead to morphological and functional changes. Studies have demonstrated that activation of HSCs by various stimuli such as toxins, microbial infection, or metabolic overload can promote the fibrotic changes in liver by production of ECM. Herein, we provide current knowledge about the basic characteristics of HSCs and the mechanism by which they are activated.

• Land and Housing Review
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• v.2 no.2
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• pp.93-99
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• 2011

Urban agriculture is drawing people's attention along with environmental problems and recent changes in population and society such as the expansion of the aged, and various related discussions are going on for expanding the base. The purpose of this study was to suggest the application of urban agriculture in the permanently rental apartment complex to build a social welfare. Aiming at the introduction of urban agriculture in permanently rental apartment complexes, this study presented the roles and necessities of urban agriculture in response to environmental changes at home and overseas, explained the current state of permanently leased apartment complexes, estimated the land area usable for urban agriculture in existing complexes, and proposed strategies for the introduction of urban agriculture.

• The Journal of Korean Physical Therapy
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• v.8 no.1
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• pp.99-108
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• 1996

The purpose of this review are to determine of role of physical therapist in silver industry, and to give the information about elderly person when silver industry will be needed in 21 centry. Current literature so physiological changes that occur in humans owing to aging is reviewed. Also, psychological changes are discussed. There are main important roles in silver industry. One is proper exercise prescription for helth care and the other is effective therapy for the various disease. It will help the elderly person who needs independent ADL.

• Journal of the Korean Institute of Educational Facilities
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• v.19 no.6
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• pp.25-36
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• 2012

University campuses have been developed along with the historical development of mankind in association with the characteristics of urban changes. In particular, regarding the master plan reflecting periodic characteristics, now is the time to grope for crucial roles today that we are pursuing international growth of universities. Also, with the development of cities, in terms of the aspects of campus development, various borderline extension strategies are explored due to the physical limitation. And with the program methods through the exchange with the local community, we are concretizing this through the formation of new campuses. Seoul National University, the subject of this paper, is groping for ways of extension through the SNU-Valley Project with its Gwanak campus. Along with this, it is looking for ways of cubic borderline extension by forming Siheung international campus. The conclusion drawn through above contents is as written below: First, universities located in cites have relatively more limitations in the extension of campus space along with the development of urban space changes. To overcome this, various ways like political or physical space extension strategies are being explored. Second, along with the physical strategies visually shown in suggesting university campus master plans, we can recognize the importance of suggesting vision through specialization strategies. Third, it is about the importance of improving relationship with the local community. With the approaches based on human resources and reasonable connection of space, this also plays roles in enhancing the urbanity of the campus. Fourth, we can see the aspects of campus' urban function enhancing. It is needed to connect urban context that a region has with environment and grope for ways to enhance centrality, connection, and accessibility in it.

• Journal of Korean Public Health Nursing
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• v.6 no.1
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• pp.5-14
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• 1992

The role of Community Health Practitioner(CHP) should be continuously adapted to the social changes and the needs for health care services. That is the reason CHP needs to be retrained through the continuing education program. This paper showed CHP's roles to be reinforced by analyzing his present . task performance and ability in seven task areas as well as the changes of the social environment. In addition, this paper presented retraining areas needed for the reinforcement of the CHP's role in the future, and the development strategy of related continuing education package. The major results are as follows: 1. CHP's main practice area is health care services and management & guidance, whereas the development of health information system is neglected. 2. As a result, CHP plays a role mainly as a health care supplier, a consultant and a health instructor. Therefore CHP's roles to be reinforced are management of the community health system, act as a spokesman and a team member, promotion, assessment, collection & maintenance of information, coordination and research. 3. The areas to be reinforced in CHP's continuing education are (]) aged people's health, (2)?drinking & smoking, (3)?young people's health(including drug and sexualissues), (4) rehabilitation, (5)?administration and management for community health, (6)?partnership & membership, (7) local residents' participation and community development, (8) collection & treatment of health information and (9) environmental issues for community health. 4. The priority in developing continuing education package should be given to the area, which is encountered often in rural area but important, and has a good opportunity to be resolved. The health management of aged people was selected as a top priority by members of the Community Nursing Academic Society. 5. It is recommended that the instruction materials be accommodated to the small scale workshop or seminar in order that CHPs can participate actively in the continuing education program.

• Journal of Agricultural Extension & Community Development
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• v.3 no.2
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• pp.219-232
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• 1996

The Crop Units and Agricultural Cooperatives is experiencing many difficulties with national and international environmental changes. For the developing of Crop Units and Agricultural Cooperatives, Crop Units and Agricultural Cooperatives make endeavor to lead members` spontaneous participation and the efficient communication between members, and to offer the efficient extension services and support activities for improvement of members` economic and social status.

• BMB Reports
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• v.42 no.7
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• pp.393-400
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• 2009

High-density lipoprotein (HDL) is a proven biomarker for the monitoring of changes in antioxidant and anti-inflammation capability of body fluids. The beneficial virtues of HDL are highly dependent on its lipids and protein compositions, and their ratios. In normal state, the HDL particle is enriched with lipids and several HDL-associated enzymes, which are responsible for its antioxidant activity. Lower HDL-cholesterol levels (<40 mg/dL) have been recognized as an independent risk factor for coronary artery disease, as well as being a known component of metabolic syndrome. Functional and structural changes of HDL have been recognized as factors pivotal to the evaluation of HDL-quality. In this review, I have elected to focus on the functional and structural correlations of HDL and the roles of HDL-associated apolipoproteins and enzymes. Recent clinical applications of HDL have also been reviewed, particularly the therapeutic targeting of HDL metabolism and reconstituted HDL; these techniques represent promising emerging strategies for the treatment of cardiovascular disease, for drug or gene therapy.

• Journal of the Korea Society of Computer and Information
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• v.23 no.7
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• pp.27-37
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• 2018

Enterprises that don't adapt to the changes can be weeded out, because IT sector is one of the most rapid rate of changes in business. The optimized job education and training are an essential part for the enterprises to handle the advanced and developed technologies, so the needs for the positive investments to the education and training about their employees and transformational leadership have been increased. This study verified how the transformational leadership of representatives in the IT enterprises affects the satisfaction of their ordering agencies as well as the transfer of education and training can be the intermediary role to them. From the results of the statistical analysis about questionnaire survey of 251 IT enterprises, dispatched their employees to public institutions in Ulsan, several significant outcomes are founded as follows. First, the transformational leadership of representative in the IT enterprises influenced the transfer of education and training positively. Second, the transfer of education and training positively affected the satisfaction of ordering agencies. Third, the satisfaction of ordering agencies are also affected from the transformational leadership. Finally, the some roles was influenced by the charisma of transformational leadership, and also, completely, the inspirational motivation and the intellectual stimulation of transformational leadership was affected by the intermediary roles to the satisfaction of ordering agencies. Based on the results of this study, representatives in the IT enterprises can be expected by the positive company results from improving the satisfaction of ordering agencies through the transformational leadership, which allow active investment in education and training about their employees and construction of pragmatic system through the education and training results for the organization, superiors and colleague.

• The Plant Pathology Journal
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• v.28 no.3
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• pp.259-269
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• 2012

Protein phosphatase 2A (PP2A), a family of serine/threonine protein phosphatases, plays an important role in balancing the phosphorylation status of cellular proteins for regulating diverse biological functions in eukaryotic organisms. Despite intensive studies in mammals, limited information on its role is available in filamentous fungi. Here, we investigated the functional roles of genes for a putative B' delta regulatory subunit (FgPP2AR) and a catalytic subunit (FgPP2AC) of PP2A in a filamentous ascomycete, Fusarium graminearum. Molecular characterization of an insertional mutant of this plant pathogenic fungus allowed us to identify the roles of FgPP2AR. Targeted gene replacement and complementation analyses demonstrated that the deletion of FgPP2AR, which was constitutively expressed in all growth stages, caused drastic changes in hyphal growth, conidia morphology/germination, gene expression for mycotoxin production, sexual development and pathogenicity. In particular, overproduction of aberrant cylindrical-shaped conidia is suggestive of arthroconidial induction in the ${\Delta}FgPP2AR$ strain, which has never been described in F. graminearum. In contrast, the ${\Delta}FgPP2AC$ strain was not significantly different from its wild-type progenitor in conidiation, trichothecene gene expression, and pathogenicity; however, it showed reduced hyphal growth and no perithecial formation. The double-deletion ${\Delta}FgPP2AR;{\Delta}FgPP2AC$ strain had more severe defects than single-deletion strains in all examined phenotypes. Taken together, our results indicate that both the putative regulatory and catalytic subunits of PP2A are involved in various cellular processes for fungal development in F. graminearum.

• BMB Reports
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• v.45 no.10
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• pp.554-559
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• 2012

Oligosaccharide modification by N-acetylglucosaminyltransferase-V (GnT-V), a glycosyltransferase encoded by the Mgat5 gene that catalyzes the formation of ${\beta}1$,6GlcNAc (N-acetylglucosamine) branches on N-glycans, is thought to be associated with cancer growth and metastasis. Overexpression of GnT-V in cancer cells enhances the signaling of growth factors such as epidermal growth factor by increasing galectin-3 binding to polylactosamine structures on receptor N-glycans. In contrast, GnT-V deficient mice are born healthy and lack ${\beta}1$,6GlcNAc branches on N-glycans, but develop immunological disorders due to T-cell dysfunction at 12-20 months of age. We have developed Mgat5 transgenic (Tg) mice (GnT-V Tg mice) using a ${\beta}$-actin promoter and found characteristic phenotypes in skin, liver, and T cells in the mice. Although the GnT-V Tg mice do not develop spontaneous cancers in any organs, there are differences in the response to external stimuli between wild-type and GnT-V Tg mice. These changes are similar to those seen in cancer progression but are unexpected in some aspects. In this review, we summarize what is known about GnT-V functions in skin and liver cells as a means to understand the physiological roles of GnT-V in mice.