• Food Science of Animal Resources
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• v.31 no.5
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• pp.719-726
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• 2011

Pediococcus pentosaceus JWS 939 (JWS 939) is a nonpathogenic bacteriocin-producing probiotic isolated from the duck intestine. This study assessed the immunomodulatory effects of JWS 939 and compared them with those of Lactobacillus rhamnosus GG (LGG), a well-known immune enhancer. The immune-enhancing effects of JWS 939 were measured by measuring the production of nitric oxide (NO) and cytokines in C57BL/6 mouse peritoneal macrophages. In addition, to assess the immune enhancement abilities of JWS 939, in vivo, a Listeria monocytogenes challenge mice model was used. The results showed that heat-killed JWS 939 induced more NO and interleukin (IL)-$1{\beta}$ production in mouse peritoneal macrophages than in LGG, and that oral administration of viable JWS 939 in mice increased more NO, IL-$1{\beta}$, and tumor necrosis factor (TNF)-${\alpha}$ level than in LGG in serum upon L. monocytogenes challenge. In addition, mice fed with JWS 939 had a longer survival time after lethal challenge with L. monocytogenes, and these effects were stronger than those induced by LGG. Collectively, P. pentosaceus JWS 939 is a remarkable strain that, by releasing bacteriocin and enhancing host immune responses, may have potential as a duck feed additive to suppress pathogens.

• Korean journal of aerospace and environmental medicine
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• v.24 no.2
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• pp.21-27
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• 2014

We aimed to study about the effect of acute hyper-gravity (HG) on the allergic immune response in a murine model of allergic asthma. Thirty-two BALB/c mice were used. In Group A (control group, n=8), mice were sensitized and challenged with saline. Group B (HG control group, n=8) were exposed to HG (10 Gz, 1 hour) after intraperitoneal and intranasal saline challenge. Group C (asthma group, n=8) received intraperitoneal and intranasal ovalbumin (OVA) challenge. Group D (HG asthma group, n=8) were exposed to HG after intraperitoneal and intranasal OVA challenge. We evaluated serum total and OVA-specific IgE; serum titers of cytokines; and histopathologic examination of lung. As a result, titers of Serum total and OVA-specific IgE were not significantly different between groups. Compared to Group C, mice in Group D showed significant increase of Th2 cytokines (IL-4, IL-13), cytokines involved in eosinophilia (IL-3, IL-5, GM-CSF) and those involved in cell-medicated immunity (IFN-γ). In histopathologic examination, lungs of Group D showed significantly more infiltration of inflammatory cells compared to Group C. However, these differences were not so significant between Groups A and B. In conclusion, acute HG could exacerbate allergic asthma in experimental animals.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.287-287
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• 2023

Surface water-groundwater interaction (SWGI) is an important hydrological process that influences both the quantity and quality of water resources. However, regional scale SWGI model calibration and uncertainty analysis have been a challenge because integrated models inherently carry a vast number of parameters, modeling assumptions, and inputs, potentially leaving little time and budget to explore questions related to model performance and forecasting. In this study, we have proposed the application of iterative ensemble smoother (IES) for uncertainty analysis and calibration of the widely used integrated surface-subsurface model, SWAT-MODFLOW. SWAT-MODFLOW integrates Soil and Water Assessment Tool (SWAT) and a three-dimensional finite difference model (MODFLOW). The model was calibrated using a parameter estimation tool (PEST). The major advantage of the employed IES is that the number of model runs required for the calibration of an ensemble is independent of the number of adjustable parameters. The pilot point approach was followed to calibrate the aquifer parameters, namely hydraulic conductivity, specific storage, and specific yield. The parameter estimation process for the SWAT model focused primarily on surface-related parameters. The uncertainties both in the streamflow and groundwater level were assessed. The work presented provides valuable insights for future endeavors in coupled surface-subsurface modeling, data collection, model development, and informed decision-making.

• Korean Journal of Biological Psychiatry
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• v.8 no.1
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• pp.71-78
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• 2001

The current understanding of the neurobiology of anxiety is generally based on experimental animal model, empirical effective psychopharmacological agents, chemical and naturalistic challenge paradigms, and psychoendocinological assessment. This article focuses on reviewing neuroanantomical, neuroendocinological and neurofunctional research of anxiety disorder. In the decade ahead, we anticipate that extension of current research and the new integrated approach promise novel insight into mechanism of anxiety.

• YAKHAK HOEJI
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• v.37 no.5
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• pp.453-457
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• 1993

Platelet anti-aggregating activities were tested with analogs of protocatechuic acid and gallic acid. Six of them which showed comparable inhibitory effects with aspirin against collagen induced platelet aggregation were selected and their anti-thrombotic effects were evaluated in the mouse thrombosis model and compared with those of aspirin and paeonol. At the dose of 50 mg/kg, p.o., ethyl gailate(13) treated group showed higher % of recovery within 6 min of thrombotic challenge and lower mortality within 5 min than aspirin treated group.

• International Commerce and Information Review
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• v.7 no.1
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• pp.19-33
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• 2005

Although the fast advancing information infrastructure makes the connectivity possible to reach almost anywhere, it does not ensure a successful development of e-commerce for every country. The challenge will not come only from the technology, but also from the people. To examine the effect of cultural differences on the perception for Internet shopping, shoppers from two different countries - the U.S. and Korea - were chosen, and the perception for Internet shopping from each is contrasted.

• Proceeding of EDISON Challenge
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• 2017.03a
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• pp.383-391
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• 2017

본 논문은 1nm 직경인 NW-TFET의 전류구동 능력을 $sp3d5s^*$ model을 통해 분석하였다. 직경이 줄어들수록 띠구조의 밴드 갭이 커지는 것이 확인되었으며, 직경이 줄면 터널링 전류 량이 현저히 줄어, 적절한 재료선택이 필요할 것으로 예측된다. 실리콘과 게르마늄을 동일 조건하에 분석한 결과, 게르마늄 기반 TFET은 실리콘 기반 TFET의 스위칭 성능을 유지 하면서도, $10^6{\sim}10^8$배 정도의 전류 량을 개선 시킬 수 있을 것으로 기대된다.

• Proceeding of EDISON Challenge
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• 2015.03a
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• pp.488-490
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• 2015

In this paper, the selfie stick which can involved in small bag is designed to make easier and smaller. Model the diameter of the selfie to achieve light weight for the fixed length using FreeCAD. After modeling, check durability using 'Netgen' and 'Calculix'.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.05a
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• pp.603-604
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• 2005

• Proceedings of the Korea Contents Association Conference
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• 2018.05a
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• pp.563-564
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• 2018

컴퓨팅사고(computational thinking)란 기존의 인간사고와는 달리 컴퓨터를 활용하여 문제를 해결하는 과정에서의 여러가지 특성과 기질을 포함하는 문제해결과정이다. 이는 SW중심사회와 4차산업혁명의 도래로 인해 인공지능과 신경망 등 첨단의 소프트웨어 기술을 발전시킬 수 있는 기반이 되며, 매우 복잡한 문제를 알고리즘적인 방법으로 해결하는데 쓰일 수 있어서, 효율적인 결과를 보여줄 수 있다. 본 논문에서는 비버 챌린지 기반의 컴퓨팅사고력 향상을 위한 학습모델을 제안하였다.