• 대한한방내과학회지
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• 제20권1호
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• pp.153-166
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• 1999

SAENGMAEGSAN(SMS) has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. The effect of SMS on the vascular system is not known. The purpose of this study was to determine the effect of SMS on blood pressure, regio-nal cerebral blood flow(rCBF). 1. Blood pressure did not change by SMS in rats. 2. rCBF was increased by SMS in a dose-dependent manner. 3. Pretreatment with propranolol. methylene blue and indomethacin significantly inhibited SMS induced increase in rCBF. These results suggest that SMS causes a diverse response of blood pressure, regional cerebral blood flow (rCBF) and pial arterial diameter. The increase in rCBF is also mediated by prostaglandins. cyclic GMP and adrenergic ${\beta}$receptor.

• Current Optics and Photonics
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• 제1권5호
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• pp.433-439
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• 2017

The rodent model has been used frequently to understand stroke pathophysiology, due to its low cost and the large spectrum of genetic strains available. Here, we present a diffuse speckle contrast analysis system (DSCA) with a $1{\times}2$ optical switch that was used to non-invasively assess cerebral blood flow (CBF) changes in the rat during intraluminal suturing for middle cerebral artery occlusion (MCAO) surgery. The blood flow index (BFI) in the left hemisphere was lower than that in the right hemisphere because the left middle cerebral artery was occluded. Furthermore, the performance of the DSCA system was compared with that of commercial laser Doppler flowmetry. The changes in the BFI measured by the two systems were correlated strongly. The DSCA system was less sensitive to motion artifacts and able to measure relatively deep tissue flow in the rat's brain. In conclusion, the DSCA system secured CBF monitoring during surgery in a rodent model without craniotomy.

• 동의신경정신과학회지
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• 제15권2호
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• pp.173-180
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• 2004

Objectives : The purpose of this study is to investigate the change of cerebral blood flow velocity by different types of suggestion in normal subject. Methods : Suggestion of ascending qi inducement and descending qi inducement which were recomposed from autogenic training, was operated on 60 normal subjects individually. Then cerebral blood flow velocity was examined by Transcranial doppler ultrasonography(TCD) each 5 minutes before and after suggestion. Results : The result shows that cerebral blood flow(CBF) velocity was increased significantly in suggestion of ascending qi inducement and CBF velocity was decreased significally after 1 minute in suggestion of descending qi inducement. Conclusion : Suggestion could have affected to CBF velocity, and also different types of suggestion could have affected to the change of brain blood flow. Various clinical studies should be completed on patients in the future.

• 성인간호학회지
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• 제26권2호
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• pp.171-180
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• 2014

Purpose: This study was to investigate the effects of upper meridian massage on cerebral blood flow, emotions, and sleep of the institutionalized elderly. Methods: This study was a nonequivalent control group pre- and post-test design. The participants were 50 elderly (26 in the experimental group; 24 in the control group) living in the institutions. Data were collected between July 9 and September 1, 2011. The data were analyzed using descriptive statistics, t-test, and $x^2$-test, Repeated Measures ANOVA, and Cronbach's ${\alpha}$ coefficient. Each participant in the experimental group received the upper meridian massage for 10 minutes, 4 times per week for 2 weeks. Each participant's cerebral blood flow and self-reported questionnaires were tested before treatment, after 1 week and 2 weeks during treatment sessions. Results: There were significant differences in sleep and emotions after 1 week and 2 weeks during treatment sessions. But cerebral blood flow measured by common carotid artery pulsatility index (CCA PI) and common carotid artery resistance index (CCA RI) demonstrated significant differences in 2 week point in time. Conclusion: These results indicated that upper meridian massage could be an effective intervention for improving cerebral blood flow, emotions, and sleep of the institutionalized elderly.

• Journal of Ginseng Research
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• 제26권3호
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• pp.132-138
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• 2002

본 연구에서는 혈류량의 변화를 실시간으로 측정할 수 있는 레이져 도플러 혈류량측정장치를 이용하여 피부혈류 및 뇌혈류량에 미치는 고려홍삼의 사포닌과 비사포닌의 효능을 연구하고자 고려홍삼의 정맥내 복강내 및 구강내로 주입하고 혈류의 변화를 관찰하여 다음과 같은 결론을 얻었다. 고려 홍삼의 사포닌 성분은 피부혈류량에는 영향을 주지 않으나 뇌혈류량을 증가시키는 효능이 있다. 고려 홍삼의 비사포닌 성분은 피부혈류량 및 뇌혈류량에 거의 영향을 주지 않았다. 고려홍삼사포닌에 의한 뇌혈류량의 증가는 복강내 및 경구로 투여할 경우는 관찰할 수 있으나 정맥내로 직접 투여할 경우는 관찰되지 않았다. 이상의 결과를 종합해 볼 때 고려홍삼의 사포닌 성분은 뇌혈류량을 증가시키는 혈류개선작용이 있는 것으로 사료된다.

• 동의생리병리학회지
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• 제16권1호
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• pp.99-103
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• 2002

Geopungdodam-tang(GDT) have been used in oriental medicine for many centuries as a therapeutic agent of apoplexy. The mechanism of GDT on the cerebral blood flow is not known. The purpose of this Study was to investigate effects of GDT on the pial arterial diameter and action mechanism of GDT-induced increased regional cerebral blood flow(rCBF). The changes of regional cerebral blood f1ow(rCBF) was determinated by Laser-Doppler Flowmetry(LDF), and the changes of pial arterial diametet were determinated by video microscopy methods and video analyzer. The results were as follows ; 1. Pial arterial diameter was significantly increased by GDT in a dose-dependent manner. 2. Pretreatment with L-NNA significantly inhibited GDT induced increased rCBF. 3. Pretreatment with methylene blue significantly inhibited GDT induced increased rCBF. 4. Pretreatment with indomethacin inhibited GDT induced increased rCBF. These results suggest that GDT causes a diverse response of cerebral hemodynamics(rCBF and pial arterial diameter). The cerebral hemodynamics is also mediated by nitric oxide synthase, cyclic GMP(guanylyl cydase) and prostaglandin(cyclooxygenase).

• Journal of Acupuncture Research
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• 제15권2호
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• pp.227-236
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• 1998

This study dealed with the effects of the blood pressure and regional cerebral blood fIow(rCBF) on acupuncture and moxibustion treatment to the acu-point equivalent to K 1 of sprague dawley rats(SDR). Acupuncture treatment of K 1 significantly decreased BP in SDR. 2. Acupuncture treatment of K 1 significantly increased rCBF in SDR. 3. Moxibustion treatment of K 1 significantly increased BP in SDR. 4. Moxibustion treatment of K 1 significantly increased rCBF in SDR. These results suggest that acupuncture and moxibustion causes a diverse response of blood pressure and reginal cerebral blood flow. During the moxibustion treatment of K 1 increased BP and rCBF, but after moxibustion recorved BP and rCBF. During the acupunture tretment of K 1 decreased BP and then recorved, rCBF was significantly increased.

• 한국멀티미디어학회논문지
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• 제21권5호
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• pp.609-616
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• 2018

In this paper, we designed a multimodal bio-signal measurement system to observe changes in the brain nervous system and vascular system during sleep. Changes in the nervous system and the cerebral blood flow system in the brain during sleep induce a unique correlation between the changes in the nervous system and the blood flow system. Therefore, it is necessary to simultaneously observe changes in the brain nervous system and changes in the blood flow system to observe the sleep state. To measure the change of the nervous system, EEG, EOG and EMG signal used for the sleep stage analysis were designed. We designed a system for measuring cerebral blood flow changes using functional near-infrared spectroscopy. Among the various imaging methods to measure blood flow and metabolism, it is easy to measure simultaneously with EEG signal and it can be easily designed for miniaturization of equipment. The sleep stage was analyzed by the measured data, and the change of the cerebral blood flow was confirmed by the change of the sleep stage.

• Biomolecules & Therapeutics
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• 제12권2호
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• pp.68-73
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• 2004

This study was performed to investigate the regulatory mechanism of cerebral blood How of adenosine $A_2$ receptor agonist in the rats, and to define whether its mechanism is mediated by nitric oxide (NO), adenylate cyclase and guanylate cyclase. In pentobarbital-anesthetized, pancuronium-paralyzed and artificially ventilated male Sprague-Dawley rats, all drugs were applied topically to the cerebral cortex. Blood flow from cerebal cortex was measured using laser-Doppler flowmetry. Topical application of an adenosine $A_2$ receptor agonist [5'-(N-cyclopropyl)-carboxamidoadenosine (CPCA; 4 umol/l)] increased cerebral blood flow. This effect of CPCA (4 umol/l) was blocked by pretreatment with NO synthase inhibitor [$N^G$-nitro-L-argine methylester (L-NAME; 140 umol/l)] and adenylate cyclase inhibitor [MDL-12,330 (20 umol/l)]. But the effect of CPCA (4 umol/l) was not blocked by pretreatment with guanylate cyclase inhibitor [LY-83,583 (10 umol/l)]. These results suggest that adenosine $A_2$ receptor increases cerebral blood How. It seems that this action of adenosine $A_2$ receptor is mediated via the NO and the activation of adenylate cyclase in the cerebral cortex of the rats.

• 한국정보통신학회논문지
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• 제21권9호
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• pp.1752-1760
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• 2017

뇌경색의 대표적인 치료법과 예방법중 하나는 대뇌혈류를 증가시키는 방법이다. 대뇌 부위로 가는 혈류량을 우회적으로 증가시켜 최종대뇌 손상부위를 최소화 하는 것을 목표로 한다. 이와 같은 대뇌 혈류를 증가시키는 방법은 약물에 의한 치료방법과, 수술에 의한 방법 등 칩습적으로 행해져왔다. 하지만 이러한 침습적인 방법은 환자에게 수술의 부담을 주며 합병증 등의 위험에 노출되어 있는 단점이 있다. 본 논문에서는 이러한 침습적인 치료방법의 단점을 보완하고자 비침습적 대뇌 혈류 증가 장치를 제안한다. 기존의 대뇌 혈류 증가 장치의 단점을 보완하기 위해 가압식 측정법을 적용하여 환자의 사지 혈압을 정확하게 측정하고 사지압박을 실시하여 대뇌부위로 가는 혈류량을 우회적으로 증가시켜 혈류증강 치료를 실시한다. 이는 기존의 침습적 대뇌혈류증강 치료와 비교하여 합병증의 우려가 없고 환자에게 부담을 주지 않으며 대뇌혈류량을 의미 있게 증가시키기 때문에 환자에게 선택적으로 사용될 수 있다.