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http://dx.doi.org/10.5142/JGR.2002.26.3.132

Effects of Crude Saponin and Saponin-free Fraction of Korea Red Ginseng on the Skin and Cerebral Blood Flow in the Rats  

Kim, Shin-Hee (Department of Physiology, College of Medicine, Chungnam National University)
Kim, Cuk-Seong (Department of Physiology, College of Medicine, Chungnam National University)
Park, Jin-Bong (Department of Physiology, College of Medicine, Chungnam National University)
Han, Chan-Soo (Department of Physiology, College of Medicine, Chungnam National University)
Kim, Kwang-Jin (Department of Physiology, College of Medicine, Chungnam National University)
Kim, Shin-Hye (Department of Physiology, College of Medicine, Konyang University)
Kim, Se-Hoon (Department of Physiology, College of Medicine, Konyang University)
Nam, Ki-Yeul (Ginseng & Tobacco Research Institute)
Jeon, Byeong-Hwa (Department of Physiology, College of Medicine, Chungnam National University)
Publication Information
Journal of Ginseng Research / v.26, no.3, 2002 , pp. 132-138 More about this Journal
Abstract
To study the effect of Korea red ginseng (KCG) on the skin and cerebral blood flow, we evaluated the change of skin perfusion rate and cerebral perfusion rate after the intravenous, intraperitoneal, and oral administration of crude saponin (CS) and saponin-free fraction (SFF) of KRG in the rats. The change of skin perfusion rate and cerebral perfusion rate was measured laser doppler flowmetry. The intravenous injections of CS or SFF of KRG and intraperitoneal injection of SFF of KRG did not change the relative skin and cerebral blood flow in the rats. When the rats were treated by the intraperitoneal injection of CS of KRG, relative cerebral blood flow was significantly increased with a time-dependent manner, however, relative skin blood flow was not influenced by the them. Oral administration of CS of KRG slightly increased skin blood flow in the rats. Also, the change of cerebral blood flow by transient bilateral carotid arterial clamp in the CS-treated rats was significantly decreased, compared with control groups. From the above results, it was suggested that Korea red ginseng have a increasing property of cerebral blood flow in the rats.
Keywords
Korea Red Ginseng; Cerebral blood flow; Skin blood flow; Laser Doppler flowmeter.;
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