• 대한지역사회작업치료학회지
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• 제3권1호
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• pp.43-53
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• 2013

목적 : 본 연구에서는 소뇌 실조증 환자에게 시각되먹임 프로그램 훈련을 적용 후 균형과 일상생활수행에 어떠한 변화를 나타내는지 확인해 보고자 한다. 연구방법 : 대전 모 재활병원에서 소뇌 실조증으로 진단받고 입원 중인 대상자 1명을 대상으로 주 5회기씩 총 2주간에 걸쳐 중재를 시행하였고, 사후 2주를 포함하여 총 4주간 실시하였다. 중재 전 후, 사후 균형의 변화를 확인하기 위하여 BIORescue 프로그램을 활용하여 안정성의 한계(Limit of stability; LOS)와 롬버그 검사를 시행하였고, 다른 균형평가로는 버그 균형척도를 시행하였다. 일상생활수행에 미치는 영향을 알아보기 위하여 COPM을 실시하여 분석하였다. 결과 : 소뇌 실조증 환자에게 안정성의 한계와 롬버그 검사, 버그 균형척도에서 중재 후 변화를 확인하였고, 유지가 되는 것을 확인할 수 있었다. 일상생활수행에서도 목욕하기, 이동하기, 교통수단의 이용, 세탁하기, 모임활동 5개 영역 모두 수행도와 만족도가 향상 되었다. 결론 : 소뇌 실조증 환자에게 균형향상을 위하여 시각되먹임 프로그램이 유용하게 적용되어질 수 있을 것으로 보여 진다.

• 대한한방내과학회지
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• 제38권2호
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• pp.270-275
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• 2017

Objective: We describe the case of a patient with a cerebellar infarction, with dizziness and ataxia who was treated with traditional Korean medicine. Methods: The patient was treated with the herbal medicine Jaeumgeonbi-tang. Acupuncture and moxibustion therapy were also administered on a daily basis. Dizziness was evaluated using the Numeric Rating Scale, and spontaneous movement was observed daily. Results: After the administration of Jaeumgeonbi-tang, the patient's dizziness and ataxia improved. Conclusion: This case shows that traditional Korean medicine appears to be effective in improving side effects of a cerebellar infarction.

• 사상체질의학회지
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• 제22권4호
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• pp.113-123
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• 2010

1. Objectives This study is about three cerebellar infarction patients with dizziness and ataxia. In this study, we evaluated the effects of Sasang constitutional treatment and suggested using the 'Equilibrium Function Test' as scale. 2. Methods These three patients were treated by Sasang constitutional herbal medications based on "Donguisusebowon". Acupuncture & moxa therapy and west medications were limited as much as possible. We evaluated the symptoms through two methods, the Visual Analogue Scale and the Equilibrium Function Test. 3. Results and Conclusions Dizziness and ataxia that were these three patients' chief complaints were improved. This case study shows that Sasang constitutional herbal medications are an effective treatment for cerebellar infarction patients.

• Journal of Ginseng Research
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• 제48권4호
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• pp.425-427
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• 2024

This study presents a preliminary exploration into the effect of Korean Red Ginseng (KRG) on the cerebellum in individuals with cerebellar atrophy. Over a three month-long period, nine subjects received a 4.5g of KRG daily, with assessments including the ARS, ADAS-Cog, and FDG-PET/CT scans. Results revealed a notable improvement in ataxia and cognitive function without a significant correlation between them. PET/CT scans and SUVR analyses supported these findings, showing an increase in cerebellar glucose uptake after KRG intake. These outcomes suggest a potential pleiotropic effect of KRG on cerebellar function.

• 대한물리의학회지
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• 제11권4호
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• pp.105-114
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• 2016

PURPOSE: This study is to investigate the therapeutic effect of Tetrax on balance dysfunction caused by ataxia in cerebellar stroke. METHODS: A total of thirty subjects with cerebellar stroke were recruited. The participants was divided into two groups, the experimental (n=15) and the control group (n=15). Tetrax training and conventional physical therapy (CPT) were performed in experimental group, whereas the patients in the control group were treated with CPT twice a day. Each session of the Tetrax and CPT was carried out for 30 minutes, 5 times per week for 4 weeks. Korean version of the Scale for the Assessment and Rating of Ataxia (K-SARA) was the primary outcome measure, and the secondary outcomes covered Berg balance scale (BBS), falling index (FI), Timed up and go (TUG), and modified Barthel index of Korean version (K-MBI). All outcome measures were evaluated before and after 4 weeks. RESULTS: K-SARA was decreased significantly after 4 weeks intervention in both the experimental (p<.05) and the control group (p<.05). Furthermore, the experimental group produced significantly better outcomes in K-SARA, BBS, FI, and TUG compared with the control group (p=.012, p=.027, p=.008, and p=.048). There were significant correlations between K-SARA and BBS, FI, TUG, and K-MBI (p<.001, p<.001, p=.004, and p<.001). CONCLUSION: The restoration of ataxia was related with the improvement of the balance, falling risk, mobility, and activity of daily living. Tetrax training was effectively aided recovery of ataxia after cerebellar stroke.

• Journal of Genetic Medicine
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• 제18권2호
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• pp.127-131
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• 2021

Autosomal recessive spinocerebellar ataxia 20 (SCAR20; OMIM #616354) is a recently described disorder that is characterized by ataxia, intellectual disability, cerebellar atrophy, macrocephaly, coarse face, and absent speech. It is caused by loss-of-function mutations in SNX14. To date, all cases with homozygous pathogenic variants have been identified in consanguineous families. This report describes the first Korean cases of SCAR20 family caused by homozygous variants in SNX14. Two siblings were referred to our clinic because of severe global developmental delay. They presented similar facial features, including a high forehead, long philtrum, thick lips, telecanthus, depressed nasal bridge, and broad base of the nose. Because the older sibling was unable to walk and newly developed ataxia, repeated brain magnetic resonance imaging (MRI) was performed at the age of 4 years, revealing progressive cerebellar atrophy compared with MRI performed at the age of 2 years. The younger sibling's MRI revealed a normal cerebellum at the age of 2 years. Whole-exome sequencing was performed, and homozygous variants, such as c.2746-2A>G, were identified in SNX14 from the older sibling. Sanger sequencing confirmed homozygous SNX14 variants in the two siblings as well as a heterozygous variant in both parents. This report extends our knowledge of the phenotypic and mutational spectrum of SCAR20. We also highlight the importance of deep phenotyping for the diagnosis of SCAR20 in individuals with developmental delay, ataxia, cerebellar atrophy, and distinct facial features.

• Annals of Clinical Neurophysiology
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• 제3권2호
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• pp.151-155
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• 2001

SCA 1 is an autosomal dominant disorder. The phenotypic manifestations of SCA 1 are not specific, and thus, the diagnosis of SCA 1 rests on molecular genetic testing. The number of CAG repeats ranges from 6-44 in normal alleles and from 39-81 repeats in disease-causing alleles(chromosomal locus 6p22-23). The main clinical features of SCA 1 are ataxia, dysarthria, ophthalmoparesis, extrapyramidal signs without retinal degeneration. A 24-year-old woman with suspected family history presented with progressive cerebellar ataxia, dysarthria, ptosis, titubation and general weakness. Brain MRI revealed a moderate cerebellar atrophy. A genomic polymerase chain reaction(PCR) analysis showed 66 repeats at the SCA 1 locus.

• 대한한방내과학회지
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• 제41권5호
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• pp.800-805
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• 2020

Objectives: The aim of this study was to report the effect of Korean medicine treatment on a cerebellar infarction patient suffering from vertigo, ataxia, and nausea. Methods: We treated the patient with herbal medicine (Cheonghunhwadam-tang), acupuncture, and physical therapy. Clinical symptoms were assessed with a numeral rating scale (NRS), the Dizziness Handicap Inventory (DHI), and Study Short Form-36 (SF-36). Results: After 24 days of treatment, the vertigo, ataxia, and nausea symptoms were all improved, and the NRS, DHI, and SF-36 scores showed improvement. Conclusion: This case shows that Korean medicine treatments were effective in alleviating the symptoms of cerebellar infarction.

• 대한수의학회지
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• 제54권3호
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• pp.193-196
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• 2014

A 2-year old castrated male Alaskan malamute was referred with primary complaints of marked anemia, hemeglobinuria and depression. Laboratory tests revealed canine babesiois with severe anemia. The dog was treated by blood transfusion and beneril (diminazene aceturate, 3.5 mg/kg IM). Two days after Beneril injection, the dog suddenly showed ataxia progressing to paresis. MRI revealed irregularly diffused lesions in the cerebellum. The case was tentatively diagnosed as cerebellar encephalopathy caused by diminazene toxicity. The dog successfully recovered following steroid therapy.

• 대한한방소아과학회지
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• 제19권2호
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• pp.41-50
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• 2005

저자는 Brain MRI 상 Cerebellar atrophy로 인한 척수소뇌성 운동실조증으로 진단받은 6세 환아의 Ataxia, Dysarthria, 두부진전증(頭部振顫症), 안진(眼振) 등에 대해 한방적 치료 후 호전도가 있었기에 이에 증례보고(證例報告)하는 바이다. 특히 두진(頭振), 안진(眼振)과 같은 진전(振顫)질환과 실조증에 대하여 두침(頭鍼)시술이 유효성이 컸으며, 오지(五遲) 오연증(五軟證)에 대하여서 간(肝), 신정격(腎正格)과 육미지황탕(六味地黃湯)의 장기 투여가 효과가 있었다. 일반적인 SCA, ADCA가 청, 장년기 이후에 발생하고 유전적인 경향이 큰 것에 반해 재태(在胎)시 큰 이상없이 생후 특발적으로 발생한 척수 소뇌성 운동실조에 대하여서는 한방적으로 증례보고(證例報告) 된 바가 드문 실정으로 유, 소아의 이러한 질환에 대한 진일보된 연구과 함께 평가척도나 치료방법적인 면에서의 고찰(考察)이 더욱 필요하리라 사료된다.