• Restorative Dentistry and Endodontics
• /
• v.19 no.2
• /
• pp.549-567
• /
• 1994

Restoration of severly damaged teeth after endodontic treatment had been an interest to many dentists, and it is a fact that there have been lots of studies about it. In these days, although we have used Para-Post, pins, threaded steel post, cast gold post and core, and so on, as a method of restoration frequently, it has been in controversy with the influence of them on the teeth and surrounding periodontal tissue. In this study, we assume that the crown of the upper incisor have severly damaged, so, after the root canal therapy, 4 types of restoration had been carried out; 1) coronal-radicular amalgam restoration, 2) after setting up the Para-Post, restore with composite resin core only, 3) after setting up the Para-Post; restore with amalgam core, then cover with the PPM crown 4) after setting up the Para-Post, restore with composite core, then cover with the PPM crown. After restoration, in order to observe the concentration of stress at internal portion of the teeth and the sourrounding periodontal tissue, developing a 2-dimensional finite element model of labiopalatal section, then loading forces from 3 direction - direction of 45 degrees from lingual side near the incisal edge, horizontal direction from labial height of contour, vertical direction at the incisal edge-were applied. The analyzed results were as follows: 1. Stress of the normal central incisor was concentrated on the dentin aroundpulp chamber, labiocervical portion of a tooth and root apex, but with the alveolar bone, in the case of load from the direction of 45 degrees from lingual side near the incisal edge showed remarkable concentration of stress: 2. Coronal-radicular amalgam technique -showed less concentration of stress on the root and surrounding periodontal tissue than the restoration with the Para-Post. 3. The von Mises equivalent stress on the Para-Post showed maximum value at root-core junction rather than both ends and model with PPM restoration with amalgam core showed the least concentration of stress. Only the force from horizontal direction showed large shear stress on internal portion of the root, root apex and alveolar bone. 4. PPM crown with composite core rarely showed the concentration of stress on root and periodontal tissue. 5. As for alveolar bone, remarkable shear stress was concentrated on labial and palatal side by horizontal load.

• The Journal of Korean Academy of Prosthodontics
• /
• v.41 no.5
• /
• pp.582-595
• /
• 2003

Statement of problem : Most posts are metallic, but in response to the need for a post that possesses optical properties compatible with an all-ceramic crown. an esthetic post has been developed. Although there have been many studies about the esthetic post materials, 3-dimensional finite element studies about the stress distribution of them are in rare. Purpose : The purpose of this study is to investigate comparatively the distribution of stresses of the restored, endodontically treated maxillary incisors with the esthetic post materials and the displacement on the cement layer on simulated occlusal loading by using a 3-dimensional finite element analysis model. Material and method : Four 3-dimensional finite element models were constructed in a view of a maxillary central incisor, a post, a core, and the supporting tissues to investigate the stresses in various esthetic posts and cores and the displacement on the cement layer (Model 1 ; Cast gold post and core, Model 2 ; Glass fiber post with composite core, Model 3 ; Zirconia post with composite core. Model 4 ; Zirconia post with ceramic core). Force of 300N was applied to the incisal edge and the cingulum (centric stop point) with the angle of 135-degree to the long axis of the tooth. Results : 1. The stresses and displacement on the incisal edge were higher than on the cingulum 2. The stresses in dentin were the highest in Model 2 (Glass fiber post with composite core), and the second was Model 3, the third Model 1, and the lowest Model 4. 3. The stresses in post and core were the highest in Model 4 (Zirconia post with ceramic core), and the second was Model 1, the third Model 3, and the lowest Model 2. 4. The displacement on the cement layer was the highest in Model 2 (Glass fiber post with composite core), and the second was Model 3, the third Model 1, and the lowest Model 4. Conclusion : When a functional maximum bite force was applied, the distribution of stresses or the esthetic post and core materials and the displacement on the cement layer were a little different. It seems that restoring extensively damaged incisors with esthetic post and core materials would be decided according to the remaining tooth structure.

• Analytical Science and Technology
• /
• v.32 no.2
• /
• pp.48-55
• /
• 2019

The simple and effective analytical method for the quality control of a novel scalp tonic formulation has been developed and optimized in terms of HPLC conditions and sample preparation method, meanwhile, the optimization of preparation condition was using response surface methodology (RSM) based on central composite design (CCD). Oleanolic acid was selected as marker compound because of its bioactivities for alopecia therapy. The developed analytical method and extraction condition were successfully qualified. Coefficient of determination ($r^2$) for the calibration was 0.9997 with a line passing through the origin point in the range of 0.1-100 mg/mL. The limit of detection (LOD) and the limit of quantitation (LOQ) were 17.5 ng/mL and 55.0 ng/mL, respectively. The intra-day and inter-day precision of the method were 0.5-1.4 % and 0.7-1.8 % in relative standard deviation, respectively, while those accuracy were 99.5-100.9 % and 100.0-102.2 %, respectively. The repeatability of oleanolic acid in samples ranged of 0.3-1.9 % based on peak area and 0.3-0.7 % for retention time. Recoveries from samples were 95.0-99.4 % with lower than 1.8 % in relative standard deviation. Overall, the developed analytical method will be used for quality control of this commercial scalp tonic products successfully.

• Journal of Life Science
• /
• v.31 no.8
• /
• pp.761-770
• /
• 2021

In this study, the optimal medium composition for enhancing protease production was established by the Bacillus strain isolated from Makgeolli, a traditional fermented food, using the response surface methodology. B. amyloliquefaciens SRCM115785 was selected as the protease producer by productivity analysis and identified by 16S rRNA gene sequencing. Plackett-Burman design (PBD) was introduced to analyze the effect of each component on protease production among the 11 selected medium components. As a result, glucose, yeast extract, and beef extract were finally selected as factors for enhancing protease production. Central composite design (CCD) analysis was designed as a method to determine the optimal concentration of each component for protease production and the concentration of each medium composition for maximum protease production was predicted to glucose 6.75 g/l, yeast extract 12.42 g/l and beef extract 17.48 g/l. The suitability of the experimental model was proved using ANOVA analysis and as a result of quantitative analysis to prove this, the amount of increase was 230.47% compared to the LB medium used as a control. Through this study, the optimization of medium composition for enhancing protease production was established, and based on this, it is expected that it can be efficient use of protease as an industrial enzyme.

• Steel and Composite Structures
• /
• v.25 no.3
• /
• pp.271-286
• /
• 2017

The use of Hollow Structural Sections (HSS) provides an alternative for steel buildings in seismic zones, with the advantage over WF columns that the HSS columns have similar resistance along both axes and enhanced performance under flexure, compression and torsion with respect to other columns sections. The HSS columns have shown satisfactory performance under seismic loads, such as observed in buildings with steel moment frames in the Honshu earthquake (2011). The purpose of this research is to propose a new moment connection, EP-HSS ("End-plate to Hollow Structural Section"), using a wide flange beam and HSS column where the end plate falls outside the range of prequalification established in the ANSI/AISC 358-10 Specification, as an alternative to the traditional configuration of steel moment frames established in current codes. The connection was researched through analytical, numerical (FEM), and experimental studies. The results showed that the EP-HSS allowed the development of inelastic action on the beam only, avoiding stress concentrations in the column and developing significant energy dissipation. The experiments followed the qualification protocols established in the ANSI/AISC 341-10 Specification satisfying the required performance for highly ductile connections in seismic zones, thereby ensuring satisfactory performance under seismic actions without brittle failure mechanisms.

• Structural Engineering and Mechanics
• /
• v.63 no.3
• /
• pp.303-315
• /
• 2017

This paper presents a review on getting a Weighted Multi-Objective Optimization (WMO) of Tuned Mass Damper (TMD) parameters based on Response Surface Methodology (RSM) coupled central composite design and Weighted Desirability Function (WDF) to attenuate the earthquake vibration of a jacket supported Offshore Wind Turbine (OWT). To optimize the parameters (stiffness and damping coefficient) of damper, the frequency ratio and damping ratio were considered as a design variable and the top displacement and frequency response were considered as objective functions. The optimization has been carried out under only El Centro earthquake results and after obtained the optimal parameters, more two earthquakes (California and Northridge) has been performed to investigate the performance of optimal damper. The obtained results also compared with the different conventional TMD's designed by Den Hartog's, Sadek et al.'s and Warburton's method. From the results, it was found that the optimal TMD based on RSM shows better response than the conventional damper. It is concluded that the proposed response model offers an efficient approach regarding the TMD optimization.

• Transactions of the Korean Society of Machine Tool Engineers
• /
• v.15 no.5
• /
• pp.65-71
• /
• 2006

This paper presents the robust design of gripper part for a high-speed LCD(Liquid Crystal Display) transfer system. In this paper, the $1^{st}$ DOE(Design of Experiment) is conducted to find out main-effect factors for the design of gripper part. Thirty-six analysis are performed using $ANSYS^{(R)}$ and their results are statistically analyzed using $MINITAB^{(R)}$, which shows that the factors, i.e., First-width, Second-width, Rec-width, and thickness of gripper part, are more important than other factors. The main effect plots shows that the maximum deflection and mass of gripper part are minimized by increasing First-width, Second-width, Rec-width and thickness. The $2^{nd}$ DOE is conducted to obtain RSM(Response Surface Method) equation. The CCD(Central Composite Design) technique with four factors is used. Optimum design is conducted using the RSM equation. Genetic algorithm is used for optimal design. Six sigma robust design is conducted to find out a guideline for control range of design parameter. To obtain six sigma level quality, the standard deviations of design parameters are shown to be controlled within 5% of average design value.

• Journal of Microbiology and Biotechnology
• /
• v.30 no.8
• /
• pp.1116-1123
• /
• 2020

Velvet antler (VA) is a historically traditional medicinal supplement and is well known in Asian countries for its pharmaceutical and health benefits. The objectives for this study were to optimize the hot water extraction (HWE) of VA for the Korean VA industry, and to determine the most effective pretreatment method among microwave (MW), ultrasonication (US), and enzymatic (EZ) techniques. Using response surface methodology, optimum extraction temperatures and times were determined by central composite design configuration based on extraction yield and sialic acid content. Various quality parameters of VA extract including yield, soluble solid, protein, and sialic acid contents were also compared with the conjunction of HWE and pretreatment. The yield and sialic acid content of VA extract were determined to be 40% and 0.73 mg/g, respectively, under an optimum temperature of 100℃ at 24 h of extraction time. The yields from VA extracts pretreated with MW, US, and EZ were 17.42%, 19.73%, and 29.15%, respectively. Among the tested commercial enzymes, pepsin was the most effective proteolytic enzyme and led to the highest yield (47.65%), soluble solids (4.03 °brix), protein (1.12 mg/ml), and sialic acid (3.04 mg/ml) contents from VA extract.

• Archives of Pharmacal Research
• /
• v.29 no.9
• /
• pp.795-799
• /
• 2006

Peptides, although high efficacy and specificity in their physiological function, usually have low therapeutical activities due to their poor bioavailability when administrated orally. Nanoparticles have been regarded as a useful vector for targeted drug delivery system because they can protect drug from being degraded quickly and pass the gastrointestinal barriers. Here we described a novel oral N-trimethyl chitosan nanoparticles formulation containing thymopentin (Tp5-TMC-NP). N-trimethyl chitosan (TMC) was synthesized and then used to prepare Tp5-TMC-NP by ionotropic gelation. A three-factor, five-level CCD (Central Composite Design) design was used in the optimization procedure, with HPLC as the analyzing method. The resulting Tp5-TMC-NP had a regular spherical surface and a narrow particle size range with a mean diameter of 110.6 nm. The average entrapment efficiency was 78.8%. The lyophilized Tp5-TMC-NP formulation was stable in $4^{\circ}C\;or\;-20^{\circ}C$ after storage of 3 months without obvious changes in morphology, particle size, pH and entrapment ratio. The results of the flow cytometer determination showed that the ratio of $CD4^+/CD8^+$ of Wistar female rat given Tp5-TMC-NP (ig) was 2.59 time that of the group given Tp5 (ig).

• International Journal of Fuzzy Logic and Intelligent Systems
• /
• v.1 no.1
• /
• pp.87-94
• /
• 2001

Silicon nitride films grown by plasma-enhanced chemical vapor deposition (PECVD) are useful for a variety of applications, including anti-reflecting coatings in solar cells, passivation layers, dielectric layers in metal/insulator structures, and diffusion masks. PECVD systems are controlled by many operating variables, including RF power, pressure, gas flow rate, reactant composition, and substrate temperature. The wide variety of processing conditions, as well as the complex nature of particle dynamics within a plasma, makes tailoring SiN film properties very challenging, since it is difficult to determine the exact relationship between desired film properties and controllable deposition conditions. In this study, SiN PECVD modeling using optimized neural networks has been investigated. The deposition of SiN was characterized via a central composite experimental design, and data from this experiment was used to train and optimize feed-forward neural networks using the back-propagation algorithm. From these neural process models, the effect of deposition conditions on film properties has been studied. A recipe synthesis (optimization) procedure was then performed using the optimized neural network models to generate the necessary deposition conditions to obtain several novel film qualities including high charge density and long lifetime. This optimization procedure utilized genetic algorithms, hybrid combinations of genetic algorithm and Powells algorithm, and hybrid combinations of genetic algorithm and simplex algorithm. Recipes predicted by these techniques were verified by experiment, and the performance of each optimization method are compared. It was found that the hybrid combinations of genetic algorithm and simplex algorithm generated recipes produced films of superior quality.