• Food Science and Biotechnology
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• v.16 no.1
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• pp.159-162
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• 2007

Optimization of the fermentation medium for phenylethyl alcohol (PEA) production by Pichia anomala SKM-T was performed. The carbon source (glucose), nitrogen source (L-phenylalanine), and initial pH value were independent variables of the optimized medium. The central composite rotatable design was used for the experimental design and the analysis of the results. The optimum medium composition for the maximal production (621.27 mg/L) of PEA was found to be an initial pH of 5.03, and concentrations of L-phenylalanine at 6.53 and glucose at 6.11 g/L (w/v). This experimental finding is in close agreement with the model prediction (702.79 mg/L; desirability 0.884) with an 11.6% difference.

• Journal of Korean Society for Quality Management
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• v.43 no.3
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• pp.453-466
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• 2015

Purpose: The purpose of this study is to design a systematic method to estimate optimal operation conditions of design variables for an electronic device alignment system. Method: The 2-level factorial design and the central composite design are used in order to plan experiments. Based on the experiment results, a regression model is established to find optimal conditions for the design variables. Results: 3 of 5 design variables are selected as major factors that affect the alignment system significantly. The optimized condition for each variable is estimated by using a sequential experiment plan and a quadratic regression model. Conclusion: The method designed in this study provides an efficient and systematic plan to select the optimized operation condition for the design variables. The method is expected to improve inspection accuracy of the system and reduce the development cost and period.

• Journal of Environmental Science International
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• v.20 no.7
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• pp.907-917
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• 2011

This study investigated the application of experimental design methodology to optimization of conditions of air-plasma and oxygen-plasma oxidation of N, N-Dimethyl-4-nitrosoaniline (RNO). The reactions of RNO degradation were described as a function of the parameters of voltage ($X_1$), gas flow rate ($X_2$) and initial RNO concentration ($X_3$) and modeled by the use of the central composite design. In pre-test, RNO degradation of the oxygen-plasma was higher than that of the air-plasma though low voltage and gas flow rate. The application of response surface methodology (RSM) yielded the following regression equation, which is an empirical relationship between the RNO removal efficiency and test variables in a coded unit: RNO removal efficiency (%) = $86.06\;+\;5.00X_1\;+\;14.19X_2\;-\;8.08X_3\;+\;3.63X_1X_2\;-\;7.66X_2^2$ (air-plasma); RNO removal efficiency (%) = $88.06\;+\;4.18X_1\;+\;2.25X_2\;-\;4.91X_3\;+\;2.35X_1X_3\;+\;2.66X_1^2\;+\;1.72X_3^2$ (oxygen-plasma). In analysis of the main effect, air flow rate and initial RNO concentration were most important factor on RNO degradation in air-plasma and oxygen-plasma, respectively. Optimized conditions under specified range were obtained for the highest desirability at voltage 152.37 V, 135.49 V voltage and 5.79 L/min, 2.82 L/min gas flow rate and 25.65 mg/L, 34.94 mg/L initial RNO concentration for air-plasma and oxygen-plasma, respectively.

• Steel and Composite Structures
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• v.25 no.4
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• pp.457-472
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• 2017

The objective of this paper is to investigate the flexural behavior of concrete-filled round-ended steel tubes (CFRTs) under bending. Beam specimens were tested to investigate the mechanical behavior of the CFRTs, including four CFTs with different concrete strengths and steel ratios, and three CFRTs with varied aspect ratios. The load vs. deflection relationships and the failure modes for CFRTs were analyzed in detail. The composite action between the core concrete and steel tube was also discussed and examined based on the experimental results. In addition, ABAQUS program was used to develop the full-scale finite element model and analyze the effect of different parameters on the moment vs. curvature curves of the CFRTs bending about the major and minor axis, respectively. Furthermore, design formulas were proposed to estimate the ultimate moment and the flexural stiffness of the CFRTs, and the simplified theoretical model of the moment vs. curvature curves was also developed. The predicted results showed satisfactory agreement with the experimental and FE results. Finally, the differences of the experimental, FE and predicted results using the existing codes were illustrated.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.1439-1440
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• 2011

• Applied Chemistry for Engineering
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• v.29 no.6
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• pp.682-689
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• 2018

In this paper, the stability criteria of cosmeceuticals emulsion containing Broussonetia kazinoki extracts was established using the central composite design model. As optimization conditions of the emulsification using the central composite design model, concentrations of the emulsifier and emulsion stabilizer were used as a quantitative factor while emulsion stability index (ESI) and polydispersity index (PDI) were used as a reaction value. The targeted values of ESI and PDI were estimated as over 60% and the minimum number, respectively. Optimized concentrations of the emulsifier and emulsion stabilizer were 3.73 and 3.07 wt%, respectively, from the emulsification optimization based on ESI and PDI values. The estimated reaction values of ESI and PDI were 60% and 0.585, respectively. As concentrations of the emulsifier and emulsion stabilizer increased, the stability of the emulsion prepared tended to increase. The emulsifier was one of the most influential factors for ESI than the emulsion stabilizer. On the other hand, the PDI value was similarly affected by both the emulsion and emulsion stabilizer. The ESI of the cosmeceuticals emulsion prepared under experimental conditions deduced from the central synthesis planning model showed at least about 45% of the stability. However, all of the emulsions were separated after 4 weeks from the initial preparation. When the concentration of the emulsifier was more than 3.72 wt%, the ESI value was over 60%. Also the layer separation rate decreased with increasing the emulsion stabilizer concentration.

• Food Engineering Progress
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• v.15 no.2
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• pp.97-115
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• 2011

A review about the application of response surface methodology in the optimization of food technology is presented. The theoretical principles of response surface methodology and steps for its application are described. The response surface methodologies : three-level full factorial, central composite, Box-Behnken, and Doehlert designs are compared in terms of characteristics and efficiency. Furthermore, recent references of their uses in food technology are presented. A comparison between the response surface designs (three-level full factorial, central composite, Box-Behnken and Doehlert design) has demonstrated that the Box-Behnken and Doehlert designs are slightly more efficient than the central composite design but much more efficient than the three-level full factorial designs.

• Journal of the Korea Society for Simulation
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• v.23 no.3
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• pp.11-17
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• 2014

The central composite design (CCD) is often used to estimate the second-order linear model. This paper uses a correlation induction strategy of common random numbers (CRN) in simulation experiment and utilizes the induced correlations to obtain better estimates for the second-order linear model. This strategy assigns the CRN to all design points in the CCD. An appropriate selection of the axial points in CCD makes the weighted least squares (WLS) estimator be equivalent to ordinary least squares (OLS) estimator in estimating the linear model parameters of CCD. We analytically investigate the efficiency of this strategy in estimation of model parameters. Under certain conditions, this correlation induction strategy yields better results than independent random number strategy in estimating model parameters except intercept. The simulation experiment on a selected model supports such results. We expect a suggested random number assignment is useful in application of CCD in simulation experiments.

• Journal of Korean Society on Water Environment
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• v.26 no.1
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• pp.35-43
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• 2010

This experimental design and response surface methodology (RSM) have been applied to the investigation of the electrocoagulation/flotation of dye wastewater. The electrocoagulation/flotation reactions were mathematically described as a function of parameters current (A), NaCl concentration (B), initial RhB concentration (C) and time (D) being modeled by use of the central composite design (CCD). The application of RSM using the CCD yielded the following regression equation, which is an empirical relationship between the RhB removal (%) and test variables in RhB removal (%) = $-300.42+129.21{\cdot}Current+46.99{\cdot}NaCl-0.11{\cdot}RhB-+43.71{\cdot}Time-5.67{\cdot}Current{\cdot}NaCl-3.18{\cdot}Current{\cdot}Time-2.41{\cdot}NaCl{\cdot}Time-19.79{\cdot}Current^2-2.27{\cdot}NaCl^2-1.59{\cdot}Time^2$. the model predictions agreed well with the experimentally observed result ($R^{2}=0.9728$). The estimated ridge of maximum response and optimal conditions for RhB removal (%) using canonical analysis was 99.4% (A: 1,77 A, NaCl concentration: 2.23 g/L, RhB concentration: 56.12 mg/L, Time: 9.98 min). To confirm this optimum condition, three additional experiments were performed and RhB removal (%) were within range of 86.87% (95% PI low)~111.93% (95% PI high) obtained.

• Journal of Korean Society of Steel Construction
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• v.23 no.5
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• pp.607-614
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• 2011

This study deals with thegeometrical nonlinear dynamic behavior of laminated plates made of advanced composite materials (ACMs), which contain central cutouts. Based on the first-order shear deformation plate theory (FSDT), the Newmark method and Newton-Raphson iteration wereused for the nonlinear dynamic solution. The effects of the cutout sizes and lay-up sequences on the nonlinear dynamic response for various parameters werestudied using a nonlinear dynamic finite element program that was developed for this study. The several numerical results agreed well with those reported by other investigators for square composite plates with or without central cutouts, and the new results reported in this paper showed significant interactions between the cutout and the layup sequence in the laminate. Key observation points are discussed and a brief design guide for laminates with central cutouts is given.