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http://dx.doi.org/10.14478/ace.2018.1071

Preparation of Cosmeceuticals Containing Broussonetia kazinoki Extracts: Optimization Using Central Composite Design Method  

Hong, Seheum (Department of Polymer Science and Engineering, Dankook University)
Park, Bo Ra (Department of Chemical Engineering, Dankook University)
Lee, Seung Bum (Department of Chemical Engineering, Dankook University)
Publication Information
Applied Chemistry for Engineering / v.29, no.6, 2018 , pp. 682-689 More about this Journal
Abstract
In this paper, the stability criteria of cosmeceuticals emulsion containing Broussonetia kazinoki extracts was established using the central composite design model. As optimization conditions of the emulsification using the central composite design model, concentrations of the emulsifier and emulsion stabilizer were used as a quantitative factor while emulsion stability index (ESI) and polydispersity index (PDI) were used as a reaction value. The targeted values of ESI and PDI were estimated as over 60% and the minimum number, respectively. Optimized concentrations of the emulsifier and emulsion stabilizer were 3.73 and 3.07 wt%, respectively, from the emulsification optimization based on ESI and PDI values. The estimated reaction values of ESI and PDI were 60% and 0.585, respectively. As concentrations of the emulsifier and emulsion stabilizer increased, the stability of the emulsion prepared tended to increase. The emulsifier was one of the most influential factors for ESI than the emulsion stabilizer. On the other hand, the PDI value was similarly affected by both the emulsion and emulsion stabilizer. The ESI of the cosmeceuticals emulsion prepared under experimental conditions deduced from the central synthesis planning model showed at least about 45% of the stability. However, all of the emulsions were separated after 4 weeks from the initial preparation. When the concentration of the emulsifier was more than 3.72 wt%, the ESI value was over 60%. Also the layer separation rate decreased with increasing the emulsion stabilizer concentration.
Keywords
cosmeceuticals; central composite design model; Broussonetia kazinoki; ESI; PDI;
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1 J.-Y. Park, H. J. Yuk, H. W. Ryu, S. H. Lim, K. S. Kim, K. H. Park, Y. B. Ryu, and W. S. Lee, Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors, J. Enzyme Inhib. Med. Chem., 32(1), 504-512 (2017).   DOI
2 J. Ikuta, Y. Hano, T. Nomura, Y. Kawakami, and T. Sato, Components of Broussonetia kazinoki SIEB. I.: Structures of two new isoprenylated flavans an d five new isoprenylated 1, 3-diphenylpropane derivatives, Chem. Pharm. Bull, 34(5), 1968-1979 (1986).   DOI
3 S. A. Park, J. H. Ha, and S. N. Park, Antioxidative activity and component analysis of Broussonetia kazinoki SIEB Extracts, Appl. Chem. Eng., 24(2), 177-183 (2013).
4 A. Nesterenko, A. Drelich, H. Clausse, D. Lu, and I. Pezron, Influence of a mixed particle/surfactant emulsifier system on water- in-oil emulsion stability, Colloids Surf. A, 457, 49-57 (2014).   DOI
5 M. N. Yukuyama, D. D. M. Ghisleni, T. J. A. Pinto, and N. A. Bou-Chacra, Nanoemulsion: Process selection and application in cosmetics - A Review, Int. J. Cosmet. Sci., 38, 13-24 (2016).   DOI
6 P. S. Chang, M. G. Shin, and W. M. Lee, Relationship between emulsion stability index and HLB value of emulsifier in the analysis of W/O emulsion stability, J. Korean Soc. Anal. Sci., 7(2), 237-243 (1994).
7 A. Aguilera-Miguel, E. López-Gonzalez, V. Sadtler, A. Durand, P. Marchal, C. Castel, and L. Choplin, Hydrophobically modified dextrans as stabilizers for O/W highly concentrated emulsions. Comparison with commercial non-ionic polymeric stabilizers, Colloids Surf. A, 550, 155-166 (2018).   DOI
8 P. A. Leggieri, M. Senra, and L. Soh, Cloud point and crystallization in fatty acid ethyl ester biodiesel mixtures with and without additives, Fuel, 222, 243-249 (2018).   DOI
9 A. C. Braun, D. Ilko, B. Merget, H. Gieseler, O. Germershaus, U. Holzgrabe, and L. Meinel, Predicting critical micelle concentration and micelle molecular weight of polysorbate 80 using compendial methods, Eur. J. Pharm. Biopharm., 94, 559-568 (2015).   DOI
10 A. Zdziennicka, K. Szymczyk, J. Krawczyk, and B. Janczuk, Critical micelle concentration of some surfactants and thermodynamic parameters of their micellization, Fluid Phase Equilib., 322-323, 126-134 (2012).   DOI
11 G. Lefebvre, J. Riou, G. Bastiat, E. Roger, K. Frombach, J.-C. Gimel, P. Saulnier, and B. Calvignac, Spontaneous nano-emulsification: Process optimization and modeling for the prediction of the nanoemulsion's size and polydispersity, Int. J. Pharm., 534(1-2), 220-228 (2017).   DOI
12 H. Sis and M. Birinci, Effect of nonionic and ionic surfactants on zeta potential and dispersion properties of carbon black powders, Colloids Surf. A, 341(1-3), 60-67 (2009).   DOI
13 J. Y. Yeon, B. R. Shin, T. G. Kim, and J. M. Seo, A study on emulsion stability of O/W and W/S emulsion according to HLB of emulsifier, J. Soc. Cosmet. Sci. Korea, 40(3), 227-236 (2014)   DOI
14 H.-J. Lee, J.-H. Park, D.-I. Jang, and J.-H. Ryu, Antioxidant components from Broussonetia kazinoki, Yakhak Hoeji, 41(4), 439-443 (1997).
15 K.-Y. Kim and N.-K. Lee, Herbal extracts research trend that have effects on melanin production and control, Korean J. Aesthet. Cosmetol., 12(4), 453-461 (2017).