• The Journal of Korean Institute of Communications and Information Sciences
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• v.39B no.3
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• pp.151-161
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• 2014

3GPP LTE-Advanced (Release 10) system specifies carrier aggregation (CA) to enable high data rate on using multiple frequency bands, including the variout CA-specific deployment scenarios. Considering one of those scenarios in which the different directional sector antenna is employed by each frequency band, we propose a per-carrier cell selection scheme that can improve the average throughput of the cell-edge users by allowing each user equipment (UE) to select the frequency band of the adjacent cell. Furthermore, a distributed algorithm for inter-cell copperative scheduling in this scheme is proposed to support proportional fairness among the cells. It has been shown that the proposed scheduling algorithm for the per-carrier cell selection scheme improves the cell-edge user throughput roughly by 50% over that of the conventional scheme.

• The Transactions of the Korea Information Processing Society
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• v.6 no.11S
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• pp.3260-3268
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• 1999

As the proliferation of multimedia traffic over High-speed Internet increases, ATM network will be vital to adopt as backbone network over various parts of Internet. In this paper, we investigate the performance of TCP/IP traffic flow over ABR and UBR of ATM service to study for the high throughput and good fairness by simulation technique. Although TCP is run in the transport layer, it is controlled by several methods, e.g, EPD, PPD, RED, EFCI, ER etc, in ATM layer when TCP uses the ABR/UBR service. Therefore, if one cell is discarded in ATM layer, a packet of TCp will be laost. And, also, along with the increasing of the number of VC among switches, the throughput and fairness will be degraded. In order to improve these degradations, we propose the effective parameter control operations of EFCI and ER on ABR service, and also suggest the buffer management methods on UBR service. Finally, through the simulation results, the improved throughput and fairness are shown.

• Journal of Internet Computing and Services
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• v.19 no.2
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• pp.9-15
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• 2018

This paper proposes an energy efficient adaptive relay station ON/OFF scheme with different frequency reuse factors (FRFs) to enhance the system throughput and reduce the transmission energy consumption for the transparent mode of 2-hop cellular relay networks (CRNs) based on orthogonal frequency division multiple access and time division duplex. In the proposed scheme, the base station turns on or off the relay stations (RSs) when they are overutilized and undertuilized based on the traffic density of the cell coverage, respectively. Through the simulation results, we show that the proposed scheme outperforms the conventional CRN in terms of the energy consumption with the same system throughput. Further, in order to increase the system throughput with low energy consumption, the best way is FRF 1 when the number of operating RSs is up to 4 and FRF 2 otherwise.

• Proceedings of the Korea Information Processing Society Conference
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• 2016.04a
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• pp.83-85
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• 2016

C-RAN (Cloud Radio Access Network) structure is the most popular approach for 5G stander, it employs CoMP (Coordinated Multiple Points Transmission/Reception) to enhance frequency utilization and increase throughput for cell-edge users. C-RAN mainly includes two parts: baseband units (BBU) and remote radio heads (RRH). In this paper we propose a new resource block allocation (spectrum allocation) scheme by the permutation and combination of BBUs, and we also use the CoMP (Coordinated Multiple Points Transmission/Reception) technique according to the different environment to improve the spectrum utilization and reduce resource waste in different environment. The simulation results expound that the scheme significantly enhances throughput and improves the spectrum utilization.

• The Journal of the Korea Contents Association
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• v.10 no.4
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• pp.19-27
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• 2010

In recent years, high-throughput genome-wide RNA interference screening is emerging as an essential tool to biologists in understanding complex cellular processes. The manual analysis of the large number of images produced in each study spends much time and the labor. Hence, automatic cellular image analysis becomes an urgent need, where segmentation is the first and one of the most important steps. However, those factors such as the region overlapping, a variety of shapes, and non-uniform local characteristics of cellular images become obstacles to efficient cell segmentation. To avoid the problem, a new watershed-based cell segmentation algorithm using a localized segmentation method and a feature vector is proposed in this paper. Localized approach in segmentation resolves the problems caused by a variety of shapes and non-uniform characteristics. In addition, the poor performance of segmentation in overlapped regions can be improved by taking advantage of a feature vector whose component features complement each other. Simulation results show that the proposed method improves the segmentation performance compared to the method in Cellprofiler.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.6B
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• pp.697-709
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• 2011

For improvement of wireless Internet service quality at vehicle's moving speed, it is advised to reduce the service disruption time by reducing the handover frequency on vehicle's moving path. Particularly, it is advantageous to avoid the handover to cell whose dwell time is short or can be ignored in terms of service continuity and average throughput. This paper proposes the handover scheme that is suitable for vehicle in order to improve the wireless Internet service quality. In the proposed scheme, the handover process continues to be learned before being modeled to Discrete-Time Markov Chain (DTMC). This modeling reduces the handover frequency by preventing the handover to cell that could provide service sufficiently to passenger even when vehicle passed through the cell but there was no need to perform handover. In order to verify the proposed scheme, we observed the average number of handovers, the average RSSI and the average throughput on various moving paths that vehicle moved in the given urban environment. The experiment results confirmed that the proposed scheme was able to provide the improved wireless Internet service to vehicle that moved to some degree of consistency.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.11 no.4
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• pp.104-111
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• 2012

It is advantageous to avoid the handover to cell whose dwell time is short or can be ignored in terms of service continuity and average throughput. This paper proposes the handover scheme that is suitable for vehicle in order to improve the wireless Internet service quality. In the proposed scheme, the handover process continues to be learned before being modeled to Discrete-Time Markov Chain (DTMC). This modeling reduces the handover frequency by preventing the handover to cell that could provide service sufficiently to passenger even when vehicle passed through the cell but there was no need to perform handover. In order to verify the proposed scheme, we observed the average number of handovers, the average RSSI and the average throughput on various moving paths that vehicle moved in the given urban environment.

• Journal of Advanced Navigation Technology
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• v.16 no.1
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• pp.96-102
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• 2012

The goal of mobile internet system is to provide a high-data-rate, low-latency and optimized packet radio access technology supporting flexible bandwidth deployments. Therefore, network architecture is designed with the goal to support packet-switched traffic with seamless mobility, quality of service and minimal latency. An important requirement for the mobile internet system is improved cell-edge BER performance and data throughput. This is to provide some level of service consistency in terms of geographical coverage as well as in terms of available data throughput within the communication coverage area. In a cellular system, however, the signal to interference plus noise power ratio gap between cell-center and cell-edge users can be of the order of 20 [dB]. The disparity can be even higher in a communication coverage limited cellular system. This leads to vastly lower data throughputs for the cell-edge users relative to cell-center users creating a large QoS gap. This paper proposes a analytical approach that tries to reduce inter-cell interference, and shows the SIR and BER performance according to the OFDM system parameters in mobile Internet environment.

• Molecules and Cells
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• v.44 no.7
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• pp.500-516
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• 2021

Cardiac hypertrophic signaling cascades resulting in heart failure diseases are mediated by protein phosphorylation. Recent developments in mass spectrometry-based phosphoproteomics have led to the identification of thousands of differentially phosphorylated proteins and their phosphorylation sites. However, functional studies of these differentially phosphorylated proteins have not been conducted in a large-scale or high-throughput manner due to a lack of methods capable of revealing the functional relevance of each phosphorylation site. In this study, an integrated approach combining quantitative phosphoproteomics and cell-based functional screening using phosphorylation competition peptides was developed. A pathological cardiac hypertrophy model, junctate-1 transgenic mice and control mice, were analyzed using label-free quantitative phosphoproteomics to identify differentially phosphorylated proteins and sites. A cell-based functional assay system measuring hypertrophic cell growth of neonatal rat ventricle cardiomyocytes (NRVMs) following phenylephrine treatment was applied, and changes in phosphorylation of individual differentially phosphorylated sites were induced by incorporation of phosphorylation competition peptides conjugated with cell-penetrating peptides. Cell-based functional screening against 18 selected phosphorylation sites identified three phosphorylation sites (Ser-98, Ser-179 of Ldb3, and Ser-1146 of palladin) displaying near-complete inhibition of cardiac hypertrophic growth of NRVMs. Changes in phosphorylation levels of Ser-98 and Ser-179 in Ldb3 were further confirmed in NRVMs and other pathological/physiological hypertrophy models, including transverse aortic constriction and swimming models, using site-specific phospho-antibodies. Our integrated approach can be used to identify functionally important phosphorylation sites among differentially phosphorylated sites, and unlike conventional approaches, it is easily applicable for large-scale and/or high-throughput analyses.

• Journal of Sensor Science and Technology
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• v.29 no.2
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• pp.100-104
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• 2020

Thus far, several in vivo biosensing platforms have been proposed to measure the mechanical contractility of cultured cardiomyocytes. However, the low sensitivity and screening rate of the developed sensors severely limit their practical applications. In addition, intensive research and development in cardiovascular disease demand a high-throughput drug-screening platform based on biomimetic engineering. To overcome the drawbacks of the current state-of-the-art methods, we propose a high-throughput drug-screening platform based on 16 functional high-sensitivity well plates. The proposed system simulates the physiological accuracy of the heart function in an in vitro environment. We fabricated 64 cantilevers using highly flexible and optically transparent silicone rubber and placed in 16 independent wells. Nanogrooves were imprinted on the surface of the cantilever to promote cell alignment and maturation. The adverse effects of the cardiovascular drugs on the cultured cardiomyocytes were systematically investigated. The 64 cantilevers demonstrated a highly reliable and reproducible mechanical contractility of the drug-treated cardiomyocytes. Real-time high-throughput screening and simultaneous evaluation of the cardiomyocyte mechanical contractility under multiple drugs verified that the proposed system could be used as an efficient drugtoxicity test platform.