• Journal of Korean Neurosurgical Society
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• v.64 no.4
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• pp.505-513
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• 2021

Objective : The adaptive immune response following subarachnoid hemorrhage (SAH) is not well understood. We evaluated and compared the T cell receptor (TCR) immune repertoire of good-grade and poor-grade SAH patients to elucidate the T cell immunology after ictus. Methods : Peripheral blood from six SAH patients was collected at two different times, admission and at the 7-day follow-up. Composition and variation of the TCR β-chain (TCRB) complimentary determining regions (CDR) 3 repertoire was examined using high-throughput sequencing; the analysis was based on sampling time and disease severity (good vs. poor-grade SAH). Results : Clonality at admission and follow-up were 0.059 (0.037-0.038) and 0.027 (0.014-0.082) (median, 25th-75th percentile). Poor-grade SAH (0.025 [0.011-0.038]) was associated with significantly lower clonality than good-grade SAH (0.095 [0.079-0.101]). Poor-grade SAH patients had higher diversity scores than good-grade SAH patients. CDR length was shorter in good-grade SAH vs. poor-grade SAH. Differences in clonotype distribution were more prominent in TCRBV gene segments than TCRBJ segments. TCRBV19-01/TCRBJ02-04 and TCRBV28-01/TCRBJ02-04 were the most increased and the most decreased V-J pairs in the 7-day follow-up compared to admission in good-grade SAH. The most increased and decreased V-J pairs in poor-grade SAH patients were TCRBV28-01/TCRBJ02-06 and TCRBV30-01/TCRBJ02-04, respectively. Conclusion : The TCRB repertoire is dynamic in nature following SAH. TCRB repertoire may facilitate our understanding of adaptive immune response according to SAH severity.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.5A
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• pp.469-474
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• 2006

In this paper, we develop a method that derive the average sector throughput of HSDPA system. This proposed method reflects the effects of AMC, scheduling and multi-code transmission, and is performed by simple calculation procedures such as link budget analysis. Link budget table is used to estimate a cell coverage in general. We modify the link budget table in order to calculate C/I of the user according to the location of the user in CDMA packet system employing AMC. Furthermore, we utilize the proposed method to analyze the effects of scheduling and multi-code transmission.

• Information and Communications Magazine
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• v.26 no.12
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• pp.35-48
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• 2009

본고에서는 LTE-Advance 및 802.16m 시스템에서 cell throughput 향상, cell coverage 확장 및 group mobility 지원을 위해 도입된 relaying 기술 및 이에 대한 표준화 동향에 대해 알아본다.

• ETRI Journal
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• v.38 no.2
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• pp.291-301
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• 2016

In this paper, we study an optimized block-diagonal zero-forcing (BD-ZF) precoder in a two-tiered cognitive network consisting of a macro cell (MC) and a small cell (SC). By exploiting multiuser multiple-input and multiple-output Vandermonde-subspace frequency-division multiplexing (VFDM) transmission, a cognitive SC can coexist with an MC. We first devise a cross-tier precoder based on the idea of VFDM to cancel the interference from the SC to the MC. Then, we propose an optimized BD-ZF intra-tier precoder (ITP) to suppress multiuser interference and maximize the throughput in the SC. In the case where the dimension of a provided null space is larger than that required by the BD-ZF ITP, the optimized BD-ZF ITP can collect all limited channel gain by optimizing rotating and selecting matrices. Otherwise, the optimized BD-ZF ITP is validated to be equivalent to the conventional BD-ZF ITP in terms of throughput. Numerical results are presented to demonstrate the throughput improvement of the proposed optimized BD-ZF ITP and to discover the impact of imperfect channel state information.

• Journal of Communications and Networks
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• v.18 no.3
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• pp.420-428
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• 2016

In this paper, we investigate the scheduling and power allocation for coordinated multi-point transmission in downlink long term evolution advanced (LTE-A) systems, where orthogonal frequency division multiple-access is used. The proposed scheme jointly optimizes user selection, power allocation, and modulation and coding scheme (MCS) selection to maximize the weighted sum throughput with fairness consideration. Considering practical constraints in LTE-A systems, the MCSs for the resource blocks assigned to the same user need to be the same. Since the optimization problem is a combinatorial and non-convex one with high complexity, a low-complexity algorithm is proposed by separating the user selection and power allocation into two subproblems. To further simplify the optimization problem for power allocation, the instantaneous signal-to-interference-plus-noise ratio (SINR) and the average SINR are adopted to allocate power in a single cell and multiple coordinated cells, respectively. Simulation results show that the proposed scheme can improve the average system throughput and the cell-edge user throughput significantly compared with the existing schemes with limited feedback.

• Korean Journal of Materials Research
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• v.34 no.2
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• pp.63-71
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• 2024

Slipchip offers advantages such as high-throughout, low cost, and simple operation, and therefore, it is one of the technologies with the greatest potential for high-throughput, single-cell, and single-molecule analyses. Slipchip devices have achieved remarkable advances over the past decades, with its simplified molecular diagnostics gaining particular attention, especially during the COVID-19 pandemic and in various infectious diseases scenarios. Medical testing based on nucleic acid amplification in the Slipchip has become a promising alternative simple and rapid diagnostic tool in field situations. Herein, we present a comprehensive review of Slipchip device advances in molecular diagnostics, highlighting its use in digital recombinase polymerase amplification (RPA), loop-mediated isothermal amplification (LAMP), and polymerase chain reaction (PCR). Slipchip technology allows users to conduct reliable droplet transfers with high-throughput potential for single-cell and molecule analyses. This review explores the device's versatility in miniaturized and rapid molecular diagnostics. A complete Slipchip device can be operated without special equipment or skilled handling, and provides high-throughput results in minimum settings. This review focuses on recent developments and Slipchip device challenges that need to be addressed for further advancements in microfluidics technology.

• Proceedings of the Korea Information Processing Society Conference
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• 2004.05a
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• pp.1351-1354
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• 2004

기존의 CDMA 1x EV-DO 시스템에서 비실시간 서비스는 Propotional Fairness 알고리즘을 사용해 셀내의 모든 유저에게 fairness를 제공했지만, throughput이 낮았다. 그래서, 이 논문에서는 이를 개선한 cell의 downlink에서 비실시간 서비스를 스케줄링시 fairness를 제공하면서, throughput을 향상시킬 수 있는 방안을 제안하고 구현하였다.

• Proceedings of the IEEK Conference
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• 2002.06a
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• pp.85-88
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• 2002

Maintaining a proper level of cell lead, system throughput can be maximized by a transmission rate control over the uplink in DS/CDMA cellular system to support integrated services of real-time and delay-tolerant traffic. We find that the cell load-based rate control scheme can be further enhanced by taking the varying channel condition into account In conjunction with some fair scheduling algorithm. Our simulation results show that the proposed scheme outperforms the original cell load-based rate control with the round-robin sharing scheduling scheme.

• Biomolecules & Therapeutics
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• v.22 no.4
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• pp.355-362
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• 2014

We have developed a fully automated high throughput drug screening (HTDS) system based on the microfluidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell culture chambers where the sequential combinatorial concentrations of two different drugs can be generated by two microfluidic diffusive mixers. Each diffusive mixer has two integrated micropumps connected to the media and the drug reservoirs respectively for generating the desired combination without the need for any extra equipment to perfuse the solution such as syringe pumps. The cell array is periodically exposed to the drug combination with the programmed LabVIEW system during a couple of days without extra handling after seeding the cells into the microfluidic device and also, this device does not require the continuous generation of solutions compared to the previous systems. Therefore, the total amount of drug being consumed per experiment is less than a few hundred micro liters in each reservoir. The utility of this system is demonstrated through investigating the viability of the prostate cancer PC3 cell line with the combinational treatments of curcumin and tumor necrosis factor-alpha related apoptosis inducing ligand (TRAIL). Our results suggest that the system can be used for screening and optimizing drug combination with a small amount of reagent for combinatorial chemotherapy against cancer cells.

• ETRI Journal
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• v.36 no.4
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• pp.554-563
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• 2014

The burgeoning growth of real-time applications, such as interactive video and VoIP, places a heavy demand for a high data rate and guarantee of QoS from a network. This is being addressed by fourth generation networks such as Long-Term Evolution (LTE). But, the mobility of user equipment that needs to be handed over to a new evolved node base-station (eNB) while maintaining connectivity with high data rates poses a significant challenge that needs to be addressed. Handover (HO) normally takes place at cell borders, which normally suffers high interference. This inter-cell interference (ICI) can affect HO procedures, as well as reduce throughput. In this paper, soft frequency reuse (SFR) and multiple preparations (MP), so-called SFRAMP, are proposed to provide a seamless and fast handover with high throughput by keeping the ICI low. Simulation results using LTE-Sim show that the outage probability and delay are reduced by 24.4% and 11.9%, respectively, over the hard handover method - quite a significant result.