Korean Journal of Materials Research (한국재료학회지)

Materials Research Society of Korea (한국재료학회)
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Slipchip Device Development in Molecular Diagnostics

  • Qingtian Yin (Department of Mechanical and Aerospace Engineering, NYU Tandon School of Engineering) ;
  • Huiwen Bai (Department of Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Science, University of Pennsylvania) ;
  • Ruijie Li (Technical Institute of Physics and Chemistry, Chinese Academy of Sciences) ;
  • Youngung Seok (Department of Biotechnology and Bioengineering, Chonnam National University)
  • Received : 2024.01.23
  • Accepted : 2024.01.24
  • Published : 2024.02.27
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Abstract

Slipchip offers advantages such as high-throughout, low cost, and simple operation, and therefore, it is one of the technologies with the greatest potential for high-throughput, single-cell, and single-molecule analyses. Slipchip devices have achieved remarkable advances over the past decades, with its simplified molecular diagnostics gaining particular attention, especially during the COVID-19 pandemic and in various infectious diseases scenarios. Medical testing based on nucleic acid amplification in the Slipchip has become a promising alternative simple and rapid diagnostic tool in field situations. Herein, we present a comprehensive review of Slipchip device advances in molecular diagnostics, highlighting its use in digital recombinase polymerase amplification (RPA), loop-mediated isothermal amplification (LAMP), and polymerase chain reaction (PCR). Slipchip technology allows users to conduct reliable droplet transfers with high-throughput potential for single-cell and molecule analyses. This review explores the device's versatility in miniaturized and rapid molecular diagnostics. A complete Slipchip device can be operated without special equipment or skilled handling, and provides high-throughput results in minimum settings. This review focuses on recent developments and Slipchip device challenges that need to be addressed for further advancements in microfluidics technology.

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