• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.6A
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• pp.666-675
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• 2008

The IEEE 802.22 standard is being developed with the target of improving the efficiency of spectrum utilization and importing the new wireless communication service. The WRAN standard based on Cognitive Radio is being processed for sharing TV bands. In this paper, the efficient spectrum allocation scheme and the optimal power allocation scheme, Partial Constant Power Water Filling (PCPWF), are proposed to maximize the channel capacity and spectrum efficiency and minimize the interference between adjacent cells. And we maximize the system throughput and fairness by using proposed dynamic cell plan that efficiently allocates channel. The results of the simulations are presented to verify the utilization of our proposed scheme.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.41 no.12
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• pp.1721-1735
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• 2016

Power-efficient base station (BS) operation is one of the important issues in future green cellular networks. Previously well-known BS operation schemes, the cell zooming scheme and the cell wilting and blossoming scheme, require tight cooperation between cells in cellular networks. With the previous schemes, the non-cooperative BSs of a serving cell and neighboring cells could cause coverage holes between the cells, thereby seriously degrading the quality of service as well as the power saving efficiency of the cellular networks. In this paper, we propose a novel power-efficient BS operation scheme for green downlink heterogeneous cellular networks, in which the networks virtually adjust the coverage of a serving macrocell (SM) and neighboring macrocells (NMs) without adjusting the transmission power of the BSs when the SM is lightly loaded, and the networks turn off the BS of the SM when none of active users are associated with the SM. Simulation results show that our proposed scheme significantly improves the power saving efficiency without degrading the quality of service (e.g., system throughput) of a downlink heterogeneous LTE network and outperforms the previous schemes in terms of system throughput and power saving efficiency. In particular, with the proposed scheme, macrocells are able to operate independently without the cooperation of a SM and NMs for green heterogeneous cellular networks.

• Archives of Pharmacal Research
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• v.23 no.3
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• pp.246-251
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• 2000

In most tissues, apoptosis plays a pivotal role in normal development and for regulating cell number, thus inappropriate apoptosis underlies a variety of diseases. Caspase-3 is one of a family of caspases that are mainly involved in the apoptotic signal transduction pathway, where caspase-3 acts as an effect molecule to proteolytically cleave intracellular substrates that are necessary for maintaining cell survival. Recent evidences show that apoptotic cell death can be blocked by inhibiting caspase-3, suggesting its inhibitors have potential to be therapeutic drugs for the diseases related with inappropriate apoptosis. We have established a screening system to search caspase-3 inhibitors from chemical libraries stocked in our institute. The enzyme assay is configured entirely in 96-well format, which is easily adapted for high throughput screening. Before performing mass screening, 80 in-house compounds were screened as a preliminary experiment, and we found that morin hydrate inhibited caspase-3 by 66.4 % at the final concentration of 20 ${\mu}g/m{\ell}$.

• Molecules and Cells
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• v.44 no.3
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• pp.136-145
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• 2021

Senescent cells that gradually accumulate during aging are one of the leading causes of aging. While senolytics can improve aging in humans as well as mice by specifically eliminating senescent cells, the effect of the senolytics varies in different cell types, suggesting variations in senescence. Various factors can induce cellular senescence, and the rate of accumulation of senescent cells differ depending on the organ. In addition, since the heterogeneity is due to the spatiotemporal context of senescent cells, in vivo studies are needed to increase the understanding of senescent cells. Since current methods are often unable to distinguish senescent cells from other cells, efforts are being made to find markers commonly expressed in senescent cells using bulk RNA-sequencing. Moreover, single-cell RNA (scRNA) sequencing, which analyzes the transcripts of each cell, has been utilized to understand the in vivo characteristics of the rare senescent cells. Recently, transcriptomic cell atlases for each organ using this technology have been published in various species. Novel senescent cells that do not express previously established marker genes have been discovered in some organs. However, there is still insufficient information on senescent cells due to the limited throughput of the scRNA sequencing technology. Therefore, it is necessary to improve the throughput of the scRNA sequencing technology or develop a way to enrich the rare senescent cells. The in vivo senescent cell atlas that is established using rapidly developing single-cell technologies will contribute to the precise rejuvenation by specifically removing senescent cells in each tissue and individual.

• Journal of Communications and Networks
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• v.13 no.1
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• pp.32-42
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• 2011

Frequency reuse among relay stations (RSs) in a down-link access zone is widely adopted for throughput enhancement in IEEE 802.16j relay networks. Since the areas covered by the RSs or the base station (BS) may overlap, some mobile stations (MSs) at the border between two neighboring transmitting stations (RS or BS) using an identical frequency band may suffer severe interference or outage. This co-channel interference within the cell degrades the quality of service (QoS) fairness among the MSs as well as the system throughput. Exclusive use of a frequency band division (orthogonal resource allocation) among RSs can solve this problem but would cause degradation of the system throughput. We observe a trade-off between system throughput and QoS fairness in the previously reported schemes based on frequency reuse. In this paper, we propose a new frequency reuse scheme that achieves high system throughput with a high fairness level in QoS, positioning our scheme far above the trade-off curve formed by previous schemes. We claim that our scheme is beneficial for applications in which a high QoS level is required even for the MSs at the border. Exploiting the features of a directional antenna in the BS, we create a new zone in the frame structure. In the new zone, the RSs can serve the subordinate MSs at the border and prone to interference. In a 3-RS topology, where the RSs are located at points $120^{\circ}$ apart from one another, the throughput and Jain fairness index are 10.64 Mbps and 0.62, respectively. On the other hand, the throughput for the previously reported overlapped and orthogonal allocation schemes is 8.22 Mbps (fairness: 0.48) and 3.99 Mbps (fairness: 0.80), respectively. For a 6-RS topology, our scheme achieves a throughput of 18.38 Mbps with a fairness of 0.68; however, previous schemes with frequency reuse factors of 1, 2, 3, and 6 achieve a throughput of 15.24 Mbps (fairness: 0.53), 12.42 Mbps (fairness: 0.71),8.84 Mbps (fairness: 0.88), and 4.57 Mbps (fairness: 0.88), respectively.

• Journal of Microbiology and Biotechnology
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• v.26 no.2
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• pp.213-225
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• 2016

To reduce attrition in drug development, it is crucial to consider the development and implementation of translational phenotypic assays as well as decipher diverse molecular mechanisms of action for new molecular entities. High-throughput fluorescence and confocal microscopes with advanced analysis software have simplified the simultaneous identification and quantification of various cellular processes through what is now referred to as high-content screening (HCS). HCS permits automated identification of modifiers of accessible and biologically relevant targets and can thus be used to detect gene interactions or identify toxic pathways of drug candidates to improve drug discovery and development processes. In this review, we summarize several HCS-compatible, biochemical, and molecular biology-driven assays, including immunohistochemistry, RNAi, reporter gene assay, CRISPR-Cas9 system, and protein-protein interactions to assess a variety of cellular processes, including proliferation, morphological changes, protein expression, localization, post-translational modifications, and protein-protein interactions. These cell-based assay methods can be applied to not only 2D cell culture but also 3D cell culture systems in a high-throughput manner.

• Journal of Satellite, Information and Communications
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• v.12 no.4
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• pp.162-165
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• 2017

In an effort to compensate the rising of the data throughput demand nowadays, there have been many research works to optimize the radio resource and increase the capacity of the network. At the present, small cell network, mmWave band and beamforming technology are leading the trend and becoming the core solutions of the fifth generation (5G) cellular networks. Since the propagation characteristics of radio wave in the mmWave band is quite different from the conventional bands, the communication systems which work in these bands have to be redesigned. In this paper, a 3D simulation model is discussed for cellular network at 60 GHz in outdoor environments. Coverage analysis and system performance is carried out for a small cell system in the typical urban environment including street canyon simulation scenario. In addition, the beamforming technique is considered to evaluate the throughput improvement. Simulation results show that the mmWave small cell systems is expected to be one of the major candidate technologies to satisfy the requirements of 5G in terms of data rate.

• BMB Reports
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• v.44 no.11
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• pp.705-712
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• 2011

Advances in the fields of proteomics and genomics have necessitated the development of high-throughput screening methods (HTS) for the systematic transformation of large amounts of biological/chemical data into an organized database of knowledge. Microfluidic systems are ideally suited for high-throughput biochemical experimentation since they offer high analytical throughput, consume minute quantities of expensive biological reagents, exhibit superior sensitivity and functionality compared to traditional micro-array techniques and can be integrated within complex experimental work flows. A range of basic biochemical and molecular biological operations have been transferred to chip-based microfluidic formats over the last decade, including gene sequencing, emulsion PCR, immunoassays, electrophoresis, cell-based assays, expression cloning and macromolecule blotting. In this review, we highlight some of the recent advances in the application of microfluidics to biochemistry and molecular biology.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38A no.4
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• pp.360-370
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• 2013

When best-effort traffic users are supported in a downlink small-cell network, conventional schemes assign the channels experiencing low co-channel interference at each base station and provide a better downlink performance to the user near its serving base station, so that conventional schemes are not suitable to fairly support all users. In this paper, we propose a decentralized frequency reuse scheme for a small-cell network, where each basestation chooses a set of channels to fairly support the best-effort traffic users regardless of the distances to their serving basestation. After performing the conventional scheme that each basestation selects the channels which are not used in its adjacent basestations, it updates assigned channels improving the performance of low throughput users in a fully distributed manner with mitigating the overall throughput performance loss. The computer simulation demonstrates that the average throughput performance of the 10th percentile throughput users is improved up to 15% in some case compared to that of the conventional scheme, while allowing the overall throughput loss around 3%.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.6
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• pp.9-17
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• 2014

Heterogeneous network (HetNet) is a network consisting of macrocells overlaid with small cells. In HetNet, the interference from macrocell to small cell users is a major cause of performance degradation of small cell users and enhanced inter-cell interference coordination (eICIC) is needed to mitigate the interference. Previous works on eICIC gives limited performance gain because these works focus on maximizing long-term throughput and rarely consider varying channel conditions over frames. This paper proposes a new algorithm which dynamically coordinates interference and schedules users on each frame to maximize the total utility of the network with lower computational complexity than exhaustive search. Simulation results show that the proposed algorithm achieves higher total throughput than the throughput with the conventional algorithm, and has higher fairness index than the conventional algorithm when there large number of users.