• Nuclear Engineering and Technology
• /
• v.52 no.2
• /
• pp.429-447
• /
• 2020

The considered simulation tasks are based on an electrometallurgical process development strategy and associated telemanipulator simulation systems are proposed with various scales of experimental facilities. Fundamentally, target facilities are assumed to be operated only by remote handling systems because the considered process is operated in hazardous environments. Futhermore, the feasibility at various scales should be experimentally verified with gradual increase in throughput. In this regard, bench, engineering, and pilot-scale simulation systems are important early-stage tools for assessing the practical operability of the target process with the material handling systems. Such simulation systems are highly customized for applications and are a precursor to larger pilot and demonstration-scale plants. This paper introduced and classified the developed simulator systems for this approach at various scales using remote handling systems which were assembled inside a virtual target facility, and the manmachine interface was included for a more realistic operation of the simulator. The results obtained for each simulator show the feasibility and requirement for improvement of the systems for the considered test issues with respect to the operation and maintenance of the process.

• The Plant Pathology Journal
• /
• v.24 no.3
• /
• pp.245-268
• /
• 2008

The outcome of plant-pathogen interactions is influenced significantly by endogenous small molecules that coordinate plant defence responses. There is currently tremendous scientific and commercial interest in identifying chemicals whose exogenous application activates plant defences and affords protection from pathogen infection. In this review, we provide a survey of compounds known to induce disease resistance in plants, with particular emphasis on how each compound was originally identified, its putative or demonstrated mechanism of defence induction, and the known biological target(s) of each chemical. Larger polymeric structures and peptides/proteins are also discussed in this context. The quest for novel defence-inducing molecules would be aided by the capability for high-throughput analysis of candidate compounds, and we describe some issues associated with the development of these types of screens. Subsequent characterization of hits can be a formidable challenge, especially in terms of identifying chemical targets in plant cells. A variety of powerful molecular tools are available for this characterization, not only to provide insight into methods of plant defence activation, but also to probe fundamental biological processes. Furthermore, these investigations can reveal molecules with significant commercial potential as crop protectants, although a number of factors must be considered for this potential to be realized. By highlighting recent progress in the application of chemical biology techniques for the modulation of plant-pathogen interactions, we provide some perspective on the exciting opportunities for future progress in this field of research.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.7
• /
• pp.3025-3033
• /
• 2016

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative hematopoietic stem cell disorder. Deregulated BCR-ABL fusion tyrosine kinase activity is the main cause of CML disease pathogenesis, making BCR-ABL an ideal target for inhibition. Current tyrosine kinase inhibitors (TKIs) designed to inhibit BCR-ABL oncoprotein activity, have completely transformed the prognosis of CML. Interruption of TKI treatment leads to minimal residual disease reside (MRD), thought to reside in TKI-insensitive leukaemia stem cells which remain a potential reservoir for disease relapse. This highlights the need to develop new therapeutic strategies for CML either as small molecule master TKIs or phytopharmaceuticals derived from nature to achieve chronic molecular remission. This review outlines the past, present and future therapeutic approaches for CML including coverage of relevant mechanisms, whether ABL dependent or independent, and epigenetic factors responsible for developing resistance against TKIs. Appearance of mutant clones along the course of therapy either pre-existing or induced due to therapy is still a challenge for the clinician. A proposed in-vitro model of generating colony forming units from CML stem cells derived from diagnostic samples seems to be achievable in the era of high throughput technology which can take care of single cell genomic profiling.

• Journal of Advanced Navigation Technology
• /
• v.12 no.6
• /
• pp.598-603
• /
• 2008

Relay system is a promising technique for the high downlink throughput or coverage extension in the next generation wireless systems. In this paper, the transmit scheme for orthogonal frequency division multiplexing (OFDM) based relay system with hierarchical modulation is designed. Without using much power from the base station, the proposed scheme can guarantee the cell edge users to get high data rates as the inner cell users. In the simulation, the performance of proposed scheme was compared with the conventional one in which there is no hierarchical modulation. Numerical results show that the proposed scheme can save much power whether the unicast case or multicast case.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.27 no.8B
• /
• pp.752-759
• /
• 2002

The capacity of the cell varies with the load of the home and neighboring cells. But most call admission control (CAC) algorithms do not consider the cell loading. In this paper a dynamic call admission control is proposed in a WCDMA system with traffic asymmetry. The proposed algorithm changes the CAC thresholds of new call and handoff call based on channel condition. The blocking and dropping probabilities can be controlled by adjusting these thresholds. The proposed algorithm guarantees the Qos of call class and priority between new call and handoff call. In addition, it can minimize the grade of service (GOS) value with the system throughput maintained.

• Journal of Communications and Networks
• /
• v.13 no.4
• /
• pp.327-338
• /
• 2011

With the incitation to reduce power consumption and the aggressive reuse of spectral resources, there is an inevitable trend towards the deployment of small-cell networks by decomposing a traditional single-tier network into a multi-tier network with very high throughput per network area. However, this cell size reduction increases the complexity of network operation and the severity of cross-tier interference. In this paper, we consider a downlink two-tier network comprising of a multiple-antenna macrocell base station and a single femtocell access point, each serving multiples users with a single antenna. In this scenario, we treat the following beamforming optimization problems: i) Total transmit power minimization problem; ii) mean-square error balancing problem; and iii) interference power minimization problem. In the presence of perfect channel state information (CSI), we formulate the optimization algorithms in a centralized manner and determine the optimal beamformers using standard convex optimization techniques. In addition, we propose semi-decentralized algorithms to overcome the drawback of centralized design by introducing the signal-to-leakage plus noise ratio criteria. Taking into account imperfect CSI for both centralized and semi-decentralized approaches, we also propose robust algorithms tailored by the worst-case design to mitigate the effect of channel uncertainty. Finally, numerical results are presented to validate our proposed algorithms.

• Molecules and Cells
• /
• v.37 no.5
• /
• pp.357-364
• /
• 2014

Medulloblastoma, the most common malignant brain tumor in children, is a disease whose mechanisms are now beginning to be uncovered by high-throughput studies of somatic mutations, mRNA expression patterns, and epigenetic profiles of patient tumors. One emerging theme from studies that sequenced the tumor genomes of large cohorts of medulloblastoma patients is frequent mutation of RNA binding proteins. Proteins which bind multiple RNA targets can act as master regulators of gene expression at the post-transcriptional level to co-ordinate cellular processes and alter the phenotype of the cell. Identification of the target genes of RNA binding proteins may highlight essential pathways of medulloblastomagenesis that cannot be detected by study of transcriptomics alone. Furthermore, a subset of RNA binding proteins are attractive drug targets. For example, compounds that are under development as anti-viral targets due to their ability to inhibit RNA helicases could also be tested in novel approaches to medulloblastoma therapy by targeting key RNA binding proteins. In this review, we discuss a number of RNA binding proteins, including Musashi1 (MSI1), DEAD (Asp-Glu-Ala-Asp) box helicase 3 X-linked (DDX3X), DDX31, and cell division cycle and apoptosis regulator 1 (CCAR1), which play potentially critical roles in the growth and/or maintenance of medulloblastoma.

• Journal of Communications and Networks
• /
• v.9 no.3
• /
• pp.330-341
• /
• 2007

This work analyzes the performance of the parallel packet switch (PPS) with a sliding window (SW) method. The PPS involves numerous packet switches that operate independently and in parallel. The conventional PPS dispatch algorithm adopts a round robin (RR) method. The class of PPS is characterized by deployment of parallel low-speed switches whose all memory buffers run more slowly than the external line rate. In this work, a novel SW packet switching method for PPS, called SW-PPS, is proposed. The SW-PPS employs memory space more effectively than the existing PPS using RR algorithm. Under identical Bernoulli and bursty data traffic, the SW-PPS provided significantly improved performance when compared to PPS with RR method. Moreover, this investigation presents a novel mathematical analytical model to evaluate the performance of the PPS using RR and SW method. Under various operating conditions, our proposed model and analysis successfully exhibit these performance characteristics including throughput, cell delay, and cell drop rate.

• Journal of Digestive Cancer Research
• /
• v.10 no.2
• /
• pp.82-91
• /
• 2022

Gastrointestinal cancer accounts for one-third of the overall cancer occurrence worldwide. Pancreatic ductal adenocarcinoma (PDAC) is a type of gastrointestinal cancer that is known to be one of the most fatal among all cancer types, with a 5-year survival rate of less than 8%. Chemotherapy combined with surgical resection is its probable curative option. However, surgery is accessible for only 10-15% of patients diagnosed with PDAC. Organoids show self-organizing capacities and resemble the original tissue in terms of morphology and function. Organoids can also be cultured with high effectiveness from tumor tissues derived from each patient, making them an extremely fitting model for translational uses and improving personalized cancer medicine. Enhancing drug screening platforms is necessary to apply personalized medicinebased organoids in clinical settings.

• Korean Journal of Environmental Biology
• /
• v.34 no.2
• /
• pp.107-115
• /
• 2016

Currently, there are 442 operating nuclear power plants in the world, and 62 more are under construction. According to this reasoning, the treatment of radioactive waste is important to prevent the environmental ecosystem including humans, animals, and plants. Especially, a leakage of radioactive waste causes not only regional problem but also serious global one. In this study, we demonstrate the effect of radioisotopes (e.g., cesium, strontium, and cobalt) on a 3D culture cell. To develop the 3D cell culture system, we used a 96-well-culture plate with biocompatible agarose hydrogel. Using this method, we can perform the 3D cell culture system with three different cell lines such as HeLa, HepG2, and COS-7. In addition, we conducted a cell viability test in the presence of radioisotopes. Interestingly, the 3D morphological cells showed 42% higher cell viability than those on the 2D against cesium. This result indicates that the 3D platform provides cells morphological and physiological characteristic similar to in vivo grown tissues. Moreover, it overcomes the limitation of conventional cell culture system that can't reflect in vivo systems. Finally, we believe that the proposed approach can be applied a new strategy for simple high-throughput screening and accurate evaluation of metal toxicity assay.