• 제목/요약/키워드: Cell selectivity

검색결과 211건 처리시간 0.034초

이중대역 오프셋 카세그레인 반사판 안테나용 메타재질구조 모사 주파수 선택표면 부반사판 설계 (Design of Metamaterial-Inspired FSS Sub-Reflector for a Dual-Band Offset Cassegrain Reflector Antenna)

  • 김현수;강승택;;전진수;박정훈
    • 한국위성정보통신학회논문지
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    • 제10권2호
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    • pp.34-39
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    • 2015
  • 본 논문에서는, 오프셋 카세그레인 반사판 안테나가 물리적 크기의 증가없이 Ku와 Ka 이중대역 신호를 다룰 수 있는 구조로 설계된다. 계산시간 및 구현비용을 고려하여, 주반사판 대신에 부반사판에 Ka대역 신호는 반사시키고 Ku대역은 통과시키는 주파수 선택성을 부여한다. 쌍곡선 부반사판 표면의 주파수 선택표면은 8각형 금속 링을 위 아래로 둔 다층매질의 단위 쎌의 주기적 형태로 구성된다. 정밀한 전자기 모의시험을 통해 제안한 구조가 19 GHz와 45 GHz에서 동작함을 확인한다.

Molecular Motions of [N(C2H5)4]+ and [N(CH3)4]+ ions by 1H Nuclear Magnetic Resonance Relaxation in [N(C2H5)4]2CoCl4 and [N(CH3)4]2CoCl4 Single Crystals

  • Yoon, Su-A;Lim, Ae-Ran
    • 한국자기공명학회논문지
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    • 제15권2호
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    • pp.146-156
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    • 2011
  • The line widths and spin-lattice relaxation times of protons in $[N(C_2H_5)_4]_2CoCl_4$ and $[N(CH_3)_4]_2CoCl_4$ single crystals were investigated in the temperature range 160-400 K. The temperature dependences of the spin-lattice relaxation times are attributed to the molecular motions of the ethyl and methyl groups in the $[N(C_2H_5)_4]^+$ and $[N(CH_3)_4]^+$ ions respectively. The NMR line widths indicate that the ethyl groups in $[N(C_2H_5)_4]_2CoCl_4$ have one more degree of freedom than the methyl groups in $[N(CH_3)_4]_2CoCl_4$. The experimental results are interpreted in terms of the reorientations of the methyl and ethyl groups.

Anticancer Loaded Multi-wall Carbon Nanotube for Targeting Tumors

  • Wang, Wenping;Choi, Jung-Il;Kang, Sang-Soo;Nam, Tae-Hyun;Khang, Dong-Woo
    • 한국재료학회:학술대회논문집
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    • 한국재료학회 2011년도 춘계학술발표대회
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    • pp.52.2-52.2
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    • 2011
  • Flat form technology for constructing anticancer loaded multi-walled carbon nanotubes (mwCNTs) was introduced in this study. Conventional anticancer drugs, such as MTX (Methotrexate), cisplatin, DOX (Doxorubicin hydrochloride), DAU (Daunorubicin) and EPI (epirubicin) were bio-conjugated with folic acid (FA) for selective targeting tumor cells. Loading efficiencies of the used anticancer drugs on mwCNTs have shown different order of bindings depending on the molecular bind affinity of NH (amine) formation on mwCNTs. MTT assays have shown increased selective target efficiency of FA conjugated mwCNTs on breast cancer cell growth inhibition. All results collectively indicated promising application of mwCNTs as a smart inorganic nanomaterial for selective targeting drug delivery vehicle at tumor tissues.

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A Quinoline-thiooxorhodamine Conjugate for Fluorescent Hg2+ Recognition in Aqueous Media and Living Cells

  • Tang, Lijun;Wen, Xin;Dai, Xin;Wu, Di;Huang, Zhenlong
    • Bulletin of the Korean Chemical Society
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    • 제35권11호
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    • pp.3326-3330
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    • 2014
  • A quinoline-thiooxorhodamine conjugate fluorescent sensor (1) has been synthesized. Sensor 1 exhibits high selectivity and sensitivity to $Hg^{2+}$ in $H_2O$/DMSO (95/5, v/v, HEPES 20 mM, pH = 7.4) solution with fluorescence detection. Other tested metal ions do not induce any significant fluorescence intensity changes. Sensor 1 interacts with $Hg^{2+}$ through a 1:1 binding stoichiometry with a good anti-inference ability. In addition, fluorescent imaging of $Hg^{2+}$ in Hela cells is also successfully demonstrated.

Effect of Feed Allowance on Selection, Intake and Nutrient Utilization of Green Maize (Zea mays) by Goats

  • Dutta, N.;Sharma, K.;Hasan, Q.Z.
    • Asian-Australasian Journal of Animal Sciences
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    • 제13권4호
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    • pp.483-486
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    • 2000
  • The influence of feed allowance on intake and nutrient utilization by Barbari goats given green maize (Zea mays) and potential feeding value of left-overs were studied. The goats were offered food at 3 levels to give left-overs of about 20% (T-1), 35% (T-2) and 50% (T-3) DM of offered amount. A marked effect of refusal rate on intake and digestibility of nutrients was found. The DMI, g/kg $W^{0.75}$ increased from 39.86 in T-1 to 50.91 and 66.55 g in groups T-2 and T-3, respectively. Allowing selective consumption at higher levels (T-2 and T-3), the intake of TDN and DCP from green maize was found not only to meet the maintenance requirement but provided surplus energy and protein for substantial production. The variability in diet selectivity between goats under different treatments was pronounced. As the level of food excess increased to T-3, the left overs had a higher IVDMD and crude protein and decreased cell wall constituents (p<0.05). Considering the substantial increase in intake and digestibility from feeding green maize at high allowances to goats, further studies are needed to develop practical feeding strategies.

글로우 방전을 이용한 혈청과 뇨의 분석기술 개발 (Development of Analytical Techniques for Human Serum and Urine by Using Glow Discharge)

  • 이상천;최경수;손은호;심영진
    • 분석과학
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    • 제11권3호
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    • pp.167-173
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    • 1998
  • Electrothermal Vaporization-Hollow Cathode Glow Discharge-Atomic Emission Spectrometer(ETV-HCGD-AES)를 이용하여 혈청과 뇨에 함유된 중금속 원소들의 분석을 시도하였다. 먼저 글로우 방전셀을 목적에 맞게 설계하고, 미국 NIST로부터 구입한 표준시료인 혈청과 뇨를 사용하여 미량분석을 위한 기초실험을 수행하였다. 전처리를 하지 않은 시료의 분석에서 새로이 개발한 ETV-HCGD-AES는 수은이나 납 등의 검출에서 ICP-OES보다 상대적으로 전처리가 거의 필요없었으며 감도와 선택성에서도 우수함을 관찰하였다.

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과불소계 술폰화 이오노머막을 이용한 고부가가치 화학품 제조 (Perfluorinated Sulfonic Acid Ionomer Membranes for Valued Chemical Production)

  • 심재구;박인기;이창현
    • 멤브레인
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    • 제26권2호
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    • pp.152-158
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    • 2016
  • 클로알칼리(CA) 멤브레인 셀은 대표적인 염수전해 시스템으로서 가성소다와 염소를 생산하는 염수전기분해 프로세스이다. CA 멤브레인 프로세스는 타 공정에 비해 낮은 에너지 소모량을 가져 CA산업에서 가장 선호되는 공정이다. CA프로세스에 사용되는 과불소계 술폰화 이오노머막은 CA프로세스의 핵심구성 요소이며, 양이온을 선택적으로 이동시키는 역할 및 배리어적인 역할을 제공한다. 하지만, CA 구동을 위해 충족되어야 하는 요소들에 대한 정보가 제한적이기 때문에 알맞은 CA분리막 적용을 위한 제품 간의 연구가 필요하다. 본 연구에서는 실제 셀 구동을 바탕으로 하여 상용 고불소계 분리막의 이온전도경향 및 전기화학적 성능 등을 평가하였다.

Effect of Linker for Immobilization of Glutathione on BSA-Assembled Controlled Pore Glass Beads

  • Chen, Li-Hua;Choi, Young-Seo;Park, Jung-Won;Kwon, Joseph;Wang, Rong-Shun;Lee, Tae-Hoon;Ryu, Sung-Ho;Park, Joon-Won
    • Bulletin of the Korean Chemical Society
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    • 제25권9호
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    • pp.1366-1370
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    • 2004
  • Controlled pore glass bead was modified with bovine serum albumin (BSA), and glutathione (GSH) was immobilized through three kinds of linkers on top of BSA. Bis(3-sulfo-N-hydroxysuccinimide suberate) sodium salt $(BS^3)$, N-hydroxysuccinimide 3-(2-pyridyldithio)propionate (SPDP), or N-hydroxysuccinimide 4-maleimidobutyrate (GMBS) was introduced into the BSA-bound matrix. Subsequently, GSH was immobilized by addition of thiol side chain into the maleimido moiety, replacing a disulfide group, or formation of an amide group upon releasing 3-sulfo-N-hydroxysuccimide group. It was observed that conjugation methodology played a critical role for activity of the immobilized GSH. SDS-PAGE chromatogram showed that the matrix of glutathione immobilized on BSA through GMBS manifested high selectivity towards glutathione-S-transferase (GST) in cell lysate.

용존 산소 측정용 초소형 Clark-type 센서에 대한 연구 (A Study on the Microfabricated Clark-type Sensor for Measuring Dissolved Oxygen)

  • 박정일;장종현;최명기;이동영;김영미;박정호
    • 전기학회논문지
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    • 제56권8호
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    • pp.1450-1454
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    • 2007
  • This paper presents a microfabricated Clark-type sensor which exactly can measure dissolved oxygen in the cell containing solution. We designed, fabricated, and characterized a microfabircated Clark-type oxygen sensor for measuring dissolved oxygen. The microfabricated oxygen sensor consists of 3-electrodes on a glass substrate, a FEP (Fluorinated ethylene propylene) oxygen-permeable membrane, and PDMS (Polydimethylsiloxane) reservoir for storing sample solution. Thin-film Ag/AgCl was employed as a reference electrode and its durability was verified by obtaining a stable open circuit potential for 2 hours against a commercial Ag/AgCl electrode and a stable cyclic voltammetry curve. Selectivity, response time, and linearity of the fabricated oxygen sensor were also verified well by cyclic voltammetry and amperometry depending. The fabricated oxygen sensor showed a 90% response time of 40sec and an excellent linearity with a correlation coefficient of 0.994.

Allosteric Probe-Based Colorimetric Assay for Direct Identification and Sensitive Analysis of Methicillin Resistance of Staphylococcus aureus

  • Juan Chu;Xiaoqin Zhao
    • Journal of Microbiology and Biotechnology
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    • 제34권3호
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    • pp.681-688
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    • 2024
  • The accurate and rapid detection of methicillin-resistance of Staphylococcus aureus (SA) holds significant clinical importance. However, the methicillin-resistance detection strategies commonly require complicated cell lysis and gene extraction. Herein, we devised a novel colorimetric approach for the sensitive and accurate identification of methicillin-resistance of SA by combining allosteric probe-based target recognition with self-primer elongation-based target recycling. The PBP2a aptamer in the allosteric probe successfully identified the target MRSA, leading to the initiation of self-primer elongation based-cascade signal amplification. The peroxidase-like hemin/G-quadruplex undergo an isothermal autonomous process that effectively catalyzes the oxidation of ABTS2- and produces a distinct blue color, enabling the visual identification of MRSA at low concentrations. The method offers a shorter duration for bacteria cultivation compared to traditional susceptibility testing methods, as well as simplified manual procedures for gene analysis. The overall amplification time for this test is 60 min, and it has a detection limit of 3 CFU/ml. In addition, the approach has exceptional selectivity and reproducibility, demonstrating commendable performance when tested with real samples. Due to its advantages, this colorimetric assay exhibits considerable potential for integration into a sensor kit, thereby offering a viable and convenient alternative for the prompt and on-site detection of MRSA in patients with skin and soft tissue infections.