• 동의생리병리학회지
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• 제23권5호
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• pp.1139-1144
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• 2009

This study was purposed to research the anti-cancer effects of Bistortae Rhizoma. A total extract of Bistortae Rhizoma decoction was prepared. By measuring the cell proliferation, apoptosis, morphology and cytokine level from the extracts, the influence on HepG2 cell, SNU-1 cell and A549 cell was compared. The Bistortae Rhizoma decoction extract did not control HepG2 cell proliferation but controlled SNU-1 cell and A549 cell proliferation. In particular, the inhibitory effect on SNU-1 cell proliferation was highest. The Bistortae Rhizoma decoction extract showed to increase the apoptosis of the HepG2 ceil, SNU-1 cell and A549 cell in a dose-dependent manner. In particular, the promotion effect of the apoptosis was highest in SNU-1 cell. Among the various fraction extracts of the Bistortae Rhizoma decoction, n-BuOH extraction showed the greatest increase of the apoptosis of the HepG2 cell. The Bistortae Rhizoma decoction extract decreased dose-dependently the secretion of the TGF-$\beta$ in the HepG2 cell, SNU-1 cell and A549 cell and increased the secretion of the TNF-$\alpha$ and the IFN-$\gamma$. These results suggest that the total extract of Bistortae Rhizoma decoction has anti-cancer effect against SNU-1 cell and A549 cell.

• 대한본초학회지
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• 제22권4호
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• pp.187-199
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• 2007

Objectives : The present study purposed to compare the antioxidant effect, anti inflammatory effect and cancer cell multiplication inhibition effect of Fructificatio Inonoti Obliqui aqueous extract according to extraction temperature. Methods : We medicated animal models, which had experimental oxidation, with Fructificatio Inonoti Obliqui total extract and $50^{\circ}C$ low temperature leachate, and performed hematological analysis and blood chemical analysis with measuring SOD, GSH, catalase, NO and MDA content in the liver. In addition, we made comparative observation of anti inflammatory effect and anti-cancer effect. Results : Compared to the control group, both the group medicated with Fructificatio Inonoti Obliqui total extract and with $50^{\circ}C$ low-temperature leachate were found to decrease the number of thrombocytes in blood plasma and NO content while to increase SOD activity and catalase activity significantly. Both groups also showed anti-inflammatory effect against THP-1 cells and a multiplication inhibition effect against liver cancer cells and stomach cancer cells significantly. Conclusions : Both Fructificatio Inonoti Obliqui total extract and Fructificatio Inonoti Obliqui $50^{\circ}C$ low-temperature leachate have significant antioxidant effect, anti inflammatory effect and anti cancer effect.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2002년도 춘계학술대회 논문집
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• pp.684-687
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• 2002

The authors have developed two devices which cuts the spend fuel rod to an optimal size and extracts fuel pellet from the pieces of cut fuel rods. These devices are so important to reduce radioactive wastes that some advanced countries developed their own methods and devices. The authors have benchmarked from these methods and devices. For spent fuel rod cutting, the tube cutting method has been chosen. some mechanical properties of the fuel tube and pellet has been carefully considered for an optimal cutting size. For fuel pellet extraction, a mechanically extracting method has been adopted. The existing chemical method have turned out to be inappropriate because it produced large amount of radioactive wastes, in spite of its high fuel recovery characteristics. The developed method has an advantage that it can be applied to other fuel rods that have different shapes and sizes. The two devices are set up and operated in the hot cell where people can not go in, so that the devices have been designed to be controlled remotely and modulated for easy maintenance. And the performance of the devices has been tested by using simulated fuel rod. From the experimental results, the devices are supposed to be useful for reducing radioactive wastes.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년 학술대회 논문집 정보 및 제어부문
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• pp.139-141
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• 2006

Quantum-dot Cellular Automata (QCA) is one of the most promising next generation nano-electronic devices which will inherit the throne of CMOS which is the domineering implementation technology of large scale low power digital systems. In late 1990s, the basic operations of the QCA cell were already demonstrated on a hardware implementation. Also, design tools and simulators were developed. Nevertheless, its design technology is not quite ready for ultra large scale designs. This paper proposes a new approach which enables the QCA designs to inherit the verification methodologies and tools of CMOS designs, as well. First, a set of disciplinary rules strictly restrict the cell arrangement not to deviate from the predefined structures but to guarantee the deterministic digital behaviors. After the gate and interconnect structures of the QCA design are identified, the signal integrity requirements including the input path balancing of majority gates, and the prevention of the noise amplification are checked. And then the digital logic is extracted and stored in the OpenAccess common engineering database which provides a connection to a large pool of CMOS design verification tools. Towards validating the proposed approach, we designed a 2-bit QCA adder. The digital logic is extracted, translated into the Verilog net list, and then simulated using a commercial software.

• 한국기계가공학회지
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• 제13권3호
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• pp.35-41
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• 2014

Poly(g-glutamic acid) (g-PGA) is a very promising biodegradable polymer that is produced by microorganism of Bacillus subtilis. Because g-PGA is water-soluble, anionic, biodegradable, and even edible, its potential applications have been studied from an industrial standpoint. In this study, we fabricated porous g-PGA foams by means of a freeze-solvent extraction method for tissue-engineering applications. Porous g-PGA foams were chemically cross-linked using a hexamethylene diisocyanate solution. An aqueous basic solution was used to neutralize g-PGA foam for cell culturing. During an in vitro cell culture study, it was observed that primary rabbit ear chondrocytes were well at tached and spread over the surface oft hree-dimensional cross-linkedg-PGA foam. From these results, it is concluded that cross-linkedg-PGA foam is aprom is in gmaterial for tissue-engineering applications, especially those pertaining to the regeneration of human cartilage.

• 한국식품영양학회지
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• 제9권4호
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• pp.413-418
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• 1996

식물 세포벽으로부터 펙틴을 추출하는데 있어 펙틴의 중합도를 높인 고 기능의 펙틴을 추출하기 위해 펙틴의 효소추출법을 사용하여 기존의 고온 산처리 펙틴 추출법과 비교하여 다음과 같은 결론을 얻었다. 1. 불용성의 WAIP로부터 일련의 산 추출 공정과 hemicellulase를 이용한 일련의 효소 추출 공정을 거친 결과, 추출물의 수율은 효소 추출법이 더 높았다. 2. 효소 추출법에 있어 추출 조건을 다양하게 변화시켜 가며 수율을 검토한 결과, 최적의 추출 조건은 hemicellulase 1.5g을 24hr동안 38$^{\circ}C$에서 반응시킨 것으로 나타났다. 3. 펙틴의 주요 성분인 galacturonic acid 함량으로 추출물의 펙틴 순도와 수율을 비교한 결과 산 추출물에 비해 효소 추출물은 수율은 높은 대신 순도가 낮았고 메톡실 함량은 비슷하였다. 4. 효소 추출법에서 추출한 펙틴물질은 중성당 분석, GC, HPLC 등을 통해 성분을 정밀하게 분석하고 다양한 방법으로 고기능 펙틴을 추출할 수 있는 조건도 찾고, 그를 통해 정확한 식물 세포벽 모델이 제시될 수 있을 것이다.

• Imaging Science in Dentistry
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• 제36권3호
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• pp.163-168
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• 2006

A 60-year-old female, who complained of delayed healing and swelling after extraction of left lower second molar during chemotherapy, visited our department. She had a history of a resection surgery of breast cancer and postoperative radiotherapy. The conventional radiographs showed diffuse permeative bone destruction in posterior mandibular body, which gave the first radiologic impression of osteonecrosis associated with radiotherapy or chemotherapy. And bone metastasis from the breast cancer was also considered in the differential diagnosis. On the enhanced computed tomography (ECT) the posterior mandibular body was occupied by a large expansile lesion showing central low attenuation with peripheral rim enhancement. Magnetic resonance images revealed that the low attenuated area on ECT did not show as high signal intensity as water on T2 weighted image and indicated solid component of a tumor. The final diagnosis was central squamous cell carcinoma. We present the diagnostic imaging features of the patient with special emphasis on the differential diagnosis.

• 한국자원식물학회지
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• 제5권2호
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• pp.85-93
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• 1992

This experiment was Conducted ta screening for the anti-cancer efficacy from the wild plants which are naturally growing in the Korea. The results are as follows. The results were shown thatZea may L. nad significantly effects on mediculal efficacy anganist anti-tumor by usulg the totalpacked cell volume methods and also, severals plants, such as Sofonum nigrum, Patrinia hispidoBunge, Eragrostis, ferrugenia Beauv, Salaginela pouzolgiana Spring, Platrycarya strobilacea Bunge,Codonopsis lanceolata Benth. et Hook fil. which are collected from Giri and Mooju mountain in Koreaand Nagano in Japan were showed effects on auti-tumor. But the pharmaceologial activities ofPharbitis nil Choisy was believed to strong effec on anti - cancer tumors, while toxicity of its wasshown high that induced te kill all used mice. Extraction of Patrinia hispida Bunge, Pharbitis nilChoisy, Toilis japonica DC, Eragrostis erruginea Beauv. and Forsythia koreana Nakai showed effec-tively supressed on growth rate of cancer tumor by the below 50 percent of T/C ratio at 30mg /mlof extraction from plant. That Is strong activity while Reynouxria japonica Houtt. was observed onlymild activities. The above results many possibly suggest that Patrinia hispido Bunge and Eragrostisferrugina Beauv. inhibited the growth of cancer tumor by the both total packed cell volume methodand cytotoxicity method. Although basic research is still going on, we will find out an accurate moth-od for developing useful medicinal plant to improve pharmacological activites against anti-cancertumor, especialy, in Eragrostis ferruginea Beauv.

• 한국약용작물학회지
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• 제23권2호
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• pp.155-160
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• 2015

This research evaluate antioxidant and skin-whitening effect of Abeliophyllum distichum Nakai by extraction processes. First, antioxidant effects were follows: EE (70% ethanol extract) showed higher DPPH scavenging activity of 69.66% than WE (hot water exract) 59.13% at $0.3mg/m{\ell}$, also UE's (70% ethanol extract by sonication process) higher than EE. Reducing power was that also EE showed higher than WE, and it was the highest value with UE's because of ultrasonic pretreatment. Next, the whitening effect tyrosinase inhibition activity was measured that EE was 23.88%, WE's was 16.69%, and UE was 23.34%. Ultrasonic pretreatment did not influence to tyrosinase inhibition activity. Cell viability showed low cell toxicity in all groups. UE's inhibited melanin synthesis, 55.1%, that is higher than EE and WE, 52.7% and 39.5%, respectively. As a result, we confirmed that antioxidant activities and skin-whitening effect by extraction process. Also, this results confirmed that the Abeliophyllum distichum Nakai extracts worth as cosmetic materials.

• Current Photovoltaic Research
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• 제7권1호
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• pp.21-27
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• 2019

Lifetime of Si photovoltaics modules are about 25 years and a large amount of waste modules are expected to be discharged in the near future. Therefore, the extraction and collection of valuable metals out of discharged Si modules will be one of the important technologies. In this study, we demonstrated that supercritical $CO_2$ extraction method can be effectively used to remove Cu, one of the abundant elements in the module, as well as its oxide form, $Cu_2O$. Especially, we proved that the addition of hexane as co-solvent is effective for the removal of both materials. The optimal ratio of $CO_2$ and hexane was 4:1 at a fixed temperature and pressure of $250^{\circ}C$ and 250 bar, respectively. In addition, it was proven that the removal of $Cu_2O$ was preceded via reduction of $Cu_2O$ to Cu.