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http://dx.doi.org/10.14775/ksmpe.2014.13.3.035

Fabrication of Poly(γ-glutamic acid) Porous Scaffold for Tissue Engineering Applications  

Jeon, Hyeon Ae (Department of Polymer Science and Engineering, Kumoh National Institute of Technology)
Lee, Seung Wook (Department of Polymer Science and Engineering, Kumoh National Institute of Technology)
Kwon, Oh Hyeong (Department of Polymer Science and Engineering, Kumoh National Institute of Technology)
Publication Information
Journal of the Korean Society of Manufacturing Process Engineers / v.13, no.3, 2014 , pp. 35-41 More about this Journal
Abstract
Poly(g-glutamic acid) (g-PGA) is a very promising biodegradable polymer that is produced by microorganism of Bacillus subtilis. Because g-PGA is water-soluble, anionic, biodegradable, and even edible, its potential applications have been studied from an industrial standpoint. In this study, we fabricated porous g-PGA foams by means of a freeze-solvent extraction method for tissue-engineering applications. Porous g-PGA foams were chemically cross-linked using a hexamethylene diisocyanate solution. An aqueous basic solution was used to neutralize g-PGA foam for cell culturing. During an in vitro cell culture study, it was observed that primary rabbit ear chondrocytes were well at tached and spread over the surface oft hree-dimensional cross-linkedg-PGA foam. From these results, it is concluded that cross-linkedg-PGA foam is aprom is in gmaterial for tissue-engineering applications, especially those pertaining to the regeneration of human cartilage.
Keywords
Poly(${\gamma}$-glutamic acid); Porous Scaffold; Freeze-Solvent Extraction method; Tissue Engineering; Chondrocyte;
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