• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.2
• /
• pp.487-492
• /
• 2012

Trace element zinc deficiency or excess is implicated in the development or progression of some cancers. The exact role of zinc in the etiology of colon cancer is unclear. To cast light on this question, an experimental model of colon carcinogenesis was applied here. Six week old rats were given sub cutaneous injections of DMH (30 mg/kg body weight) twice a week for three months and sacrificed after 4 months (precancer model) and 6 months (cancer model). Plasma zinc levels showed a significant decrease (p<0.05) at 4 months and a greater significant decrease at 6 months (p<0.01) as compared with controls. In the large intestine there was a significant decrease in tissue zinc levels (p<0.005) and in CuZnSOD, and alkaline phosphatase activity (p<0.05) in the pre-cancerous model and a greater significant decrease in tissue zinc (p<0.0001), and in CuZnSOD and alkaline phosphatase activity (p<0.001), in the carcinoma model. The tissue zinc levels showed a significant decrease in the small intestine and stomach (p<0.005) and in liver (p<0.05) in the cancer model. 87% of the rats in the precancer group and 92% rats in the cancer group showed histological evidence of precancerous lesions and carcinomas respectively in the colon mucosa. This study suggests that the decrease in plasma zinc, tissue zinc and activity of zinc related enzymes are associated with the development of preneoplastic lesions and these biochemical parameters further decrease with progression to carcinoma in the colon.

• Advances in concrete construction
• /
• v.6 no.2
• /
• pp.177-197
• /
• 2018

This paper presents a case study about the damages on the structural elements of a cast in place reinforced concrete (RC) building after a big fire which was able to be controlled after six hours. The fire broke off at the $2^{nd}$ basement floor of the building, which has five basements, one ground, and two normal floors. As a result of intensely stocked ignitable materials, it spread out to the all of the upstairs. In visual inspection, most of the typical fire damages were observed (such as spalling, net-like cracks, crumbled plasters, bared or visible reinforcement). Also, failures of the $2^{nd}$ basement columns were encountered. It has been concluded that the severity failures of the columns at the $2^{nd}$ basement caused utterly deformation of the building, which is responsible for the massive damages on the beam-column connections. All of the observed damages were categorized related to the types and presented separated regarding the floors. Besides to the visual inspection, the numerical analysis was run to verify the observed damaged on the building for columns, beams, and the connection regions. It is concluded from the study that several parameters such as duration of the fire, level of the temperature influence on the damages to the RC building. Also, it is highlighted by the study that if the damaged building is considered on the overall structural system, it is not able to satisfy the minimum service requirements neither gravity loads nor earthquake conditions.

• Korean Journal of Materials Research
• /
• v.22 no.3
• /
• pp.111-117
• /
• 2012

The effect of Al addition on the precipitation behavior of a binary Mg-Zn alloy was investigated based on the changes in the morphology, distribution and element concentration of precipitates formed during aging treatment. The as-cast Mg-6.0 mass%Zn (Mg-6Zn) and Mg-6.0 mass%Zn-3.0 mass%Al (Al-added) were homogenized at 613 K for 48 h and at 673 K for 12 h; they were then solid solution treated at 673 K for 0.5 h and 1 h, respectively. The Mg-6Zn and Al-added alloys were aged at 403 K and 433 K. The peak hardness of the Al-added alloy was higher than that of the Mg-6Zn alloy at each aging temperature. Rod-like, plate-like, blocky, and lath-like precipitates were observed in the Al-added alloy aged at 433 K for 230.4 ks, although the rod-like and plate-like precipitates were observed in the TEM microstructure of the Mg-6Zn alloy aged at 433 K for 360 ks. Moreover, the precipitates in the Al-added alloy were refined and densely distributed compared with those in the Mg-6Zn alloy. The Cliff-Lorimer plots obtained by the EDS analysis of the rod-like ${\beta}_1^'$ and plate-like ${\beta}_2^'$ phases in the Al-added alloy peak aged at 433 K for 230.4 ks were examined. It was confirmed that the ${\beta}_2^'$ phases had higher concentration of solute Al atom than was present in the ${\beta}_1^'$ phases, indicating that the properties of precipitates can be changed by Al addition.

• Transactions of Materials Processing
• /
• v.29 no.3
• /
• pp.135-143
• /
• 2020

Low-cost alloying elements were added to a modified Al-6.5Si alloy and its microstructure, tensile and impact toughness properties were investigated. The alloying elements added were Mg, Zn, and Cu, and two kinds of alloy A (Mg:0.5, Zn:1, Cu:1.5 wt.%) and alloy B (Mg:2, Zn:1.5, Cu:2 wt.%) were prepared. In the as-cast Al-6.5Si alloys, Si phases were distributed at the dendrite interfaces, and Al₂Cu, Mg₂Si, Al₆ (Fe,Mn) and Al₅ (Fe,Mn)Si precipitates were also observed. The size and fraction of casting defects were measured to be higher for alloy A than for alloy B. The secondary dendrite arm spacing of alloy B was finer than that of alloy A. It was confirmed by the JMatPro S/W that the cooling rate of alloy B could be more rapid than alloy A. The alloy B had higher hardness and strength compared to the values of alloy A. However, the alloy A showed better impact toughness than alloy B. Based on the above results, the deformation mechanism of Al-6.5Si alloy and the improving method for mechanical properties were also discussed.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.32 no.2
• /
• pp.177-185
• /
• 2008

Low-cycle environmental fatigue tests of cast austenitic stainless steel CF8M at the condition of fatigue strain rate 0.04%/sec were conducted at the pressure and temperature, 15MPa, $315^{\circ}C$ of a operating pressurized water reactor (PWR). The used test rig was limited to install an extensometer at the gauge length of the cylindrical fatigue specimen inside a small autoclave. So the magnet type LVDT#s were used to measure the fatigue displacement at the specimen shoulders inside the high temperature and high pressure water autoclave. However, the displacement and strain measured at the specimen shoulders is different from the one at the gauge length for the geometry and the cyclic strain hardening effect. Displacement of the fatigue specimen gauge length calculated by FEM (finite element method) used to modify the measured displacement and fatigue life at the shoulders. A series of low cycle fatigue life tests in air and PWR conditions simulating the cyclic strain hardening effect verified that the FEM modified fatigue life was well agreed with the simulating test results. The process and method developed in this study for the environmental fatigue test inside the small sized autoclave would be so useful to produce reliable environmental fatigue curves of CF8M stainless steel in pressurized water reactors.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.34 no.7
• /
• pp.905-910
• /
• 2010

Exhaust manifolds are the first structures to be developed by hydroforming; mass production of exhaust manifolds by this method will be possible soon. This is obviously related with tight emission regulation induced by environmental problems commonly for both domestic and worldwide and standards, thus evoking its solution for domestic automakers. Compared to conventional cast products, thin-gauge tubular hydroformed exhaust manifold have superior features; for example, in the hydroformed exhaust manifold, gas decomposition during the cold-start period of the engine is reduced by lowering the heat sink, and manufacturing process is simplified since less welding is involved. The aim of this study is to develop a hydroformed exhaust manifold; the study deals with the components, the hydroforming process, and tool design of the manifolds. The performance of the exhaust system is evaluated by performing flow analysis, heat-transfer analysis, heat-stress analysis, and fatigue analysis by using a computer.

• Steel and Composite Structures
• /
• v.36 no.3
• /
• pp.321-337
• /
• 2020

Contemporary design and construction of steel-concrete composite structures employs the use of prefabricated concrete elements and demountable shear connectors in order to reduce the construction time and costs and enable dismantling of elements for their potential reuse at the end of life of buildings. Bolted shear connector with mechanical coupler is presented in this paper. The connector is assembled from mechanical coupler and rebar anchor, embedded in concrete, and steel bolt, used for connecting steel to concrete members. The behaviour and ultimate resistance of bolted connector with mechanical coupler in wide and narrow members were analysed based on push-out tests and FE analyses conducted in Abaqus software, with focus on concrete edge breakout and bolt shear failure modes. The effect of concrete strength, concrete edge distance and diameter and strength of bolts on failure modes and shear resistance was analysed. It was demonstrated that premature failure by breakout of concrete edge occurs when connectors are located 100 mm or closer from the edge in low-strength and normal-strength reinforced concrete. Furthermore, the paper presents a relatively simple model for hand calculation of concrete edge breakout resistance when bolted connectors with mechanical coupler are used. The model is based on the modification of prediction model used for cast-in and post-installed anchors loaded parallel to the edge, by implementing equivalent influence length of connector with variable diameter. Good agreement with test and FE results was obtained, thus confirming the validity of the proposed method.

• Journal of Industrial Technology
• /
• v.3
• /
• pp.103-116
• /
• 1983

Recent developments in multi-storey buildings for residential purpose have led to the extensive use of shear walls for the basic structural system. When the coupled shear wall system is used, joined together with cast-in-place concrete or mortar (or grout), the function of the continuous joints is a crucial factor in determining the safety of L.P. Precast concrete shear wall structures, because the function of the continuous joints(Vertical wall to wall joints) is to transfer froces from one element(shear wall panel) to another, and if sufficient strength and ductility is not developed in the continuous joints, the available strength in the adjoining elements may not be fully utilized. In this paper, the influence of the stiffness of vertical joints(wet vertical keyed shear joints) on the behaviour of precast shear walls is theoretically investigated. To define how the stiffness of the vertical joints affect the load carrying capacity of L.P.Precast concrete shear wall structure, the L.P.Precast concrete shear wall structure is analyzed, with the stiffness of the vertical joints varying from $K=0.07kg/mm^3$(50MN/m/m) to $K=1.43kg/mm^3$(1000MN/m/m), by using the continuous connection method. The results of the analysis shows that at the low values of the vertical stiffness, i.e. from $K=0.07kg/mm^3$(50MN/m/m) to $K=0.57kg/mm^3$(400MN/m/m), the resisting bending moment and shearing force of precast shear walls, the resisting shearing force of vertical joints and connecting beams are significantly affected. The detailed results of analysis are represented in the following figures and Tables.

• Steel and Composite Structures
• /
• v.26 no.3
• /
• pp.375-386
• /
• 2018

Existing design codes for steel-concrete composite structures give only general information about the shear connection provided by headed studs in group arrangement. Grouting of the openings in prefabricated concrete slabs, where the grouped headed studs are placed in the deck pockets is alternative to cast-in-place decks to accomplish fast execution of composite structures. This paper considers the possibility to reduce the distance between the studs within the group, bellow the Eurocode limitations. This may lead to increased competitiveness of the prefabricated construction because more studs are placed in the group if negative effectives of smaller distances between studs are limited. The main purpose of this work is to investigate these limits and propose an analytical calculation model for prediction of the shear resistance of grouped stud arrangements in the deck pockets. An advanced FEA model, validated by results of push-out experiments, is used to analyze the shear behavior of the grouped stud with smaller distance between them than recommended by EN 1994-1. Calculation model for shear resistance, which is consistent with the existing Eurocode rules, is proposed based on a newly introduced equivalent diameter of the stud group, $d_G$. The new calculation model is validated by comparison to the results of FE parametric study. The distance between the studs in the longitudinal direction and the number of stud rows and columns in the group are considered as the main variables.

• Journal of the Korean Society for Heat Treatment
• /
• v.7 no.1
• /
• pp.61-71
• /
• 1994

This study is to investigate the stress distributions, crystal orientations and magnetic properties during die-upsetting according to working temperature of Nd-Fe-B-Cu alloys. The stress distributions in the specimens during compressing process were calculated by a finite element method program(SPID). The calculated stresses were effective stress (${\sigma}_{eff}$), compression stress(${\sigma}_z$), radial direction stress(${\sigma}_r$) rotational direction stress(${\sigma}_e$) and shear stress(${\tau}_{rz}$). The stress distributions of ${\sigma}_z$, obtained by a computer simulation showed that the stress components causing the magnetic alignment during die-upsetting of the cast magnets were very high at the center-part of a specimen, and decreased toward the periphery-part of a specimen. In view of the above results the magnetic properties should be better at the center-part of a specimen than any other parts. But the measured magnetic properties were better at the mid-part. These results should be due to the fact that the specimens were casted. Normally the magnetic properties are affected by the casting process as well as by the stress levels. ${\sigma}_r$, ${\sigma}_e$ are thought to affect the liquid phase flowing and domain patterns, respectively. The influence of ${\tau}_{rz}$ was trivial, ${\sigma}_{eff}$ distributed similar throughout the specimen. The Nd-rich phase appeared at the peripheral of the specimen where the stress level of ${\sigma}_r$, ${\sigma}_z$, was low or the stress level of ${\sigma}_e$ was high. The Nd-rich phase was squeezed out during die-upsetting. This phase had an effect on the crystal orientation and grain growth. The stress distributions of alloy were irregular at the parts of the specimen where the die contacted with specimen.