• 대한한방내과학회지
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• 제39권1호
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• pp.44-68
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• 2018

Objective: This study aimed to investigate the trend in the research on breast cancer using traditional Korean medicine (TKM) and establish the direction for further study. Methods: Breast cancer studies using Korean medicine were searched using the Oriental Medicine Advanced Searching Integrated System (OASIS). The search term was 'breast' and there was no restriction in year. The searched studies were analyzed according to the type of research. Results: 1. 83 studies were searched. The types and numbers of study were as follows: 42 were in vitro studies, 5 were in vivo studies, 12 were studies for review, and 27 were clinical research including case reports. 2. Various cell lines such as MCF-7, MDA-MB-231, SKBR3, and MCF-10A were used for in vitro studies. The studies reported a decrease in cell viability, induction of apoptosis, and change of expression in cancer-related genes. In vivo studies also reported induction of apoptosis, and anti-proliferative activity of herbal medicine against the cancer cells. 3. Among the clinical research, 8 were cross-sectional studies, 3 were controlled-trial, and 15 were case reports. The baseline characteristics of breast cancer patients were analyzed in the cross-sectional studies. Interventions such as pharmacopuncture, herbal medicine, massage, Qi gong, acupuncture, electroacupuncture and moxibustion were used in clinical research. 4. Research on the review of breast cancer covered various subjects as follows: herbal medicine, acupuncture, pattern identification of breast cancer in traditional Korean medicine, analysis of previous experimental studies, and clinical trials. Conclusion: We have found the applicability of TKM for treatment of breast cancer through this review. It is necessary to conduct further studies, such as well-designed clinical trials based on the results from experimental research.

• 환경영향평가
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• 제19권6호
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• pp.563-571
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• 2010

In carrying out the prior review on environmental conditions for basic plan of public waters reclamation, the important item is review on conditions of location on prearranged reclaimed land. In this study, environmental assessment which needs careful consideration in the first stage of selecting location is presented by analyzing environmental impact assessment on public waters reclamation projects for about 10 years. The assessment index for alternative comparison is divided into two parts according to importance level. What is most important in alternative comparison is the comparison on direct influence due to reclamation. In other words, it figures out damaged extent of natural shoreline as well as intertidal and infralittoral zones. Comparing influence extent due to reclamation through the 1st comparison on this is regarded as to be important. In case there is no significant difference by alternatives through the 1st assessment, the 2nd assessment should be carried out. In the 2nd assessment indexes are damaged quantity of benthic organism, change in seawater current, erosion, accumulation and exchangeable rate of seawater. The plan for selecting optimal location which minimizes environmental influence in establishing public waters reclamation plan is demonstrated through model cases. For this, 3 districts which have similar environment and scale are selected, and then comparison on location alternative is made through environmental assessment index. In addition, the comparison on 3 arrangement alternatives are conducted, targeting certain areas. It is thought that carrying out comparison review on respective areas in the same cities and counties, not merely comparing arrangement plan by selecting 1 targeting area in advance, is the most appropriate. Besides, selection of arrangement plan considering environment, which minimizes damage of natural shoreline and influence due to change of seawater current is required in alternative comparison on arrangement plan as well. In case of the prior review on environmental conditions though alternative comparison method presented in this study is carried out, it is safely said that the influence on ocean environment due to public waters reclamation can be minimized.

• 생물정신의학
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• 제26권1호
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• pp.1-7
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• 2019

Since non-cardiac chest discomfort (NCCD) can result in substantial healthcare burden and lower quality of life, interventions such as cognitive behavioral therapy (CBT) have been investigated for the relief of NCCD. In this review, we aimed to summarize the evidence on the efficacy of the CBT for the treatment of NCCD while introducing a newly-developed computerized CBT program for NCCD. Studies applying CBT to individuals with NCCD were searched for from both English and Korean electronic databases. Among 37 studies, 11 randomized controlled trials, 4 case-control studies, 1 case series, and 2 review articles were eligible for this review. Efficacy of conventional CBT for NCCD was shown in a series of studies as most of them reported improved symptom severity of NCCD or NCCD-related anxiety. However, a substantial variability existed among these studies in participants, treatment procedures and durations. High attrition rates were also reported in these studies on conventional CBT. Computerized CBT could be an alternative to the conventional CBT as it can be standardized and more easily accessible, but it was only reported in one previous study. In addition to the literature review, we presented a newly-developed computerized CBT program for NCCD which may overcome some of the limitations of conventional CBT. A computerized CBT could be an alternative treatment of NCCD, however, need further studies on its usefulness.

• 한국조리학회지
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• 제3권
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• pp.385-421
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• 1997

This study was performed as placing stress on business plan preparation and investing economy analysis centered to cases upon presenting the premises of study for new foundation of food service business. The summarized results are as follows: 1. In the aspect of carrying out process of practical project, establishing the promotion strategy, the facility project program, the menu program, the facility and furniture program, organization & manning schedule, the business operation schedule, review of all laws & provisions and the allout promotion schedule in order were deployed. 2. Analysis of investing economy for review of profitability 1) In case of investment, excluding 600million for the real setate lease among the total investment of 1billion, it was required by 161, 235, 000 for interior project, 161, 110, 000 for facility & equipment, 19, 235, 000 for fittings, 27, 600, 000 for menu plate & uniform, 27, 600, 000 for furniture, 13, 800, 000 for sign article. 2) In case of loss & profit presumed the annual turnover is to be 1, 115, 856, 000 the contigent profit(before tax) is to be 148, 966, 000 which is 13.3% in comparson to the sales amount and the net profit(after tax) for this term s to be 104, 276, 000 which is 9.3% against the sales and the profitable ratio to the equity investment( 500 million) is 20.9% and it satisfies 20% of the premises of study. 3) In case of the payback period will be approximately two(2) years which indicated within three(3) years that is standard of new project evaluation term of ordinary enterprise. 4) In case of internal rate of return it will be 21.5% which is favorable profitability as taking into account of 15% that is standard of new project evaluation by ordinary enterprise based on general downtown money interest. That the investing value of Happy Day profitability is hinted as it is sufficient enough as the case under this study based upon such results and considered that securing supremacy is competitive power in case of commitment will be possible.

• Journal of Preventive Medicine and Public Health
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• 제49권2호
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• pp.97-107
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• 2016

Objectives: Research on how the risk of gastric cancer increases with Epstein-Barr virus (EBV) infection is lacking. In a systematic review that investigated studies published until September 2014, the authors did not calculate the summary odds ratio (SOR) due to heterogeneity across studies. Therefore, we include here additional studies published until October 2015 and conduct a meta-analysis with meta-regression that controls for the heterogeneity among studies. Methods: Using the studies selected in the previously published systematic review, we formulated lists of references, cited articles, and related articles provided by PubMed. From the lists, only case-control studies that detected EBV in tissue samples were selected. In order to control for the heterogeneity among studies, subgroup analysis and meta-regression were performed. Results: In the 33 case-control results with adjacent non-cancer tissue, the total number of test samples in the case and control groups was 5280 and 4962, respectively. In the 14 case-control results with normal tissue, the total number of test samples in case and control groups was 1393 and 945, respectively. Upon meta-regression, the type of control tissue was found to be a statistically significant variable with regard to heterogeneity. When the control tissue was normal tissue of healthy individuals, the SOR was 3.41 (95% CI, 1.78 to 6.51; I-squared, 65.5%). Conclusions: The results of the present study support the argument that EBV infection increases the risk of gastric cancer. In the future, age-matched and sex-matched case-control studies should be conducted.

• Radiation Oncology Journal
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• 제14권1호
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• pp.61-67
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• 1996

목적 : 접형동에 발생하는 일차성 암은 매우 드물어 전체 부비동 악성종양의 $0.3\%$를 차지한다. 접형동암이 드물게 발생되므로 많은 환자들을 분석하여 얻은 치료결과나 생존기간의 통계가 지금까지도 보고되지 않았다. 이에 본원에서 치료를 시행했던 접형동암 환자 1예의 치료경과를 보고하고자 한다. 증례 보고 : 일부 증례보고들과 소수의 환자들을 대상으로 했던 연구들을 재검토한 한 보고에 따르면 2년 생존율이 $7\%$였다. 본 증례는 접형동암으로 진단된 후 지금까지 29개월동안 생존하고 있다. 또한 척수내 전이는 암환자에서 드문 합병증인데 본 증례에서는 접형동암으로 진단된 후 25개월 만에 갑자기 하지 마비증세와 배뇨곤란을 호소하여 흉추부위를 MRI촬영한 결과 척수내 전이성종양을 3번 4번 흉추부위에서 관찰할 수 있었고 척수공동증을 그 이하부위에 동반하고 있었다. 저자들은 접형동암환자에서 척수공동증을 동반한 척수내 전이소견을 보인 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Information Science Theory and Practice
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• 제12권1호
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• pp.87-101
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• 2024

As the academic publishing environment evolves rapidly and the open science paradigm emerges, the demand for efficient and transparent peer review is growing. This study outlines efforts to actively introduce advanced concepts in scholarly communication into the submission and review system. AccessON Peer Review Management System Plus (ACOMS+), developed and operated by the Korea Institute of Science and Technology Information, is an online submission and peer review system that aims for open science. This study provides an overview of ACOMS+ and presents its four main features: open peer review, open access publishing and self-archiving, online quantitative/qualitative evaluation, and peer reviewer invitation. The directions for further developing ACOMS+ to fully support open science are also discussed. ACOMS+ is the first system in Korea to introduce the open peer review process and is distinguished as a system that supports open access publishing and digital transformation of academic journals. Furthermore, ACOMS+ is expected to contribute to the advancement of the academic publishing environment through the increasing shift toward open access publishing, transparent peer review, and open science.

• 대한기관윤리심의기구협의회지
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• 제6권2호
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• pp.38-47
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• 2024

Purpose: The purpose of this study is to compare the efficiency of 2 types of Institutional Review Boards (IRBs) for multicenter research. Methods: The 2 types are joint IRB and local IRB. For this study, we selected multicenter research reviewed and approved by joint or local IRBs between October 2019 and December 2022. We assessed the time it took for each IRB to approve the research based on the number of working days per IRB review case. We then stratified the data according to the number of participating institutions, the type of research, and the type of IRB review. Results: The results of our study show that joint IRB is more efficient than local IRB. The median IRB approval time for joint IRB was 27 days, 73.5% shorter than local IRB (27 days vs. 102 days, respectively, p<0.001). As the number of participating institutions in multicenter research increased, joint IRB reviews became more efficient regarding the required approval time than local IRB reviews. We also found that joint IRB was faster in every administrative step until new research was approved (p<0.005) when compared to local IRB. Conclusion: Our study highlights that a single review through a joint IRB can significantly reduce the time required for IRB approval of multicenter research. This approach can ensure that all participating institutions follow the same review results. Therefore, a single IRB review effectively reduces the burden of IRB for multicenter research.

• Advances in concrete construction
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• 제6권2호
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• pp.145-157
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• 2018

This paper presents a review on the use of Silica Fume (SF) as a mineral admixture in the concrete. Distinctive outcome from several researches have been demonstrated here, particularly emphasizing on the fresh and hardened properties of concrete when blended with Silica Fume (Micro-silica or Nano-silica). The results showed a substantial enhancement in the mechanical properties of concrete when replaced with SF. The review also presented a brief idea of percentage replacement of SF in case of normal and high-strength concrete. A decreasing trend in workability (slump value) has been identified when there is a increase in percentage replacement of SF. It can be concluded that the optimize percentage of replacement with SF lies in the range of 8-10% particularly for compressive strength. However the variation of blending goes up to 12-15% in case of split tensile and flexure strength of concrete. The study also demonstrates the effect of silica fume on durability parameters like water absorption, permeability, sulphate attack and chloride attack.

• 보건의료산업학회지
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• 제5권4호
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• pp.161-175
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• 2011

The purpose of this study was to expand the home-based rehabilitation services in the long term care insurance. This study was reviewed on the home-based physical therapy in the OECD. The way of this study was literature search and review. This was to reviewed Proquest, Sciencedirect, SpingerLink, Pubmed. Kew word is "home-based therapy". This was collected 71 articles and final analyzed article was 49. The results were as follows; The article number is seven in Canada, fifteen in USA, five in UK, six in Australia, three in Sweden, five in New Zealand, two in Netherlands, one in Turkey, South Korea, Japan, France, Spain, Italy respectively. Randomized controlled trial is fifty, case-control study is eleven, interview is three, literature review is two, and case report, cost-analysis, cost-effectiveness, pilot study, single blinded parallel design, demonstrative study, survey is one respectively. Physical therapist played an important role in home-based rehabilitation among OECD than nurse. Therefore, we must introduce home-based physical therapy in long term care insurance in South Korea.