• 한국인터넷방송통신학회논문지
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• 제10권2호
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• pp.129-134
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• 2010

통계청에 따르면 심혈관 등의 성인병 질환으로 연 600~800명이 사망하는 것으로 나타나고, 고혈압, 동맥경화증, 심장병, 뇌졸중 등은 혈액의 흐름에 장애가 생겨 발생하는 심혈관계질환으로 오늘날 성인병의 주종을 이루고 있는 사망률이 높은 질병으로 구분된다. 또한 사망한 심혈관질환자 중 올바른 응급처치를 했더라면 생존했을 환자가 약 40%를 차지하고 있어 응급상황 발생 시 신속한 대응이 요구된다. 따라서 본 논문에서는 AdaBoost알고리즘의 weak classifier를 결합하여 strong classifier를 생성하는 방법을 통하여 효과적인 분석으로 심전도를 측정할 수 있도록 하고, 심혈관 질환자에게 발생한 응급상황을 빠른 시간 내에 관리 데스크에 전달할 수 있는 시스템을 제안하였다. 이에 따라 심전도 센서를 기반으로 측정한 데이터를 ZigBee통신으로 단말기에 전송하고 응급 상황을 판정하여 관리데스크에 긴급경보와 모니터링을 제공함으로써 신속한 의료서비스 제공이 가능하도록 하였다.

• Journal of Yeungnam Medical Science
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• 제31권1호
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• pp.38-42
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• 2014

Cardiovascular beriberi is caused by thiamine deficiency and usually presents as high cardiac output failure associated with predominantly right-sided heart failure and rapid recovery after treatment with thiamine. Because of its rarity in developed countries, the diagnosis can often be delayed and missed. We recently experienced a case of cardiovascular beriberi with pulmonary hypertension which successfully treated with thiamine infusion. A 50-year-old man with chronic heavy alcoholics was refered to our department for dyspnea with mental change. Echocardiography showed marked right ventricular (RV) dilatation and flattening of the interventricular septum with a D-shaped deformation of the left ventricle. Moderate tricuspid valve regurgitation was found and estimated RV systolic pressure was 52 mm Hg. Because of his confused mentality and history of chronic alcohol intake, neurological disorder due to thiamine deficiency was suspected and intravenous thiamine was administered and he continuously received a daily dose of 100 mg of thiamine. Follow up echocardiography showed marked reduction of RV dilatation and improvement of a D-shaped deformation of the left ventricle. He finally diagnosed as cardiovascular beriberi on the basis of dramatic response to intravenous thiamine. Thiamine deficiency can cause reversible pulmonary hypertension, and can still be encountered in the clinical setting. Thus high index of suspicion is critically needed for diagnosis.

• Investigative Magnetic Resonance Imaging
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• 제23권4호
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• pp.316-327
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• 2019

Cardiovascular magnetic resonance imaging (CMR) is expected to be increasingly used in Korea due to technology advances and the expanded national insurance coverage of these tests. For improved patient care, it is crucial not only that CMR images are properly acquired but that they are accurately interpreted by well-trained personnel. In response to the increased demand for CMR, the Korean Society of Cardiovascular Imaging (KOSCI) has issued interpretation guidelines in conjunction with the Korean Society of Radiology (KSR). KOSCI has also created a formal Committee on CMR Guidelines to write updated practices. The members of this Committee review previously published interpretation guidelines and discuss the patterns of CMR use in Korea.

• 감성과학
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• 제20권4호
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• pp.127-134
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• 2017

시각 정보 중 색채는 인간의 감성을 일으키는 중요한 요소이다. 그러므로 감성을 유발하거나 예측하기 위해서 색의 효과를 확인하는 것은 중요하다. 본 연구는 색채에 따른 감성의 차이를 확인하고자 색채 자극에 따른 심혈관 반응을 측정하였다. 색채 자극은 Red, Green, Blue, Cyan, Mangenta, Yellow의 6가지 색상으로 구성된 이미지들을 사용하였다. 실험에 참여한 대학생 26명(남자 13명)은 Electrocardiogram (ECG) 센서를 착용하고 모니터에 제시된 각 자극을 본 후 주관감성을 평가하였다. 색채 자극에 따른 심혈관 반응 데이터는 Kruskal-wallis 검정과 Mann-Whitney 검정을 수행하여 분석하였다. 그 결과 Coherence ratio가 Green과 Magenta (p=.004), Red (p=.006), Yellow (p=.004) 색상에서 유의한 차이가 있었다. 본 연구는 색상에 따른 유효한 심혈관 반응 변수와 감성의 차이를 확인하였으며 이러한 차이는 쾌-불쾌의 감성과 관련이 있었다. 본 연구는 녹색이 쾌의 감성을 유발하고 적색이 불쾌의 감성을 유발할 수 있음을 보인 실증적인 연구로써 의의가 있다.

• Journal of Chest Surgery
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• 제54권3호
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• pp.200-205
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• 2021

Background: Various methods have been used to reduce postoperative pain after thoracic surgery. However, these methods may affect the patient's respiratory response and delay recovery from anesthesia. We aimed to evaluate the effects of fentanyl and remifentanil during extubation after video-assisted thoracic surgery (VATS). Methods: This study included 45 randomly-selected male patients who underwent VATS for pneumothorax between July 2011 and August 2012. We divided the participants into 3 groups: the F group, which received a bolus injection of 1.0 ㎍/kg of fentanyl; the R1 group, which received a 0.04 ㎍/kg/min remifentanil infusion; and the R2 group, which received a 0.08 ㎍/kg/min remifentanil infusion. Hemodynamics, pain, cough, consciousness level, and nausea were assessed for each group. Results: The number and severity of coughs were lower in the R1 and R2 groups than in the F group, and there were no differences between the R1 and R2 groups. Respiratory depression and loss of consciousness were not observed in any of the patients, and there were no differences in hemodynamics. Conclusion: In comparison with fentanyl, remifentanil did not result in a wide fluctuation of blood pressure and heart rate upon emergence from general anesthesia. Moreover, remifentanil contributed to cough suppression and postoperative pain control. Remifentanil seems to be a safe and effective analgesic after VATS.

• 대한본초학회지
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• 제24권4호
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• pp.77-86
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• 2009

Objectives : The proliferation and migration of human aortic smooth muscle cells (HASMC) in response to activation by various stimuli plays a critical role in the initiation and development of atherosclerosis. This study was conducted to examine the effects of Nelumbo nucifera leaves (NNL) on the proliferation and migration of HASMC. Additionally, the mechanisms involved in any observed effects were also evaluated. Methods : Apoptotic cells were measured by staining with FITC-labeled annexin V, followed by flow cytometric analysis. The expression level of apoptosis related proteins was confirmed by western blot. And MMP-9 activity was measured by gelatin zymography and MMP-9 expression was measured by ELISA Results : NNL completely inhibited the proliferation of HASMC via induction of the expression of apoptotic proteins including annexin V, cleaved poly ADP-ribose polymerase (PARP), and caspase-3 and -8. NNL treatment resulted in the release of cytochrome c into cytosol, a loss of mitochondrial membrane potential, a decrease in Bcl-2 and Bcl-xL and an increase in Bax expression. NNL also blocked HASMC migration via suppression of MMP-9. Conclusions : Taken together, these results indicate that NNL has the potential for use as an anti-artherosclerosis agent.

• 대한중풍순환신경학회지
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• 제11권1호
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• pp.82-88
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• 2010

Because syndrome-differentiation is one of the major characteristics in oriental medicine, there would be a possibility that the same herbal medicine show different effects on the same disease, if syndrome differentiation is ignored. In this report, we observed different response of Yukmijihwang-tang in diabetic stroke patients according to their syndrome differentiation. One case diagnosed as 'Kidney-yin deficiency syndrome' showed remarkable improvement on diabetes mellitus, whereas the serum glucose levels of the other 4 cases diagnosed as 'non Kidney-yin deficiency syndrome' were lowered little. These results are in accordance with the oriental medical theory that Yukmijihwang-tang can treat 'Kidney-yin deficiency syndrome'. Therefore, we suggest that subsequent clinical trials on oriental medicine would have to include the concept of differentiation of syndromes in order to take out the merit of oriental medicine.

• 한국응용과학기술학회지
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• 제40권6호
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• pp.1340-1349
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• 2023

Despite its profound impact on athletic performance, the significance of heart rate recovery (HRR) has been insufficiently addressed in the filed of sports science, particularly in the context of weightlifting characterized by brief and intense exertions involving heavy weights. Serving as a valuable indicator of autonomic nervous system and cardiovascular function, HRR assumes a pivotal role in weightlifting. This comprehensive review aims to delineate the specific demands for HRR in weightlifting, shedding light on the often overlooked cardiovascular considerations within training regimes focused on strength and power. The investigation scrutinizes the repercussions of HRR on weightlifting performance, seeking to elucidate how inadequate recovery intervals may result in physiological and psychological consequences. These consequences encompass a distorted perception of effort, disruption of coordination, compromised posture due to irregular breathing, and an overall decline in lifting capacity. The review systematically presents compelling evidence pertaining to heart rate response and recovery patterns during weightlifting, underscoring the critical importance of well-structured rest periods. Furthermore, the review delves into a comprehensive discussion of factors influencing HRR in weightlifting, encompassing variables such as sex, age, cardiovascular function, hydration, nutrition, and psychological aspects. Finally, a key emphasis is placed on the integration of effective HRR techniques into the training regimens of weightlifters, thereby ensuring sustained and optimized performance outcomes.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.70-70
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• 2003

Estrogen receptor is a ligand-activated transcription factor. Its action depends on the receptor, its ligand, and its coactivator proteins. As a consequence, the concentration of the receptor is a major component that governs the magnitude of the estrogen response. Despite the extensive knowledge on mechanism of estrogen receptor action, regulation of estrogen receptor itself is not very well understood. Estrogen receptor is known to be downregulated under hypoxia leading to inhibition of estrogen receptor mediated transcription activation. We have studied mechanism of loss of estrogen responsiveness under hypoxia. We found that Hif-l${\alpha}$, a major transcription factor regulating hypoxic response, inhibited transcription of estrogen response element driven luciferase gene by expression of HIF-l${\alpha}$/vp16 construct designed to contain transcription activity under normoxia. This loss of estrogen responsiveness appears to be the result of ER${\alpha}$ downregulation. ER${\alpha}$was downregulated at the levels of ligand-biding and protein within l2-24h, and the response was blocked by the proteasome inhibitor MG132, protein synthesis inhibitor cyclohexamide, and tyrosine kinase inhibitor Genistein. These results demonstrate that Hif-l${\alpha}$ downregulates ER${\alpha}$ by proteasome dependent pathway.

• 운동과학
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• 제21권1호
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• pp.111-120
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• 2012

본 연구는 복부비만 여성을 대상으로 운동 트레이닝을 통해 심폐체력의 반응의 차이가 심혈관계 위험요인 및 아디포싸이토카인 분비 및 유전자 발현에 미치는 영향을 알아보는 데 그 목적이 있다. 본 연구는 운동 트레이닝 실시 후 심폐체력 향상의 유무를 이용하여 복부비만 여성 총 48명을 운동-반응 집단(n=34)과 운동-비반응 집단(n=14)으로 나누었다. 운동 트레이닝은 주당 1200kcal를 소모하도록 설계되었으며, 중등도-활발한 운동강도, 걷기나 간단한 조깅의 형태로 12주간 실시하였다. 측정 변인으로 실험 참가 전, 후에 신체조성, 혈압, 심폐체력, 혈중지질, 글루코스, 인슐린 그리고 유리지방산을 측정하였으며, 혈중 아디포싸이토카인과 복부지방 아디포싸이토카인 유전자 발현을 분석하였다. 본 연구의 결과 운동 트레이닝 후 두 집단 모두 비만지표에서 통계적으로 유의하게 감소하였지만, 허리둘레(p=0.040), 체지방률(p=0.031) 그리고 중성지방(p=0.023)과 수축기 혈압(0.046)은 운동-반응 집단과 운동-비반응 집단에서 상호작용 효과를 보였다. 혈중 렙틴은 두 집단에서 상호작용 효과(p=0.022)가 나타났으나 복부지방 렙틴 유전자는 두 집단 모두에서 트레이닝 후(p<0.001)에 유의하게 감소하였다. 이상의 결과를 종합해보면 12주간 운동 트레이닝 실시 후 심폐체력의 향상을 보인 운동-반응 집단은 운동-비반응 집단에 비해 심혈관계 질환 위험요소와 아디포싸이토카인 분비 및 유전자 발현에 더 효과적인 것으로 나타났다. 또한 운동 트레이닝 실시 후 심폐체력의 개선이 없었던 운동-비반응 집단에서도 비만지표와 혈중 렙틴 및 렙틴 유전자 발현이 감소되는 것을 살펴봤을 때 규칙적인 운동 자체가 비록 심폐체력의 개선이 없더라도 인간의 건강상의 이점을 주는 것으로 나타났다. 따라서 심폐체력이 향상되지 않더라도 규칙적인 운동 은 비만 관련 위험요인의 감소 및 예방에 좋은 영향을 주는 것으로 사료된다.