• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2063-2068
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• 2012

Aim: Liquid-based cytology is the most often used method for cervical cancer screening, but it is relatively insensitive and frequently gives equivocal results. Used as a complementary procedure, the high-risk human papillomavirus (HPV) DNA test is highly sensitive but not very specific. The human telomerase RNA gene (TERC) is the most often amplified oncogene that is observed in cervical precancerous lesions. We assessed genomic amplification of TERC in liquid-based cytological specimens to explore the optimal strategy of using this for cervical cancer screening. Methods: Six hundred and seventy-one residual cytological specimens were obtained from outpatients aged 25 to 64 years. The specimens were evaluated by the Digene Hybrid Capture 2 (HC2) HPV DNA test and fluorescence in situ hybridization (FISH) with a chromosome probe to TERC (3q26). Colposcopic examination and histological evaluation were performed where indicated. Results: The TERC positive rate was higher in the CIN2+ (CIN2, CIN3 and SCC) group than in the normal and CIN 1 groups (90.0% vs. 10.4%, p < 0.01). In comparison with the HC2 HPV DNA test, the TERC amplification test had lower sensitivity but higher specificity (90.0% vs. 100.0%, 89.6% vs. 44.0%, respectively). TERC amplification test used in conjunction with the HC2 HPV DNA test showed a combination of 90.0% sensitivity and 92.2% specificity. Conclusion: The TERC amplification test can be used to diagnose cervical precancerous lesions. TERC and HPV DNA co-testing shows an optimal combination of sensitivity and specificity for cervical cancer screening.

• 전자공학회논문지
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• 제52권6호
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• pp.117-125
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• 2015

앉아있는 시간이 긴 현대인들에게 바른 자세를 유지하도록 하는 것은 중요하다. 자세 교정을 위한 치료는 많은 시간과 비용이 소요되며, 전문의의 지속적인 관찰이 필요하다. 그러므로 사용자 스스로 자신의 자세를 판단하고 교정하기 위한 시스템이 필요하다. 본 논문에서는 사용자의 자세 데이터를 취득하여 취득된 자세가 정상자세인지 비정상자세인지 판단한다. 사용자의 자세 데이터 취득을 위해 관성 센서를 이용한 4개 관절 기반 모션캡쳐 시스템을 제안한다. 이 시스템을 통해 대상자의 자세 데이터를 취득하고, 취득한 데이터를 기반으로 특징을 추출하여 DB를 구축한다. 구축한 DB를 K-means 클러스터링 알고리즘을 이용하여 자세 학습을 수행한 후, 정상자세와 비정상자세를 분류한다. 관절의 회전각도, 위치정보, 분석정보를 이용하여 자세분류를 수행한 결과, 정상자세 판단 성공률은 99.79%로 나타났다. 이 결과로 미루어 4개 관절에 대한 특징을 이용하여 사용자의 자세를 판단 가능하며, 향후 척추질환 예방 시스템에 적용하여 사용자의 자세를 교정하는 데 도움을 줄 수 있을 것으로 판단된다.

• Geomechanics and Engineering
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• 제30권2호
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• pp.211-218
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• 2022

This study characterizes Proctor and geophysical properties in a broad range of grading and fines contents. The results show that soil index properties such as uniformity and fines plasticity control the optimum water content and peak dry unit trends, as well as elastic wave velocity. The capillary pressure at a degree of saturation less than S = 20% plays a critical role in determining the shear wave velocity for poorly graded sandy soils. The reduction in electrical resistivity with a higher water content becomes pronounced as the water phase is connected A parallel set of compaction and geophysical properties of sand-kaolinite mixtures reveal that the threshold boundaries computed from soil index properties adequately capture the transitions from sand-controlled to kaolinite-controlled behavior. In the transitional fines fraction zone between F_F ≈ 20 and 40%, either sand or kaolinite or both sand and kaolinite could dominate the geophysical properties and all other properties associated with soil compaction behavior. Overall, the compaction and geophysical data gathered in this study can be used to gain a first-order approximation of the degree of compaction in the field and produce degree of compaction maps as a function of water content and fines fraction.

• 한국동물위생학회지
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• 제42권1호
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• pp.9-15
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• 2019

Transmissible gastroenteritis (TGE) is a disease confined to pigs of all ages, and can be a significant cause of economic loss in breeding herds, primarily because of the very high piglet mortality. The causative agent is a coronavirus, an enveloped positive strand RNA virus and closely related but non-enteropathogenic porcine respiratory coronavirus (PRCV). Although the TGEV has declined with its innocent relative, PRCV, further genome changes could not be excluded. Therefore, the herd-level immunity against this virus is important for the prevention of disease and should be carefully monitored. The aim of this study is to develop monoclonal antibody capture enzyme-linked immunosorbent assay (MAC-ELISA) which can rapidly and accurately determine a large numbers of serum samples for surveillance purpose, and to compare the ELISA with a TGEV-specific serum neutralization test. The MAC-ELISA was sufficiently achieved, and the comparison with the virus-specific serum neutralization assays for 713 sera from pig farms showed a high correlation ($r^2=0.812$, P<0.001). The specificity and sensitivity of MAC-ELISA for the serum neutralization test 91.9% and 91.6%, respectively, which means that the antibody detected by the MAC-ELISA could be said to be protective antibodies. In conclusion, the developed MAC-ELISA would be very helpful in evaluating protective antibodies against TGEV.

• 방송공학회논문지
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• 제26권1호
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• pp.88-98
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• 2021

CCTV를 사용하여 저조도와 같은 열악한 환경에서도 범죄 예방 및 특정 대상을 정확히 확인하는 것이 최근 더욱 중요해지고 있다. 저조도 환경하의 CCTV 응용에서는 눈에 거슬리지 않는 근적외선 조명을 이용하여 영상을 획득하는데, 이 경우, 비록 사람 눈에는 어두운 저조도 환경이지만 근적외선 조명을 사용하기 때문에 영상의 상세 텍스처 정보를 얻을 수 있는 장점은 있지만, CCTV 영상내의 물체 판별이나 인물 확인을 위하여 매우 요긴한 정보인 색상 정보는 얻기 힘들다는 단점이 있다. 본 논문에서는 저조도 환경에서 근적외선 조명을 사용하여 얻은 CCTV 영상으로부터 DCGAN을 사용하여 색상정보를 획득하는 방법과 이때 재구성된 색상 영상에 생기는 색상 잡음을 제거하는 방법을 제시한다.

• 대한지리학회지
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• 제47권3호
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• pp.426-439
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• 2012

본 연구의 목적은 정성적인 개인의 공간 행동을 파악하고 행동 원인을 유추해 볼 수 있는 새로운 방법을 제안하는 것이다. 이동 객체의 단순한 기하학적인 움직임에 초점을 맞추는 것을 넘어서서, 사람과 환경 사이의 관계 변화 내지는 상호작용을 파악하여 이동 객체의 행동 특성을 분석할 수 있는 모델을 제시하고자 한다. 특히, 본 연구에서는 특정 지역의 경계 근처에서의 이동 객체의 움직임에 중점을 두고 분석하였다. 이동 객체의 영향력 범위를 적용하는 새로운 접근 방법을 이용하여 정성적인 개인 공간행위 특성을 파악하였다. 본 연구에서는, 이러한 객체를 시공간적으로 확장된 점(STEP)이라 명명하였으며, 그 영향력 범위를 그 객체의 위치와 함께 잠재적 사건이나 주변과의 상호작용이 가능한 구역으로 정의한다. STEP과 특정공간간의 관계 정량화를 위해, 위상 데이터 모델을 기반으로 2차원 공간에서의 특정 영역과 STEP 사이의 위상 관계를 나타내는 12 교차점 모델이 이용되었다. 이 연구에서는 이러한 STEP 개념의 관점에서, GPS추적 데이터를 이용한 프로토타입 응용 분석결과가 제공되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.91-96
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• 2012

Objectives: To determine the prevalence of HPV and cervical neoplasia among HIV-infected women in southwestern China. Methods: Cervical cytology, HPV detection by Hybrid Capture-$2^{TM}$ assay, and diagnostic colposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyze associations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinical and laboratory parameters. Results: Colposcopic-histopathologically proven CIN2+ lesions were present in 7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes. HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than women with $cells/{\mu}L$ had higher CIN2+ prevalence after adjusting for current ART status and age (adjusted OR: 6.3, 95% CI: 1.1, 36.5). Conclusions: HIV/AIDS care and treatment programs should integrate effective cervical cancer prevention services to mitigate the risk of invasive cervical cancer among HIV-infected women in China.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1925-1928
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• 2005

In recent years, the importance of the characterization of fall for a fracture prevention system keeps increasing since fracture from a fall can lead to serious health problems. Fall is one of the major sources which increase morbidity in elderly people. In terms of the cost and the influence to the quality of life, the most serious injury with hip fractures is caused by falls. The traditional methods in characterizing fall patterns have been mainly by the epidemiological surveys. With surveys, the exact data of fall patterns can not been acquired. In this paper, we measured and analyzed with the parameters related to fall pattern such as velocities and accelerations during the motion of falls using 3D motion capture program. We acquired the parameters of the fall pattern of intentional and unexpected fall. The result showed that the variation of velocity and acceleration during fall was very important in characterizing fall pattern, which of vital importance for the development of a fracture prevention system and for the safety of the elderly

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1999년도 하계종합학술대회 논문집
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• pp.1063-1066
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• 1999

The delay of cardiac depolarization wave detection in the conventional pacemakers or AICD (automatic implantable cardioverter/ defibrillator, or ICD) has been overlooked. However, it is known that the delay may cause hemodynamic problems and may prevent the proper operation of a new automatic feature, automatic capture verification, that is to be appeared in the near-future devices. In order to reduce the effects of the delay, a delay prevention algorithm was developed and tested by applying three human electrograms. The algorithm set the sensing threshold just above the measured noise level to reduce the detection delay. It is found that the low threshold was able to reduce the delay by 20msec(average) In most cases. The implementation results showed reliability and efficacy of the algorithm, and the algorithm could be applicable to the existing hardware and software of the conventional pacemakers and AICD without any significant modifications.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.891-894
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• 2014

This study is aimed to investigate the role of paired boxed gene 1 (PAX1) methylation analysis by methylation-sensitive high-resolution melting (MS-HRM) in the detection of high grade lesions in atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H) and compared its performance with the Hybrid Capture 2 (HC2) human papillomavirus (HPV) test. In our study, 130 cases with a diagnosis of ASC-H from the cervical cytological screening by Thinprep cytologic test (TCT) technique were selected for triage. Their cervical scrapings were collected and evaluated by using PAX1 methylation analysis (MS-HRM) and high-risk HPV DNA test (HC2), followed by colposcopy and cervical biopsy. Chi-square test were used to test the differences of PAX1 methylation or HPV infection between groups. In the detection of CIN2+, the sensitivity, specificity, the PPV, NPV and the accuracy of PAX1 MS-HRM assay and high-risk HPV (HR-HPV) tests were respectively 80.6% vs 67.7%, 94.9% vs 54.5%, 83.3%, vs 31.8%, 94.0% vs 84.4%, and 91.5% vs 57.7%. The PAX1 MS-HRM assay proved superior to HR-HPV testing in the detection of high grade lesions (CIN2+) in ASC-H. This approach could screen out the majority of high grade lesion cases of ASC-H, and thus could reduce the referral rate to colposcopy.