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http://dx.doi.org/10.7314/APJCP.2012.13.1.091

HPV Prevalence and Cervical Intraepithelial Neoplasia among HIV-infected Women in Yunnan Province, China: A Pilot Study  

Zhang, Hong-Yun (Kunming Medical University)
Tiggelaar, Sarah M. (Department of Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences)
Sahasrabuddhe, Vikrant V. (Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine)
Smith, Jennifer S. (Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina,)
Jiang, Cheng-Qin (Women and Children's Hospital of Luxi County)
Mei, Run-Bo (Women and Children's Hospital of Luxi County)
Wang, Xian-Guo (Women and Children's Hospital of Luxi County)
Li, Zu-An (Women and Children's Hospital of Luxi County)
Qiao, You-Lin (Department of Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.1, 2012 , pp. 91-96 More about this Journal
Abstract
Objectives: To determine the prevalence of HPV and cervical neoplasia among HIV-infected women in southwestern China. Methods: Cervical cytology, HPV detection by Hybrid Capture-$2^{TM}$ assay, and diagnostic colposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyze associations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinical and laboratory parameters. Results: Colposcopic-histopathologically proven CIN2+ lesions were present in 7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes. HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than women with had higher CIN2+ prevalence after adjusting for current ART status and age (adjusted OR: 6.3, 95% CI: 1.1, 36.5). Conclusions: HIV/AIDS care and treatment programs should integrate effective cervical cancer prevention services to mitigate the risk of invasive cervical cancer among HIV-infected women in China.
Keywords
China; HIV/AIDS; HPV; cervical cancer; screening; prevention;
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